IL6ST Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interleukin 6 signal transducer|The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 3572)
External Link http://www.ncbi.nlm.nih.gov/gene/3572
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Genes

59 interacting proteins for IL6ST from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AR androgen receptor
CDK9 cyclin-dependent kinase 9
CMYA5 cardiomyopathy associated 5
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
CTF1 cardiotrophin 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXO1 forkhead box O1
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GRB2 growth factor receptor-bound protein 2
HCK HCK proto-oncogene, Src family tyrosine kinase
HNF4A hepatocyte nuclear factor 4, alpha
IL11 interleukin 11
IL11RA interleukin 11 receptor, alpha
IL31RA interleukin 31 receptor A
IL6 interleukin 6
IL6R interleukin 6 receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MITF microphthalmia-associated transcription factor
OSM oncostatin M
OSMR oncostatin M receptor
PIAS1 protein inhibitor of activated STAT, 1
PIAS3 protein inhibitor of activated STAT, 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAUR plasminogen activator, urokinase receptor
PRKCD protein kinase C, delta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRE protein tyrosine phosphatase, receptor type, E
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLA2 Src-like-adaptor 2
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TYK2 tyrosine kinase 2
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor