IL4R Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description interleukin 4 receptor|This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 3566)
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Genes

329 genes differentially expressed following the IL4R gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD6 CD6 molecule 3.79493
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.79493
GSTM5 glutathione S-transferase mu 5 3.79493
GJB4 gap junction protein, beta 4, 30.3kDa 3.79493
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.79493
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.79493
CEP295NL CEP295 N-terminal like 3.79493
TUBB1 tubulin, beta 1 class VI 3.79493
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.79493
CARTPT CART prepropeptide 3.79493
TAL1 T-cell acute lymphocytic leukemia 1 3.79493
RRAD Ras-related associated with diabetes 3.79493
RAX retina and anterior neural fold homeobox 3.79493
INHBC inhibin, beta C 3.79493
FGF23 fibroblast growth factor 23 3.79493
FGD2 FYVE, RhoGEF and PH domain containing 2 3.79493
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.79493
SACK1A scaffolding CK1 anchoring protein A 3.79493
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.79493
ALOX15 arachidonate 15-lipoxygenase 3.79493
GNLY granulysin 3.79493
BTN1A1 butyrophilin, subfamily 1, member A1 3.79493
CABP4 calcium binding protein 4 3.79493
GIMAP2 GTPase, IMAP family member 2 3.79493
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.79493
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.79493
STEAP4 STEAP family member 4 3.79493
RAMP3 receptor (G protein-coupled) activity modifying protein 3 3.79493
BTBD16 BTB (POZ) domain containing 16 3.79493
FAM81B family with sequence similarity 81, member B 3.79493
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.79493
TWIST1 twist family bHLH transcription factor 1 3.79493
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.79493
C5ORF46 chromosome 5 open reading frame 46 3.79493
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.79493
RNF39 ring finger protein 39 3.79493
C2ORF78 chromosome 2 open reading frame 78 3.79493
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.79493
NCKAP1L NCK-associated protein 1-like 3.79493
OR13C4 olfactory receptor, family 13, subfamily C, member 4 3.79493
RPL3L ribosomal protein L3-like 3.79493
CD68 CD68 molecule 3.79493
ACVRL1 activin A receptor type II-like 1 3.79493
S100A1 S100 calcium binding protein A1 3.79493
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 3.79493
CPLX4 complexin 4 3.79493
ETV2 ets variant 2 3.79493
AOC1 amine oxidase, copper containing 1 3.79493
SAXO3 stabilizer of axonemal microtubules 3 3.79493
LOC122539214 Zinc finger protein LOC122539214 3.79493
STING1 stimulator of interferon response cGAMP interactor 1 3.79493
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.79493
CD300LF CD300 molecule-like family member f 3.79493
HOXC13 homeobox C13 3.79493
ADRB1 adrenoceptor beta 1 3.79493
MYEOV myeloma overexpressed 3.79493
MIOX myo-inositol oxygenase 3.79493
DOK2 docking protein 2, 56kDa 3.79493
GRAP GRB2-related adaptor protein 3.79493
NSG2 neuronal vesicle trafficking associated 2 3.79493
CCN5 cellular communication network factor 5 3.79493
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.79493
SPATA31H1 SPATA31 subfamily H member 1 3.79493
CIMIP4 ciliary microtubule inner protein 4 3.79493
C20ORF204 chromosome 20 open reading frame 204 3.79493
H2BW2 H2B.W histone 2 3.79493
NFILZ NFIL3 like basic leucine zipper 3.79493
CBY2 chibby family member 2 3.79493
ELOA2 elongin A2 3.79493
RTL9 retrotransposon Gag like 9 3.79493
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.79493
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.79493
GATA3 GATA binding protein 3 3.79493
ZNF575 zinc finger protein 575 3.79493
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.79493
ZIC4 Zic family member 4 3.79493
TLE6 transducin-like enhancer of split 6 3.79493
RAB41 RAB41, member RAS oncogene family 3.79493
