INSR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description insulin receptor|After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3643)
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Genes

355 genes differentially expressed following the INSR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LOXHD1 lipoxygenase homology domains 1 2.42847
S1PR1 sphingosine-1-phosphate receptor 1 2.42847
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.42847
NHLRC4 NHL repeat containing 4 2.42847
RNF39 ring finger protein 39 2.42847
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.42847
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.42847
NPFF neuropeptide FF-amide peptide precursor 2.42847
BAHCC1 BAH domain and coiled-coil containing 1 2.42847
RPS20 ribosomal protein S20 2.42847
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.42847
TMPRSS11A transmembrane protease, serine 11A 2.42847
CLEC4G C-type lectin domain family 4, member G 2.42847
TRIM15 tripartite motif containing 15 2.42847
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.42847
LRRN4 leucine rich repeat neuronal 4 2.42847
PLK5 polo-like kinase 5 2.42847
OTP orthopedia homeobox 2.42847
C22ORF31 chromosome 22 open reading frame 31 2.42847
C9ORF152 chromosome 9 open reading frame 152 2.42847
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.42847
SMIM31 small integral membrane protein 31 2.42847
CD79A CD79a molecule, immunoglobulin-associated alpha 2.42847
GSDMA gasdermin A 2.42847
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 2.39571
NPPC natriuretic peptide C 2.39571
HEATR9 HEAT repeat containing 9 2.39571
CTRC chymotrypsin C (caldecrin) 2.39571
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.39571
SCGN secretagogin, EF-hand calcium binding protein 2.39571
HLX H2.0-like homeobox 2.39571
MVP major vault protein 2.39571
BEST3 bestrophin 3 2.39571
NRN1 neuritin 1 2.39571
NAPSA napsin A aspartic peptidase 2.39571
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.39571
MPST mercaptopyruvate sulfurtransferase 2.39571
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.39571
CD19 CD19 molecule 2.39571
BTK Bruton agammaglobulinemia tyrosine kinase 2.39571
MEF2D myocyte enhancer factor 2D 2.39571
MSC musculin 2.39571
RSPO1 R-spondin 1 2.39571
STRA8 stimulated by retinoic acid 8 2.39571
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.39571
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.39571
C1ORF141 chromosome 1 open reading frame 141 2.39571
TMEM72 transmembrane protein 72 2.39571
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 2.39571
PAX6 paired box 6 2.39571
PAX9 paired box 9 2.39571
DSG3 desmoglein 3 2.39571
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.39571
DDN dendrin 2.39571
DDT D-dopachrome tautomerase 2.39571
NRAP nebulin-related anchoring protein 2.39571
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.39571
SLC25A41 solute carrier family 25, member 41 2.39571
TPST2 tyrosylprotein sulfotransferase 2 2.39571
GJA10 gap junction protein, alpha 10, 62kDa 2.39571
FOXR1 forkhead box R1 2.39571
OR51L1 olfactory receptor, family 51, subfamily L, member 1 2.39571
FPR2 formyl peptide receptor 2 2.39571
LOC114841035 uncharacterized LOC114841035 2.39571
BNIP5 BCL2 interacting protein 5 2.39571
TCIM transcriptional and immune response regulator 2.39571
STYXL2 serine/threonine/tyrosine interacting like 2 2.39571
PHF24 PHD finger protein 24 2.39571
KY kyphoscoliosis peptidase 2.39571
ALX4 ALX homeobox 4 2.39571
PNLIPRP1 pancreatic lipase-related protein 1 2.39571
TCERG1L transcription elongation regulator 1-like 2.39571
SPATA31C2 SPATA31 subfamily C, member 2 2.39571
FAAP20 FA core complex associated protein 20 2.39571
TERB2 telomere repeat binding bouquet formation protein 2 2.39571
SPEGNB SPEG neighbor 2.39571
WASL-DT WASL divergent transcript 2.39571
LINC02268 long intergenic non-protein coding RNA 2268 2.39571
CPNE8-AS1 CPNE8 antisense RNA 1 2.39571
ZNF593OS ZNF593 opposite strand 2.39571
SMIM35 small integral membrane protein 35 2.39571
KRABD1 KRAB domain containing 1 2.39571
ARMH2 armadillo like helical domain containing 2 2.39571
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.39571
SPRR2A small proline-rich protein 2A 2.39571
WDR64 WD repeat domain 64 2.39571
