IQ 1_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the IQ 1_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.379645
FTH1 ferritin, heavy polypeptide 1 0.270221
MCL1 myeloid cell leukemia 1 0.127107
GRAMD1B GRAM domain containing 1B 0.0972039
EEF2 eukaryotic translation elongation factor 2 0.0908423
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0526841
FGB fibrinogen beta chain 0.0499789
MT1X metallothionein 1X 0.0499113
HLA-B major histocompatibility complex, class I, B 0.0475817
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0460429
CALR calreticulin 0.0451396
TPM3 tropomyosin 3 0.0445065
RPL3 ribosomal protein L3 0.0420215
POTEF POTE ankyrin domain family, member F 0.0413887
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0372859
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0365638
EIF4A1 eukaryotic translation initiation factor 4A1 0.0365564
HSPA8 heat shock 70kDa protein 8 0.0343827
B2M beta-2-microglobulin 0.0335147
PCBP2 poly(rC) binding protein 2 0.0333669
BRD2 bromodomain containing 2 0.0333098
WWOX WW domain containing oxidoreductase 0.0329676
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0329608
ADM adrenomedullin 0.0326777
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0326495
MSN moesin 0.0318983
HLA-A major histocompatibility complex, class I, A 0.0307902
DDIT4 DNA-damage-inducible transcript 4 0.0297924
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0291128
FLNA filamin A, alpha 0.0284536
APLP2 amyloid beta (A4) precursor-like protein 2 0.0260834
CCNL1 cyclin L1 0.0260463
EGR1 early growth response 1 0.0254075
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0251237
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0236848
MYH9 myosin, heavy chain 9, non-muscle 0.0234565
SFTPA2 surfactant protein A2 0.02326
EEF1G eukaryotic translation elongation factor 1 gamma 0.0227865
COPA coatomer protein complex, subunit alpha 0.0227016
EIF5 eukaryotic translation initiation factor 5 0.0221024
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0208272
AKAP12 A kinase (PRKA) anchor protein 12 0.0207428
SIK3 SIK family kinase 3 0.020732
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0207232
ITGB5 integrin, beta 5 0.0205382
RRM2 ribonucleotide reductase M2 0.0204998
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0203003
IL6 interleukin 6 0.0193889
TGM2 transglutaminase 2 0.0193061
SRRM2 serine/arginine repetitive matrix 2 0.0192299
CXCL2 chemokine (C-X-C motif) ligand 2 0.0190953
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0189591
SOD2 superoxide dismutase 2, mitochondrial 0.0185672
EIF4A2 eukaryotic translation initiation factor 4A2 0.0182975
CCL5 chemokine (C-C motif) ligand 5 0.0176728
AXL AXL receptor tyrosine kinase 0.0175093
NPC1 Niemann-Pick disease, type C1 0.0170572
TPI1 triosephosphate isomerase 1 0.0160371
RAB7A RAB7A, member RAS oncogene family 0.0158663
LOC102724023 ES1 protein homolog, mitochondrial 0.0158139
RPS9 ribosomal protein S9 0.0153953
LAMB1 laminin, beta 1 0.0152681
SFPQ splicing factor proline/glutamine-rich 0.0152659
TIMP1 TIMP metallopeptidase inhibitor 1 0.0152473
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0151618
RPN1 ribophorin I 0.0149265
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0147255
ARHGAP26 Rho GTPase activating protein 26 0.0146759
PABPN1 poly(A) binding protein, nuclear 1 0.0146084
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0143644
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0143354
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0142958
PLEC plectin 0.0140281
CYB5R3 cytochrome b5 reductase 3 0.0135893
FAM107B family with sequence similarity 107, member B 0.0135187
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0135112
SDC4 syndecan 4 0.013504
VEGFA vascular endothelial growth factor A 0.0132736
FLNB filamin B, beta 0.0131799
FGF18 fibroblast growth factor 18 0.013153
DIAPH1 diaphanous-related formin 1 0.013059
LRP10 low density lipoprotein receptor-related protein 10 0.013048
TCIM transcriptional and immune response regulator 0.0130197
SMTN smoothelin 0.0129934
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0127895
GADD45B growth arrest and DNA-damage-inducible, beta 0.0127631
DCAF8 DDB1 and CUL4 associated factor 8 0.0127532
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0127086
SRSF5 serine/arginine-rich splicing factor 5 0.012656
RBM25 RNA binding motif protein 25 0.0125445
YBX3 Y box binding protein 3 0.0124064
ENAH enabled homolog (Drosophila) 0.0123863
SPAG5 sperm associated antigen 5 0.0123067
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0121653
RPL7A ribosomal protein L7a 0.0121611
HDGF hepatoma-derived growth factor 0.0121257
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0120591
MYADM myeloid-associated differentiation marker 0.0119638
LRRC23 leucine rich repeat containing 23 0.0119623
NFE2L1 nuclear factor, erythroid 2-like 1 0.0119485

