| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | interleukin 6|This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] (NCBI Entrez Gene Database, 3569) |
| External Link | https://ncbi.nlm.nih.gov/gene/3569 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the IL6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0123093 |
| DIPK1A | divergent protein kinase domain 1A | 0.0116185 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.0109856 |
| S100P | S100 calcium binding protein P | 0.0102164 |
| HNMT | histamine N-methyltransferase | 0.00971939 |
| MFAP5 | microfibrillar associated protein 5 | 0.00922826 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00916949 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00909417 |
| OLFM1 | olfactomedin 1 | 0.00906112 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00901556 |
| POSTN | periostin, osteoblast specific factor | 0.00894905 |
| MXRA5 | matrix-remodelling associated 5 | 0.00876336 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00874897 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00869797 |
| WASHC4 | WASH complex subunit 4 | 0.00849721 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.00848394 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00846718 |
| KRT23 | keratin 23, type I | 0.00842176 |
| MAPK13 | mitogen-activated protein kinase 13 | 0.00838231 |
| KRT19 | keratin 19, type I | 0.00833014 |
| GAS1 | growth arrest-specific 1 | 0.00832211 |
| LOXL1 | lysyl oxidase-like 1 | 0.00831856 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00812742 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00804035 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.00798848 |
| FABP7 | fatty acid binding protein 7, brain | 0.00795878 |
| BEX1 | brain expressed, X-linked 1 | 0.00781106 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00768242 |
| ANXA3 | annexin A3 | 0.00762224 |
| MPZL2 | myelin protein zero-like 2 | 0.00760039 |
| OLFML3 | olfactomedin-like 3 | 0.00756051 |
| MEN1 | multiple endocrine neoplasia I | 0.00747901 |
| RAB25 | RAB25, member RAS oncogene family | 0.00732993 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00724476 |
| KRT7 | keratin 7, type II | 0.0071712 |
| ASPN | asporin | 0.00712731 |
| PER3 | period circadian clock 3 | 0.0071016 |
| CPB1 | carboxypeptidase B1 (tissue) | 0.00706528 |
| PIP | prolactin-induced protein | 0.00701445 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00700315 |
| THBS2 | thrombospondin 2 | 0.00696569 |
| CALML5 | calmodulin-like 5 | 0.0069471 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00694428 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00693489 |
| CTSZ | cathepsin Z | 0.0069304 |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.00690544 |
| ABHD6 | abhydrolase domain containing 6 | 0.00688738 |
| SEPTIN10 | septin 10 | 0.00686334 |
| COL3A1 | collagen, type III, alpha 1 | 0.00684499 |
| PCNA | proliferating cell nuclear antigen | 0.00683755 |
| TAGLN | transgelin | 0.00682059 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00681782 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.00679064 |
| CHGB | chromogranin B | 0.00678309 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00678238 |
| NREP | neuronal regeneration related protein | 0.00673558 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.00666319 |
| CLDN10 | claudin 10 | 0.00659995 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.0065946 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00658762 |
| CEL | carboxyl ester lipase | 0.00657433 |
| ZNF423 | zinc finger protein 423 | 0.0064546 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00643639 |
| RAB23 | RAB23, member RAS oncogene family | 0.00636246 |
| CPE | carboxypeptidase E | 0.00635013 |
| BGN | biglycan | 0.00624031 |
| TYRP1 | tyrosinase-related protein 1 | 0.00621715 |
| IRS1 | insulin receptor substrate 1 | 0.00618487 |
| ACKR3 | atypical chemokine receptor 3 | 0.0061763 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 0.00617346 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.00616748 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00612411 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00610489 |
| MANSC1 | MANSC domain containing 1 | 0.00608546 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.00607782 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.00607755 |
| UBE2N | ubiquitin-conjugating enzyme E2N | 0.00605539 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00604212 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.00603901 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.00599625 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00599297 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00599002 |
