IQ 1_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.208864
B2M beta-2-microglobulin 0.152176
MT2A metallothionein 2A 0.146609
HLA-B major histocompatibility complex, class I, B 0.124549
TMSB4X thymosin beta 4, X-linked 0.123702
LMO7 LIM domain 7 0.121191
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108678
CLU clusterin 0.0961667
TPT1 tumor protein, translationally-controlled 1 0.0832795
ENO1 enolase 1, (alpha) 0.0815208
IFITM1 interferon induced transmembrane protein 1 0.0793752
PODXL podocalyxin-like 0.0779001
IFITM3 interferon induced transmembrane protein 3 0.0747498
STC1 stanniocalcin 1 0.0732963
TGM2 transglutaminase 2 0.0731754
EEF2 eukaryotic translation elongation factor 2 0.0730899
HSPG2 heparan sulfate proteoglycan 2 0.0715906
SRRM2 serine/arginine repetitive matrix 2 0.0710741
RPS6 ribosomal protein S6 0.0700736
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0686019
RPS8 ribosomal protein S8 0.0684481
IGFBP6 insulin-like growth factor binding protein 6 0.0646691
PDE4D phosphodiesterase 4D, cAMP-specific 0.0632969
RPS3 ribosomal protein S3 0.0611882
LDHA lactate dehydrogenase A 0.0595676
TMSB10 thymosin beta 10 0.0591687
CD44 CD44 molecule (Indian blood group) 0.0570872
MACF1 microtubule-actin crosslinking factor 1 0.0542084
RPL7A ribosomal protein L7a 0.0536201
PLEC plectin 0.0535575
RPL8 ribosomal protein L8 0.051948
RPL11 ribosomal protein L11 0.0511674
SULF2 sulfatase 2 0.0502454
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0495769
FTL ferritin, light polypeptide 0.0490285
EIF1 eukaryotic translation initiation factor 1 0.0484794
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0478933
PCDH1 protocadherin 1 0.0461688
RPS19 ribosomal protein S19 0.0455195
EXT1 exostosin glycosyltransferase 1 0.0453179
RPL37A ribosomal protein L37a 0.044686
RPL12 ribosomal protein L12 0.0443404
MYH9 myosin, heavy chain 9, non-muscle 0.0443048
FN1 fibronectin 1 0.0437721
HLA-E major histocompatibility complex, class I, E 0.0437359
TIMP3 TIMP metallopeptidase inhibitor 3 0.0436493
CEMIP cell migration inducing protein, hyaluronan binding 0.0430688
RPL37 ribosomal protein L37 0.0426567
MT1E metallothionein 1E 0.0419488
FLNB filamin B, beta 0.0418301
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0413588
EHBP1L1 EH domain binding protein 1-like 1 0.0411499
RPS17 ribosomal protein S17 0.0399889
RPS13 ribosomal protein S13 0.0390775
PRRC2C proline-rich coiled-coil 2C 0.0378949
JAG1 jagged 1 0.0378223
KLF5 Kruppel-like factor 5 (intestinal) 0.036985
DUSP4 dual specificity phosphatase 4 0.0368406
RPL35A ribosomal protein L35a 0.0366159
RPL31 ribosomal protein L31 0.0365498
TXNIP thioredoxin interacting protein 0.036518
IFI6 interferon, alpha-inducible protein 6 0.0361335
YBX1 Y box binding protein 1 0.0361293
SFTPA2 surfactant protein A2 0.0360135
PTMA prothymosin, alpha 0.0354691
RPS12 ribosomal protein S12 0.0347189
RPL19 ribosomal protein L19 0.0347022
SLK STE20-like kinase 0.0345623
KTN1 kinectin 1 (kinesin receptor) 0.0338587
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0337176
ECE1 endothelin converting enzyme 1 0.033687
S100A10 S100 calcium binding protein A10 0.0332001
RPL9 ribosomal protein L9 0.032708
RACK1 receptor for activated C kinase 1 0.0326391
LMNA lamin A/C 0.0322794
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0322378
RPS25 ribosomal protein S25 0.0322107
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0321157
ANKRD12 ankyrin repeat domain 12 0.0316689
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0315956
SMAD3 SMAD family member 3 0.0315771
ASPH aspartate beta-hydroxylase 0.0315604
CD9 CD9 molecule 0.0314671
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0311588
GNAS GNAS complex locus 0.0311265
RPL13A ribosomal protein L13a 0.0309388
BCL2L1 BCL2-like 1 0.0309058
SVIL supervillin 0.0302705
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0302463
RPL36 ribosomal protein L36 0.0301375
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0301335
HLA-A major histocompatibility complex, class I, A 0.0299196
ANGPTL4 angiopoietin-like 4 0.0296976
ACTG1 actin gamma 1 0.0294622
CSTB cystatin B (stefin B) 0.0290233
IFI27 interferon, alpha-inducible protein 27 0.029007
NECTIN4 nectin cell adhesion molecule 4 0.0289208
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0286869
CMIP c-Maf inducing protein 0.0284666
APLP2 amyloid beta (A4) precursor-like protein 2 0.0283844

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0872814
TRIO trio Rho guanine nucleotide exchange factor -0.0527106
ITCH itchy E3 ubiquitin protein ligase -0.0418011
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0372882
NAMPT nicotinamide phosphoribosyltransferase -0.0357933
ANLN anillin, actin binding protein -0.0353819
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0332347
