INSR Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description insulin receptor|After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3643)
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100 substrates of the kinase INSR from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 99.98
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.89
TRPC6 transient receptor potential cation channel, subfamily C, member 6 99.89
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 99.85
N4BP3 NEDD4 binding protein 3 99.82
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 99.74
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 99.71
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 99.69
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 99.67
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.67
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.67
EIF1 eukaryotic translation initiation factor 1 99.58
EIF1B eukaryotic translation initiation factor 1B 99.58
LST1 leukocyte specific transcript 1 99.5
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 99.41
PTPRA protein tyrosine phosphatase, receptor type, A 99.39
GRAMD4 GRAM domain containing 4 99.37
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 99.325
MRPS27 mitochondrial ribosomal protein S27 99.32
EIF3I eukaryotic translation initiation factor 3, subunit I 99.19
IL7R interleukin 7 receptor 99.17
MYL12B myosin, light chain 12B, regulatory 99.17
CD300LB CD300 molecule-like family member b 99.1
VSTM4 V-set and transmembrane domain containing 4 99.06
USP31 ubiquitin specific peptidase 31 99.04
DCTN4 dynactin 4 (p62) 99.01
ZCCHC3 zinc finger, CCHC domain containing 3 98.99
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 98.95
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 98.93
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 98.93
TRIOBP TRIO and F-actin binding protein 98.92
ALOX5 arachidonate 5-lipoxygenase 98.91
HP1BP3 heterochromatin protein 1, binding protein 3 98.78
PDCD5 programmed cell death 5 98.77
PTPRE protein tyrosine phosphatase, receptor type, E 98.71
GPATCH11 G patch domain containing 11 98.69
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 98.67
RCN2 reticulocalbin 2, EF-hand calcium binding domain 98.6
ACE2 angiotensin I converting enzyme 2 98.58
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 98.56
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 98.55
CKS1B CDC28 protein kinase regulatory subunit 1B 98.51
DLG3 discs, large homolog 3 (Drosophila) 98.475
MCC mutated in colorectal cancers 98.42
TRPV2 transient receptor potential cation channel, subfamily V, member 2 98.4
SIGLEC10 sialic acid binding Ig-like lectin 10 98.38
HINT1 histidine triad nucleotide binding protein 1 98.36
THEMIS2 thymocyte selection associated family member 2 98.34
MCEMP1 mast cell-expressed membrane protein 1 98.18
IRS4 insulin receptor substrate 4 98.155
STAMBPL1 STAM binding protein-like 1 98.14
PDCD1 programmed cell death 1 98.14
PM20D2 peptidase M20 domain containing 2 98.12
ESYT2 extended synaptotagmin-like protein 2 98.09
PDS5B PDS5 cohesin associated factor B 98.03
MFAP1 microfibrillar-associated protein 1 98.01
PTPN7 protein tyrosine phosphatase, non-receptor type 7 98.01
TNN tenascin N 97.94
RABL6 RAB, member RAS oncogene family-like 6 97.92
TLK1 tousled-like kinase 1 97.79
RPL8 ribosomal protein L8 97.68
IRS1 insulin receptor substrate 1 97.62
PLXDC2 plexin domain containing 2 97.57
EML4 echinoderm microtubule associated protein like 4 97.51
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 97.5
KLRF2 killer cell lectin-like receptor subfamily F, member 2 97.44
ARHGAP30 Rho GTPase activating protein 30 97.44
MUC16 mucin 16, cell surface associated 97.4
PARD6B par-6 family cell polarity regulator beta 97.39
SON SON DNA binding protein 97.25
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 97.18
PRMT1 protein arginine methyltransferase 1 97.15
IFITM2 interferon induced transmembrane protein 2 96.98
TMEM132A transmembrane protein 132A 96.91
TIGIT T cell immunoreceptor with Ig and ITIM domains 96.85
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 96.85
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 96.84
DLG2 discs, large homolog 2 (Drosophila) 96.81
CLDN4 claudin 4 96.8
LURAP1L leucine rich adaptor protein 1-like 96.76
SH2D1B SH2 domain containing 1B 96.74
TLK2 tousled-like kinase 2 96.59
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 96.56
CEP170B centrosomal protein 170B 96.52
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 96.46
FAM167A family with sequence similarity 167, member A 96.43
ATXN1 ataxin 1 96.39
CENPE centromere protein E, 312kDa 96.37
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 96.35
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 96.3
RGS10 regulator of G-protein signaling 10 96.28
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 96.11
GNL1 guanine nucleotide binding protein-like 1 96.1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 96.06
CLEC12B C-type lectin domain family 12, member B 96.04
SIGLEC9 sialic acid binding Ig-like lectin 9 96.02
DAZAP2 DAZ associated protein 2 95.84
SHROOM1 shroom family member 1 95.78
TERB1 telomere repeat binding bouquet formation protein 1 95.71
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 95.65