MIOX myo-inositol oxygenase 2.39571
PRR18 proline rich 18 2.39571
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.39571
FAM171A2 family with sequence similarity 171, member A2 2.39571
SIM2 single-minded family bHLH transcription factor 2 2.39571
C10ORF67 chromosome 10 open reading frame 67 2.39571
CALCA calcitonin-related polypeptide alpha 2.39571
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.39571
ARL5C ADP-ribosylation factor-like 5C 2.39571
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 2.39571
CCR7 chemokine (C-C motif) receptor 7 2.39571
BARX2 BARX homeobox 2 2.39571
MYPN myopalladin 2.39571
TSPAN8 tetraspanin 8 2.39571
VSIG2 V-set and immunoglobulin domain containing 2 2.39571
SYT15 synaptotagmin XV 2.39571
CCDC42 coiled-coil domain containing 42 2.39571
PRG4 proteoglycan 4 2.39571
WNT9B wingless-type MMTV integration site family, member 9B 2.39571
SAMD11 sterile alpha motif domain containing 11 2.39571
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.39571
CD300LG CD300 molecule-like family member g 2.39571
CD69 CD69 molecule 2.39571
SLC7A4 solute carrier family 7, member 4 2.39571
EREG epiregulin 2.39571
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.39571
CST1 cystatin SN 2.39571
OTC ornithine carbamoyltransferase 2.39571
HHATL hedgehog acyltransferase-like 2.39571
CLRN3 clarin 3 2.39571
STK38L serine/threonine kinase 38 like 2.39571
DUOX2 dual oxidase 2 2.39571
PCDHGB2 protocadherin gamma subfamily B, 2 2.39571
PCDHGB4 protocadherin gamma subfamily B, 4 2.39571
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.39571
PLGLB2 plasminogen-like B2 2.39571
WDFY4 WDFY family member 4 2.39571
DBX2 developing brain homeobox 2 2.39571
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 2.39571
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.39571
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.39571
MRPS28 mitochondrial ribosomal protein S28 2.39571
C2ORF66 chromosome 2 open reading frame 66 2.39571
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.39571
GOLGA6B golgin A6 family, member B 2.39571
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.39571
CD28 CD28 molecule 2.39571
TRIM7 tripartite motif containing 7 2.39571
ORM2 orosomucoid 2 2.39571
TSPAN19 tetraspanin 19 2.39571
ADGRL4 adhesion G protein-coupled receptor L4 2.39571
GPR146 G protein-coupled receptor 146 2.39571
GOLGA8M golgin A8 family, member M 2.39571
CTSO cathepsin O 2.39571
CTSG cathepsin G 2.39571
SERINC4 serine incorporator 4 2.39571
EMP1 epithelial membrane protein 1 2.39571
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.39571
MRPL16 mitochondrial ribosomal protein L16 2.39571
LRRK2 leucine-rich repeat kinase 2 2.39571
C20ORF144 chromosome 20 open reading frame 144 2.39571
CTXN2 cortexin 2 2.39571
NT5C1A 5'-nucleotidase, cytosolic IA 2.39571
RAD9B RAD9 homolog B (S. pombe) 2.39571
OC90 otoconin 90 2.39571
ASCL5 achaete-scute family bHLH transcription factor 5 2.39571
NLRP3 NLR family, pyrin domain containing 3 2.39571
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.39571
CRX cone-rod homeobox 2.39571
OXER1 oxoeicosanoid (OXE) receptor 1 2.39571
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.39571
OR52I2 olfactory receptor, family 52, subfamily I, member 2 2.39571
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.39571
IL37 interleukin 37 2.39571
SPAG8 sperm associated antigen 8 2.39571
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.39571
HBZ hemoglobin, zeta 2.39571
MUC20 mucin 20, cell surface associated 2.39571
HBM hemoglobin, mu 2.39571
RHO rhodopsin 2.39571
BMP3 bone morphogenetic protein 3 2.39571
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.39571
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.39571
SPHK1 sphingosine kinase 1 2.39571
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.39571
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.39571
ADAM21 ADAM metallopeptidase domain 21 2.39571
CIB3 calcium and integrin binding family member 3 2.39571
GRAPL GRB2-related adaptor protein-like 2.39571
APOL4 apolipoprotein L, 4 2.39571
DEFB134 defensin, beta 134 2.39571
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.39571
TGM5 transglutaminase 5 2.39571
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.39571
