IMPACT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description impact RWD domain protein| (NCBI Entrez Gene Database, 55364)
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Genes

303 genes differentially expressed following the IMPACT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AGTR1 angiotensin II receptor, type 1 2.91616
ZNF467 zinc finger protein 467 2.91616
HES5 hes family bHLH transcription factor 5 2.91616
SSTR1 somatostatin receptor 1 2.91616
TM4SF20 transmembrane 4 L six family member 20 2.91616
MYBPC3 myosin binding protein C, cardiac 2.91616
RRAD Ras-related associated with diabetes 2.91616
DSG3 desmoglein 3 2.91616
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.91616
TNNI1 troponin I type 1 (skeletal, slow) 2.91616
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.91616
MUC6 mucin 6, oligomeric mucus/gel-forming 2.91616
LY86 lymphocyte antigen 86 2.91616
VTN vitronectin 2.91616
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.91616
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.91616
ENTHD1 ENTH domain containing 1 2.91616
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.91616
SPINK4 serine peptidase inhibitor, Kazal type 4 2.91616
PRELP proline/arginine-rich end leucine-rich repeat protein 2.91616
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.91616
PBOV1 prostate and breast cancer overexpressed 1 2.91616
GPR22 G protein-coupled receptor 22 2.91616
IL2RG interleukin 2 receptor, gamma 2.91616
TRPC5OS TRPC5 opposite strand 2.91616
SPHK1 sphingosine kinase 1 2.91616
RNF39 ring finger protein 39 2.91616
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.91616
KCNU1 potassium channel, subfamily U, member 1 2.91616
FGF3 fibroblast growth factor 3 2.91616
PODN podocan 2.91616
HBM hemoglobin, mu 2.91616
DLX4 distal-less homeobox 4 2.91616
FABP12 fatty acid binding protein 12 2.91616
ADAD2 adenosine deaminase domain containing 2 2.91616
REN renin 2.91616
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.91616
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.91616
C3ORF22 chromosome 3 open reading frame 22 2.91616
PRODH proline dehydrogenase (oxidase) 1 2.91616
FSCN2 fascin actin-bundling protein 2, retinal 2.91616
TTLL8 tubulin tyrosine ligase-like family member 8 2.91616
GPR78 G protein-coupled receptor 78 2.91616
PNMA6F PNMA family member 6F 2.91616
ZAR1 zygote arrest 1 2.91616
LTB4R2 leukotriene B4 receptor 2 2.91616
CLDN16 claudin 16 2.91616
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.91616
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.91616
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.91616
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.91616
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.91616
PCDHGA9 protocadherin gamma subfamily A, 9 2.91616
STING1 stimulator of interferon response cGAMP interactor 1 2.91616
CALHM5 calcium homeostasis modulator family member 5 2.91616
NHERF4 NHERF family PDZ scaffold protein 4 2.91616
C1ORF232 chromosome 1 open reading frame 230 2.91616
LOC124903372 uncharacterized LOC124903372 2.91616
SPAAR small regulatory polypeptide of amino acid response 2.91616
FYB2 FYN binding protein 2 2.91616
MAJIN membrane anchored junction protein 2.91616
TMEM270 transmembrane protein 270 2.91616
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.91616
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.91616
FCMR Fc fragment of IgM receptor 2.91616
FASTKD1 FAST kinase domains 1 2.91616
ZIC4 Zic family member 4 2.91616
TMCO2 transmembrane and coiled-coil domains 2 2.91616
SLPI secretory leukocyte peptidase inhibitor 2.91616
LRTM3 leucine rich repeat transmembrane protein 3 2.91616
RHOXF2 Rhox homeobox family, member 2 2.91616
NKX2-4 NK2 homeobox 4 2.91616
RAB41 RAB41, member RAS oncogene family 2.91616
KLHL34 kelch-like family member 34 2.91616
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.91616
DEPDC4 DEP domain containing 4 2.91616
TLR7 toll-like receptor 7 2.91616
OSTN osteocrin 2.91616
SOAT2 sterol O-acyltransferase 2 2.91616
GDF9 growth differentiation factor 9 2.91616
GPR132 G protein-coupled receptor 132 2.91616
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.91616
FAM131C family with sequence similarity 131, member C 2.91616
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.91616
TBX3 T-box 3 2.91616
PLVAP plasmalemma vesicle associated protein 2.91616
TPO thyroid peroxidase 2.91616
CNTF ciliary neurotrophic factor 2.91616
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.91616
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.91616
ANKRD62 ankyrin repeat domain 62 2.91616
KLF1 Kruppel-like factor 1 (erythroid) 2.91616
DMTN dematin actin binding protein 2.91616
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.91616
MAPK11 mitogen-activated protein kinase 11 2.91616
KLF4 Kruppel-like factor 4 (gut) 2.91616
IL36R interleukin 36 receptor 2.91616
TBXA2R thromboxane A2 receptor 2.91616
C9ORF57 chromosome 9 open reading frame 57 2.91616
MC5R melanocortin 5 receptor 2.91616
SHISA8 shisa family member 8 2.91616
ZMYND10 zinc finger, MYND-type containing 10 2.91616
CXCR6 chemokine (C-X-C motif) receptor 6 2.91616
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.91616
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.91616
EDN1 endothelin 1 2.91616
CALCRL calcitonin receptor-like 2.91616
CERKL ceramide kinase-like 2.91616
ADGRA1 adhesion G protein-coupled receptor A1 2.91616
LRCOL1 leucine rich colipase-like 1 2.91616
OR2T12 olfactory receptor, family 2, subfamily T, member 12 2.91616
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.91616
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.91616
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.91616
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.91616
CTAGE9 CTAGE family, member 9 2.91616
OR5H15 olfactory receptor, family 5, subfamily H, member 15 2.91616
PRR23B proline rich 23B 2.91616
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.91616
WFDC10A WAP four-disulfide core domain 10A 2.91616
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.91616
IL26 interleukin 26 2.91616
CPN2 carboxypeptidase N, polypeptide 2 2.91616
GJB6 gap junction protein, beta 6, 30kDa 2.91616
GBX2 gastrulation brain homeobox 2 2.91616
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.91616
SFTA2 surfactant associated 2 2.91616
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.91616
WFDC13 WAP four-disulfide core domain 13 2.91616
GOLGA8H golgin A8 family, member H 2.91616
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.91616
TMEM184A transmembrane protein 184A 2.91616
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.91616
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.91616
DLX3 distal-less homeobox 3 2.91616
SLC38A3 solute carrier family 38, member 3 2.91616
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.91616
KISS1 KiSS-1 metastasis-suppressor 2.91616
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.91616
TMEM156 transmembrane protein 156 2.91616
ALS2CL ALS2 C-terminal like 2.91616
TEX35 testis expressed 35 2.91616
MMP13 matrix metallopeptidase 13 2.91616
SOST sclerostin 2.91616
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.91616
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.91616
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.91616
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.91616
ZBTB16 zinc finger and BTB domain containing 16 2.85738
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.85738
PTPRB protein tyrosine phosphatase, receptor type, B 2.85738
KLF6 Kruppel-like factor 6 2.85447
POU3F1 POU class 3 homeobox 1 2.78973
RIOK3 RIO kinase 3 2.77775
DOHH deoxyhypusine hydroxylase/monooxygenase 2.77186
TMEM214 transmembrane protein 214 2.77181
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.72863
ICA1 islet cell autoantigen 1, 69kDa 2.71804
FSAF1 40S small subunit processome assembly factor 1 2.71749
COL25A1 collagen, type XXV, alpha 1 2.71749
ZNF100 zinc finger protein 100 2.68463
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 2.66558
ZNF329 zinc finger protein 329 2.64192
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 2.60814
PHYH phytanoyl-CoA 2-hydroxylase 2.60814
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.60207
PSIP1 PC4 and SFRS1 interacting protein 1 2.56508
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 2.55801
HOMER3 homer scaffolding protein 3 2.55291
MLX MLX, MAX dimerization protein 2.55291
IDE insulin-degrading enzyme 2.50546
MYOM1 myomesin 1 2.48384
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.43535
CENPO centromere protein O 2.41608
RAB7A RAB7A, member RAS oncogene family 2.41574
ZFP82 ZFP82 zinc finger protein 2.41574
FZD6 frizzled class receptor 6 2.41291
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 2.40137
EBF4 early B-cell factor 4 2.36034
POPDC2 popeye domain containing 2 2.36034
GSE1 Gse1 coiled-coil protein 2.35933
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.3564
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.35359
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.33585
TMEM178B transmembrane protein 178B 2.32946
ADGRG2 adhesion G protein-coupled receptor G2 2.32019
SMIM11 small integral membrane protein 11 2.30685
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.28138
EFNA2 ephrin-A2 2.26884
ISM1 isthmin 1, angiogenesis inhibitor 2.26195
IREB2 iron-responsive element binding protein 2 2.23636
GDE1 glycerophosphodiester phosphodiesterase 1 2.2301
SEC61G Sec61 gamma subunit 2.22129
NUP98 nucleoporin 98kDa 2.20903
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 2.19606
HMGXB3 HMG box domain containing 3 2.19394
FAM53A family with sequence similarity 53, member A 2.15413
SLC38A1 solute carrier family 38, member 1 2.15085
TMEM44 transmembrane protein 44 2.14872
NUP37 nucleoporin 37kDa 2.13993
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 2.13973
CRY1 cryptochrome circadian clock 1 2.11174
LEFTY2 left-right determination factor 2 2.09485