FAM153A family with sequence similarity 153, member A 3.79493
ZNF98 zinc finger protein 98 3.79493
MEP1A meprin A, alpha (PABA peptide hydrolase) 3.79493
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.79493
NCBP2L nuclear cap binding protein subunit 2-like 3.79493
IL5 interleukin 5 3.79493
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.79493
CSAG2 CSAG family, member 2 3.79493
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.79493
GPR83 G protein-coupled receptor 83 3.79493
SAMD15 sterile alpha motif domain containing 15 3.79493
PTH parathyroid hormone 3.79493
VCX3B variable charge, X-linked 3B 3.79493
SAA4 serum amyloid A4, constitutive 3.79493
C7ORF57 chromosome 7 open reading frame 57 3.79493
SBSN suprabasin 3.79493
S100B S100 calcium binding protein B 3.79493
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.79493
PAGE4 P antigen family, member 4 (prostate associated) 3.79493
AMH anti-Mullerian hormone 3.79493
NT5DC4 5'-nucleotidase domain containing 4 3.79493
KLF2 Kruppel-like factor 2 3.79493
CST1 cystatin SN 3.79493
EDN3 endothelin 3 3.79493
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.79493
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.79493
KRT15 keratin 15, type I 3.79493
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.79493
IDI2 isopentenyl-diphosphate delta isomerase 2 3.79493
ZMYND10 zinc finger, MYND-type containing 10 3.79493
TCF21 transcription factor 21 3.79493
PRSS54 protease, serine, 54 3.79493
GSTA2 glutathione S-transferase alpha 2 3.79493
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.79493
PIH1D2 PIH1 domain containing 2 3.79493
THTPA thiamine triphosphatase 3.79493
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.79493
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.79493
CRHR1 corticotropin releasing hormone receptor 1 3.79493
BPIFB1 BPI fold containing family B, member 1 3.79493
LMOD2 leiomodin 2 (cardiac) 3.79493
COX7B2 cytochrome c oxidase subunit VIIb2 3.79493
RAB40AL RAB40A, member RAS oncogene family-like 3.79493
FBXO40 F-box protein 40 3.79493
TEX12 testis expressed 12 3.79493
DUOX2 dual oxidase 2 3.79493
LRRC15 leucine rich repeat containing 15 3.79493
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.79493
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.79493
BTNL2 butyrophilin-like 2 3.79493
CD27 CD27 molecule 3.79493
RGS8 regulator of G-protein signaling 8 3.79493
GCGR glucagon receptor 3.79493
CFAP126 cilia and flagella associated protein 126 3.79493
OTP orthopedia homeobox 3.79493
ITPKA inositol-trisphosphate 3-kinase A 3.79493
RTN4RL1 reticulon 4 receptor-like 1 3.79493
GBX2 gastrulation brain homeobox 2 3.79493
GOLGA8N golgin A8 family, member N 3.79493
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.79493
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.79493
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 3.79493
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.79493
ADAM29 ADAM metallopeptidase domain 29 3.79493
PHOX2A paired-like homeobox 2a 3.79493
MMP12 matrix metallopeptidase 12 3.79493
ART1 ADP-ribosyltransferase 1 3.79493
SLC36A3 solute carrier family 36, member 3 3.79493
OPTC opticin 3.79493
PLA2G2C phospholipase A2, group IIC 3.79493
OR56B4 olfactory receptor, family 56, subfamily B, member 4 3.79493
MYADML2 myeloid-associated differentiation marker-like 2 3.79493
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.79493
AZIN2 antizyme inhibitor 2 3.79493
FZD1 frizzled class receptor 1 3.79493
POU4F1 POU class 4 homeobox 1 3.79493
ALOX15B arachidonate 15-lipoxygenase, type B 3.79493
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.79493
AGR2 anterior gradient 2 3.79493
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 3.79493
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.79493
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.79493
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.79493
NXPH1 neurexophilin 1 3.76931
C6ORF58 chromosome 6 open reading frame 58 3.74252
GPR78 G protein-coupled receptor 78 3.74252
