IL2_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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383 genes differentially expressed following the IL2_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADAM19 ADAM metallopeptidase domain 19
AHR aryl hydrocarbon receptor
AIM2 absent in melanoma 2
AK4P3 adenylate kinase 4 pseudogene 3
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA2P1 annexin A2 pseudogene 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ASCL3 achaete-scute family bHLH transcription factor 3
ASPA aspartoacylase
ATG101 autophagy related 101
BMP2 bone morphogenetic protein 2
BTC betacellulin
C10ORF2 chromosome 10 open reading frame 2
C11ORF80 chromosome 11 open reading frame 80
CALML4 calmodulin-like 4
CAPN10 calpain 10
CCDC85B coiled-coil domain containing 85B
CCR4 chemokine (C-C motif) receptor 4
CD3EAP CD3e molecule, epsilon associated protein
CD52 CD52 molecule
CD69 CD69 molecule
CDC25A cell division cycle 25A
CDCP1 CUB domain containing protein 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CISH cytokine inducible SH2-containing protein
CLDN5 claudin 5
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL3 chemokine (C-X-C motif) ligand 3
DGKG diacylglycerol kinase, gamma 90kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHD2 EH-domain containing 2
ELMO3 engulfment and cell motility 3
ESRP2 epithelial splicing regulatory protein 2
EVPL envoplakin
EVX1 even-skipped homeobox 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM57A family with sequence similarity 57, member A
FLT1 fms-related tyrosine kinase 1
FLT3LG fms-related tyrosine kinase 3 ligand
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXP3 forkhead box P3
FZD5 frizzled class receptor 5
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GFAP glial fibrillary acidic protein
GNRH2 gonadotropin-releasing hormone 2
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HABP4 hyaluronan binding protein 4
HEG1 heart development protein with EGF-like domains 1
HK2 hexokinase 2
HOXA11 homeobox A11
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFNW1 interferon, omega 1
IL10 interleukin 10
IL13 interleukin 13
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL5 interleukin 5
INHBB inhibin, beta B
INSR insulin receptor
IQCG IQ motif containing G
IRS1 insulin receptor substrate 1
ITGA9 integrin, alpha 9
JUNB jun B proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCTD12 potassium channel tetramerization domain containing 12
KIF13A kinesin family member 13A
KIF1C kinesin family member 1C
KIF21B kinesin family member 21B
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF6 Kruppel-like factor 6
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LGALSL lectin, galactoside-binding-like
LIF leukemia inhibitory factor
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC6 leucine rich repeat containing 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGIX MAGI family member, X-linked
MEGF6 multiple EGF-like-domains 6
MFSD12 major facilitator superfamily domain containing 12
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
NCS1 neuronal calcium sensor 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR6A2 olfactory receptor, family 6, subfamily A, member 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSM oncostatin M
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDE4A phosphodiesterase 4A, cAMP-specific
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP prolactin-induced protein
PLEC plectin
PLXNA3 plexin A3
PMM2 phosphomannomutase 2
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PPAP2C phosphatidic acid phosphatase type 2C
PPP4R4 protein phosphatase 4, regulatory subunit 4
PQLC2 PQ loop repeat containing 2
PRAF2 PRA1 domain family, member 2
PRKCD protein kinase C, delta
PRR7 proline rich 7 (synaptic)
PRSS50 protease, serine, 50
PTCH1 patched 1
PTH1R parathyroid hormone 1 receptor
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
REST RE1-silencing transcription factor
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS3 regulator of G-protein signaling 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOB ras homolog family member B
RNF144A ring finger protein 144A
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RPA4 replication protein A4, 30kDa
RPP25 ribonuclease P/MRP 25kDa subunit
RRP7BP ribosomal RNA processing 7 homolog B (S. cerevisiae), pseudogene
RSPH6A radial spoke head 6 homolog A (Chlamydomonas)
SH2D4A SH2 domain containing 4A
SIGLEC9 sialic acid binding Ig-like lectin 9
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SPATA2L spermatogenesis associated 2-like
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
STX11 syntaxin 11
TAS2R16 taste receptor, type 2, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TEX13A testis expressed 13A
TLR3 toll-like receptor 3
TM4SF1 transmembrane 4 L six family member 1
TM4SF5 transmembrane 4 L six family member 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS6 transmembrane protease, serine 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TPBG trophoblast glycoprotein
TRIB1 tribbles pseudokinase 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTTY1 testis-specific transcript, Y-linked 1 (non-protein coding)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP36 ubiquitin specific peptidase 36
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VSNL1 visinin-like 1
WDR62 WD repeat domain 62
WISP3 WNT1 inducible signaling pathway protein 3
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB32 zinc finger and BTB domain containing 32
ZNF215 zinc finger protein 215
ZNF343 zinc finger protein 343

decreased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2
ACF Asymmetric crying facies (Cayler cardiofacial syndrome)
ACPP acid phosphatase, prostate
ADAM2 ADAM metallopeptidase domain 2
AGBL2 ATP/GTP binding protein-like 2
AIM1L absent in melanoma 1-like
AIRE autoimmune regulator
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMELY amelogenin, Y-linked
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ARHGAP6 Rho GTPase activating protein 6
