INPP5D Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description inositol polyphosphate-5-phosphatase, 145kDa|This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 3635)
External Link http://www.ncbi.nlm.nih.gov/gene/3635
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157 interacting proteins for INPP5D from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ACTB actin, beta
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARL1 ADP-ribosylation factor-like 1
ARMC10 armadillo repeat containing 10
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
BAIAP2 BAI1-associated protein 2
BCR breakpoint cluster region
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD22 CD22 molecule
CD2AP CD2-associated protein
CD300LF CD300 molecule-like family member f
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD84 CD84 molecule
CDC42 cell division cycle 42
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CLEC4M C-type lectin domain family 4, member M
CLYBL citrate lyase beta like
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1R colony stimulating factor 1 receptor
CSF3R colony stimulating factor 3 receptor (granulocyte)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EPOR erythropoietin receptor
FAAH fatty acid amide hydrolase
FAHD1 fumarylacetoacetate hydrolase domain containing 1
FAS Fas cell surface death receptor
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FECH ferrochelatase
FGR FGR proto-oncogene, Src family tyrosine kinase
FLOT2 flotillin 2
FLT3 fms-related tyrosine kinase 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GRB2 growth factor receptor-bound protein 2
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H2AI histone cluster 1, H2ai
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1B heat shock 70kDa protein 1B
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
IL4R interleukin 4 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSR insulin receptor
IRAK2 interleukin-1 receptor-associated kinase 2
IRS1 insulin receptor substrate 1
ITFG3 integrin alpha FG-GAP repeat containing 3
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT10 keratin 10, type I
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LMNA lamin A/C
LONP1 lon peptidase 1, mitochondrial
LRRK1 leucine-rich repeat kinase 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MRPL44 mitochondrial ribosomal protein L44
MRPS25 mitochondrial ribosomal protein S25
MRVI1 murine retrovirus integration site 1 homolog
MTDH metadherin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYH9 myosin, heavy chain 9, non-muscle
MYO10 myosin X
NCK1 NCK adaptor protein 1
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NNT nicotinamide nucleotide transhydrogenase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OPA1 optic atrophy 1 (autosomal dominant)
PCNA proliferating cell nuclear antigen
PDIA5 protein disulfide isomerase family A, member 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POTEH POTE ankyrin domain family, member H
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP2B RAP2B, member of RAS oncogene family
RBM39 RNA binding motif protein 39
RPL30 ribosomal protein L30
RPS10 ribosomal protein S10
RPS23 ribosomal protein S23
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SACK1F scaffolding CK1 anchoring protein F
SDF4 stromal cell derived factor 4
SH2D1B SH2 domain containing 1B
SH3KBP1 SH3-domain kinase binding protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRSF11 serine/arginine-rich splicing factor 11
SSR4 signal sequence receptor, delta
SYK spleen tyrosine kinase
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM9SF1 transmembrane 9 superfamily member 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNPO1 transportin 1
TRIP10 thyroid hormone receptor interactor 10
TUBB8 tubulin, beta 8 class VIII
UBAC2 UBA domain containing 2
UBASH3B ubiquitin associated and SH3 domain containing B
UBC ubiquitin C
UTRN utrophin
VDAC2 voltage-dependent anion channel 2
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WASL Wiskott-Aldrich syndrome-like
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZDHHC17 zinc finger, DHHC-type containing 17
ZMPSTE24 zinc metallopeptidase STE24