| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | interleukin 21 receptor|The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 50615) |
| External Link | https://ncbi.nlm.nih.gov/gene/50615 |
| Similar Terms | |
| Downloads & Tools |
496 genes differentially expressed following the IL21R gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0170867 |
| NELL2 | NEL-like 2 (chicken) | 0.0126892 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.0126587 |
| IFRD2 | interferon-related developmental regulator 2 | 0.010631 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.0105808 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.0104562 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0103263 |
| ACTN1 | actinin, alpha 1 | 0.0102326 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0101245 |
| ANO10 | anoctamin 10 | 0.0100158 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00996404 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00988886 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00986027 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00975646 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.00975104 |
| ARG1 | arginase 1 | 0.00970167 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | 0.00961161 |
| KYNU | kynureninase | 0.00958091 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00929787 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00929446 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0090635 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 0.00902608 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 0.00900626 |
| ELAVL1 | ELAV like RNA binding protein 1 | 0.00898191 |
| HAL | histidine ammonia-lyase | 0.00880831 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.008806 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00872292 |
| LCN2 | lipocalin 2 | 0.00859013 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00854917 |
| WASHC4 | WASH complex subunit 4 | 0.00848812 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 0.00847413 |
| JMJD6 | jumonji domain containing 6 | 0.00846921 |
| ACP3 | acid phosphatase 3 | 0.0084625 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00841913 |
| ELANE | elastase, neutrophil expressed | 0.0082454 |
| SAMHD1 | SAM domain and HD domain 1 | 0.00819539 |
| DNTT | DNA nucleotidylexotransferase | 0.00812519 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.0081157 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00809268 |
| TCEAL2 | transcription elongation factor A (SII)-like 2 | 0.0080729 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00804134 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.00803548 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00786114 |
| SELL | selectin L | 0.00777404 |
| LST1 | leukocyte specific transcript 1 | 0.00776641 |
| WDR7 | WD repeat domain 7 | 0.00766733 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00766522 |
| IL7R | interleukin 7 receptor | 0.00766167 |
| HOMER2 | homer scaffolding protein 2 | 0.00760739 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 0.00757696 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.00756904 |
| CA2 | carbonic anhydrase II | 0.00751463 |
| ANXA3 | annexin A3 | 0.00748465 |
| MYRF | myelin regulatory factor | 0.00742588 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00738765 |
| S100A7 | S100 calcium binding protein A7 | 0.00737934 |
| CDK14 | cyclin-dependent kinase 14 | 0.00736759 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00733923 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00729441 |
| AK4 | adenylate kinase 4 | 0.00716736 |
| CNPY3 | canopy FGF signaling regulator 3 | 0.00714968 |
| CCR2 | chemokine (C-C motif) receptor 2 | 0.0071333 |
| RNF167 | ring finger protein 167 | 0.00705485 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00701852 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00698558 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00698392 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00697663 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00695812 |
| AOX1 | aldehyde oxidase 1 | 0.0069541 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00694559 |
| FAM111A | family with sequence similarity 111, member A | 0.00687938 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.00681524 |
| TARP | TCR gamma alternate reading frame protein | 0.0068059 |
| BLVRB | biliverdin reductase B | 0.00678169 |
| MSL1 | male-specific lethal 1 homolog (Drosophila) | 0.00675518 |
| FOXO1 | forkhead box O1 | 0.00675198 |
| MKI67 | marker of proliferation Ki-67 | 0.00675084 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00669825 |
| DEFB1 | defensin, beta 1 | 0.00668117 |
| ZNF91 | zinc finger protein 91 | 0.00667657 |
| ACP6 | acid phosphatase 6, lysophosphatidic | 0.00667425 |
| ZNF200 | zinc finger protein 200 | 0.00667286 |
| CHEK2 | checkpoint kinase 2 | 0.00666423 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.00661339 |
| TGFB3 | transforming growth factor, beta 3 | 0.00661262 |
| LYST | lysosomal trafficking regulator | 0.00660723 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00660481 |
| CCK | cholecystokinin | 0.00655549 |
| RNF130 | ring finger protein 130 | 0.00650928 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.00650147 |
| KIF1B | kinesin family member 1B | 0.0064964 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.00649133 |
| SLAMF7 | SLAM family member 7 | 0.00648312 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | 0.00647656 |
| BID | BH3 interacting domain death agonist | 0.00647546 |
