INSR Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description insulin receptor|After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3643)
External Link http://www.ncbi.nlm.nih.gov/gene/3643
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Genes

224 interacting proteins for INSR from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACP1 acid phosphatase 1, soluble
ADRB2 adrenoceptor beta 2, surface
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARF1 ADP-ribosylation factor 1
ARF6 ADP-ribosylation factor 6
ARHGAP26 Rho GTPase activating protein 26
ARHGAP5 Rho GTPase activating protein 5
ARRB2 arrestin, beta 2
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BCLAF1 BCL2-associated transcription factor 1
BCR breakpoint cluster region
BLK BLK proto-oncogene, Src family tyrosine kinase
BLVRA biliverdin reductase A
BMP2K BMP2 inducible kinase
BRD3 bromodomain containing 3
BTK Bruton agammaglobulinemia tyrosine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1ORF52 chromosome 1 open reading frame 52
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1A1L casein kinase 1, alpha 1-like
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G2 casein kinase 1, gamma 2
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DCN decorin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK4 docking protein 4
DOK5 docking protein 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA2 EPH receptor A2
EPHA5 EPH receptor A5
EPHA7 EPH receptor A7
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
FABP4 fatty acid binding protein 4, adipocyte
FER fer (fps/fes related) tyrosine kinase
FES FES proto-oncogene, tyrosine kinase
FGR FGR proto-oncogene, Src family tyrosine kinase
FRS2 fibroblast growth factor receptor substrate 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAK cyclin G associated kinase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HNF1A HNF1 homeobox A
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSRR insulin receptor-related receptor
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF20A kinesin family member 20A
KNSTRN kinetochore-localized astrin/SPAG5 binding protein
KRT27 keratin 27, type I
LYN LYN proto-oncogene, Src family tyrosine kinase
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MELK maternal embryonic leucine zipper kinase
MOK MOK protein kinase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NAMPT nicotinamide phosphoribosyltransferase
NEK9 NIMA-related kinase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLK nemo-like kinase
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PHB prohibitin
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRO protein tyrosine phosphatase, receptor type, O
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOB ras homolog family member B
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS27A ribosomal protein S27a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SGK1 serum/glucocorticoid regulated kinase 1
SH2B1 SH2B adaptor protein 1
SH2B2 SH2B adaptor protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK3 SIK family kinase 3
SLK STE20-like kinase
SMAD2 SMAD family member 2
SNX1 sorting nexin 1
SNX2 sorting nexin 2
SNX4 sorting nexin 4
SNX6 sorting nexin 6
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS6 suppressor of cytokine signaling 6
SORBS1 sorbin and SH3 domain containing 1
SPEG SPEG complex locus
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STK16 serine/threonine kinase 16
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBK1 TANK-binding kinase 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEC tec protein tyrosine kinase
TNK1 tyrosine kinase, non-receptor, 1
TOR1AIP1 torsin A interacting protein 1
TRIM28 tripartite motif containing 28
TUBG1 tubulin, gamma 1
TYK2 tyrosine kinase 2
UBC ubiquitin C
ULK3 unc-51 like kinase 3
VAV1 vav 1 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WEE1 WEE1 G2 checkpoint kinase
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta