INDOPROFEN Gene Set

Dataset	DGIdb Drug Targets 2026
Category	physical interactions
Type	drug
Description	A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein. (Chemical Entities of Biological Interest Ontology, CHEBI_76162)
External Link	https://dgidb.org/results?searchType=drug&searchTerms=INDOPROFEN
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Genes

12 interacting proteins for the INDOPROFEN drug from theDGIdb Drug Targets 2026 dataset.

Symbol	Name	Standardized Value
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.116079
RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	0.0832264
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.0464316
PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	0.04411
SMN2	survival of motor neuron 2, centromeric	0.0341938
SMN1	survival of motor neuron 1, telomeric	0.0331654
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.0331654
NPC1	Niemann-Pick disease, type C1	0.0321971
RAB9A	RAB9A, member RAS oncogene family	0.0306319
HTT	huntingtin	0.0292119
GLP1R	glucagon-like peptide 1 receptor	0.0227371
TP53	tumor protein p53	0.00958913