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.186794
VIM vimentin -0.130589
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0951212
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0929078
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0822339
AHNAK AHNAK nucleoprotein -0.079662
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0708704
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0706512
DST dystonin -0.0668471
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0650674
IER3 immediate early response 3 -0.0641762
CAVIN1 caveolae associated protein 1 -0.0604084
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0545039
S100A6 S100 calcium binding protein A6 -0.0537304
TFPI2 tissue factor pathway inhibitor 2 -0.0518489
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0503579
ERBIN erbb2 interacting protein -0.0497789
FTL ferritin, light polypeptide -0.0465965
CANX calnexin -0.0455404
TPT1 tumor protein, translationally-controlled 1 -0.0441256
ENO1 enolase 1, (alpha) -0.0439689
ELL2 elongation factor, RNA polymerase II, 2 -0.0433467
S100A10 S100 calcium binding protein A10 -0.0421831
EFNA5 ephrin-A5 -0.041821
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0417888
KDM3A lysine (K)-specific demethylase 3A -0.0414585
VCL vinculin -0.039829
BICC1 BicC family RNA binding protein 1 -0.0393032
C15ORF48 chromosome 15 open reading frame 48 -0.0392281
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0388902
RAB10 RAB10, member RAS oncogene family -0.0383225
AHR aryl hydrocarbon receptor -0.0383181
PTMA prothymosin, alpha -0.0381883
RPLP1 ribosomal protein, large, P1 -0.03812
SLC38A2 solute carrier family 38, member 2 -0.03784
STC1 stanniocalcin 1 -0.0377117
NAP1L1 nucleosome assembly protein 1-like 1 -0.0365009
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0354889
UTRN utrophin -0.0351543
EGFR epidermal growth factor receptor -0.0346608
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0344688
RPL34 ribosomal protein L34 -0.0342699
CMIP c-Maf inducing protein -0.0333168
TRIO trio Rho guanine nucleotide exchange factor -0.0333146
RASAL2 RAS protein activator like 2 -0.0325548
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0321735
CFLAR CASP8 and FADD-like apoptosis regulator -0.0313106
RAD21 RAD21 homolog (S. pombe) -0.0308187
ASPH aspartate beta-hydroxylase -0.0307151
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.030626
RPS27A ribosomal protein S27a -0.0305124
NEGR1 neuronal growth regulator 1 -0.0299295
RPS8 ribosomal protein S8 -0.0296462
THSD4 thrombospondin, type I, domain containing 4 -0.0295563
ADGRG6 adhesion G protein-coupled receptor G6 -0.0293482
CFDP1 craniofacial development protein 1 -0.0286695
BIRC6 baculoviral IAP repeat containing 6 -0.0286536
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0281106
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0280275
EIF1 eukaryotic translation initiation factor 1 -0.0278936
CUX1 cut-like homeobox 1 -0.0273889
ANXA2 annexin A2 -0.0272625
ZFR zinc finger RNA binding protein -0.0271367
USP34 ubiquitin specific peptidase 34 -0.0271295
SMAD2 SMAD family member 2 -0.0270821
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0270513
PUM2 pumilio RNA-binding family member 2 -0.0265355
GNAS GNAS complex locus -0.0264819
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0264216
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0263257
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0262606
BASP1 brain abundant, membrane attached signal protein 1 -0.0262358
RPS24 ribosomal protein S24 -0.0260349
KIF5B kinesin family member 5B -0.0257962
EHBP1 EH domain binding protein 1 -0.0256914
RSL1D1 ribosomal L1 domain containing 1 -0.0256279
ZMYND8 zinc finger, MYND-type containing 8 -0.0256259
BZW1 basic leucine zipper and W2 domains 1 -0.0255855
MAML3 mastermind-like 3 (Drosophila) -0.0254011
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.025379
SVIL supervillin -0.0250371
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0250195
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0247057
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0246226
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.024525
RPLP0 ribosomal protein, large, P0 -0.0244213
PRR16 proline rich 16 -0.0243822
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0243797
RPS25 ribosomal protein S25 -0.0242446
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0238652
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0238195
MYOF myoferlin -0.0237286
ANLN anillin, actin binding protein -0.0236336
HMGA2 high mobility group AT-hook 2 -0.0235992
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0234954
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0232514
PCNX4 pecanex 4 -0.0231694
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0231528
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0231437
KYNU kynureninase -0.0231237