| THY1 | Thy-1 cell surface antigen | 0.00597803 |
| NEBL | nebulette | 0.00595364 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.00593168 |
| COL10A1 | collagen, type X, alpha 1 | 0.0059288 |
| NCK1 | NCK adaptor protein 1 | 0.00589393 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.00588405 |
| TLCD3A | TLC domain containing 3A | 0.00583359 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00581879 |
| TRMT5 | tRNA methyltransferase 5 | 0.00578443 |
| ANOS1 | anosmin 1 | 0.00574003 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00571556 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.0056788 |
| PLLP | plasmolipin | 0.00566613 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00566327 |
| SYNJ2 | synaptojanin 2 | 0.00565657 |
| CBR3 | carbonyl reductase 3 | 0.00565449 |
| CLC | Charcot-Leyden crystal galectin | 0.00563313 |
| AURKB | aurora kinase B | 0.00563203 |
| DOK5 | docking protein 5 | 0.00560529 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0055742 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | 0.00557342 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 0.00556441 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.00556155 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | 0.00555273 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | 0.00553825 |
| VSNL1 | visinin-like 1 | 0.00552706 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00552303 |
| VWF | von Willebrand factor | 0.00551525 |
| IFT81 | intraflagellar transport 81 | 0.00547253 |
| PEG3 | paternally expressed 3 | 0.00546718 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | 0.00545336 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | 0.00545293 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 0.00544639 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.00544516 |
| MARCKSL1 | MARCKS-like 1 | 0.00543339 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.00538527 |
| RAPSN | receptor-associated protein of the synapse | 0.00538514 |
| GGCT | gamma-glutamylcyclotransferase | 0.00537578 |
| SNX7 | sorting nexin 7 | 0.00536987 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | 0.00536645 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.00536423 |
| TOR1A | torsin family 1, member A (torsin A) | 0.00535896 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00534943 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00534753 |
| C2CD5 | C2 calcium-dependent domain containing 5 | 0.0053337 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.00530211 |
| RPS5 | ribosomal protein S5 | 0.00528891 |
| PTK6 | protein tyrosine kinase 6 | 0.00526876 |
| EPYC | epiphycan | 0.00524477 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 0.00524159 |
| RGS5 | regulator of G-protein signaling 5 | 0.00523939 |
| A2M | alpha-2-macroglobulin | 0.00520451 |
| SHTN1 | shootin 1 | 0.0051991 |
| INHBB | inhibin, beta B | 0.0051715 |
| MEIS1 | Meis homeobox 1 | 0.00517012 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 0.00516787 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00516749 |
| KCTD14 | potassium channel tetramerization domain containing 14 | 0.00514001 |
| TMEM176B | transmembrane protein 176B | 0.00513937 |
| TYMS | thymidylate synthetase | 0.0050976 |
| TARDBP | TAR DNA binding protein | 0.00509107 |
| INAVA | innate immunity activator | 0.00508415 |
| SALL2 | spalt-like transcription factor 2 | 0.00508319 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.00508177 |
| SET | SET nuclear proto-oncogene | 0.00507505 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | 0.00506482 |
| TBC1D8B | TBC1 domain family, member 8B (with GRAM domain) | 0.00506444 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 0.00506205 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00505446 |
| GYG2 | glycogenin 2 | 0.00502712 |
| LDB2 | LIM domain binding 2 | 0.00502577 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | 0.0050215 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.00501398 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00500874 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.0050046 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00499604 |
| LIMA1 | LIM domain and actin binding 1 | 0.00499536 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.00498831 |
| MMP2 | matrix metallopeptidase 2 | 0.00498512 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.00498477 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00497882 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0049767 |
| CYB5R2 | cytochrome b5 reductase 2 | 0.00495951 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.00495845 |
