| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | IQ 1 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the IQ 1_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.266583 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.211881 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.203046 |
| PCDH7 | protocadherin 7 | 0.134998 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.129877 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.126566 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.122753 |
| NLGN1 | neuroligin 1 | 0.118002 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.106949 |
| ASPH | aspartate beta-hydroxylase | 0.093482 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0900945 |
| RRM2 | ribonucleotide reductase M2 | 0.0896536 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0859949 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0843643 |
| TMSB10 | thymosin beta 10 | 0.0810104 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0803571 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0799121 |
| MKI67 | marker of proliferation Ki-67 | 0.075628 |
| HMGA2 | high mobility group AT-hook 2 | 0.0718846 |
| ANXA1 | annexin A1 | 0.0707887 |
| ACTG1 | actin gamma 1 | 0.0702264 |
| CCN2 | cellular communication network factor 2 | 0.0686544 |
| EGR1 | early growth response 1 | 0.0652053 |
| TMEM41B | transmembrane protein 41B | 0.0650264 |
| YAP1 | Yes-associated protein 1 | 0.06393 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0637771 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0574753 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0569592 |
| TPM3 | tropomyosin 3 | 0.0563505 |
| EHBP1 | EH domain binding protein 1 | 0.0531101 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0523669 |
| MTAP | methylthioadenosine phosphorylase | 0.0512429 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0500581 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0497974 |
| RASAL2 | RAS protein activator like 2 | 0.0490675 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0490393 |
| VMP1 | vacuole membrane protein 1 | 0.0481705 |
| PTMA | prothymosin, alpha | 0.0463285 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0461143 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.045164 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0450943 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0450095 |
| ADIPOR2 | adiponectin receptor 2 | 0.0444778 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0435036 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0434167 |
| MMP12 | matrix metallopeptidase 12 | 0.0426081 |
| NHSL1 | NHS-like 1 | 0.0424738 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0424411 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0415106 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0409269 |
| CALR | calreticulin | 0.0399829 |
| YBX3 | Y box binding protein 3 | 0.0397004 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0391937 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0387955 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0385309 |
| RTN4 | reticulon 4 | 0.0385217 |
| PRDX1 | peroxiredoxin 1 | 0.0380979 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0380965 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0375813 |
| INTS6 | integrator complex subunit 6 | 0.037166 |
| IPO7 | importin 7 | 0.0367544 |
| TPI1 | triosephosphate isomerase 1 | 0.0365089 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0360013 |
| ENO1 | enolase 1, (alpha) | 0.0358077 |
| EDARADD | EDAR-associated death domain | 0.0357948 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0357251 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0356951 |
| TXNRD1 | thioredoxin reductase 1 | 0.0355239 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0355151 |
| JMJD1C | jumonji domain containing 1C | 0.0350615 |
| PDGFC | platelet derived growth factor C | 0.0347688 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0342137 |
| VIM | vimentin | 0.0331641 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0328287 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0328055 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0321526 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0319902 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0319461 |
| MAP1B | microtubule-associated protein 1B | 0.0315471 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0313077 |
| BCHE | butyrylcholinesterase | 0.0313037 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0312433 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0306203 |
| PCDH9 | protocadherin 9 | 0.03021 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0301648 |
| RCOR1 | REST corepressor 1 | 0.0300199 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0296997 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0294505 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0293286 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0292271 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0292082 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0289963 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.02881 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0285315 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0279525 |
| MYPN | myopalladin | 0.0275964 |
| ZNF804A | zinc finger protein 804A | 0.0274505 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.027345 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0272162 |
