INSM1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description insulinoma-associated 1|Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3642)
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Genes

325 genes differentially expressed following the INSM1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AXDND1 axonemal dynein light chain domain containing 1 3.30059
GJA3 gap junction protein, alpha 3, 46kDa 3.30059
TMPRSS11F transmembrane protease, serine 11F 3.30059
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 3.30059
FAM180A family with sequence similarity 180, member A 3.30059
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 3.30059
SLC46A3 solute carrier family 46, member 3 3.30059
IGFL4 IGF-like family member 4 3.30059
IGFL3 IGF-like family member 3 3.30059
TMEM244 transmembrane protein 244 3.30059
GJA9 gap junction protein, alpha 9, 59kDa 3.30059
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.30059
NKX3-1 NK3 homeobox 1 3.30059
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.30059
VSX2 visual system homeobox 2 3.30059
IRF5 interferon regulatory factor 5 3.30059
C1ORF87 chromosome 1 open reading frame 87 3.30059
GIGYF1 GRB10 interacting GYF protein 1 3.30059
REG4 regenerating islet-derived family, member 4 3.30059
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 3.30059
PCDHA5 protocadherin alpha 5 3.30059
OR2A2 olfactory receptor, family 2, subfamily A, member 2 3.30059
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.30059
MYBPC3 myosin binding protein C, cardiac 3.30059
GFAP glial fibrillary acidic protein 3.30059
CELA1 chymotrypsin-like elastase family, member 1 3.30059
DLX4 distal-less homeobox 4 3.30059
PNOC prepronociceptin 3.30059
PTK6 protein tyrosine kinase 6 3.30059
OXT oxytocin/neurophysin I prepropeptide 3.30059
ATOH8 atonal homolog 8 (Drosophila) 3.30059
TRPC5OS TRPC5 opposite strand 3.30059
SP6 Sp6 transcription factor 3.30059
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.30059
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.30059
LCN12 lipocalin 12 3.30059
ZNF518A zinc finger protein 518A 3.30059
XCL1 chemokine (C motif) ligand 1 3.30059
OLFM4 olfactomedin 4 3.30059
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.30059
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.30059
OOEP oocyte expressed protein 3.30059
MYOM3 myomesin 3 3.30059
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.30059
KCNRG potassium channel regulator 3.30059
POSTN periostin, osteoblast specific factor 3.30059
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.30059
TEKTL1 tektin like 1 3.30059
SCEL sciellin 3.30059
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.30059
VN1R2 vomeronasal 1 receptor 2 3.30059
DNAAF1 dynein, axonemal, assembly factor 1 3.30059
MLN motilin 3.30059
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.30059
SMPX small muscle protein, X-linked 3.30059
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 3.30059
ASB4 ankyrin repeat and SOCS box containing 4 3.30059
CLDN14 claudin 14 3.30059
AVPR1A arginine vasopressin receptor 1A 3.30059
PTH1R parathyroid hormone 1 receptor 3.30059
LY6S-AS1 LY6S antisense RNA 1 3.30059
C4ORF54 chromosome 4 open reading frame 54 3.30059
LOC124902436 talanin 3.30059
EZHIP EZH inhibitory protein 3.30059
SPEM2 SPEM family member 2 3.30059
CATSPERZ catsper channel auxiliary subunit zeta 3.30059
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 3.30059
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.30059
MT3 metallothionein 3 3.30059
SRPK3 SRSF protein kinase 3 3.30059
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.30059
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 3.30059
NPFF neuropeptide FF-amide peptide precursor 3.30059
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.30059
MYOT myotilin 3.30059
C1QTNF1 C1q and tumor necrosis factor related protein 1 3.30059
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.30059
