IQ 1_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.25054
CALR calreticulin 0.174222
AKAP12 A kinase (PRKA) anchor protein 12 0.161739
CDH13 cadherin 13 0.155076
AHNAK AHNAK nucleoprotein 0.147037
TMSB4X thymosin beta 4, X-linked 0.123111
SPTBN1 spectrin, beta, non-erythrocytic 1 0.1171
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.11413
PLAT plasminogen activator, tissue 0.108225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.105872
FLNB filamin B, beta 0.101479
NAV1 neuron navigator 1 0.0975974
FLNA filamin A, alpha 0.0943609
CD44 CD44 molecule (Indian blood group) 0.0928539
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.090155
EEF2 eukaryotic translation elongation factor 2 0.0887013
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0853712
FSTL1 follistatin-like 1 0.085205
ACTG1 actin gamma 1 0.0834585
COL5A1 collagen, type V, alpha 1 0.0820958
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0820412
THBS2 thrombospondin 2 0.0813865
FTH1 ferritin, heavy polypeptide 1 0.0742489
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.07385
APP amyloid beta (A4) precursor protein 0.0728186
MT2A metallothionein 2A 0.0717042
S100A10 S100 calcium binding protein A10 0.0712245
MYH9 myosin, heavy chain 9, non-muscle 0.0704798
ANKRD11 ankyrin repeat domain 11 0.0700594
AHNAK2 AHNAK nucleoprotein 2 0.0687836
TRIO trio Rho guanine nucleotide exchange factor 0.0672708
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0662349
ASPH aspartate beta-hydroxylase 0.0641515
ANXA2 annexin A2 0.0606388
BHLHE40 basic helix-loop-helix family, member e40 0.0601307
TPM3 tropomyosin 3 0.0599633
EFNA5 ephrin-A5 0.0592168
SRRM2 serine/arginine repetitive matrix 2 0.0588087
EGFR epidermal growth factor receptor 0.058341
MKI67 marker of proliferation Ki-67 0.0581072
PTMA prothymosin, alpha 0.0576764
DOCK5 dedicator of cytokinesis 5 0.0559281
SEPTIN9 septin 9 0.053242
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0532344
LOXL2 lysyl oxidase-like 2 0.0530121
PRRC2C proline-rich coiled-coil 2C 0.0526663
MPRIP myosin phosphatase Rho interacting protein 0.0514349
HDAC9 histone deacetylase 9 0.0511672
NFE2L1 nuclear factor, erythroid 2-like 1 0.0503036
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0495424
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0492699
MACF1 microtubule-actin crosslinking factor 1 0.0487678
RNF213 ring finger protein 213 0.0484602
CANX calnexin 0.0484446
TPM4 tropomyosin 4 0.0481163
CENPF centromere protein F, 350/400kDa 0.0476785
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.047178
LMNA lamin A/C 0.0458754
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0457152
PBX3 pre-B-cell leukemia homeobox 3 0.0455763
PLEC plectin 0.0454656
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0454044
MAP1B microtubule-associated protein 1B 0.0450687
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0448242
ENO1 enolase 1, (alpha) 0.0442716
LDHA lactate dehydrogenase A 0.0427993
NAV2 neuron navigator 2 0.0419751
SMAD3 SMAD family member 3 0.0412817
BCL2L1 BCL2-like 1 0.0411952
DSPP dentin sialophosphoprotein 0.0408602
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0405995
C1D C1D nuclear receptor corepressor 0.0400659
CAPN2 calpain 2, (m/II) large subunit 0.0398746
MCL1 myeloid cell leukemia 1 0.0379873
EIF4H eukaryotic translation initiation factor 4H 0.0374306
NT5E 5'-nucleotidase, ecto (CD73) 0.0371632
HDLBP high density lipoprotein binding protein 0.037114
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0369691
L1CAM L1 cell adhesion molecule 0.0369598
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0369223
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0368166
RRM2 ribonucleotide reductase M2 0.036574
CAVIN1 caveolae associated protein 1 0.0364555
TPR translocated promoter region, nuclear basket protein 0.0364376
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0354387
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0351331
DST dystonin 0.035011
GOLM1 golgi membrane protein 1 0.0348963
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.034728
HLA-C major histocompatibility complex, class I, C 0.0343436
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0321823
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0317701
PRELID2 PRELI domain containing 2 0.031326
HLA-B major histocompatibility complex, class I, B 0.0313092
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0311012
CTSB cathepsin B 0.0310259
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0308376
COL3A1 collagen, type III, alpha 1 0.0308303
BACE2 beta-site APP-cleaving enzyme 2 0.0305069
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0304674

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.121422
COL8A1 collagen, type VIII, alpha 1 -0.0903808
FBN1 fibrillin 1 -0.0871902
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0703099