| COL5A2 | collagen, type V, alpha 2 | 0.00495513 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.00494525 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00493752 |
| HAL | histidine ammonia-lyase | 0.0049374 |
| COL5A1 | collagen, type V, alpha 1 | 0.00492841 |
| TNS3 | tensin 3 | 0.00492721 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.00492711 |
| PDLIM5 | PDZ and LIM domain 5 | 0.00492399 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00492351 |
| SLC17A6 | solute carrier family 17 (vesicular glutamate transporter), member 6 | 0.00492068 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 0.00491559 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.00489065 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.00488238 |
| TMEM45A | transmembrane protein 45A | 0.00487622 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00487175 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.00486371 |
| DCLK1 | doublecortin-like kinase 1 | 0.00485822 |
| CFD | complement factor D (adipsin) | 0.0048569 |
| F2R | coagulation factor II (thrombin) receptor | 0.00485143 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 | 0.00484846 |
| FAR2 | fatty acyl CoA reductase 2 | 0.0048158 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.00481472 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00480162 |
| COL6A3 | collagen, type VI, alpha 3 | 0.00479604 |
| UNG | uracil-DNA glycosylase | 0.00479243 |
| CD99 | CD99 molecule | 0.00478865 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00478574 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | 0.00477393 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 0.00477198 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00476164 |
| IL20RA | interleukin 20 receptor, alpha | 0.00474801 |
| SPAG16 | sperm associated antigen 16 | 0.00474601 |
| XYLT1 | xylosyltransferase I | 0.00474109 |
| XIC | X chromosome inactivation center | 0.00472611 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00472066 |
| KLF10 | Kruppel-like factor 10 | 0.0047185 |
| SEPTIN7 | septin 7 | 0.00471429 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00470911 |
| MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | 0.00469243 |
| SIK2 | salt-inducible kinase 2 | 0.00467318 |
| CCNF | cyclin F | 0.00466164 |
| ZW10 | zw10 kinetochore protein | 0.0046559 |
| RMI1 | RecQ mediated genome instability 1 | 0.00465481 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.00464435 |
| CTSV | cathepsin V | 0.00464191 |
| VANGL1 | VANGL planar cell polarity protein 1 | 0.00464149 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.00464099 |
| HMGN1 | high mobility group nucleosome binding domain 1 | 0.00463892 |
| RXYLT1 | ribitol xylosyltransferase 1 | 0.00463762 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.00463238 |
| DVL3 | dishevelled segment polarity protein 3 | 0.00462846 |
| COL15A1 | collagen, type XV, alpha 1 | 0.00460175 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.00459536 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.00459343 |
| NAP1L3 | nucleosome assembly protein 1-like 3 | 0.00458866 |
| TFCP2 | transcription factor CP2 | 0.00458622 |
| MFAP2 | microfibrillar-associated protein 2 | 0.00455993 |
| SEPTIN8 | septin 8 | 0.0045556 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.00455223 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.00454669 |
| PLXNC1 | plexin C1 | 0.00453648 |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.0045355 |
| QDPR | quinoid dihydropteridine reductase | 0.00453254 |
| ANGPTL2 | angiopoietin-like 2 | 0.00453016 |
| FOXM1 | forkhead box M1 | 0.00452886 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.00452399 |
| GUCY2C | guanylate cyclase 2C | 0.00451882 |
| STK39 | serine threonine kinase 39 | 0.0045126 |
| RAD51AP1 | RAD51 associated protein 1 | 0.00449953 |
| FAT4 | FAT atypical cadherin 4 | 0.00449894 |
| PCLAF | PCNA clamp associated factor | 0.00449099 |
| PKP2 | plakophilin 2 | 0.00448539 |
| MCM2 | minichromosome maintenance complex component 2 | 0.0044839 |
| FEM1B | fem-1 homolog b (C. elegans) | 0.00448216 |
| CARTPT | CART prepropeptide | 0.00447925 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | 0.00447882 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.00447873 |
| CHST1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | 0.00447804 |
| LEFTY1 | left-right determination factor 1 | 0.00447715 |
| RAB28 | RAB28, member RAS oncogene family | 0.00447655 |
| SUMO3 | small ubiquitin-like modifier 3 | 0.0044567 |
| GNA14 | guanine nucleotide binding protein (G protein), alpha 14 | 0.00445311 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00444843 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.00444489 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHP1 | calcineurin-like EF-hand protein 1 | -0.0189575 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0113421 |