CFAP45 cilia and flagella associated protein 45 3.30059
SLAMF6 SLAM family member 6 3.30059
C1ORF162 chromosome 1 open reading frame 162 3.30059
SIM2 single-minded family bHLH transcription factor 2 3.30059
CCR9 chemokine (C-C motif) receptor 9 3.30059
CDKN2A cyclin-dependent kinase inhibitor 2A 3.30059
CLDN22 claudin 22 3.30059
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.30059
SYT15 synaptotagmin XV 3.30059
ACE2 angiotensin I converting enzyme 2 3.30059
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.30059
PXDC1 PX domain containing 1 3.30059
NPIPB8 nuclear pore complex interacting protein family, member B8 3.30059
GDF9 growth differentiation factor 9 3.30059
IL1R1 interleukin 1 receptor, type I 3.30059
VCX3A variable charge, X-linked 3A 3.30059
CATSPER1 cation channel, sperm associated 1 3.30059
C5AR2 complement component 5a receptor 2 3.30059
PSKH2 protein serine kinase H2 3.30059
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.30059
MAB21L1 mab-21-like 1 (C. elegans) 3.30059
ALOXE3 arachidonate lipoxygenase 3 3.30059
BCO1 beta-carotene oxygenase 1 3.30059
VWA7 von Willebrand factor A domain containing 7 3.30059
THBD thrombomodulin 3.30059
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.30059
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.30059
TREH trehalase (brush-border membrane glycoprotein) 3.30059
C16ORF78 chromosome 16 open reading frame 78 3.30059
CALML5 calmodulin-like 5 3.30059
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.30059
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.30059
APOD apolipoprotein D 3.30059
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.30059
C9ORF64 chromosome 9 open reading frame 64 3.30059
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.30059
SPINK9 serine peptidase inhibitor, Kazal type 9 3.30059
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.30059
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.30059
TCEA3 transcription elongation factor A (SII), 3 3.30059
ANKRD55 ankyrin repeat domain 55 3.30059
EFCAB12 EF-hand calcium binding domain 12 3.30059
ABLIM3 actin binding LIM protein family, member 3 3.30059
POU4F2 POU class 4 homeobox 2 3.30059
EOMES eomesodermin 3.30059
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.30059
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.30059
GJC2 gap junction protein, gamma 2, 47kDa 3.30059
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.30059
ITGAD integrin, alpha D 3.30059
NXF2B nuclear RNA export factor 2B 3.30059
MYLK2 myosin light chain kinase 2 3.30059
GSTA1 glutathione S-transferase alpha 1 3.30059
CRHBP corticotropin releasing hormone binding protein 3.30059
CTSF cathepsin F 3.30059
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.30059
CA5A carbonic anhydrase VA, mitochondrial 3.30059
PGR progesterone receptor 3.30059
PSG9 pregnancy specific beta-1-glycoprotein 9 3.30059
TCAP titin-cap 3.30059
GCGR glucagon receptor 3.30059
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.30059
CHRDL2 chordin-like 2 3.30059
GPR150 G protein-coupled receptor 150 3.30059
CD80 CD80 molecule 3.30059
POTEF POTE ankyrin domain family, member F 3.30059
DEFB134 defensin, beta 134 3.30059
TAS2R41 taste receptor, type 2, member 41 3.30059
PF4V1 platelet factor 4 variant 1 3.30059
TGM6 transglutaminase 6 3.30059
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.30059
NNMT nicotinamide N-methyltransferase 3.30059
SYTL4 synaptotagmin-like 4 3.30059
RERGL RERG/RAS-like 3.30059
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.30059
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.30059
ARID3B AT rich interactive domain 3B (BRIGHT-like) 3.30059
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.30059
FGF9 fibroblast growth factor 9 3.30059
TWIST1 twist family bHLH transcription factor 1 3.30059
POU3F2 POU class 3 homeobox 2 3.30059
PITX2 paired-like homeodomain 2 3.30059
SCIN scinderin 3.30059
NUTM2D NUT family member 2D 3.30059
SNAI2 snail family zinc finger 2 3.30059