| GSTT1 | glutathione S-transferase theta 1 | 0.00646838 |
| ZNF318 | zinc finger protein 318 | 0.00643195 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00641958 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.0064002 |
| BNC2 | basonuclin 2 | 0.00632458 |
| OCRL | oculocerebrorenal syndrome of Lowe | 0.00632081 |
| C7 | complement component 7 | 0.00629268 |
| AASS | aminoadipate-semialdehyde synthase | 0.00624226 |
| PRKCA | protein kinase C, alpha | 0.00623521 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00622464 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.00621275 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | 0.00620223 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 0.0062019 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 0.00617689 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00615041 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.00614996 |
| HK3 | hexokinase 3 (white cell) | 0.00611831 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.00611543 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00610865 |
| LYZ | lysozyme | 0.00606771 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.00605408 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.00600599 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | 0.00600527 |
| MSRB1 | methionine sulfoxide reductase B1 | 0.00600505 |
| CDSN | corneodesmosin | 0.00597681 |
| TFF1 | trefoil factor 1 | 0.00596368 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 0.00595452 |
| PXDN | peroxidasin | 0.00595397 |
| CYP4F2 | cytochrome P450, family 4, subfamily F, polypeptide 2 | 0.00594914 |
| FHOD3 | formin homology 2 domain containing 3 | 0.00594873 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.00593209 |
| MMP10 | matrix metallopeptidase 10 | 0.00590805 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.00588916 |
| IL6ST | interleukin 6 signal transducer | 0.00587668 |
| GLG1 | golgi glycoprotein 1 | 0.00587498 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00584679 |
| FAR2 | fatty acyl CoA reductase 2 | 0.00581216 |
| LOX | lysyl oxidase | 0.00579586 |
| PTGES | prostaglandin E synthase | 0.00579455 |
| KLK10 | kallikrein-related peptidase 10 | 0.00578826 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00578799 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00577245 |
| SERINC3 | serine incorporator 3 | 0.00576734 |
| TMC5 | transmembrane channel-like 5 | 0.0057497 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.00573583 |
| RNASEH2A | ribonuclease H2, subunit A | 0.00571533 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.0057124 |
| EPN2 | epsin 2 | 0.0057105 |
| NANOG | Nanog homeobox | 0.00570807 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.0056995 |
| CLEC4A | C-type lectin domain family 4, member A | 0.00569357 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0056812 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.00567679 |
| SLC16A2 | solute carrier family 16, member 2 (thyroid hormone transporter) | 0.00567494 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.00566661 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 0.00563659 |
| MRPL57 | mitochondrial ribosomal protein L57 | 0.00562039 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.00561052 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.00560492 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00559485 |
| PRKCB | protein kinase C, beta | 0.00556949 |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.00555561 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00554463 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.00554407 |
| SLC12A8 | solute carrier family 12, member 8 | 0.00553732 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.00553134 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.00552859 |
| RBM39 | RNA binding motif protein 39 | 0.00552648 |
| CDA | cytidine deaminase | 0.00550232 |
| ZNF432 | zinc finger protein 432 | 0.00550053 |
| CDC42SE1 | CDC42 small effector 1 | 0.00548945 |
| NDC1 | NDC1 transmembrane nucleoporin | 0.00547837 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.00546927 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00546518 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 0.00545679 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00543091 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.00541993 |
| NTS | neurotensin | 0.00541049 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | 0.0054072 |
| BMP4 | bone morphogenetic protein 4 | 0.0053959 |
| SIRPA | signal-regulatory protein alpha | 0.00538836 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0053746 |
| WDR43 | WD repeat domain 43 | 0.00537306 |
| CALML5 | calmodulin-like 5 | 0.00536768 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.00536214 |
| SHTN1 | shootin 1 | 0.00535533 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 0.00535438 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.00533722 |
| CD2 | CD2 molecule | 0.00533656 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.0053225 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 0.00531947 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.00530623 |
| CLGN | calmegin | 0.00530433 |
| S100A12 | S100 calcium binding protein A12 | 0.00529575 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.00529488 |
| PLBD1 | phospholipase B domain containing 1 | 0.00528811 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.00528707 |
| ZYX | zyxin | 0.00528702 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.00528237 |