| MT1X | metallothionein 1X | -0.0113226 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.0109297 |
| KIAA0100 | KIAA0100 | -0.00980649 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.00968404 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00961105 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00898423 |
| KLF9 | Kruppel-like factor 9 | -0.0088297 |
| ATF3 | activating transcription factor 3 | -0.00876014 |
| IL7R | interleukin 7 receptor | -0.00860309 |
| MT1G | metallothionein 1G | -0.00857039 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.00855143 |
| GMPR | guanosine monophosphate reductase | -0.00852712 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00850116 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.0083715 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00833416 |
| FKBP11 | FK506 binding protein 11, 19 kDa | -0.0080015 |
| GDF15 | growth differentiation factor 15 | -0.00793965 |
| KIAA0125 | KIAA0125 | -0.00791246 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.00779134 |
| NPTX2 | neuronal pentraxin II | -0.00777774 |
| H1-2 | H1.2 linker histone, cluster member | -0.00771897 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00763436 |
| TSC22D1 | TSC22 domain family, member 1 | -0.00759625 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00745412 |
| MXRA7 | matrix-remodelling associated 7 | -0.00728823 |
| MT1F | metallothionein 1F | -0.00725138 |
| BST2 | bone marrow stromal cell antigen 2 | -0.0072377 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00709783 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00703938 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00701528 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -0.0069919 |
| REG1A | regenerating islet-derived 1 alpha | -0.00694663 |
| NPR3 | natriuretic peptide receptor 3 | -0.00691659 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00688347 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00687149 |
| DUSP5 | dual specificity phosphatase 5 | -0.00686222 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.00684774 |
| PROM1 | prominin 1 | -0.00672439 |
| RBPMS | RNA binding protein with multiple splicing | -0.00670768 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00659207 |
| MT1E | metallothionein 1E | -0.00658774 |
| CTH | cystathionine gamma-lyase | -0.00658528 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00656986 |
| CD38 | CD38 molecule | -0.00654465 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00651266 |
| EMP3 | epithelial membrane protein 3 | -0.00648987 |
| MT1H | metallothionein 1H | -0.0064855 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | -0.00633309 |
| BAG3 | BCL2-associated athanogene 3 | -0.00632754 |
| TPD52L1 | tumor protein D52-like 1 | -0.00631952 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.00625701 |
| TRIP6 | thyroid hormone receptor interactor 6 | -0.00621374 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.00612075 |
| SIRT3 | sirtuin 3 | -0.0061142 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00608832 |
| FAM46C | family with sequence similarity 46, member C | -0.00606542 |
| CD52 | CD52 molecule | -0.00604781 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -0.00604442 |
| STOM | stomatin | -0.00601274 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00599872 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.0059741 |
| MT1HL1 | metallothionein 1H-like 1 | -0.00596722 |
| TMPRSS2 | transmembrane protease, serine 2 | -0.00593758 |
| TBXA2R | thromboxane A2 receptor | -0.00590465 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00589991 |
| HIRA | histone cell cycle regulator | -0.00589656 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0058949 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00589321 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00588219 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.00587845 |
| UPP1 | uridine phosphorylase 1 | -0.00584713 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -0.00582558 |
| HMOX1 | heme oxygenase 1 | -0.00581563 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00580683 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00577582 |
| NKX3-1 | NK3 homeobox 1 | -0.00576295 |
| EZR | ezrin | -0.00571702 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.00570549 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00569028 |
| FOXD1 | forkhead box D1 | -0.00568387 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.00565839 |
| KLF2 | Kruppel-like factor 2 | -0.00562784 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -0.00561639 |
