IL4 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description interleukin 4|The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3565)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_IL4
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Genes

195 co-expressed genes for IL4 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAM20 ADAM metallopeptidase domain 20
ADAMTSL3 ADAMTS-like 3
AIM2 absent in melanoma 2
AKAP3 A kinase (PRKA) anchor protein 3
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANXA10 annexin A10
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ATF2 activating transcription factor 2
ATF6B activating transcription factor 6 beta
ATP10B ATPase, class V, type 10B
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN3 ataxin 3
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BRD4 bromodomain containing 4
C6 complement component 6
CA3 carbonic anhydrase III
CADM4 cell adhesion molecule 4
CALN1 calneuron 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCIN calicin
CCL16 chemokine (C-C motif) ligand 16
CCR3 chemokine (C-C motif) receptor 3
CDC73 cell division cycle 73
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CDH8 cadherin 8, type 2
CDKL5 cyclin-dependent kinase-like 5
CEP162 centrosomal protein 162kDa
COL19A1 collagen, type XIX, alpha 1
COL8A1 collagen, type VIII, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPB2 carboxypeptidase B2 (plasma)
CRHR1 corticotropin releasing hormone receptor 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTSB cathepsin B
DEPDC5 DEP domain containing 5
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DMD dystrophin
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DOK5 docking protein 5
DRD1 dopamine receptor D1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDN3 endothelin 3
ELL2 elongation factor, RNA polymerase II, 2
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EXOC4 exocyst complex component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM153B family with sequence similarity 153, member B
FAM63B family with sequence similarity 63, member B
FGA fibrinogen alpha chain
FGF2 fibroblast growth factor 2 (basic)
FLJ16124
FOSL1 FOS-like antigen 1
FSHR follicle stimulating hormone receptor
FZD5 frizzled class receptor 5
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCA grancalcin, EF-hand calcium binding protein
GCM1 glial cells missing homolog 1 (Drosophila)
GJB5 gap junction protein, beta 5, 31.1kDa
GLRA3 glycine receptor, alpha 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR1 G protein-coupled receptor 1
GPR15 G protein-coupled receptor 15
GPR171 G protein-coupled receptor 171
GPR19 G protein-coupled receptor 19
GRIK1 glutamate receptor, ionotropic, kainate 1
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HCG8 HLA complex group 8
HCRTR2 hypocretin (orexin) receptor 2
HNF1A HNF1 homeobox A
HOXB7 homeobox B7
HOXC11 homeobox C11
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNA1 interferon, alpha 1
IFNA14 interferon, alpha 14
IFNW1 interferon, omega 1
IL3 interleukin 3
IL4 interleukin 4
IL7 interleukin 7
IPO9 importin 9
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE3 jade family PHD finger 3
JRKL JRK-like
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KPNA1 karyopherin alpha 1 (importin alpha 5)
KRT2 keratin 2, type II
KRT34 keratin 34, type I
LDB3 LIM domain binding 3
LECT2 leukocyte cell-derived chemotaxin 2
LGI1 leucine-rich, glioma inactivated 1
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP4 low density lipoprotein receptor-related protein 4
LRRC48 leucine rich repeat containing 48
MAGEA8 melanoma antigen family A8
MAGEA9 melanoma antigen family A9
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MID2 midline 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MPZL1 myelin protein zero-like 1
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NCKIPSD NCK interacting protein with SH3 domain
NEB nebulin
NHEJ1 nonhomologous end-joining factor 1
NOS2 nitric oxide synthase 2, inducible
NPAS2 neuronal PAS domain protein 2
NPFF neuropeptide FF-amide peptide precursor
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTNG2 netrin G2
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OTC ornithine carbamoyltransferase
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PAX6 paired box 6
PAX7 paired box 7
PCDHB17P protocadherin beta 17 pseudogene
PCM1 pericentriolar material 1
PDCD1 programmed cell death 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PHF10 PHD finger protein 10
PHLDB1 pleckstrin homology-like domain, family B, member 1
PHOX2B paired-like homeobox 2b
PLXNA3 plexin A3
PNLIPRP2 pancreatic lipase-related protein 2
POU6F2 POU class 6 homeobox 2
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PSD pleckstrin and Sec7 domain containing
PSG1 pregnancy specific beta-1-glycoprotein 1
PTPRS protein tyrosine phosphatase, receptor type, S
PVR poliovirus receptor
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD51D RAD51 paralog D
RB1CC1 RB1-inducible coiled-coil 1
RBMS3 RNA binding motif, single stranded interacting protein 3
REPS2 RALBP1 associated Eps domain containing 2
RNF24 ring finger protein 24
ROR2 receptor tyrosine kinase-like orphan receptor 2
RSC1A1 regulatory solute carrier protein, family 1, member 1
RXRG retinoid X receptor, gamma
RYR3 ryanodine receptor 3
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SFRP4 secreted frizzled-related protein 4
SIX6 SIX homeobox 6
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC46A3 solute carrier family 46, member 3
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOAT2 sterol O-acyltransferase 2
SOCS6 suppressor of cytokine signaling 6
SPAG11B sperm associated antigen 11B
SPRR2C small proline-rich protein 2C (pseudogene)
SRPK3 SRSF protein kinase 3
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAC SH3 and cysteine rich domain
STXBP5L syntaxin binding protein 5-like
SULT4A1 sulfotransferase family 4A, member 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
T T, brachyury homolog (mouse)
TACC2 transforming, acidic coiled-coil containing protein 2
TBX19 T-box 19
TENM4 teneurin transmembrane protein 4
THPO thrombopoietin
THRA thyroid hormone receptor, alpha
TLL1 tolloid-like 1
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TRIO trio Rho guanine nucleotide exchange factor
TSPYL1 TSPY-like 1
TTTY1 testis-specific transcript, Y-linked 1 (non-protein coding)
UBE4B ubiquitination factor E4B
VIP vasoactive intestinal peptide
WISP3 WNT1 inducible signaling pathway protein 3
ZBTB14 zinc finger and BTB domain containing 14
ZNF132 zinc finger protein 132
ZNF157 zinc finger protein 157
ZNF202 zinc finger protein 202
ZSCAN26 zinc finger and SCAN domain containing 26