IL4R Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interleukin 4 receptor|This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 3566)
External Link http://www.ncbi.nlm.nih.gov/gene/3566
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Genes

86 interacting proteins for IL4R from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AMOTL2 angiomotin like 2
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARSB arylsulfatase B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD3B ATPase family, AAA domain containing 3B
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD40 CD40 molecule, TNF receptor superfamily member 5
CEP170 centrosomal protein 170kDa
CSPP1 centrosome and spindle pole associated protein 1
DOCK7 dedicator of cytokinesis 7
DOK2 docking protein 2, 56kDa
ERBB2IP erbb2 interacting protein
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM122B family with sequence similarity 122B
FES FES proto-oncogene, tyrosine kinase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HSPA8 heat shock 70kDa protein 8
IK IK cytokine, down-regulator of HLA II
IKZF2 IKAROS family zinc finger 2 (Helios)
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IQCE IQ motif containing E
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KAT5 K(lysine) acetyltransferase 5
KIF25 kinesin family member 25
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1
LECT1 leukocyte cell derived chemotaxin 1
LMNA lamin A/C
LMO7 LIM domain 7
LRPPRC leucine-rich pentatricopeptide repeat containing
MAPK14 mitogen-activated protein kinase 14
MAX MYC associated factor X
MFGE8 milk fat globule-EGF factor 8 protein
MICALL2 MICAL-like 2
MIPEP mitochondrial intermediate peptidase
MLH3 mutL homolog 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NCF1 neutrophil cytosolic factor 1
NLRX1 NLR family member X1
NRXN3 neurexin 3
PDZD2 PDZ domain containing 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCDBP protein kinase C, delta binding protein
PRKCZ protein kinase C, zeta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTRF polymerase I and transcript release factor
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RCOR3 REST corepressor 3
RIMS2 regulating synaptic membrane exocytosis 2
RIN3 Ras and Rab interactor 3
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
SCO2 SCO2 cytochrome c oxidase assembly protein
SDK1 sidekick cell adhesion molecule 1
SEC31B SEC31 homolog B (S. cerevisiae)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLA2 Src-like-adaptor 2
SOCS1 suppressor of cytokine signaling 1
SOCS5 suppressor of cytokine signaling 5
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA31E1 SPATA31 subfamily E, member 1
SPEG SPEG complex locus
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TTN titin
TUBA4A tubulin, alpha 4a
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
XDH xanthine dehydrogenase
XYLT1 xylosyltransferase I
ZCCHC11 zinc finger, CCHC domain containing 11