| F12 | coagulation factor XII (Hageman factor) | -0.00561264 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00557792 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.00557499 |
| WTAP | Wilms tumor 1 associated protein | -0.00555682 |
| TFB2M | transcription factor B2, mitochondrial | -0.005506 |
| HIST1H2BK | histone cluster 1, H2bk | -0.00550484 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.0054991 |
| ACP3 | acid phosphatase 3 | -0.00548116 |
| IL6ST | interleukin 6 signal transducer | -0.00547137 |
| CLU | clusterin | -0.00546427 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00546357 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.00544731 |
| IDS | iduronate 2-sulfatase | -0.00544306 |
| CTSB | cathepsin B | -0.00544011 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | -0.00542611 |
| S100A10 | S100 calcium binding protein A10 | -0.00541276 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | -0.00539831 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.00537848 |
| BUD31 | BUD31 homolog (S. cerevisiae) | -0.00535448 |
| STK17A | serine/threonine kinase 17a | -0.00533345 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0053251 |
| GPX1 | glutathione peroxidase 1 | -0.00530791 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.00529059 |
| REG3A | regenerating islet-derived 3 alpha | -0.0052665 |
| COG7 | component of oligomeric golgi complex 7 | -0.00524584 |
| CRHBP | corticotropin releasing hormone binding protein | -0.00523517 |
| HSPA4L | heat shock 70kDa protein 4-like | -0.00522608 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0052216 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00522154 |
| BTN3A1 | butyrophilin, subfamily 3, member A1 | -0.00521792 |
| CA2 | carbonic anhydrase II | -0.00519333 |
| XPO7 | exportin 7 | -0.00519233 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00517073 |
| LSP1 | lymphocyte-specific protein 1 | -0.00516266 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | -0.00516037 |
| UBB | ubiquitin B | -0.0051519 |
| WASL | Wiskott-Aldrich syndrome-like | -0.00509409 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00508823 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00508764 |
| GOLIM4 | golgi integral membrane protein 4 | -0.00507985 |
| COQ8A | coenzyme Q8A | -0.00503589 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00502926 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.0050255 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00501834 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00501519 |
| UROD | uroporphyrinogen decarboxylase | -0.00500528 |
| SHFM1 | split hand/foot malformation (ectrodactyly) type 1 | -0.00500219 |
| GSPT1 | G1 to S phase transition 1 | -0.00499044 |
| MIR22HG | MIR22 host gene | -0.00496093 |
| TMEM248 | transmembrane protein 248 | -0.00495908 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.00495215 |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | -0.00495003 |
| HBD | hemoglobin, delta | -0.00494593 |
| RAB29 | RAB29, member RAS oncogene family | -0.0049414 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | -0.00493869 |
| GLRX | glutaredoxin (thioltransferase) | -0.00493327 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | -0.0049268 |
| RAB13 | RAB13, member RAS oncogene family | -0.00492027 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.0049191 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.00489429 |
| BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor | -0.00488078 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.00486968 |
| ODC1 | ornithine decarboxylase 1 | -0.00486488 |
| MPC1 | mitochondrial pyruvate carrier 1 | -0.00486315 |
| AREG | amphiregulin | -0.00485797 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | -0.00485267 |
| FAM222B | family with sequence similarity 222, member B | -0.00485151 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.00484432 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00483508 |
| TBC1D31 | TBC1 domain family, member 31 | -0.00483226 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00482882 |
| SLC6A15 | solute carrier family 6 (neutral amino acid transporter), member 15 | -0.00482843 |
| TES | testin LIM domain protein | -0.00482779 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00481523 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00481106 |
| CAST | calpastatin | -0.00480263 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00480072 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -0.00479366 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.00478651 |
| CXORF40A | chromosome X open reading frame 40A | -0.00478432 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | -0.00475922 |