KLK14 kallikrein-related peptidase 14 3.23087
ACTA2 actin, alpha 2, smooth muscle, aorta 3.23087
NPR2 natriuretic peptide receptor 2 3.19823
PTGR3 prostaglandin reductase 3 3.19823
LIF leukemia inhibitory factor 3.1188
DSTYK dual serine/threonine and tyrosine protein kinase 3.09732
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 3.07278
VCF1 VCP nuclear cofactor family member 1 3.05553
ARL4D ADP-ribosylation factor-like 4D 3.03085
FMO3 flavin containing monooxygenase 3 2.95673
KIAA0232 KIAA0232 2.86059
SYT12 synaptotagmin XII 2.66325
ADAM33 ADAM metallopeptidase domain 33 2.66076
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.56544
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.55985
REEP3 receptor accessory protein 3 2.54637
RPL23A ribosomal protein L23a 2.54637
PIH1D2 PIH1 domain containing 2 2.53965
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.53965
ATP13A4 ATPase type 13A4 2.49279
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.46789
SPATS2 spermatogenesis associated, serine-rich 2 2.42076
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 2.40929
ZBTB42 zinc finger and BTB domain containing 42 2.37084
NRSN1 neurensin 1 2.37084
LRRC36 leucine rich repeat containing 36 2.37084
H4C1 H4 clustered histone 1 2.37084
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 2.37084
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 2.34912
CBX2 chromobox homolog 2 2.34912
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.33203
ZNF883 zinc finger protein 883 2.32223
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.29354
GNRHR gonadotropin-releasing hormone receptor 2.29132
SSH3 slingshot protein phosphatase 3 2.29132
IFITM1 interferon induced transmembrane protein 1 2.29088
MRPS12 mitochondrial ribosomal protein S12 2.29088
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.26305
ASMTL acetylserotonin O-methyltransferase-like 2.25068
GPRC5B G protein-coupled receptor, class C, group 5, member B 2.24602
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.24507
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 2.20659
FOXJ2 forkhead box J2 2.19611
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.17675
SMIM26 small integral membrane protein 26 2.17433
BCL2L12 BCL2-like 12 (proline rich) 2.14775
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 2.14483
FHL1 four and a half LIM domains 1 2.1389
TGOLN2 trans-golgi network protein 2 2.1389
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.11955
KIF3A kinesin family member 3A 2.11955
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.11955
FLYWCH2 FLYWCH family member 2 2.10554
DCAF6 DDB1 and CUL4 associated factor 6 2.08399
PLBD2 phospholipase B domain containing 2 2.06992
HTRA1 HtrA serine peptidase 1 2.06804
RIMKLA ribosomal modification protein rimK-like family member A 2.05438
ZMAT3 zinc finger, matrin-type 3 2.03885

decreased expression

Symbol Name Standardized Value
HEPHL1 hephaestin-like 1 -3.30059
NPNT nephronectin -3.30059
MROH6 maestro heat-like repeat family member 6 -3.30059
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -3.30059
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -3.30059
LBHD1 LBH domain containing 1 -3.30059
NPR1 natriuretic peptide receptor 1 -3.19492
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -3.19492
PADI3 peptidyl arginine deiminase, type III -3.19492
PTPRQ protein tyrosine phosphatase, receptor type, Q -3.19492
LAMP3 lysosomal-associated membrane protein 3 -3.19492
IRF4 interferon regulatory factor 4 -3.19492
IZUMO3 IZUMO family member 3 -3.19492
LRG1 leucine-rich alpha-2-glycoprotein 1 -3.19492
TRIM73 tripartite motif containing 73 -3.19492
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -3.19492
SGPP2 sphingosine-1-phosphate phosphatase 2 -3.19492
IQCJ IQ motif containing J -3.19492
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -3.19492
NOD2 nucleotide-binding oligomerization domain containing 2 -3.19492
SPNS2 spinster homolog 2 (Drosophila) -3.19492
