IQ 1_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.540424
COL6A3 collagen, type VI, alpha 3 0.224201
MT2A metallothionein 2A 0.177436
FTH1 ferritin, heavy polypeptide 1 0.158588
VEGFA vascular endothelial growth factor A 0.142516
EEF2 eukaryotic translation elongation factor 2 0.112887
CALR calreticulin 0.102103
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0990464
IGFBP3 insulin-like growth factor binding protein 3 0.0776184
CD44 CD44 molecule (Indian blood group) 0.0716908
CDH13 cadherin 13 0.0693403
ACTG1 actin gamma 1 0.0682045
B2M beta-2-microglobulin 0.0583782
NDRG1 N-myc downstream regulated 1 0.0583639
HLA-B major histocompatibility complex, class I, B 0.0580561
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0569442
MYH9 myosin, heavy chain 9, non-muscle 0.056603
TGFBI transforming growth factor, beta-induced, 68kDa 0.0547581
VIM vimentin 0.0531857
ADM adrenomedullin 0.0465683
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0456615
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0441593
GOLGB1 golgin B1 0.0425628
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0424559
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0405921
PLEC plectin 0.0405849
RPS8 ribosomal protein S8 0.0402606
FTL ferritin, light polypeptide 0.0401708
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0398933
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0375326
IL6 interleukin 6 0.0370492
LOXL2 lysyl oxidase-like 2 0.0369638
EGFR epidermal growth factor receptor 0.0362454
TMSB10 thymosin beta 10 0.0355113
CXCL8 chemokine (C-X-C motif) ligand 8 0.035465
HLA-A major histocompatibility complex, class I, A 0.0349678
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0346859
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0345972
EXT1 exostosin glycosyltransferase 1 0.0345122
NAV1 neuron navigator 1 0.0325851
RPL37A ribosomal protein L37a 0.0314291
TMSB4X thymosin beta 4, X-linked 0.0307239
IFI6 interferon, alpha-inducible protein 6 0.0302891
CTSB cathepsin B 0.0301173
RPS19 ribosomal protein S19 0.0300533
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0296473
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0294324
ENO1 enolase 1, (alpha) 0.0287646
ZBTB20 zinc finger and BTB domain containing 20 0.028749
RPL7A ribosomal protein L7a 0.0283695
SRRM2 serine/arginine repetitive matrix 2 0.0280995
HSPA8 heat shock 70kDa protein 8 0.0274094
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0273816
RPL19 ribosomal protein L19 0.0269319
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0268084
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0267989
RPL35A ribosomal protein L35a 0.0263947
APP amyloid beta (A4) precursor protein 0.0259596
LPP LIM domain containing preferred translocation partner in lipoma 0.0255903
EIF1 eukaryotic translation initiation factor 1 0.0253939
COL6A1 collagen, type VI, alpha 1 0.025351
RPS17 ribosomal protein S17 0.0252792
SQSTM1 sequestosome 1 0.02454
RPL23 ribosomal protein L23 0.0243267
EEF1G eukaryotic translation elongation factor 1 gamma 0.0239442
RPS6 ribosomal protein S6 0.0238197
NOTCH2 notch 2 0.0234843
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0234083
ITGA11 integrin, alpha 11 0.0231849
COL6A2 collagen, type VI, alpha 2 0.0229225
IFITM3 interferon induced transmembrane protein 3 0.0228656
MYO10 myosin X 0.0228254
BRD2 bromodomain containing 2 0.0225058
RPS12 ribosomal protein S12 0.0224205
ENO2 enolase 2 (gamma, neuronal) 0.0222209
COL5A1 collagen, type V, alpha 1 0.0220624
RPL12 ribosomal protein L12 0.0220575
ANKRD12 ankyrin repeat domain 12 0.0220547
NFE2L1 nuclear factor, erythroid 2-like 1 0.0219734
RPS3 ribosomal protein S3 0.0216067
ASPH aspartate beta-hydroxylase 0.0213174
STC1 stanniocalcin 1 0.0210718
TPM4 tropomyosin 4 0.0209513
RPL9 ribosomal protein L9 0.0209431
NALF1 NALCN channel auxiliary factor 1 0.020869
HDAC9 histone deacetylase 9 0.0204768
FLNA filamin A, alpha 0.020067
NAV2 neuron navigator 2 0.0199853
RPL28 ribosomal protein L28 0.019916
RND3 Rho family GTPase 3 0.0198388
CYB5R3 cytochrome b5 reductase 3 0.0197668
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0195201
TMED9 transmembrane emp24 protein transport domain containing 9 0.0192191
RPL3 ribosomal protein L3 0.0188727
CALU calumenin 0.0187997
SFTPA2 surfactant protein A2 0.0187563
RPN1 ribophorin I 0.0187156
RPL8 ribosomal protein L8 0.0183375
RPL31 ribosomal protein L31 0.0183337
JAG1 jagged 1 0.0181137

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.374581
COL1A1 collagen, type I, alpha 1 -0.0989581
ATP13A3 ATPase type 13A3 -0.0648351
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0516576
TRIO trio Rho guanine nucleotide exchange factor -0.045578
SPAG9 sperm associated antigen 9 -0.0417809