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0636574
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0630707
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0609684
SUCNR1 succinate receptor 1 -0.0575494
COL1A2 collagen, type I, alpha 2 -0.0553869
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0517833
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0466252
SOD2 superoxide dismutase 2, mitochondrial -0.0457116
ABI3BP ABI family, member 3 (NESH) binding protein -0.0435269
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0425773
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0420011
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0411699
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0402907
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.039682
IGFBP3 insulin-like growth factor binding protein 3 -0.0383827
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0377652
MYADM myeloid-associated differentiation marker -0.0376125
IFIH1 interferon induced with helicase C domain 1 -0.0371102
HILPDA hypoxia inducible lipid droplet-associated -0.0369876
VIM vimentin -0.0364241
S100A6 S100 calcium binding protein A6 -0.036367
PRSS23 protease, serine, 23 -0.0361803
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0342855
MT1X metallothionein 1X -0.0319289
FNDC3A fibronectin type III domain containing 3A -0.0315333
TAGLN2 transgelin 2 -0.0314939
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0294799
MX2 MX dynamin-like GTPase 2 -0.0293191
S100A4 S100 calcium binding protein A4 -0.0268939
WTAP Wilms tumor 1 associated protein -0.0259282
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0250124
AUTS2 autism susceptibility candidate 2 -0.0249607
SAMD9 sterile alpha motif domain containing 9 -0.024881
NT5C2 5'-nucleotidase, cytosolic II -0.0248679
UBC ubiquitin C -0.0248623
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0247137
PFN1 profilin 1 -0.0245688
TPM1 tropomyosin 1 (alpha) -0.0245621
DPYSL3 dihydropyrimidinase-like 3 -0.0242165
TENT5A terminal nucleotidyltransferase 5A -0.0232522
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.023094
WARS1 tryptophanyl-tRNA synthetase 1 -0.0229898
SDK1 sidekick cell adhesion molecule 1 -0.0228788
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.0228081
GOLGA4 golgin A4 -0.0226752
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0220376
SRPK2 SRSF protein kinase 2 -0.0219001
SPAG9 sperm associated antigen 9 -0.0218384
SBF2 SET binding factor 2 -0.0218314
RTN4 reticulon 4 -0.0215373
TAPBP TAP binding protein (tapasin) -0.0213621
MSI2 musashi RNA-binding protein 2 -0.0212707
JAZF1 JAZF zinc finger 1 -0.0210691
SLC38A1 solute carrier family 38, member 1 -0.0210589
OASL 2'-5'-oligoadenylate synthetase-like -0.0204473
PIAS1 protein inhibitor of activated STAT, 1 -0.0198868
PICALM phosphatidylinositol binding clathrin assembly protein -0.0197493
MXI1 MAX interactor 1, dimerization protein -0.0197384
ARL4C ADP-ribosylation factor-like 4C -0.0197266
MAP4 microtubule-associated protein 4 -0.0196998
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0196766
PRKD3 protein kinase D3 -0.0196421
SORBS2 sorbin and SH3 domain containing 2 -0.0196082
IFI44 interferon-induced protein 44 -0.0195869
TFG TRK-fused gene -0.0193959
ZNF207 zinc finger protein 207 -0.019004
FAM162A family with sequence similarity 162, member A -0.018989
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.018693
KDM6A lysine (K)-specific demethylase 6A -0.0185854
FRMD5 FERM domain containing 5 -0.0185834
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0184238
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0184187
FNDC3B fibronectin type III domain containing 3B -0.0183824
ADAM9 ADAM metallopeptidase domain 9 -0.0182511
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0180953
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.017834
ATP13A3 ATPase type 13A3 -0.0177552
KIFAP3 kinesin-associated protein 3 -0.0176905
CXXC5 CXXC finger protein 5 -0.0176874
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0176098
PCGF5 polycomb group ring finger 5 -0.0175067
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0173488
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0171349
IER3 immediate early response 3 -0.0168605
GPC6 glypican 6 -0.0167844
ARL15 ADP-ribosylation factor-like 15 -0.0167378
MEIS2 Meis homeobox 2 -0.0166401
KMT2C lysine (K)-specific methyltransferase 2C -0.0163118
FGF13 fibroblast growth factor 13 -0.0161637
SOX9 SRY (sex determining region Y)-box 9 -0.0157724
ZNF292 zinc finger protein 292 -0.0157186
RAB1A RAB1A, member RAS oncogene family -0.0156046
CCL5 chemokine (C-C motif) ligand 5 -0.0155998
CD109 CD109 molecule -0.0155262
SSBP2 single-stranded DNA binding protein 2 -0.0153997
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0151914