IMPDH1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description IMP (inosine 5'-monophosphate) dehydrogenase 1|The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 3614)
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8 interacting proteins for IMPDH1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
GMNN geminin, DNA replication inhibitor
HTRA1 HtrA serine peptidase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
LAMP2 lysosomal-associated membrane protein 2
SUMO4 small ubiquitin-like modifier 4
UBC ubiquitin C
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6