ETV7 ets variant 7 3.74252
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3.63525
ARHGAP10 Rho GTPase activating protein 10 3.46966
ZDHHC9 zinc finger, DHHC-type containing 9 3.45971
CKAP2L cytoskeleton associated protein 2-like 3.15963
FMNL2 formin-like 2 3.09267
RPL28 ribosomal protein L28 3.09063
WDR43 WD repeat domain 43 2.95195
RUFY3 RUN and FYVE domain containing 3 2.86563
AIDA axin interactor, dorsalization associated 2.83868
RGPD6 RANBP2-like and GRIP domain containing 6 2.77582
POPDC2 popeye domain containing 2 2.77582
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) 2.69198
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.60406
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 2.57175
ZSWIM6 zinc finger, SWIM-type containing 6 2.56011
TEP1 telomerase-associated protein 1 2.53441
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 2.5134
TRAK1 trafficking protein, kinesin binding 1 2.50734
UBQLN2 ubiquilin 2 2.46327
ZDHHC22 zinc finger, DHHC-type containing 22 2.42707
CALHM2 calcium homeostasis modulator 2 2.40347
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.40347
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.3761
NPM3 nucleophosmin/nucleoplasmin 3 2.3761
STARD6 StAR-related lipid transfer (START) domain containing 6 2.37369
NPFFR1 neuropeptide FF receptor 1 2.37369
MRPL11 mitochondrial ribosomal protein L11 2.36648
ARMC9 armadillo repeat containing 9 2.36145
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2.35789
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 2.349
APOC1 apolipoprotein C-I 2.349
SH3YL1 SH3 and SYLF domain containing 1 2.33398
SCNN1A sodium channel, non voltage gated 1 alpha subunit 2.32196
LRRC31 leucine rich repeat containing 31 2.32196
FITM2 fat storage-inducing transmembrane protein 2 2.30215
JAKMIP1 janus kinase and microtubule interacting protein 1 2.30215
NOXRED1 NADP-dependent oxidoreductase domain containing 1 2.30215
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.30215
KYNU kynureninase 2.29803
IGFBP7 insulin-like growth factor binding protein 7 2.28742
ARR3 arrestin 3, retinal (X-arrestin) 2.28742
MICU1 mitochondrial calcium uptake 1 2.28624
DEUP1 deuterosome assembly protein 1 2.28183
PGK1 phosphoglycerate kinase 1 2.22957
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 2.2283
APTX aprataxin 2.21737
ELL elongation factor RNA polymerase II 2.20181
PRMT2IP PRMT2 interacting protein 2.20181
FBN2 fibrillin 2 2.19405
DARS1 aspartyl-tRNA synthetase 1 2.16546
AGBL5 ATP/GTP binding protein-like 5 2.14692
CHN1 chimerin 1 2.11567
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.11415
PRPF3 pre-mRNA processing factor 3 2.06493
DOP1A DOP1 leucine zipper like protein A 2.05766
IKBIP IKBKB interacting protein 2.05766
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.03633
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.01449
WDR81 WD repeat domain 81 2.0121
UQCRC1 ubiquinol-cytochrome c reductase core protein I 2.01157

decreased expression

Symbol Name Standardized Value
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -3.79493
GJB5 gap junction protein, beta 5, 31.1kDa -3.79493
FMO1 flavin containing monooxygenase 1 -3.79493
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -3.79493
ACSS1 acyl-CoA synthetase short-chain family member 1 -3.79493
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -3.79493
GLIPR1 GLI pathogenesis-related 1 -3.79493
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -3.74252
LYST lysosomal trafficking regulator -3.74252
TBX15 T-box 15 -3.74252
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -3.74252
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -3.74252
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -3.74252
NFE2 nuclear factor, erythroid 2 -3.74252
TEX101 testis expressed 101 -3.74252
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -3.74252
SLC46A1 solute carrier family 46 (folate transporter), member 1 -3.74252
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -3.74252
RGPD1 RANBP2-like and GRIP domain containing 1 -3.74252