GLTPD2 glycolipid transfer protein domain containing 2 2.39571
TMPRSS13 transmembrane protease, serine 13 2.39571
RBBP8NL RBBP8 N-terminal like 2.38139
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 2.36594
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 2.36594
DPPA4 developmental pluripotency associated 4 2.35404
RPS6 ribosomal protein S6 2.35404
ZNF256 zinc finger protein 256 2.34997
C5AR2 complement component 5a receptor 2 2.32854
ERCC8 excision repair cross-complementation group 8 2.31445
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 2.30277
KIAA1614 KIAA1614 2.27597
LIAT1 ligand of ATE1 2.27597
ACSS3 acyl-CoA synthetase short-chain family member 3 2.26889
LPAR4 lysophosphatidic acid receptor 4 2.24503
TBC1D23 TBC1 domain family, member 23 2.2257
THYN1 thymocyte nuclear protein 1 2.21522
NT5C3A 5'-nucleotidase, cytosolic IIIA 2.21522
H1-1 H1.1 linker histone, cluster member 2.21522
GPX1 glutathione peroxidase 1 2.21522
CFAP70 cilia and flagella associated protein 70 2.21519
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 2.18587
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.18587
CARD8 caspase recruitment domain family, member 8 2.17025
ELOF1 elongation factor 1 homolog (S. cerevisiae) 2.16183
FLYWCH1 FLYWCH-type zinc finger 1 2.16167
BECN1 beclin 1, autophagy related 2.14168
WIPI2 WD repeat domain, phosphoinositide interacting 2 2.1243
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 2.11244
CHRAC1 chromatin accessibility complex 1 2.10927
GLRX glutaredoxin (thioltransferase) 2.10915
PANX1 pannexin 1 2.09328
MRPL36 mitochondrial ribosomal protein L36 2.06885
H1-2 H1.2 linker histone, cluster member 2.06508
BTBD7 BTB (POZ) domain containing 7 2.06181
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.06181
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 2.04492
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 2.03039
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.03039
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.0191
CDIN1 CDAN1 interacting nuclease 1 2.01011
KLF7 Kruppel-like factor 7 (ubiquitous) 2.00097

decreased expression

Symbol Name Standardized Value
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.42847
DEF6 differentially expressed in FDCP 6 homolog (mouse) -2.42847
INSR insulin receptor -2.42847
BHMT betaine--homocysteine S-methyltransferase -2.42847
PTCD1 pentatricopeptide repeat domain 1 -2.39571
TMEM79 transmembrane protein 79 -2.39571
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.39571
KDM6B lysine (K)-specific demethylase 6B -2.39571
BMP8A bone morphogenetic protein 8a -2.39571
CCDC92B coiled-coil domain containing 92B -2.39571
GAP43 growth associated protein 43 -2.39571
FGD4 FYVE, RhoGEF and PH domain containing 4 -2.39571
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.39571
SGMS2 sphingomyelin synthase 2 -2.39571
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.39571
VSIG10L V-set and immunoglobulin domain containing 10 like -2.39571
CASP9 caspase 9, apoptosis-related cysteine peptidase -2.39571
SNX9 sorting nexin 9 -2.39571
CFAP161 cilia and flagella associated protein 161 -2.39571
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -2.39571
ARC activity-regulated cytoskeleton-associated protein -2.39571
FKBPL FK506 binding protein like -2.39571
C2ORF72 chromosome 2 open reading frame 72 -2.39571
CCER2 coiled-coil glutamate-rich protein 2 -2.39571
GOLGA6L10 golgin A6 family-like 10 -2.39571
SLC67A1 solute carrier family 67 member 1 -2.39571
DYM dymeclin -2.39571
COL23A1 collagen, type XXIII, alpha 1 -2.39571
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.39571
LIPG lipase, endothelial -2.39571
AKAP5 A kinase (PRKA) anchor protein 5 -2.39571
DLG2 discs, large homolog 2 (Drosophila) -2.39571
STK11 serine/threonine kinase 11 -2.39571
SPEF2 sperm flagellar 2 -2.39571
NRM nurim (nuclear envelope membrane protein) -2.39571
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.39571
CTTNBP2NL CTTNBP2 N-terminal like -2.39571
FBXO48 F-box protein 48 -2.39571
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.39571
MAT1A methionine adenosyltransferase I, alpha -2.39571
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.39571
ADGRG5 adhesion G protein-coupled receptor G5 -2.38139
KDM1A lysine (K)-specific demethylase 1A -2.3635