| STX10 | syntaxin 10 | 0.00526274 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00524567 |
| HEATR1 | HEAT repeat containing 1 | 0.00524324 |
| PDZD2 | PDZ domain containing 2 | 0.00521604 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00521208 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00519773 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00519621 |
| PRKD1 | protein kinase D1 | 0.00519345 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00517935 |
| NOP16 | NOP16 nucleolar protein | 0.00517714 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00516772 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00516444 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00515998 |
| CFI | complement factor I | 0.00514428 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.00512556 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00510408 |
| SALL1 | spalt-like transcription factor 1 | 0.00508323 |
| VAMP5 | vesicle-associated membrane protein 5 | 0.00506465 |
| INSR | insulin receptor | 0.00505968 |
| AXL | AXL receptor tyrosine kinase | 0.00505198 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00504938 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00504755 |
| CORO1C | coronin, actin binding protein, 1C | 0.00504506 |
| MGAM | maltase-glucoamylase | 0.00504076 |
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 0.00503235 |
| MYDGF | myeloid-derived growth factor | 0.00503206 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00502249 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00502101 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00501206 |
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 0.00498581 |
| ODAM | odontogenic, ameloblast asssociated | 0.00497076 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.00496767 |
| REG1A | regenerating islet-derived 1 alpha | 0.00495633 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.00495196 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | 0.00494024 |
| EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 | 0.00493456 |
| LTA4H | leukotriene A4 hydrolase | 0.0049298 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00492812 |
| MMD | monocyte to macrophage differentiation-associated | 0.00492556 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.00491623 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.00489869 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.00489421 |
| IRF8 | interferon regulatory factor 8 | 0.00488963 |
| IRS2 | insulin receptor substrate 2 | 0.00488937 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.00488883 |
| CHRDL1 | chordin-like 1 | 0.00488713 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.00488412 |
| PRTN3 | proteinase 3 | 0.00488127 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.00487495 |
| ATXN7L3B | ataxin 7-like 3B | 0.00487008 |
| NVL | nuclear VCP-like | 0.00486967 |
| SET | SET nuclear proto-oncogene | 0.00486665 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.0048656 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.00486542 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.031318 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0216121 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0160464 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0157319 |
| KRT19 | keratin 19, type I | -0.0153557 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.0137866 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.0134188 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.0132285 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0130002 |
| GNAS | GNAS complex locus | -0.0127397 |
| PMP22 | peripheral myelin protein 22 | -0.0126618 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.0122378 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.012062 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0119836 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0118918 |
| IL6 | interleukin 6 | -0.0118536 |
| ADIRF | adipogenesis regulatory factor | -0.0118444 |
| ECM1 | extracellular matrix protein 1 | -0.0116195 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.0114685 |
| MAGEA3 | melanoma antigen family A3 | -0.0114427 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0111374 |
| PEG10 | paternally expressed 10 | -0.0110673 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.0108531 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.0107411 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.0107263 |
| RTN2 | reticulon 2 | -0.0107073 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.0106716 |
| CLEC3B | C-type lectin domain family 3, member B | -0.0104689 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.0104654 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.0104387 |
| TXLNA | taxilin alpha | -0.0104341 |
| HOPX | HOP homeobox | -0.0103514 |
| C1QB | complement component 1, q subcomponent, B chain | -0.010221 |
| KRT5 | keratin 5, type II | -0.0100824 |
| NNMT | nicotinamide N-methyltransferase | -0.0100343 |
| C1QA | complement component 1, q subcomponent, A chain | -0.0100277 |
| APOD | apolipoprotein D | -0.00999586 |
| PROM1 | prominin 1 | -0.00996941 |
| SIK1 | salt-inducible kinase 1 | -0.00996931 |
| STXBP2 | syntaxin binding protein 2 | -0.00996774 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00979763 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.00969521 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00959691 |
| CTSD | cathepsin D | -0.0095293 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00952494 |