ARL4C ADP-ribosylation factor-like 4C
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BTN3A1 butyrophilin, subfamily 3, member A1
BTN3A3 butyrophilin, subfamily 3, member A3
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CAMK1G calcium/calmodulin-dependent protein kinase IG
CBLN1 cerebellin 1 precursor
CCDC64 coiled-coil domain containing 64
CCDC81 coiled-coil domain containing 81
CCNG2 cyclin G2
CD160 CD160 molecule
CD34 CD34 molecule
CD72 CD72 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEL carboxyl ester lipase
CFAP44 cilia and flagella associated protein 44
CHGB chromogranin B
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLCA1 chloride channel accessory 1
CLDN16 claudin 16
CLEC2B C-type lectin domain family 2, member B
CNR2 cannabinoid receptor 2 (macrophage)
CNTD2 cyclin N-terminal domain containing 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CST1 cystatin SN
CUX2 cut-like homeobox 2
CXCR2 chemokine (C-X-C motif) receptor 2
CXORF21 chromosome X open reading frame 21
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPTOR DEP domain containing MTOR-interacting protein
DLEC1 deleted in lung and esophageal cancer 1
EFNA4 ephrin-A4
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERC2 ELKS/RAB6-interacting/CAST family member 2
EVI2A ecotropic viral integration site 2A
EYA1 EYA transcriptional coactivator and phosphatase 1
F13B coagulation factor XIII, B polypeptide
FAM110B family with sequence similarity 110, member B
FAM124B family with sequence similarity 124B
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLT3 fms-related tyrosine kinase 3
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
FZD2 frizzled class receptor 2
FZD3 frizzled class receptor 3
GALR3 galanin receptor 3
GDF5 growth differentiation factor 5
GOLPH3L golgi phosphoprotein 3-like
GPRC5D G protein-coupled receptor, class C, group 5, member D
GPX2 glutathione peroxidase 2
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
H2AFJ H2A histone family, member J
H2AFY2 H2A histone family, member Y2
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HHIPL2 HHIP-like 2
HIST1H2AG histone cluster 1, H2ag
HIST1H3C histone cluster 1, H3c
HKDC1 hexokinase domain containing 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA5 homeobox A5
HSF2BP heat shock transcription factor 2 binding protein
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IL18 interleukin 18
IL25 interleukin 25
INHA inhibin, alpha
ISL1 ISL LIM homeobox 1
JCHAIN joining chain of multimeric IgA and IgM
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0319L KIAA0319-like
KIAA1462 KIAA1462
KLHDC8A kelch domain containing 8A
LINC00302 long intergenic non-protein coding RNA 302
LINC00472 long intergenic non-protein coding RNA 472
LINC01558 long intergenic non-protein coding RNA 1558
LIPF lipase, gastric
LRP2BP LRP2 binding protein
LRRC37A leucine rich repeat containing 37A
MAB21L2 mab-21-like 2 (C. elegans)
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP2K6 mitogen-activated protein kinase kinase 6
MARC1 mitochondrial amidoxime reducing component 1
MARC2 mitochondrial amidoxime reducing component 2
MEOX1 mesenchyme homeobox 1
METTL7A methyltransferase like 7A
MISP mitotic spindle positioning
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MMP7 matrix metallopeptidase 7
MOGAT2 monoacylglycerol O-acyltransferase 2
MYCT1 myc target 1
MYLK myosin light chain kinase
NACAD NAC alpha domain containing
NAP1L2 nucleosome assembly protein 1-like 2
NDOR1 NADPH dependent diflavin oxidoreductase 1
NKX3-2 NK3 homeobox 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NUAK1 NUAK family, SNF1-like kinase, 1
NXF2 nuclear RNA export factor 2
ODAM odontogenic, ameloblast asssociated
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCD1 phospholipase C, delta 1
PLCH1 phospholipase C, eta 1
PLCL1 phospholipase C-like 1
PLEK pleckstrin
PNRC1 proline-rich nuclear receptor coactivator 1
POU2AF1 POU class 2 associating factor 1
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKG1 protein kinase, cGMP-dependent, type I
PROM1 prominin 1
PRSS16 protease, serine, 16 (thymus)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASL12 RAS-like, family 12
REC114 REC114 meiotic recombination protein
RGS2 regulator of G-protein signaling 2
RHOBTB1 Rho-related BTB domain containing 1
RIN2 Ras and Rab interactor 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RORB RAR-related orphan receptor B
RPL3L ribosomal protein L3-like
SARNP SAP domain containing ribonucleoprotein
SCGB2A2 secretoglobin, family 2A, member 2
SCHIP1 schwannomin interacting protein 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SDCCAG8 serologically defined colon cancer antigen 8
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SESN1 sestrin 1
SLA Src-like-adaptor
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLN sarcolipin
SNAI2 snail family zinc finger 2
SNPH syntaphilin
SPATA1 spermatogenesis associated 1
SSTR5 somatostatin receptor 5
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYT1 synaptotagmin I
TAGLN3 transgelin 3
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCEAL4 transcription elongation factor A (SII)-like 4
TEK TEK tyrosine kinase, endothelial
TG thyroglobulin
TGM3 transglutaminase 3
THAP10 THAP domain containing 10
TMEM140 transmembrane protein 140
TMEM19 transmembrane protein 19
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNNT3 troponin T type 3 (skeletal, fast)
TNS3 tensin 3
TRIB2 tribbles pseudokinase 2
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TSPAN7 tetraspanin 7
TTC23 tetratricopeptide repeat domain 23
TXNIP thioredoxin interacting protein
UNC93B1 unc-93 homolog B1 (C. elegans)
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VILL villin-like
WSCD2 WSC domain containing 2
ZNF230 zinc finger protein 230
ZNF362 zinc finger protein 362
ZNF391 zinc finger protein 391
ZNF408 zinc finger protein 408
ZNF446 zinc finger protein 446
ZNF571 zinc finger protein 571
ZNF629 zinc finger protein 629
ZNF695 zinc finger protein 695
ZSCAN16 zinc finger and SCAN domain containing 16