IL6ST Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description interleukin 6 signal transducer|The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 3572)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_IL6ST
Similar Terms
Downloads & Tools

Genes

54 co-expressed genes for IL6ST from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACAD11 acyl-CoA dehydrogenase family, member 11
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARL8B ADP-ribosylation factor-like 8B
ATMIN ATM interactor
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
C1ORF198 chromosome 1 open reading frame 198
CASC4 cancer susceptibility candidate 4
CCDC25 coiled-coil domain containing 25
CHST10 carbohydrate sulfotransferase 10
CLDND1 claudin domain containing 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DDHD2 DDHD domain containing 2
DLG1 discs, large homolog 1 (Drosophila)
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFCAB14 EF-hand calcium binding domain 14
EPT1 ethanolaminephosphotransferase 1
ERBB2IP erbb2 interacting protein
FAM219A family with sequence similarity 219, member A
FBXW11 F-box and WD repeat domain containing 11
GFM2 G elongation factor, mitochondrial 2
GLT8D1 glycosyltransferase 8 domain containing 1
GLTP glycolipid transfer protein
GOLGA7 golgin A7
GORASP1 golgi reassembly stacking protein 1, 65kDa
IL6ST interleukin 6 signal transducer
IPO5 importin 5
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KIF3B kinesin family member 3B
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MTCH2 mitochondrial carrier 2
MTMR4 myotubularin related protein 4
MYO10 myosin X
MYO9A myosin IXA
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
PACS2 phosphofurin acidic cluster sorting protein 2
PHAX phosphorylated adaptor for RNA export
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
RAB22A RAB22A, member RAS oncogene family
RDX radixin
RTN4 reticulon 4
SH2B1 SH2B adaptor protein 1
SIRT2 sirtuin 2
SPRED2 sprouty-related, EVH1 domain containing 2
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D10B TBC1 domain family, member 10B
TEX261 testis expressed 261
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM30A transmembrane protein 30A
TNS2 tensin 2
TSNAX translin-associated factor X
WSB1 WD repeat and SOCS box containing 1
XPOT exportin, tRNA