| CLTC | clathrin, heavy chain (Hc) | 0.0268905 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL24 | kelch-like family member 24 | -0.0315598 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.030781 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.025721 |
| ZNF292 | zinc finger protein 292 | -0.0219771 |
| ZNF207 | zinc finger protein 207 | -0.0208969 |
| RPL35A | ribosomal protein L35a | -0.0206982 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0205093 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.019897 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.019699 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0193995 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0193102 |
| FTL | ferritin, light polypeptide | -0.0189039 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0187782 |
| TFG | TRK-fused gene | -0.0185639 |
| OGA | O-GlcNAcase | -0.0185305 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.01763 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0173188 |
| XPO1 | exportin 1 | -0.0169528 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0168883 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0165821 |
| RPS20 | ribosomal protein S20 | -0.0161116 |
| RPL34 | ribosomal protein L34 | -0.0159535 |
| PCBP2 | poly(rC) binding protein 2 | -0.0157222 |
| TNRC6B | trinucleotide repeat containing 6B | -0.015617 |
| SNX2 | sorting nexin 2 | -0.0147978 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0147016 |
| RPS29 | ribosomal protein S29 | -0.0146475 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0142437 |
| RPS12 | ribosomal protein S12 | -0.0141823 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0140653 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0140491 |
| RPS16 | ribosomal protein S16 | -0.0138226 |
| RPL23 | ribosomal protein L23 | -0.0137846 |
| CDK19 | cyclin-dependent kinase 19 | -0.0137635 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0136205 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0134491 |
| RPS23 | ribosomal protein S23 | -0.0133251 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0132172 |
| RPL28 | ribosomal protein L28 | -0.012782 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0126753 |
| RPL13A | ribosomal protein L13a | -0.0126238 |
| CERT1 | ceramide transporter 1 | -0.0124812 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0124764 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0124316 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0124068 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.012323 |
| NEK7 | NIMA-related kinase 7 | -0.0122175 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.0121831 |
| WASF2 | WAS protein family, member 2 | -0.0121785 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0121615 |
| FOXO3 | forkhead box O3 | -0.0120923 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0120855 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0120089 |
| RPLP1 | ribosomal protein, large, P1 | -0.0119732 |
| WDR43 | WD repeat domain 43 | -0.0119717 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0118471 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0117863 |
| RPS2 | ribosomal protein S2 | -0.0117736 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0113532 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0111464 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | -0.0111165 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0110835 |
| ELP2 | elongator acetyltransferase complex subunit 2 | -0.0109899 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.0109678 |
| COG5 | component of oligomeric golgi complex 5 | -0.0109589 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0109469 |
| GOLGA4 | golgin A4 | -0.0109371 |
| PHF21A | PHD finger protein 21A | -0.0109123 |
| RBM39 | RNA binding motif protein 39 | -0.0108532 |
| OXR1 | oxidation resistance 1 | -0.0107399 |
| RPL7 | ribosomal protein L7 | -0.0107315 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | -0.0106863 |
| PREPL | prolyl endopeptidase-like | -0.0106766 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | -0.0106757 |
| SYT1 | synaptotagmin I | -0.0105481 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0105385 |
| TMEM39A | transmembrane protein 39A | -0.0105084 |
| TAPBP | TAP binding protein (tapasin) | -0.0104086 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0103758 |
| RPS27A | ribosomal protein S27a | -0.0103569 |
| PCNX1 | pecanex 1 | -0.0103429 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0102555 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0102171 |
| TNPO3 | transportin 3 | -0.0101229 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0100811 |
| RPL5 | ribosomal protein L5 | -0.010002 |
| TUT4 | terminal uridylyl transferase 4 | -0.00998855 |
| VAT1 | vesicle amine transport 1 | -0.00998342 |
| RPL26 | ribosomal protein L26 | -0.009941 |
| NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit | -0.00982859 |
| YTHDC1 | YTH domain containing 1 | -0.00975189 |
| PI4KB | phosphatidylinositol 4-kinase, catalytic, beta | -0.00973574 |
| RNF11 | ring finger protein 11 | -0.00969103 |
| ZFP64 | ZFP64 zinc finger protein | -0.0096897 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.00966267 |
| SETD2 | SET domain containing 2 | -0.00965862 |
| ANO10 | anoctamin 10 | -0.00956925 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.00955383 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | -0.00955302 |
| CDK7 | cyclin-dependent kinase 7 | -0.0094366 |