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0406136
ZNF292 zinc finger protein 292 -0.039726
NAMPT nicotinamide phosphoribosyltransferase -0.0366861
USP3 ubiquitin specific peptidase 3 -0.0356755
LOX lysyl oxidase -0.034638
CANX calnexin -0.0340562
COL1A2 collagen, type I, alpha 2 -0.0332408
ELL2 elongation factor, RNA polymerase II, 2 -0.0324105
QKI QKI, KH domain containing, RNA binding -0.031883
LMAN1 lectin, mannose-binding, 1 -0.0315868
TFG TRK-fused gene -0.0315027
ZFAND3 zinc finger, AN1-type domain 3 -0.0290535
RLF rearranged L-myc fusion -0.0275945
IER3 immediate early response 3 -0.0273594
FBN1 fibrillin 1 -0.0273062
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0271053
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0255328
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0248803
ANXA2 annexin A2 -0.0248696
KDM3A lysine (K)-specific demethylase 3A -0.0246779
CAVIN1 caveolae associated protein 1 -0.0245041
RAD21 RAD21 homolog (S. pombe) -0.0240887
SQLE squalene epoxidase -0.0238071
WSB1 WD repeat and SOCS box containing 1 -0.0237851
PRRC1 proline-rich coiled-coil 1 -0.0230909
MARCHF6 membrane associated ring-CH-type finger 6 -0.0230535
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0230003
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0221885
RAB1A RAB1A, member RAS oncogene family -0.0221849
ICAM1 intercellular adhesion molecule 1 -0.0220825
IL6ST interleukin 6 signal transducer -0.0219835
RASA2 RAS p21 protein activator 2 -0.0214754
BZW1 basic leucine zipper and W2 domains 1 -0.0205491
GOLGA4 golgin A4 -0.0204852
CADM1 cell adhesion molecule 1 -0.0203859
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0202322
NPEPPS aminopeptidase puromycin sensitive -0.0199129
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0191325
FAM162A family with sequence similarity 162, member A -0.0188796
TMEM39A transmembrane protein 39A -0.0187599
RHEB Ras homolog enriched in brain -0.0184751
PGK1 phosphoglycerate kinase 1 -0.0183884
TM4SF1 transmembrane 4 L six family member 1 -0.0180203
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0178057
RBM39 RNA binding motif protein 39 -0.0176094
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0174392
RYBP RING1 and YY1 binding protein -0.0173765
TSC22D2 TSC22 domain family, member 2 -0.0172156
SEPTIN7 septin 7 -0.017139
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0168143
OGA O-GlcNAcase -0.0166298
SEC24A SEC24 family member A -0.0165602
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0164723
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0164628
TOP2B topoisomerase (DNA) II beta 180kDa -0.0163789
IER3IP1 immediate early response 3 interacting protein 1 -0.0163536
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.016325
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0162057
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0161882
GOLT1B golgi transport 1B -0.0161865
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0161204
RRBP1 ribosome binding protein 1 -0.0160587
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0159405
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.015903
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0157515
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0157058
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0156426
NAP1L1 nucleosome assembly protein 1-like 1 -0.0155832
TMEM263 transmembrane protein 263 -0.0154729
MAP4 microtubule-associated protein 4 -0.0154404
CSDE1 cold shock domain containing E1, RNA-binding -0.0153824
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0152481
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0150675
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0149638
S100A6 S100 calcium binding protein A6 -0.0148723
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0148064
AZIN1 antizyme inhibitor 1 -0.0147523
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0147261
TRAM1 translocation associated membrane protein 1 -0.0147065
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0145982
ARHGAP35 Rho GTPase activating protein 35 -0.0145202
YME1L1 YME1-like 1 ATPase -0.0145169
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0144671
ANKRD10 ankyrin repeat domain 10 -0.014447
PXDN peroxidasin -0.014386
FOXJ3 forkhead box J3 -0.014214
HMGB2 high mobility group box 2 -0.0142107
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0141386
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0140513
CLIC4 chloride intracellular channel 4 -0.0138095
POSTN periostin, osteoblast specific factor -0.0137225
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0136627
SH3GLB1 SH3-domain GRB2-like endophilin B1 -0.0134817
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.013478