ALCAM activated leukocyte cell adhesion molecule -0.0313469
RBM39 RNA binding motif protein 39 -0.0312856
SBF2 SET binding factor 2 -0.029791
CANX calnexin -0.0283069
SULF1 sulfatase 1 -0.0280399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0274003
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0260757
VCL vinculin -0.0259146
KDM3A lysine (K)-specific demethylase 3A -0.0254026
SPAG9 sperm associated antigen 9 -0.0251226
H1-0 H1.0 linker histone -0.0248779
MEF2A myocyte enhancer factor 2A -0.0247397
C4BPB complement component 4 binding protein, beta -0.0241229
OGA O-GlcNAcase -0.0227438
MORF4L2 mortality factor 4 like 2 -0.0222306
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0222156
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0217969
SEC31A SEC31 homolog A (S. cerevisiae) -0.0216072
FOXO1 forkhead box O1 -0.0215557
LNPEP leucyl/cystinyl aminopeptidase -0.021431
DPYD dihydropyrimidine dehydrogenase -0.0201921
DIAPH3 diaphanous-related formin 3 -0.0201584
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0201539
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0193325
DLG1 discs, large homolog 1 (Drosophila) -0.0192477
MARCHF6 membrane associated ring-CH-type finger 6 -0.019246
IARS1 isoleucyl-tRNA synthetase 1 -0.019031
LMAN1 lectin, mannose-binding, 1 -0.018889
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0185677
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0183462
NF1 neurofibromin 1 -0.0183167
RUNX1 runt-related transcription factor 1 -0.0182888
SRP54 signal recognition particle 54kDa -0.0181956
CUL4B cullin 4B -0.018072
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0180272
KDM6A lysine (K)-specific demethylase 6A -0.0175536
KDM5B lysine (K)-specific demethylase 5B -0.0174231
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0167751
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.016741
ANKRD33B ankyrin repeat domain 33B -0.0163775
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0163738
ZMYM2 zinc finger, MYM-type 2 -0.0162732
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0161541
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0160103
TM9SF3 transmembrane 9 superfamily member 3 -0.015781
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0156951
SUCO SUN domain containing ossification factor -0.0154915
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0153575
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.015208
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0151514
COG5 component of oligomeric golgi complex 5 -0.0149481
NBAS neuroblastoma amplified sequence -0.0147701
PSD3 pleckstrin and Sec7 domain containing 3 -0.0145451
RLF rearranged L-myc fusion -0.0144537
MON2 MON2 homolog (S. cerevisiae) -0.0143381
SNX14 sorting nexin 14 -0.0143043
BRWD3 bromodomain and WD repeat domain containing 3 -0.0142568
INSIG2 insulin induced gene 2 -0.0142549
DENND4C DENN/MADD domain containing 4C -0.0142504
EMP1 epithelial membrane protein 1 -0.0142185
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0142069
PDIA3 protein disulfide isomerase family A, member 3 -0.0141713
USP3 ubiquitin specific peptidase 3 -0.0141358
WSB1 WD repeat and SOCS box containing 1 -0.0140191
BLZF1 basic leucine zipper nuclear factor 1 -0.0139479
TMEM165 transmembrane protein 165 -0.0137769
BIRC6 baculoviral IAP repeat containing 6 -0.0137764
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0137558
SKIC3 SKI3 subunit of superkiller complex -0.0136366
QKI QKI, KH domain containing, RNA binding -0.0136205
TPX2 TPX2, microtubule-associated -0.0136031
RAB1A RAB1A, member RAS oncogene family -0.0135961
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0135728
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0135715
PHKB phosphorylase kinase, beta -0.0133792
EHBP1 EH domain binding protein 1 -0.0130732
ARL5B ADP-ribosylation factor-like 5B -0.0130412
VMP1 vacuole membrane protein 1 -0.0130306
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0130103
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0129333
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0129272
FNDC3B fibronectin type III domain containing 3B -0.0128966
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0128321
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0128134
TRA2A transformer 2 alpha homolog (Drosophila) -0.0127602
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0127593
EXOC6B exocyst complex component 6B -0.0125865
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0125433
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0124794
NBEAL1 neurobeachin-like 1 -0.0123892
MXI1 MAX interactor 1, dimerization protein -0.0123741
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0123423
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0123326