IL2RB Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interleukin 2 receptor, beta|The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3560)
External Link http://www.ncbi.nlm.nih.gov/gene/3560
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Genes

95 interacting proteins for IL2RB from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ADAP1 ArfGAP with dual PH domains 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APC adenomatous polyposis coli
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF6 ADP-ribosylation factor 6
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
B2M beta-2-microglobulin
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
CD247 CD247 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD8A CD8a molecule
CD8B CD8b molecule
CISH cytokine inducible SH2-containing protein
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
EIF3B eukaryotic translation initiation factor 3, subunit B
EPS8 epidermal growth factor receptor pathway substrate 8
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRB2 growth factor receptor-bound protein 2
GSN gelsolin
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HLA-A major histocompatibility complex, class I, A
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LCK LCK proto-oncogene, Src family tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCKAP1 NCK-associated protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
SGK1 serum/glucocorticoid regulated kinase 1
SGMS1 sphingomyelin synthase 1
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLA2 Src-like-adaptor 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
UBC ubiquitin C
UGCG UDP-glucose ceramide glucosyltransferase
VAV2 vav 2 guanine nucleotide exchange factor
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2