| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/IL2_UP.V1_UP |
| Similar Terms | |
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383 genes differentially expressed following the IL2_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| AATK | apoptosis-associated tyrosine kinase |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 |
| ADAM19 | ADAM metallopeptidase domain 19 |
| AHR | aryl hydrocarbon receptor |
| AIM2 | absent in melanoma 2 |
| AK4P3 | adenylate kinase 4 pseudogene 3 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 |
| ANXA2P1 | annexin A2 pseudogene 1 |
| AP3M2 | adaptor-related protein complex 3, mu 2 subunit |
| ASCL3 | achaete-scute family bHLH transcription factor 3 |
| ASPA | aspartoacylase |
| ATG101 | autophagy related 101 |
| BMP2 | bone morphogenetic protein 2 |
| BTC | betacellulin |
| C10ORF2 | chromosome 10 open reading frame 2 |
| C11ORF80 | chromosome 11 open reading frame 80 |
| CALML4 | calmodulin-like 4 |
| CAPN10 | calpain 10 |
| CCDC85B | coiled-coil domain containing 85B |
| CCR4 | chemokine (C-C motif) receptor 4 |
| CD3EAP | CD3e molecule, epsilon associated protein |
| CD52 | CD52 molecule |
| CD69 | CD69 molecule |
| CDC25A | cell division cycle 25A |
| CDCP1 | CUB domain containing protein 1 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) |
| CISH | cytokine inducible SH2-containing protein |
| CLDN5 | claudin 5 |
| CNKSR2 | connector enhancer of kinase suppressor of Ras 2 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 |
| DGKG | diacylglycerol kinase, gamma 90kDa |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 |
| DUSP2 | dual specificity phosphatase 2 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP6 | dual specificity phosphatase 6 |
| EGR1 | early growth response 1 |
| EGR2 | early growth response 2 |
| EGR3 | early growth response 3 |
| EHD2 | EH-domain containing 2 |
| ELMO3 | engulfment and cell motility 3 |
| ESRP2 | epithelial splicing regulatory protein 2 |
| EVPL | envoplakin |
| EVX1 | even-skipped homeobox 1 |
| F2RL2 | coagulation factor II (thrombin) receptor-like 2 |
| FAM57A | family with sequence similarity 57, member A |
| FLT1 | fms-related tyrosine kinase 1 |
| FLT3LG | fms-related tyrosine kinase 3 ligand |
| FOS | FBJ murine osteosarcoma viral oncogene homolog |
| FOSL1 | FOS-like antigen 1 |
| FOSL2 | FOS-like antigen 2 |
| FOXP3 | forkhead box P3 |
| FZD5 | frizzled class receptor 5 |
| GABARAPL3 | GABA(A) receptors associated protein like 3, pseudogene |
| GABRB3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 |
| GADD45B | growth arrest and DNA-damage-inducible, beta |
| GALNT8 | polypeptide N-acetylgalactosaminyltransferase 8 |
| GFAP | glial fibrillary acidic protein |
| GNRH2 | gonadotropin-releasing hormone 2 |
| GPT | glutamic-pyruvate transaminase (alanine aminotransferase) |
| HABP4 | hyaluronan binding protein 4 |
| HEG1 | heart development protein with EGF-like domains 1 |
| HK2 | hexokinase 2 |
| HOXA11 | homeobox A11 |
| HTR4 | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled |
| IFNW1 | interferon, omega 1 |
| IL10 | interleukin 10 |
| IL13 | interleukin 13 |
| IL18RAP | interleukin 18 receptor accessory protein |
| IL1A | interleukin 1, alpha |
| IL5 | interleukin 5 |
| INHBB | inhibin, beta B |
| INSR | insulin receptor |
| IQCG | IQ motif containing G |
| IRS1 | insulin receptor substrate 1 |
| ITGA9 | integrin, alpha 9 |
| JUNB | jun B proto-oncogene |
| KCNA3 | potassium channel, voltage gated shaker related subfamily A, member 3 |
| KCNE5 | potassium channel, voltage gated subfamily E regulatory beta subunit 5 |
| KCNG1 | potassium channel, voltage gated modifier subfamily G, member 1 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 |
| KCTD12 | potassium channel tetramerization domain containing 12 |
| KIF13A | kinesin family member 13A |
| KIF1C | kinesin family member 1C |
| KIF21B | kinesin family member 21B |
| KIR2DL5A | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A |
| KLF6 | Kruppel-like factor 6 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 |
| LGALSL | lectin, galactoside-binding-like |
| LIF | leukemia inhibitory factor |
