IQ 1_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.258197
B2M beta-2-microglobulin 0.216471
LCN2 lipocalin 2 0.199023
SPTBN1 spectrin, beta, non-erythrocytic 1 0.141765
SMAD3 SMAD family member 3 0.14044
FTH1 ferritin, heavy polypeptide 1 0.13932
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.118719
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.11666
AREG amphiregulin 0.111559
TSC22D1 TSC22 domain family, member 1 0.105423
ANXA2 annexin A2 0.0998662
ACTG1 actin gamma 1 0.0884342
HLA-B major histocompatibility complex, class I, B 0.0796066
MYO1E myosin IE 0.0790613
DSCAM Down syndrome cell adhesion molecule 0.0754761
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0724802
PKM pyruvate kinase, muscle 0.0708406
CALR calreticulin 0.0678479
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0665807
GCLC glutamate-cysteine ligase, catalytic subunit 0.0656092
TPT1 tumor protein, translationally-controlled 1 0.0653472
FTL ferritin, light polypeptide 0.0625459
SRRM2 serine/arginine repetitive matrix 2 0.0613545
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.05921
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0584666
AKAP13 A kinase (PRKA) anchor protein 13 0.0573135
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0572816
EZR ezrin 0.0572684
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.054197
FAT1 FAT atypical cadherin 1 0.0518464
RPL19 ribosomal protein L19 0.0504046
LOC102724023 ES1 protein homolog, mitochondrial 0.0503956
EXT1 exostosin glycosyltransferase 1 0.0503129
EFNB2 ephrin-B2 0.0494965
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0491908
SDC4 syndecan 4 0.0480169
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.047317
UBC ubiquitin C 0.0454673
LDHA lactate dehydrogenase A 0.0442713
HLA-C major histocompatibility complex, class I, C 0.0432584
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0426767
ARHGAP5 Rho GTPase activating protein 5 0.0426644
PRRC2C proline-rich coiled-coil 2C 0.0423336
EEF2 eukaryotic translation elongation factor 2 0.0422085
PADI1 peptidyl arginine deiminase, type I 0.0416254
CTSB cathepsin B 0.0406042
EIF1 eukaryotic translation initiation factor 1 0.0380492
SFTPA2 surfactant protein A2 0.0376608
ZC3H13 zinc finger CCCH-type containing 13 0.0373064
PTMA prothymosin, alpha 0.0370237
EGR1 early growth response 1 0.0368892
ASPH aspartate beta-hydroxylase 0.0368413
HLA-A major histocompatibility complex, class I, A 0.0362761
KRT18 keratin 18, type I 0.0362176
RUNX1 runt-related transcription factor 1 0.0358484
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0357381
EREG epiregulin 0.0349362
ERN1 endoplasmic reticulum to nucleus signaling 1 0.034778
RPL7A ribosomal protein L7a 0.0346463
AHI1 Abelson helper integration site 1 0.0339931
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0337667
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0335652
MAP7 microtubule-associated protein 7 0.0332368
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0331661
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0331214
KRT8 keratin 8, type II 0.0330127
SHB Src homology 2 domain containing adaptor protein B 0.0329842
PGK1 phosphoglycerate kinase 1 0.0329281
KLF5 Kruppel-like factor 5 (intestinal) 0.0316612
PDZD8 PDZ domain containing 8 0.0315093
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0306968
FHL2 four and a half LIM domains 2 0.0305036
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0302475
ENO1 enolase 1, (alpha) 0.0301893
LOC112694756 uncharaterized LOC112694756 0.0297732
SEPTIN9 septin 9 0.0297505
TMED9 transmembrane emp24 protein transport domain containing 9 0.0296221
STK24 serine/threonine kinase 24 0.0295338
TMSB4X thymosin beta 4, X-linked 0.0291745
POTEF POTE ankyrin domain family, member F 0.029166
CTBP2 C-terminal binding protein 2 0.0290364
RPL26 ribosomal protein L26 0.0290131
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0289311
EIF4A1 eukaryotic translation initiation factor 4A1 0.0287867
PDIA3 protein disulfide isomerase family A, member 3 0.0287115
RPS6 ribosomal protein S6 0.0283814
YBX3 Y box binding protein 3 0.0279693
TJP1 tight junction protein 1 0.0279563
EPCAM epithelial cell adhesion molecule 0.0279538
TMEM65 transmembrane protein 65 0.02795
ABHD2 abhydrolase domain containing 2 0.0278944
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0277399
APP amyloid beta (A4) precursor protein 0.027698
TMC5 transmembrane channel-like 5 0.02753
RPL23 ribosomal protein L23 0.0274883
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0271209
PERP PERP, TP53 apoptosis effector 0.027019
ATP11A ATPase, class VI, type 11A 0.0265712
RPS17 ribosomal protein S17 0.0262324
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0261598

decreased expression

Symbol Name Standardized Value
LYZ lysozyme -0.0930586
EPSTI1 epithelial stromal interaction 1 (breast) -0.0904607
NPSR1 neuropeptide S receptor 1 -0.0805089
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0722258