PCDHB9 protocadherin beta 9 -3.19492
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.19492
MIP major intrinsic protein of lens fiber -3.19492
IRF2-DT IRF2 divergent transcript -3.19492
PLA2G12B phospholipase A2, group XIIB -3.19492
SDS serine dehydratase -3.19492
INSM1 insulinoma-associated 1 -3.19492
LHX2 LIM homeobox 2 -3.19492
ORM2 orosomucoid 2 -3.19492
GARIN1A golgi associated RAB2 interactor 1A -3.19492
MEPE matrix extracellular phosphoglycoprotein -3.19492
TMEM225B transmembrane protein 225B -3.19492
DRC1 dynein regulatory complex subunit 1 -3.19492
LOC124906010 uncharacterized LOC124906010 -3.19492
ZNF835 zinc finger protein 835 -3.19492
ZC3H11C zinc finger CCCH-type containing 11C -3.19492
PGA5 pepsinogen 5, group I (pepsinogen A) -3.19492
FRK fyn-related Src family tyrosine kinase -3.19492
WDR64 WD repeat domain 64 -3.19492
CLRN1 clarin 1 -3.19492
AGXT2 alanine--glyoxylate aminotransferase 2 -3.19492
AANAT aralkylamine N-acetyltransferase -3.19492
TTC16 tetratricopeptide repeat domain 16 -3.19492
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -3.06853
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -2.98514
SRI sorcin -2.95323
SLC66A3 solute carrier family 66 member 3 -2.86836
CDC16 cell division cycle 16 -2.86059
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.74911
TBC1D4 TBC1 domain family, member 4 -2.7055
PRRT1 proline-rich transmembrane protein 1 -2.66076
OGDHL oxoglutarate dehydrogenase-like -2.64884
ZNF181 zinc finger protein 181 -2.64884
ZSCAN10 zinc finger and SCAN domain containing 10 -2.63704
ERP44 endoplasmic reticulum protein 44 -2.59967
CPN1 carboxypeptidase N, polypeptide 1 -2.56735
MIB1 mindbomb E3 ubiquitin protein ligase 1 -2.55815
SYNDIG1L synapse differentiation inducing 1-like -2.52372
MLF1 myeloid leukemia factor 1 -2.47728
TM2D3 TM2 domain containing 3 -2.46789
SYT15B synaptotagmin 15B -2.4542
CFAP161 cilia and flagella associated protein 161 -2.45023
TTC33 tetratricopeptide repeat domain 33 -2.43797
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -2.43271
TNNI3K TNNI3 interacting kinase -2.3851
TMEM178B transmembrane protein 178B -2.37769
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.37084
IRAK2 interleukin-1 receptor-associated kinase 2 -2.35161
TMEM258 transmembrane protein 258 -2.33203
KNL1 kinetochore scaffold 1 -2.26305
GLRX glutaredoxin (thioltransferase) -2.26222
VWDE von Willebrand factor D and EGF domains -2.26092
CNGA4 cyclic nucleotide gated channel alpha 4 -2.25068
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.25068
ANGPTL4 angiopoietin-like 4 -2.25068
FXYD6 FXYD domain containing ion transport regulator 6 -2.25068
ANGPT4 angiopoietin 4 -2.25068
FSIP1 fibrous sheath interacting protein 1 -2.248
USB1 U6 snRNA biogenesis 1 -2.24706
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.24487
SYCE1L synaptonemal complex central element protein 1-like -2.24487
PTER phosphotriesterase related -2.23299
BCLAF1 BCL2-associated transcription factor 1 -2.23299
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.22472
PXN paxillin -2.20659
ECRG4 ECRG4 augurin precursor -2.20635
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -2.19611
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.19611
TMEM123 transmembrane protein 123 -2.19611
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.18415
HID1 HID1 domain containing -2.15447
AHCYL2 adenosylhomocysteinase-like 2 -2.14792
CSMD2 CUB and Sushi multiple domains 2 -2.09709
FAM168A family with sequence similarity 168, member A -2.07981
CHMP4B charged multivesicular body protein 4B -2.06992
RTN4 reticulon 4 -2.06146
MMP25 matrix metallopeptidase 25 -2.04723
BAAT bile acid CoA:amino acid N-acyltransferase -2.03885
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.03885
SHISAL2B shisa like 2B -2.03885
TMEM190 transmembrane protein 190 -2.03885
SYNPO synaptopodin -2.03885
VASH2 vasohibin 2 -2.03794
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -2.03164