ZNG1F Zn regulated GTPase metalloprotein activator 1F 2.09477
CIMAP3 ciliary microtubule associated protein 3 2.09468
GAL3ST1 galactose-3-O-sulfotransferase 1 2.07786
RNF2 ring finger protein 2 2.07786
ASB16 ankyrin repeat and SOCS box containing 16 2.07511
BEST1 bestrophin 1 2.06605
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 2.05588
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.05499
LGALS7B lectin, galactoside-binding, soluble, 7B 2.05119
TNMD tenomodulin 2.05119
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.05119
RANBP3L RAN binding protein 3-like 2.05119
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2.04576
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.04191
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.03988

decreased expression

Symbol Name Standardized Value
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.91616
MRPL51 mitochondrial ribosomal protein L51 -2.91616
FLYWCH2 FLYWCH family member 2 -2.91616
RNF10 ring finger protein 10 -2.91616
PCDHA4 protocadherin alpha 4 -2.91616
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.91616
SGK2 serum/glucocorticoid regulated kinase 2 -2.91616
TOR2A torsin family 2, member A -2.91616
H3C11 H3 clustered histone 11 -2.78583
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.78382
TBC1D3L TBC1 domain family, member 3L -2.77186
IRF2-DT IRF2 divergent transcript -2.77186
TWIST1 twist family bHLH transcription factor 1 -2.77186
ASCL2 achaete-scute family bHLH transcription factor 2 -2.77186
LPO lactoperoxidase -2.77186
SNPH syntaphilin -2.77186
SFTPB surfactant protein B -2.77186
UNC93A unc-93 homolog A (C. elegans) -2.77186
GDF6 growth differentiation factor 6 -2.77186
FAM43B family with sequence similarity 43, member B -2.77186
PCDHB10 protocadherin beta 10 -2.77186
EGFLAM EGF-like, fibronectin type III and laminin G domains -2.77186
SLC46A3 solute carrier family 46, member 3 -2.77186
S100A2 S100 calcium binding protein A2 -2.77186
HAS1 hyaluronan synthase 1 -2.77186
TMEM88 transmembrane protein 88 -2.77186
EMP1 epithelial membrane protein 1 -2.77186
POTEF POTE ankyrin domain family, member F -2.77186
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.77186
ANKRD55 ankyrin repeat domain 55 -2.77186
LRRC38 leucine rich repeat containing 38 -2.77186
AMN amnion associated transmembrane protein -2.77186
PLGLB2 plasminogen-like B2 -2.77186
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 -2.66316
DPP8 dipeptidyl-peptidase 8 -2.60457
DCST2 DC-STAMP domain containing 2 -2.58338
IL11 interleukin 11 -2.55828
PCDH9 protocadherin 9 -2.55828
METTL25B methyltransferase like 25B -2.50729
RAD51C RAD51 paralog C -2.49601
C2CD4C C2 calcium-dependent domain containing 4C -2.47642
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.42435
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.39364
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.37265
TIMP2 TIMP metallopeptidase inhibitor 2 -2.34675
RPSA ribosomal protein SA -2.32787
ZSCAN5A zinc finger and SCAN domain containing 5A -2.29415
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 -2.26195
S100A10 S100 calcium binding protein A10 -2.25615
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -2.25498
UBIAD1 UbiA prenyltransferase domain containing 1 -2.24236
CPTP ceramide-1-phosphate transfer protein -2.22922
PTGES3L prostaglandin E synthase 3 (cytosolic)-like -2.21808
PLK2 polo-like kinase 2 -2.20025
ELMOD1 ELMO/CED-12 domain containing 1 -2.1821
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -2.17902
FAM186B family with sequence similarity 186, member B -2.17902
PVALEF parvalbumin like EF-hand containing -2.17902
LBP lipopolysaccharide binding protein -2.17902
NME8 NME/NM23 family member 8 -2.17902
CYTH1 cytohesin 1 -2.17902
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.17547
GLYATL2 glycine-N-acyltransferase-like 2 -2.16943
AUP1 ancient ubiquitous protein 1 -2.15684
PM20D2 peptidase M20 domain containing 2 -2.13133
EID1 EP300 interacting inhibitor of differentiation 1 -2.13133
LMBRD2 LMBR1 domain containing 2 -2.11688
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.11665
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.10775
LINGO2 leucine rich repeat and Ig domain containing 2 -2.10725
TRIM13 tripartite motif containing 13 -2.10725
OSCAR osteoclast associated, immunoglobulin-like receptor -2.09485
IMPACT impact RWD domain protein -2.07786
FGFBP3 fibroblast growth factor binding protein 3 -2.07786
TMEM208 transmembrane protein 208 -2.07729
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -2.06575
C1QTNF4 C1q and tumor necrosis factor related protein 4 -2.05588
IQANK1 IQ motif and ankyrin repeat containing 1 -2.05588
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.05119
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -2.03988
TRIM5 tripartite motif containing 5 -2.03786
MYL7 myosin, light chain 7, regulatory -2.03786
SNCB synuclein, beta -2.02531
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.02531
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.00974