| RNF19B | ring finger protein 19B | -0.00947101 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | -0.00940558 |
| BEX4 | brain expressed, X-linked 4 | -0.00939049 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00931471 |
| EFHD1 | EF-hand domain family, member D1 | -0.00930147 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00922508 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00913834 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00906919 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | -0.00903291 |
| RGCC | regulator of cell cycle | -0.00901091 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00888332 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00884984 |
| XIC | X chromosome inactivation center | -0.00884787 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00872875 |
| STAB1 | stabilin 1 | -0.00868072 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00863734 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00863076 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00853005 |
| TAC1 | tachykinin, precursor 1 | -0.00850164 |
| ANGPT1 | angiopoietin 1 | -0.00845874 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.00845579 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00839425 |
| MB | myoglobin | -0.00837841 |
| PERP | PERP, TP53 apoptosis effector | -0.00835037 |
| SLC16A6 | solute carrier family 16, member 6 | -0.00833672 |
| WASL | Wiskott-Aldrich syndrome-like | -0.00832895 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00828886 |
| GGT1 | gamma-glutamyltransferase 1 | -0.00825093 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.00823289 |
| OLFML2A | olfactomedin-like 2A | -0.00819308 |
| MMP1 | matrix metallopeptidase 1 | -0.00818335 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00816082 |
| PLXND1 | plexin D1 | -0.00813792 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00812338 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00809561 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00805977 |
| LAMA5 | laminin, alpha 5 | -0.00803499 |
| LAMB1 | laminin, beta 1 | -0.00802074 |
| SQLE | squalene epoxidase | -0.00796453 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00795603 |
| KRT6B | keratin 6B, type II | -0.00791478 |
| SMAD7 | SMAD family member 7 | -0.00789484 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.00788796 |
| FOLR1 | folate receptor 1 (adult) | -0.0078842 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.00788367 |
| TSPAN13 | tetraspanin 13 | -0.0078826 |
| SMYD3 | SET and MYND domain containing 3 | -0.00787339 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00782742 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00781211 |
| S100A11 | S100 calcium binding protein A11 | -0.0077988 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.0077975 |
| POSTN | periostin, osteoblast specific factor | -0.00778094 |
| SGCE | sarcoglycan, epsilon | -0.00777928 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00776151 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00775585 |
| THBD | thrombomodulin | -0.00774844 |
| MEIS1 | Meis homeobox 1 | -0.00771552 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -0.00770559 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00770466 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.00770035 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00769737 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00768209 |
| EMP1 | epithelial membrane protein 1 | -0.0076737 |
| NEFM | neurofilament, medium polypeptide | -0.00766979 |
| ITM2A | integral membrane protein 2A | -0.00764788 |
| CLU | clusterin | -0.00764028 |
| PRKCZ | protein kinase C, zeta | -0.00758016 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00755208 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.00755205 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.0075378 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.0074967 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00749078 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.00747103 |
| SPAG6 | sperm associated antigen 6 | -0.00746674 |
| CHGB | chromogranin B | -0.00742899 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00740298 |
| DUSP5 | dual specificity phosphatase 5 | -0.00735776 |
| KRT6A | keratin 6A, type II | -0.0073524 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00733284 |
| EPS8L2 | EPS8-like 2 | -0.00730587 |
| PDGFD | platelet derived growth factor D | -0.00729556 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00728843 |
| CCNA2 | cyclin A2 | -0.00727207 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00726117 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00725784 |
| HMGB3 | high mobility group box 3 | -0.00724744 |
| DSP | desmoplakin | -0.00723282 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00722148 |
| AHR | aryl hydrocarbon receptor | -0.00718732 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.00717375 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | -0.00714738 |
| LUM | lumican | -0.00713249 |
| SLC27A6 | solute carrier family 27 (fatty acid transporter), member 6 | -0.00712722 |
| KRT17 | keratin 17, type I | -0.00710987 |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 | -0.00709722 |
| FAM189A2 | family with sequence similarity 189, member A2 | -0.00707872 |
| TTN | titin | -0.00707183 |
| KAZN | kazrin, periplakin interacting protein | -0.00703974 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.00699512 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.00697477 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00695747 |
| CCNG2 | cyclin G2 | -0.00694844 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00694002 |
| RGS1 | regulator of G-protein signaling 1 | -0.00690774 |
| SIKE1 | suppressor of IKBKE 1 | -0.00690569 |
| IER5 | immediate early response 5 | -0.00688161 |
| STK26 | serine/threonine protein kinase 26 | -0.00688065 |
| TXNIP | thioredoxin interacting protein | -0.00687871 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00686399 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.006845 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00681393 |
| KRT14 | keratin 14, type I | -0.00681009 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00680965 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00680301 |
| MAOA | monoamine oxidase A | -0.00677954 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.00674201 |
| MACROD1 | MACRO domain containing 1 | -0.00673785 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00671059 |
| RGS16 | regulator of G-protein signaling 16 | -0.00670262 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00669263 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00663979 |
| EXPH5 | exophilin 5 | -0.00662757 |
| COL2A1 | collagen, type II, alpha 1 | -0.00662585 |
| DCLK1 | doublecortin-like kinase 1 | -0.00662232 |
| CD34 | CD34 molecule | -0.00661158 |
| PKM | pyruvate kinase, muscle | -0.00659162 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00658677 |
| IL1B | interleukin 1, beta | -0.00658462 |
| RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | -0.00657286 |
| KRT7 | keratin 7, type II | -0.00654846 |
| SCPEP1 | serine carboxypeptidase 1 | -0.00653341 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.00651836 |
| PXDC1 | PX domain containing 1 | -0.00649517 |
| CD14 | CD14 molecule | -0.00645733 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00642531 |
| ISL1 | ISL LIM homeobox 1 | -0.00641796 |
| BTG2 | BTG family, member 2 | -0.00641533 |
| TCF4 | transcription factor 4 | -0.00639177 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00638591 |
| AEBP1 | AE binding protein 1 | -0.00638191 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.00637878 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00634378 |
| CHMP2A | charged multivesicular body protein 2A | -0.00633032 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | -0.00631812 |
| COLEC12 | collectin sub-family member 12 | -0.0063166 |
| MYLIP | myosin regulatory light chain interacting protein | -0.00628767 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0062784 |
| PKP1 | plakophilin 1 | -0.00627675 |
| MAGED1 | melanoma antigen family D1 | -0.00627384 |
| BICC1 | BicC family RNA binding protein 1 | -0.00626189 |
| AUTS2 | autism susceptibility candidate 2 | -0.00625292 |
| TRIM8 | tripartite motif containing 8 | -0.00624399 |
| TSPAN12 | tetraspanin 12 | -0.00623952 |
| PLXNA2 | plexin A2 | -0.00620001 |
| RET | ret proto-oncogene | -0.00619966 |
| TAGLN | transgelin | -0.0061738 |
| GGTLC1 | gamma-glutamyltransferase light chain 1 | -0.00615943 |
| NFASC | neurofascin | -0.00615078 |
| KRT18 | keratin 18, type I | -0.00614817 |
| STMN2 | stathmin 2 | -0.00612764 |
| RAD21 | RAD21 homolog (S. pombe) | -0.00611223 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.00609588 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00608772 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.00608532 |
| WBP5 | WW domain binding protein 5 | -0.00606935 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.0060376 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.00603692 |
| CD163 | CD163 molecule | -0.00603675 |
| TOB1 | transducer of ERBB2, 1 | -0.0060323 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.00602691 |
| EVA1B | eva-1 homolog B (C. elegans) | -0.00601401 |
| NRIP3 | nuclear receptor interacting protein 3 | -0.00598026 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -0.00597548 |
| FGF9 | fibroblast growth factor 9 | -0.0059714 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.00595744 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -0.00592754 |
| MTMR1 | myotubularin related protein 1 | -0.00591115 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.00591054 |
| PTK2B | protein tyrosine kinase 2 beta | -0.00589882 |
| VAMP2 | vesicle-associated membrane protein 2 (synaptobrevin 2) | -0.00589626 |
| NPEPL1 | aminopeptidase-like 1 | -0.00588733 |
| CHKB | choline kinase beta | -0.00588669 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00587878 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.0058679 |
| BCL7B | B-cell CLL/lymphoma 7B | -0.0058496 |
| COIL | coilin | -0.00581594 |
| DLX5 | distal-less homeobox 5 | -0.00581291 |
| MACROH2A1 | macroH2A.1 histone | -0.0058049 |
| PRAME | preferentially expressed antigen in melanoma | -0.00579471 |
| TRIM29 | tripartite motif containing 29 | -0.00579239 |
| ADRA2A | adrenoceptor alpha 2A | -0.0057769 |
| INSM1 | insulinoma-associated 1 | -0.00575902 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.00574729 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00573917 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00573793 |
| CHN2 | chimerin 2 | -0.00572859 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.00572142 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | -0.00570678 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00570255 |
| PLTP | phospholipid transfer protein | -0.00569796 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.00569054 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -0.00568293 |
| NOTCH1 | notch 1 | -0.00568028 |
