INS Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description insulin|After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 3630)
External Link http://www.ncbi.nlm.nih.gov/gene/3630
Similar Terms
Downloads & Tools

Genes

73 interacting proteins for INS from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APP amyloid beta (A4) precursor protein
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CPE carboxypeptidase E
CPN1 carboxypeptidase N, polypeptide 1
CRYAB crystallin, alpha B
CTSB cathepsin B
CTSD cathepsin D
CTSE cathepsin E
DCN decorin
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
ERO1L ERO1-like (S. cerevisiae)
ERO1LB ERO1-like beta (S. cerevisiae)
GCG glucagon
GCK glucokinase (hexokinase 4)
GHRL ghrelin/obestatin prepropeptide
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRB10 growth factor receptor-bound protein 10
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB1 heat shock 27kDa protein 1
IDE insulin-degrading enzyme
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KMT2A lysine (K)-specific methyltransferase 2A
LRP2 low density lipoprotein receptor-related protein 2
MAPK6 mitogen-activated protein kinase 6
MYO5A myosin VA (heavy chain 12, myoxin)
NOV nephroblastoma overexpressed
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNA phosphatidylinositol transfer protein, alpha
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRA protein tyrosine phosphatase, receptor type, A
RAB27A RAB27A, member RAS oncogene family
RB1 retinoblastoma 1
SGK1 serum/glucocorticoid regulated kinase 1
SH2B2 SH2B adaptor protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC30A6 solute carrier family 30 (zinc transporter), member 6
SLC30A7 solute carrier family 30 (zinc transporter), member 7
SORBS1 sorbin and SH3 domain containing 1
STX1A syntaxin 1A (brain)
SYTL4 synaptotagmin-like 4
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TXNDC17 thioredoxin domain containing 17
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)