| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | IQ 1 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the IQ 1_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.437564 |
| FN1 | fibronectin 1 | 0.285008 |
| IGF2 | insulin-like growth factor 2 | 0.193896 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.182995 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.165983 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.148786 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.144356 |
| MT2A | metallothionein 2A | 0.141455 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.113804 |
| SVIL | supervillin | 0.111409 |
| C3 | complement component 3 | 0.104618 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0999963 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0819165 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0782846 |
| DSPP | dentin sialophosphoprotein | 0.0762069 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0726158 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0663816 |
| SDC4 | syndecan 4 | 0.0647944 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0588972 |
| AHSG | alpha-2-HS-glycoprotein | 0.0560719 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0548746 |
| VEGFA | vascular endothelial growth factor A | 0.0538464 |
| FAT1 | FAT atypical cadherin 1 | 0.0518069 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0517496 |
| PEG3 | paternally expressed 3 | 0.0509406 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0507757 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0495195 |
| BCL2L1 | BCL2-like 1 | 0.0485844 |
| APOA1 | apolipoprotein A-I | 0.0481936 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.04665 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0456031 |
| ACTG1 | actin gamma 1 | 0.0453254 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0448007 |
| FAM107B | family with sequence similarity 107, member B | 0.0446063 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.043846 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0432031 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0417369 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0398004 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0388337 |
| FOXP1 | forkhead box P1 | 0.0387924 |
| ENO1 | enolase 1, (alpha) | 0.0386062 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0373313 |
| JAG1 | jagged 1 | 0.036918 |
| KRT8 | keratin 8, type II | 0.0365222 |
| CALR | calreticulin | 0.0360289 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0346279 |
| TMSB10 | thymosin beta 10 | 0.0337626 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0326145 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0322299 |
| SMAD3 | SMAD family member 3 | 0.0298487 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0297683 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0295241 |
| RPL3 | ribosomal protein L3 | 0.0289857 |
| TNS1 | tensin 1 | 0.0275858 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0266222 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0259152 |
| DUSP6 | dual specificity phosphatase 6 | 0.0258248 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0256902 |
| RPS17 | ribosomal protein S17 | 0.0249579 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0247347 |
| FLNB | filamin B, beta | 0.0247058 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0243667 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0242958 |
| RPL7A | ribosomal protein L7a | 0.0240733 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.023976 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0239349 |
| CPE | carboxypeptidase E | 0.0238225 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0236432 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.023048 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0229266 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0226843 |
| KRT18 | keratin 18, type I | 0.0220737 |
| FLNA | filamin A, alpha | 0.0220662 |
| UBC | ubiquitin C | 0.0219425 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0219088 |
| TOP1 | topoisomerase (DNA) I | 0.0217166 |
| RPL19 | ribosomal protein L19 | 0.0215358 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0214839 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0214507 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0213575 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0211976 |
| RPS8 | ribosomal protein S8 | 0.0211462 |
| ITGB5 | integrin, beta 5 | 0.02109 |
| B2M | beta-2-microglobulin | 0.020909 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0203281 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.020294 |
| DSTN | destrin (actin depolymerizing factor) | 0.0202821 |
| ASPH | aspartate beta-hydroxylase | 0.0201874 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0201841 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0200546 |
| LMO7 | LIM domain 7 | 0.0200473 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0199451 |
| PLEC | plectin | 0.019937 |
| CCN2 | cellular communication network factor 2 | 0.0197243 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0196687 |
| CNKSR3 | CNKSR family member 3 | 0.0196034 |
| FTL | ferritin, light polypeptide | 0.0195985 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0193365 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0193363 |
| RPL4 | ribosomal protein L4 | 0.0192802 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | -0.0628512 |
| GPC6 | glypican 6 | -0.0622194 |
| GPC3 | glypican 3 | -0.0448004 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0404255 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0400136 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0392442 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0375189 |
| CP | ceruloplasmin (ferroxidase) | -0.0356113 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0353558 |
| RBM39 | RNA binding motif protein 39 | -0.0346703 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0323897 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0323295 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0310401 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0281932 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0264326 |
| EHBP1 | EH domain binding protein 1 | -0.0251102 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0246938 |
| PLIN2 | perilipin 2 | -0.0245398 |
| MSI2 | musashi RNA-binding protein 2 | -0.0243434 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0239506 |
| PATJ | PATJ crumbs cell polarity complex component | -0.023789 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0230731 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0226936 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0225911 |
| CANX | calnexin | -0.0219302 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0210369 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0202625 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0201993 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0201364 |
| RPL34 | ribosomal protein L34 | -0.01988 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0193897 |
| ZNF644 | zinc finger protein 644 | -0.017362 |
| ITGAV | integrin, alpha V | -0.0173123 |
| APOA2 | apolipoprotein A-II | -0.0167962 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0164916 |
| OSMR | oncostatin M receptor | -0.0164221 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0162415 |
| TUT4 | terminal uridylyl transferase 4 | -0.0159404 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0159178 |
| PTCHD4 | patched domain containing 4 | -0.0158169 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0157439 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0156559 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0154859 |
| RPS24 | ribosomal protein S24 | -0.0153152 |
| SQSTM1 | sequestosome 1 | -0.015295 |
| ZNF33A | zinc finger protein 33A | -0.0152444 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0148229 |
| CD2AP | CD2-associated protein | -0.0148057 |
| NPR2 | natriuretic peptide receptor 2 | -0.0147918 |
| GNAS | GNAS complex locus | -0.0145793 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0143933 |
| FOXK2 | forkhead box K2 | -0.0143258 |
| AK1 | adenylate kinase 1 | -0.0141687 |
| GOLGA4 | golgin A4 | -0.0141585 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.014132 |
| VCL | vinculin | -0.0141022 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0140174 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0139182 |
| NCOA7 | nuclear receptor coactivator 7 | -0.013908 |
| ATP10A | ATPase, class V, type 10A | -0.0137799 |
| RIGI | RNA sensor RIG-I | -0.0135305 |
| RHOB | ras homolog family member B | -0.0134841 |
| RPLP1 | ribosomal protein, large, P1 | -0.0134365 |
| NF1 | neurofibromin 1 | -0.0133625 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0133463 |
| MAP4 | microtubule-associated protein 4 | -0.0132105 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0131976 |
| TRIM26 | tripartite motif containing 26 | -0.0131681 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0131127 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0130667 |
| PERP | PERP, TP53 apoptosis effector | -0.0129266 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0127563 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0127409 |
| ITGA1 | integrin, alpha 1 | -0.012722 |
| TCF12 | transcription factor 12 | -0.0126712 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0126686 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0125315 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0125222 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0124725 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0124612 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0122469 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0122329 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0120451 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0119947 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0119673 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.0119568 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0119377 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.011872 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0116409 |
| TMEM51 | transmembrane protein 51 | -0.0116331 |
| MX2 | MX dynamin-like GTPase 2 | -0.0116318 |
| RPLP0 | ribosomal protein, large, P0 | -0.0116295 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0115746 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0115016 |
| SBF2 | SET binding factor 2 | -0.0112381 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0110444 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0110262 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0110057 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0107768 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0107719 |