MUC20 mucin 20, cell surface associated -3.74252
SOX8 SRY (sex determining region Y)-box 8 -3.74252
NDRG1 N-myc downstream regulated 1 -3.74252
PCDHB12 protocadherin beta 12 -3.74252
C11ORF96 chromosome 11 open reading frame 96 -3.74252
GOLGA8M golgin A8 family, member M -3.74252
SVOP SV2 related protein homolog (rat) -3.74252
TMPRSS7 transmembrane protease, serine 7 -3.74252
QRFP pyroglutamylated RFamide peptide -3.74252
NMBR neuromedin B receptor -3.74252
ALKAL1 ALK and LTK ligand 1 -3.74252
KLHDC1 kelch domain containing 1 -3.74252
GARIN1A golgi associated RAB2 interactor 1A -3.74252
ZNF831 zinc finger protein 831 -3.74252
RHEX regulator of hemoglobinization and erythroid cell expansion -3.74252
ADGRG3 adhesion G protein-coupled receptor G3 -3.74252
NOX3 NADPH oxidase 3 -3.74252
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -3.74252
MLX MLX, MAX dimerization protein -3.6951
LYPD1 LY6/PLAUR domain containing 1 -3.65355
ARG1 arginase 1 -3.63031
SYCE3 synaptonemal complex central element protein 3 -3.63031
ICAM3 intercellular adhesion molecule 3 -3.40933
CCDC24 coiled-coil domain containing 24 -3.40331
BST1 bone marrow stromal cell antigen 1 -3.0768
C5AR1 complement component 5a receptor 1 -2.84144
RPH3A rabphilin 3A -2.84144
CGNL1 cingulin-like 1 -2.77127
LAMC3 laminin, gamma 3 -2.74943
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.74061
PUDP pseudouridine 5'-phosphatase -2.67927
PORCN porcupine homolog (Drosophila) -2.6484
RNF14 ring finger protein 14 -2.62814
LEFTY2 left-right determination factor 2 -2.62622
NALCN sodium leak channel, non selective -2.59359
ZNF671 zinc finger protein 671 -2.53298
TMEM35B transmembrane protein 35B -2.4828
MYRFL myelin regulatory factor-like -2.3761
LBP lipopolysaccharide binding protein -2.36377
CD200R1 CD200 receptor 1 -2.36377
CNGA4 cyclic nucleotide gated channel alpha 4 -2.36377
H4C2 H4 clustered histone 2 -2.36078
TMEM121B transmembrane protein 121B -2.36078
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.36078
SFTPD surfactant protein D -2.36078
POLH polymerase (DNA directed), eta -2.36026
HINFP histone H4 transcription factor -2.34789
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.33398
ANO9 anoctamin 9 -2.32169
LEFTY1 left-right determination factor 1 -2.30342
TAC1 tachykinin, precursor 1 -2.30342
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.27628
EPM2AIP1 EPM2A (laforin) interacting protein 1 -2.26029
PLIN2 perilipin 2 -2.25987
ZNF157 zinc finger protein 157 -2.25216
ZNF891 zinc finger protein 891 -2.23519
LTB4R leukotriene B4 receptor -2.23391
BEX2 brain expressed X-linked 2 -2.2266
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.22588
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.21737
RINT1 RAD50 interactor 1 -2.20713
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.20713
ZNF16 zinc finger protein 16 -2.19495
TTC27 tetratricopeptide repeat domain 27 -2.19495
LMTK3 lemur tyrosine kinase 3 -2.19235
SPRED2 sprouty-related, EVH1 domain containing 2 -2.18967
KCNK5 potassium channel, two pore domain subfamily K, member 5 -2.18953
CLCN3 chloride channel, voltage-sensitive 3 -2.18766
ZNF717 zinc finger protein 717 -2.18047
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.1798
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.17536
FAM171B family with sequence similarity 171, member B -2.14886
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -2.14692
ZNF658 zinc finger protein 658 -2.13888
KCTD18 potassium channel tetramerization domain containing 18 -2.12013
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -2.11659
STYX serine/threonine/tyrosine interacting protein -2.11659
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.09247
RBM46 RNA binding motif protein 46 -2.08337
ARMCX2 armadillo repeat containing, X-linked 2 -2.06168
ABTB3 ankyrin repeat and BTB domain containing 3 -2.06095
CUL1 cullin 1 -2.05315
METTL25 methyltransferase like 25 -2.05179
FBN1 fibrillin 1 -2.05119
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -2.01449