INPP5D Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description inositol polyphosphate-5-phosphatase, 145kDa|This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 3635)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_INPP5D
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Genes

43 co-expressed genes for INPP5D from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ARF6 ADP-ribosylation factor 6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C17ORF62 chromosome 17 open reading frame 62
CBFB core-binding factor, beta subunit
CD48 CD48 molecule
CD53 CD53 molecule
CDV3 CDV3 homolog (mouse)
CORO1A coronin, actin binding protein, 1A
CSK c-src tyrosine kinase
CSNK1G2 casein kinase 1, gamma 2
CYTIP cytohesin 1 interacting protein
ELF4 E74-like factor 4 (ets domain transcription factor)
GRK6 G protein-coupled receptor kinase 6
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI16 interferon, gamma-inducible protein 16
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KDM5A lysine (K)-specific demethylase 5A
LAPTM5 lysosomal protein transmembrane 5
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
PHF11 PHD finger protein 11
PSD4 pleckstrin and Sec7 domain containing 4
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1B RAP1B, member of RAS oncogene family
RNF4 ring finger protein 4
SASH3 SAM and SH3 domain containing 3
SIPA1 signal-induced proliferation-associated 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK10 serine/threonine kinase 10
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1