| LILRB4 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
| LRRC6 | leucine rich repeat containing 6 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAGIX | MAGI family member, X-linked |
| MEGF6 | multiple EGF-like-domains 6 |
| MFSD12 | major facilitator superfamily domain containing 12 |
| MPP6 | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) |
| NCS1 | neuronal calcium sensor 1 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 |
| OR10J1 | olfactory receptor, family 10, subfamily J, member 1 |
| OR6A2 | olfactory receptor, family 6, subfamily A, member 2 |
| OR7E47P | olfactory receptor, family 7, subfamily E, member 47 pseudogene |
| OSM | oncostatin M |
| PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 |
| PDE4A | phosphodiesterase 4A, cAMP-specific |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase |
| PIP | prolactin-induced protein |
| PLEC | plectin |
| PLXNA3 | plexin A3 |
| PMM2 | phosphomannomutase 2 |
| POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) |
| PPAP2C | phosphatidic acid phosphatase type 2C |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 |
| PQLC2 | PQ loop repeat containing 2 |
| PRAF2 | PRA1 domain family, member 2 |
| PRKCD | protein kinase C, delta |
| PRR7 | proline rich 7 (synaptic) |
| PRSS50 | protease, serine, 50 |
| PTCH1 | patched 1 |
| PTH1R | parathyroid hormone 1 receptor |
| PTPN7 | protein tyrosine phosphatase, non-receptor type 7 |
| PUS1 | pseudouridylate synthase 1 |
| PUS7 | pseudouridylate synthase 7 (putative) |
| PYCRL | pyrroline-5-carboxylate reductase-like |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| REST | RE1-silencing transcription factor |
| RGCC | regulator of cell cycle |
| RGS16 | regulator of G-protein signaling 16 |
| RGS3 | regulator of G-protein signaling 3 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) |
| RHOB | ras homolog family member B |
| RNF144A | ring finger protein 144A |
| RNF20 | ring finger protein 20, E3 ubiquitin protein ligase |
| RPA4 | replication protein A4, 30kDa |
| RPP25 | ribonuclease P/MRP 25kDa subunit |
| RRP7BP | ribosomal RNA processing 7 homolog B (S. cerevisiae), pseudogene |
| RSPH6A | radial spoke head 6 homolog A (Chlamydomonas) |
| SH2D4A | SH2 domain containing 4A |
| SIGLEC9 | sialic acid binding Ig-like lectin 9 |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
| SLC34A1 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 |
| SOCS1 | suppressor of cytokine signaling 1 |
| SOCS2 | suppressor of cytokine signaling 2 |
| SPATA2L | spermatogenesis associated 2-like |
| SPHK1 | sphingosine kinase 1 |
| SPP1 | secreted phosphoprotein 1 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| STX11 | syntaxin 11 |
| TAS2R16 | taste receptor, type 2, member 16 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) |
| TEX13A | testis expressed 13A |
| TLR3 | toll-like receptor 3 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TM4SF5 | transmembrane 4 L six family member 5 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| TMPRSS6 | transmembrane protease, serine 6 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A |
| TNFRSF1B | tumor necrosis factor receptor superfamily, member 1B |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 |
| TNFRSF4 | tumor necrosis factor receptor superfamily, member 4 |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 |
| TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 |
| TPBG | trophoblast glycoprotein |
| TRIB1 | tribbles pseudokinase 1 |
| TRMU | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase |
| TTTY1 | testis-specific transcript, Y-linked 1 (non-protein coding) |
| URB2 | URB2 ribosome biogenesis 2 homolog (S. cerevisiae) |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) |
| USP36 | ubiquitin specific peptidase 36 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor |
| VSNL1 | visinin-like 1 |
| WDR62 | WD repeat domain 62 |
| WISP3 | WNT1 inducible signaling pathway protein 3 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing |
| ZBTB32 | zinc finger and BTB domain containing 32 |
| ZNF215 | zinc finger protein 215 |