| ALB | albumin | -0.00475551 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00475062 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.00472485 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.00470704 |
| SRGN | serglycin | -0.00470226 |
| PCDH9 | protocadherin 9 | -0.00468781 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00468721 |
| LCN2 | lipocalin 2 | -0.00468014 |
| ERAL1 | Era-like 12S mitochondrial rRNA chaperone 1 | -0.00466156 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | -0.00466012 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | -0.00464947 |
| CXORF40B | chromosome X open reading frame 40B | -0.00464925 |
| RETREG1 | reticulophagy regulator 1 | -0.00464651 |
| BPGM | 2,3-bisphosphoglycerate mutase | -0.00463312 |
| COCH | cochlin | -0.00463164 |
| MXI1 | MAX interactor 1, dimerization protein | -0.00463136 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00462944 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.00462598 |
| NUTF2 | nuclear transport factor 2 | -0.0046195 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.00461312 |
| CYP2C8 | cytochrome P450, family 2, subfamily C, polypeptide 8 | -0.00460973 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | -0.00460053 |
| PRAME | preferentially expressed antigen in melanoma | -0.00459555 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | -0.00459106 |
| RHCG | Rh family, C glycoprotein | -0.00458786 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.00455587 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | -0.00453748 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00452846 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.0045265 |
| TGDS | TDP-glucose 4,6-dehydratase | -0.00452385 |
| FAM117A | family with sequence similarity 117, member A | -0.00451618 |
| MT2A | metallothionein 2A | -0.00449348 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.00448943 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.00446229 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.00444564 |
| IRF4 | interferon regulatory factor 4 | -0.00444358 |
| UBFD1 | ubiquitin family domain containing 1 | -0.00444052 |
| NOTCH2 | notch 2 | -0.00443461 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00442912 |
| AHNAK | AHNAK nucleoprotein | -0.00442366 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0044145 |
| FCMR | Fc fragment of IgM receptor | -0.00441306 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -0.00440986 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00439062 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0043796 |
| JMJD6 | jumonji domain containing 6 | -0.00436625 |
| NOTCH2NL | notch 2 N-terminal like | -0.00436542 |
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | -0.00435924 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.00434125 |
| SLC22A1 | solute carrier family 22 (organic cation transporter), member 1 | -0.00433127 |
| CREM | cAMP responsive element modulator | -0.00432788 |
| EGR1 | early growth response 1 | -0.00432743 |
| SIX2 | SIX homeobox 2 | -0.00432721 |
| SLC16A4 | solute carrier family 16, member 4 | -0.00432696 |
| RIT1 | Ras-like without CAAX 1 | -0.0043242 |
| GADD45G | growth arrest and DNA-damage-inducible, gamma | -0.00430659 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.00430646 |
| ZNF593 | zinc finger protein 593 | -0.00430572 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0043005 |
| GANAB | glucosidase, alpha; neutral AB | -0.00429491 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.00429345 |
| TSC22D3 | TSC22 domain family, member 3 | -0.00428048 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | -0.00427642 |
| ARG2 | arginase 2 | -0.00426735 |
| PRR5 | proline rich 5 (renal) | -0.00426569 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00425841 |
| MX1 | MX dynamin-like GTPase 1 | -0.00425274 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00425173 |
| PIGR | polymeric immunoglobulin receptor | -0.00424793 |
| ERGIC3 | ERGIC and golgi 3 | -0.00423745 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00423471 |
| IFT20 | intraflagellar transport 20 | -0.00423315 |
| BRD4 | bromodomain containing 4 | -0.0042183 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.00420398 |
| OGA | O-GlcNAcase | -0.00420137 |
| CTSS | cathepsin S | -0.00419992 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.00419817 |
| UTP3 | UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) | -0.00418834 |
| NUP85 | nucleoporin 85kDa | -0.00418388 |
| ELOA | elongin A | -0.00418339 |
| TRAF4 | TNF receptor-associated factor 4 | -0.00416939 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00415049 |
| ALX1 | ALX homeobox 1 | -0.00414508 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.00413379 |
