IQ 1_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.235978
B2M beta-2-microglobulin 0.151871
SPTBN1 spectrin, beta, non-erythrocytic 1 0.124585
LMO7 LIM domain 7 0.120007
CALR calreticulin 0.117777
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.111273
TMC5 transmembrane channel-like 5 0.106804
TMSB10 thymosin beta 10 0.101878
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.100737
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0992664
KRT18 keratin 18, type I 0.0968541
EMP1 epithelial membrane protein 1 0.0847455
TMSB4X thymosin beta 4, X-linked 0.0837594
EZR ezrin 0.0827692
ANXA2 annexin A2 0.0724095
FTL ferritin, light polypeptide 0.0707243
MYH9 myosin, heavy chain 9, non-muscle 0.0705034
SEPTIN9 septin 9 0.0694997
LOC102724023 ES1 protein homolog, mitochondrial 0.0690004
LCN2 lipocalin 2 0.0644204
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0639382
KRT8 keratin 8, type II 0.0638391
PTMA prothymosin, alpha 0.0614957
ACTG1 actin gamma 1 0.060548
DSPP dentin sialophosphoprotein 0.0569368
RPL7A ribosomal protein L7a 0.0563427
GDA guanine deaminase 0.0558039
RNF213 ring finger protein 213 0.0522717
VEGFA vascular endothelial growth factor A 0.0520629
SRRM2 serine/arginine repetitive matrix 2 0.05188
POTEF POTE ankyrin domain family, member F 0.0505578
PLEC plectin 0.0501215
RPS19 ribosomal protein S19 0.0501075
EEF2 eukaryotic translation elongation factor 2 0.0485913
MBNL2 muscleblind-like splicing regulator 2 0.0482795
RPL19 ribosomal protein L19 0.0470696
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.04574
FAT1 FAT atypical cadherin 1 0.0457253
HLA-B major histocompatibility complex, class I, B 0.0449767
RPL23 ribosomal protein L23 0.0448897
NFE2L1 nuclear factor, erythroid 2-like 1 0.0445378
IFI27 interferon, alpha-inducible protein 27 0.0435306
MYOF myoferlin 0.0433472
SMAD3 SMAD family member 3 0.0425636
CLDN4 claudin 4 0.04247
HSPA8 heat shock 70kDa protein 8 0.0411106
RPS17 ribosomal protein S17 0.0400631
RPN1 ribophorin I 0.0396107
ACTN4 actinin, alpha 4 0.0373701
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0370047
AREG amphiregulin 0.0365939
HLA-A major histocompatibility complex, class I, A 0.0365035
RPS3 ribosomal protein S3 0.0364303
GOLM1 golgi membrane protein 1 0.0357259
SFTPA2 surfactant protein A2 0.0353804
APLP2 amyloid beta (A4) precursor-like protein 2 0.0353222
MPRIP myosin phosphatase Rho interacting protein 0.0345111
TMEM45B transmembrane protein 45B 0.0339574
BCL2L1 BCL2-like 1 0.0338901
PCDH1 protocadherin 1 0.0319987
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0318807
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0317062
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.030999
UGCG UDP-glucose ceramide glucosyltransferase 0.0308535
S100P S100 calcium binding protein P 0.0308137
IFI6 interferon, alpha-inducible protein 6 0.0305025
CLDN7 claudin 7 0.0303878
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0303615
ITGA6 integrin, alpha 6 0.0302804
LMNA lamin A/C 0.0301317
ANXA11 annexin A11 0.0299548
PKM pyruvate kinase, muscle 0.0297557
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0297219
EIF4A2 eukaryotic translation initiation factor 4A2 0.0286751
RBM47 RNA binding motif protein 47 0.0283079
DOCK5 dedicator of cytokinesis 5 0.0282283
EEF1G eukaryotic translation elongation factor 1 gamma 0.028114
EIF4H eukaryotic translation initiation factor 4H 0.027389
ASPH aspartate beta-hydroxylase 0.0272531
ANXA1 annexin A1 0.026888
PGK1 phosphoglycerate kinase 1 0.0266938
EIF1 eukaryotic translation initiation factor 1 0.0263553
PTPRK protein tyrosine phosphatase, receptor type, K 0.0262679
S100A10 S100 calcium binding protein A10 0.0261376
NCOR2 nuclear receptor corepressor 2 0.0259474
CTSB cathepsin B 0.0257826
TPM3 tropomyosin 3 0.0257812
AKAP13 A kinase (PRKA) anchor protein 13 0.0252042
TNS4 tensin 4 0.0247043
TUBB4B tubulin, beta 4B class IVb 0.0246781
ATP11A ATPase, class VI, type 11A 0.0244784
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0243849
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0241983
CEMIP cell migration inducing protein, hyaluronan binding 0.0239016
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0238259
CST3 cystatin C 0.0238102
MYH14 myosin, heavy chain 14, non-muscle 0.0238034
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0237678
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0236335
ITGB4 integrin, beta 4 0.0233029

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.277386
NPSR1 neuropeptide S receptor 1 -0.213041
GMDS GDP-mannose 4,6-dehydratase -0.0988438
MAML2 mastermind-like 2 (Drosophila) -0.0892325
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0742085
CANX calnexin -0.0601932
IARS1 isoleucyl-tRNA synthetase 1 -0.0598639