| ZNF343 | zinc finger protein 343 |
| Symbol | Name |
|---|---|
| A4GNT | alpha-1,4-N-acetylglucosaminyltransferase |
| ABCD2 | ATP-binding cassette, sub-family D (ALD), member 2 |
| ACF | Asymmetric crying facies (Cayler cardiofacial syndrome) |
| ACPP | acid phosphatase, prostate |
| ADAM2 | ADAM metallopeptidase domain 2 |
| AGBL2 | ATP/GTP binding protein-like 2 |
| AIM1L | absent in melanoma 1-like |
| AIRE | autoimmune regulator |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase |
| AMELY | amelogenin, Y-linked |
| APOBEC1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 |
| ARHGAP6 | Rho GTPase activating protein 6 |
| ARL4C | ADP-ribosylation factor-like 4C |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 |
| ASPHD1 | aspartate beta-hydroxylase domain containing 1 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 |
| BTN3A1 | butyrophilin, subfamily 3, member A1 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit |
| CACNG3 | calcium channel, voltage-dependent, gamma subunit 3 |
| CAMK1G | calcium/calmodulin-dependent protein kinase IG |
| CBLN1 | cerebellin 1 precursor |
| CCDC64 | coiled-coil domain containing 64 |
| CCDC81 | coiled-coil domain containing 81 |
| CCNG2 | cyclin G2 |
| CD160 | CD160 molecule |
| CD34 | CD34 molecule |
| CD72 | CD72 molecule |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CEL | carboxyl ester lipase |
| CFAP44 | cilia and flagella associated protein 44 |
| CHGB | chromogranin B |
| CHRNB4 | cholinergic receptor, nicotinic, beta 4 (neuronal) |
| CLCA1 | chloride channel accessory 1 |
| CLDN16 | claudin 16 |
| CLEC2B | C-type lectin domain family 2, member B |
| CNR2 | cannabinoid receptor 2 (macrophage) |
| CNTD2 | cyclin N-terminal domain containing 2 |
| COLQ | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase |
| CST1 | cystatin SN |
| CUX2 | cut-like homeobox 2 |
| CXCR2 | chemokine (C-X-C motif) receptor 2 |
| CXORF21 | chromosome X open reading frame 21 |
| CYP46A1 | cytochrome P450, family 46, subfamily A, polypeptide 1 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
| DEPTOR | DEP domain containing MTOR-interacting protein |
| DLEC1 | deleted in lung and esophageal cancer 1 |
| EFNA4 | ephrin-A4 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 |
| EVI2A | ecotropic viral integration site 2A |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 |
| F13B | coagulation factor XIII, B polypeptide |
| FAM110B | family with sequence similarity 110, member B |
| FAM124B | family with sequence similarity 124B |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
| FLT3 | fms-related tyrosine kinase 3 |
| FUT9 | fucosyltransferase 9 (alpha (1,3) fucosyltransferase) |
| FZD2 | frizzled class receptor 2 |
| FZD3 | frizzled class receptor 3 |
| GALR3 | galanin receptor 3 |
| GDF5 | growth differentiation factor 5 |
| GOLPH3L | golgi phosphoprotein 3-like |
| GPRC5D | G protein-coupled receptor, class C, group 5, member D |
| GPX2 | glutathione peroxidase 2 |
| GUCY1A2 | guanylate cyclase 1, soluble, alpha 2 |
| H2AFJ | H2A histone family, member J |
| H2AFY2 | H2A histone family, member Y2 |
| HBP1 | HMG-box transcription factor 1 |
| HDAC5 | histone deacetylase 5 |
| HHIPL2 | HHIP-like 2 |
| HIST1H2AG | histone cluster 1, H2ag |
| HIST1H3C | histone cluster 1, H3c |
| HKDC1 | hexokinase domain containing 1 |
| HNRNPA3P1 | heterogeneous nuclear ribonucleoprotein A3 pseudogene 1 |
| HOXA5 | homeobox A5 |
| HSF2BP | heat shock transcription factor 2 binding protein |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled |
| IL18 | interleukin 18 |
| IL25 | interleukin 25 |
| INHA | inhibin, alpha |
| ISL1 | ISL LIM homeobox 1 |
| JCHAIN | joining chain of multimeric IgA and IgM |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like |
| KCNS1 | potassium voltage-gated channel, modifier subfamily S, member 1 |
| KDM5D | lysine (K)-specific demethylase 5D |
| KIAA0319L | KIAA0319-like |
| KIAA1462 | KIAA1462 |
| KLHDC8A | kelch domain containing 8A |
| LINC00302 | long intergenic non-protein coding RNA 302 |
| LINC00472 | long intergenic non-protein coding RNA 472 |
| LINC01558 | long intergenic non-protein coding RNA 1558 |