RIGI RNA sensor RIG-I -0.0711691
RABGAP1L RAB GTPase activating protein 1-like -0.065643
GMDS GDP-mannose 4,6-dehydratase -0.0652757
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0601252
XAF1 XIAP associated factor 1 -0.0588175
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0539448
BTBD9 BTB (POZ) domain containing 9 -0.0521466
TSHZ2 teashirt zinc finger homeobox 2 -0.050705
PLSCR1 phospholipid scramblase 1 -0.048143
MAML2 mastermind-like 2 (Drosophila) -0.0476842
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0467549
FNDC3B fibronectin type III domain containing 3B -0.0451188
ZMYND8 zinc finger, MYND-type containing 8 -0.0424428
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0416785
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0405194
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0401588
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0396076
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.038592
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0384495
ARHGAP26 Rho GTPase activating protein 26 -0.0383423
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0382847
SSH2 slingshot protein phosphatase 2 -0.0377629
STS steroid sulfatase (microsomal), isozyme S -0.0373536
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.03708
ZBTB20 zinc finger and BTB domain containing 20 -0.0341186
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0335501
PRKCA protein kinase C, alpha -0.0328071
TRIO trio Rho guanine nucleotide exchange factor -0.0314029
PLSCR2 phospholipid scramblase 2 -0.0306172
SP100 SP100 nuclear antigen -0.0292285
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0290488
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0284071
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0281062
PATJ PATJ crumbs cell polarity complex component -0.0280676
SYT1 synaptotagmin I -0.0276815
BABAM2 BRISC and BRCA1 A complex member 2 -0.0274824
PMP22 peripheral myelin protein 22 -0.026923
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0265172
RAD51B RAD51 paralog B -0.026039
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0256598
ATP10B ATPase, class V, type 10B -0.0255169
PCED1B PC-esterase domain containing 1B -0.025228
MECOM MDS1 and EVI1 complex locus -0.0242597
NCOA7 nuclear receptor coactivator 7 -0.0240073
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0237815
IFIH1 interferon induced with helicase C domain 1 -0.0231425
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0230663
OASL 2'-5'-oligoadenylate synthetase-like -0.0226013
SAMD12 sterile alpha motif domain containing 12 -0.0225034
XRN1 5'-3' exoribonuclease 1 -0.0218171
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.021602
IGFBP3 insulin-like growth factor binding protein 3 -0.0212622
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.02072
MX1 MX dynamin-like GTPase 1 -0.020718
MED13L mediator complex subunit 13-like -0.0199543
MBD5 methyl-CpG binding domain protein 5 -0.0199051
POF1B premature ovarian failure, 1B -0.0198969
EXOC4 exocyst complex component 4 -0.0198022
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0196516
SCARB1 scavenger receptor class B, member 1 -0.0196362
DGKH diacylglycerol kinase, eta -0.0196117
STK39 serine threonine kinase 39 -0.0193563
NKD1 naked cuticle homolog 1 (Drosophila) -0.0192276
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0191433
CATSPERB catsper channel auxiliary subunit beta -0.0190477
CTSD cathepsin D -0.0190211
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0189717
KDM4C lysine (K)-specific demethylase 4C -0.0185457
PTGR1 prostaglandin reductase 1 -0.0185276
PDE4D phosphodiesterase 4D, cAMP-specific -0.0184221
UBAC2 UBA domain containing 2 -0.0183875
PRKG1 protein kinase, cGMP-dependent, type I -0.0183673
SAMD9 sterile alpha motif domain containing 9 -0.0183584
RBM39 RNA binding motif protein 39 -0.0183275
PIAS1 protein inhibitor of activated STAT, 1 -0.0181588
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0180904
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0178657
NF1 neurofibromin 1 -0.0178046
TAS2R14 taste receptor, type 2, member 14 -0.017763
FBXO39 F-box protein 39 -0.017758
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0174325
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0172591
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0172395
DIAPH3 diaphanous-related formin 3 -0.0171739
TMEM62 transmembrane protein 62 -0.0168321
ZNF609 zinc finger protein 609 -0.0168168
NT5C2 5'-nucleotidase, cytosolic II -0.0167565
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0165576
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0163918
TCF12 transcription factor 12 -0.0163149
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0162394
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0162323
GCC2 GRIP and coiled-coil domain containing 2 -0.0161156
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0159899
TRIM25 tripartite motif containing 25 -0.0159766
SETX senataxin -0.0156527