RAB3IP RAB3A interacting protein -2.34502
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -2.33173
ETV3 ets variant 3 -2.31736
ODR4 odr-4 GPCR localization factor homolog -2.3169
ATG7 autophagy related 7 -2.29823
IDUA iduronidase, alpha-L- -2.29741
CIMAP3 ciliary microtubule associated protein 3 -2.29741
STC2 stanniocalcin 2 -2.27449
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.26364
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein -2.22333
MRFAP1L2 Morf4 family associated protein 1 like 2 -2.21862
LOC390937 Ets2 repressor factor-like -2.21522
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.21522
ZNF492 zinc finger protein 492 -2.21522
AGTR1 angiotensin II receptor, type 1 -2.21522
CD1D CD1d molecule -2.21522
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -2.21522
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.21522
PCDHA6 protocadherin alpha 6 -2.21522
SMIM17 small integral membrane protein 17 -2.21522
RHEX regulator of hemoglobinization and erythroid cell expansion -2.21522
MUCL3 mucin like 3 -2.21522
CCDC178 coiled-coil domain containing 178 -2.21522
ERFE erythroferrone -2.21522
TTLL13 tubulin tyrosine ligase like 13 -2.21522
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.21522
GMCL1 germ cell-less, spermatogenesis associated 1 -2.21522
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.21522
CLOCK clock circadian regulator -2.21522
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.21522
TSLIG3C tRNA splicing ligase complex subunit 3C -2.21522
H4C14 H4 clustered histone 14 -2.21522
HCST hematopoietic cell signal transducer -2.21522
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.21522
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -2.21522
GPR12 G protein-coupled receptor 12 -2.21522
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -2.21522
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.21522
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.21522
TLDC2 TBC/LysM-associated domain containing 2 -2.21522
FGF9 fibroblast growth factor 9 -2.21522
PRSS22 protease, serine, 22 -2.21522
SCIN scinderin -2.21522
RDH16 retinol dehydrogenase 16 (all-trans) -2.21522
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.21522
LCN2 lipocalin 2 -2.21522
CCDC68 coiled-coil domain containing 68 -2.21522
CBX8 chromobox homolog 8 -2.21522
TUBB1 tubulin, beta 1 class VI -2.21522
GLRB glycine receptor, beta -2.21522
A1CF APOBEC1 complementation factor -2.21522
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.21522
C2ORF80 chromosome 2 open reading frame 80 -2.21522
MRO maestro -2.21522
PHTF1 putative homeodomain transcription factor 1 -2.20989
ZIC3 Zic family member 3 -2.19833
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 -2.19584
ADAL adenosine deaminase-like -2.18904
FAM163A family with sequence similarity 163, member A -2.18172
METTL6 methyltransferase like 6 -2.18172
RPA2 replication protein A2, 32kDa -2.1657
SH3BP4 SH3-domain binding protein 4 -2.15199
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.14513
TMEM102 transmembrane protein 102 -2.14168
PMP22 peripheral myelin protein 22 -2.14168
OSBPL10 oxysterol binding protein-like 10 -2.13038
CREB3 cAMP responsive element binding protein 3 -2.10918
CALD1 caldesmon 1 -2.09189
MYO3A myosin IIIA -2.09085
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.08328
UST uronyl-2-sulfotransferase -2.08226
SLC49A3 solute carrier family 49 member 3 -2.0793
TRAM1L1 translocation associated membrane protein 1-like 1 -2.0793
NKD2 naked cuticle homolog 2 (Drosophila) -2.0793
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -2.07336
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -2.07336
KLB klotho beta -2.07077
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.04874
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -2.04874
STOML1 stomatin (EPB72)-like 1 -2.04874
GFUS GDP-L-fucose synthase -2.03039
TMEM19 transmembrane protein 19 -2.03039
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -2.03039
TSPAN17 tetraspanin 17 -2.03039
PRR16 proline rich 16 -2.03039
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.02358
LIMD1 LIM domains containing 1 -2.0191
AHRR aryl-hydrocarbon receptor repressor -2.0191
FMN1 formin 1 -2.01273
MRPS31 mitochondrial ribosomal protein S31 -2.00897