| LIPF | lipase, gastric |
| LRP2BP | LRP2 binding protein |
| LRRC37A | leucine rich repeat containing 37A |
| MAB21L2 | mab-21-like 2 (C. elegans) |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 |
| MARC1 | mitochondrial amidoxime reducing component 1 |
| MARC2 | mitochondrial amidoxime reducing component 2 |
| MEOX1 | mesenchyme homeobox 1 |
| METTL7A | methyltransferase like 7A |
| MISP | mitotic spindle positioning |
| MLLT4-AS1 | MLLT4 antisense RNA 1 (head to head) |
| MMP7 | matrix metallopeptidase 7 |
| MOGAT2 | monoacylglycerol O-acyltransferase 2 |
| MYCT1 | myc target 1 |
| MYLK | myosin light chain kinase |
| NACAD | NAC alpha domain containing |
| NAP1L2 | nucleosome assembly protein 1-like 2 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 |
| NKX3-2 | NK3 homeobox 2 |
| NR1I2 | nuclear receptor subfamily 1, group I, member 2 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 |
| NXF2 | nuclear RNA export factor 2 |
| ODAM | odontogenic, ameloblast asssociated |
| P2RY4 | pyrimidinergic receptor P2Y, G-protein coupled, 4 |
| PAK3 | p21 protein (Cdc42/Rac)-activated kinase 3 |
| PBX1 | pre-B-cell leukemia homeobox 1 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa |
| PDE6B | phosphodiesterase 6B, cGMP-specific, rod, beta |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) |
| PLCD1 | phospholipase C, delta 1 |
| PLCH1 | phospholipase C, eta 1 |
| PLCL1 | phospholipase C-like 1 |
| PLEK | pleckstrin |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| POU2AF1 | POU class 2 associating factor 1 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma |
| PRKG1 | protein kinase, cGMP-dependent, type I |
| PROM1 | prominin 1 |
| PRSS16 | protease, serine, 16 (thymus) |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 |
| RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
| RASL12 | RAS-like, family 12 |
| REC114 | REC114 meiotic recombination protein |
| RGS2 | regulator of G-protein signaling 2 |
| RHOBTB1 | Rho-related BTB domain containing 1 |
| RIN2 | Ras and Rab interactor 2 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) |
| RORB | RAR-related orphan receptor B |
| RPL3L | ribosomal protein L3-like |
| SARNP | SAP domain containing ribonucleoprotein |
| SCGB2A2 | secretoglobin, family 2A, member 2 |
| SCHIP1 | schwannomin interacting protein 1 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit |
| SDCCAG8 | serologically defined colon cancer antigen 8 |
| SEC14L2 | SEC14-like 2 (S. cerevisiae) |
| SEMA6D | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D |
| SESN1 | sestrin 1 |
| SLA | Src-like-adaptor |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 |
| SLC24A1 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 |
| SLN | sarcolipin |
| SNAI2 | snail family zinc finger 2 |
| SNPH | syntaphilin |
| SPATA1 | spermatogenesis associated 1 |
| SSTR5 | somatostatin receptor 5 |
| SULT1B1 | sulfotransferase family, cytosolic, 1B, member 1 |
| SYT1 | synaptotagmin I |
| TAGLN3 | transgelin 3 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 |
| TEK | TEK tyrosine kinase, endothelial |
| TG | thyroglobulin |
| TGM3 | transglutaminase 3 |
| THAP10 | THAP domain containing 10 |
| TMEM140 | transmembrane protein 140 |
| TMEM19 | transmembrane protein 19 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 |
| TNNT3 | troponin T type 3 (skeletal, fast) |
| TNS3 | tensin 3 |
| TRIB2 | tribbles pseudokinase 2 |
| TRPM1 | transient receptor potential cation channel, subfamily M, member 1 |
| TSPAN7 | tetraspanin 7 |
| TTC23 | tetratricopeptide repeat domain 23 |
| TXNIP | thioredoxin interacting protein |
| UNC93B1 | unc-93 homolog B1 (C. elegans) |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked |
| VILL | villin-like |
| WSCD2 | WSC domain containing 2 |
| ZNF230 | zinc finger protein 230 |
| ZNF362 | zinc finger protein 362 |
| ZNF391 | zinc finger protein 391 |
| ZNF408 | zinc finger protein 408 |
| ZNF446 | zinc finger protein 446 |
| ZNF571 | zinc finger protein 571 |
| ZNF629 | zinc finger protein 629 |
| ZNF695 | zinc finger protein 695 |
| ZSCAN16 | zinc finger and SCAN domain containing 16 |