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0562345
FGFR2 fibroblast growth factor receptor 2 -0.0522499
EHBP1 EH domain binding protein 1 -0.0456494
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0449229
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0436102
GOLGA4 golgin A4 -0.0431258
PDIA3 protein disulfide isomerase family A, member 3 -0.0418232
FNDC3B fibronectin type III domain containing 3B -0.041682
AGR2 anterior gradient 2 -0.0410339
TRPS1 trichorhinophalangeal syndrome I -0.0406629
NF1 neurofibromin 1 -0.0400328
TMEM123 transmembrane protein 123 -0.0388113
RBM39 RNA binding motif protein 39 -0.0382296
KDM3A lysine (K)-specific demethylase 3A -0.0376459
ZNF292 zinc finger protein 292 -0.0367071
SEC31A SEC31 homolog A (S. cerevisiae) -0.0364225
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0363441
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0355157
TFRC transferrin receptor -0.0345059
BIRC6 baculoviral IAP repeat containing 6 -0.0336738
RTN3 reticulon 3 -0.0333824
VMP1 vacuole membrane protein 1 -0.0329998
VCL vinculin -0.0329133
ARHGAP32 Rho GTPase activating protein 32 -0.0315962
TCF12 transcription factor 12 -0.0311583
EXOC4 exocyst complex component 4 -0.0311197
KPNB1 karyopherin (importin) beta 1 -0.0308204
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0306106
RPS24 ribosomal protein S24 -0.0298159
DLG1 discs, large homolog 1 (Drosophila) -0.0297802
ACACA acetyl-CoA carboxylase alpha -0.0295613
TAS2R14 taste receptor, type 2, member 14 -0.0295378
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0294942
CAMKMT calmodulin-lysine N-methyltransferase -0.0293737
INSIG1 insulin induced gene 1 -0.0293087
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0287976
WARS1 tryptophanyl-tRNA synthetase 1 -0.0285757
CDK13 cyclin-dependent kinase 13 -0.0282967
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0282963
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0278774
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0278136
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0277558
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0277137
CADPS2 Ca++-dependent secretion activator 2 -0.0271976
SAMD12 sterile alpha motif domain containing 12 -0.0270393
RAD51B RAD51 paralog B -0.027035
PDIA6 protein disulfide isomerase family A, member 6 -0.0270186
AHR aryl hydrocarbon receptor -0.0269293
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0269181
ADIPOR2 adiponectin receptor 2 -0.0269151
RAB1A RAB1A, member RAS oncogene family -0.0267193
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.026533
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0264034
COG5 component of oligomeric golgi complex 5 -0.0262448
POF1B premature ovarian failure, 1B -0.0262267
TES testin LIM domain protein -0.0258436
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0257064
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0256687
CDK6 cyclin-dependent kinase 6 -0.0253837
ATXN1 ataxin 1 -0.0253008
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0251263
H1-0 H1.0 linker histone -0.0250797
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0249317
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0248984
PICALM phosphatidylinositol binding clathrin assembly protein -0.0247868
GARS1 glycyl-tRNA synthetase 1 -0.0246877
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0243813
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0241688
CD46 CD46 molecule, complement regulatory protein -0.0237486
TPT1 tumor protein, translationally-controlled 1 -0.0230564
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0229038
PATJ PATJ crumbs cell polarity complex component -0.0225716
MON2 MON2 homolog (S. cerevisiae) -0.0220911
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0220861
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0217644
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0217331
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.02167
WDR45B WD repeat domain 45B -0.0214297
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0212588
DENND1A DENN/MADD domain containing 1A -0.0211279
NCOA7 nuclear receptor coactivator 7 -0.0208495
NFIA nuclear factor I/A -0.0208477
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0206698
PLCB4 phospholipase C, beta 4 -0.0205847
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0204599
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0204417
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0202069
BTBD9 BTB (POZ) domain containing 9 -0.0201569
LCORL ligand dependent nuclear receptor corepressor-like -0.0200225
XAF1 XIAP associated factor 1 -0.0199518
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0199345
TAOK1 TAO kinase 1 -0.0198915
FAF1 Fas (TNFRSF6) associated factor 1 -0.019779