| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | IQ 1 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the IQ 1_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.172243 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.134777 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.12832 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.120728 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.118285 |
| TXNRD1 | thioredoxin reductase 1 | 0.117546 |
| TPM3 | tropomyosin 3 | 0.0947607 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0855287 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0854933 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0763531 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0608421 |
| TPI1 | triosephosphate isomerase 1 | 0.0573894 |
| POTEF | POTE ankyrin domain family, member F | 0.0541458 |
| EGR1 | early growth response 1 | 0.0514126 |
| YBX1 | Y box binding protein 1 | 0.0502082 |
| BRD2 | bromodomain containing 2 | 0.0500776 |
| KRT18 | keratin 18, type I | 0.0498953 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0485336 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0470916 |
| PTMA | prothymosin, alpha | 0.0470323 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0459147 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0456944 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0455284 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0448363 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0434348 |
| GRAMD1B | GRAM domain containing 1B | 0.0433017 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0430963 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0426536 |
| ACTG1 | actin gamma 1 | 0.0426253 |
| YBX3 | Y box binding protein 3 | 0.0417416 |
| RTN4 | reticulon 4 | 0.0405832 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0400786 |
| RRM2 | ribonucleotide reductase M2 | 0.0397144 |
| LDHB | lactate dehydrogenase B | 0.0382376 |
| HSPA8 | heat shock 70kDa protein 8 | 0.037921 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0360524 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.035381 |
| IPO7 | importin 7 | 0.0347676 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0346818 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.034309 |
| PKM | pyruvate kinase, muscle | 0.0337587 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0332352 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0325748 |
| MKI67 | marker of proliferation Ki-67 | 0.0322254 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0315763 |
| TPM2 | tropomyosin 2 (beta) | 0.0314059 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0307637 |
| PCBP2 | poly(rC) binding protein 2 | 0.0307163 |
| MAGEA4 | melanoma antigen family A4 | 0.0306336 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0296808 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0291319 |
| GPHN | gephyrin | 0.0288929 |
| HOMER1 | homer scaffolding protein 1 | 0.0286367 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0284931 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0278691 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0278231 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0277314 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0276849 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0274416 |
| ACTN1 | actinin, alpha 1 | 0.0263704 |
| RPL3 | ribosomal protein L3 | 0.026316 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0262902 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0262312 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0258564 |
| KCMF1 | potassium channel modulatory factor 1 | 0.025836 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0256534 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0253162 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0248845 |
| MSH6 | mutS homolog 6 | 0.024473 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0243279 |
| PNN | pinin, desmosome associated protein | 0.0241079 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.024104 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0238812 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0237639 |
| PHIP | pleckstrin homology domain interacting protein | 0.0236644 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0231523 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0230309 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0226547 |
| CCNL1 | cyclin L1 | 0.0226071 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0223779 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0223778 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0220097 |
| SET | SET nuclear proto-oncogene | 0.0219654 |
| PER1 | period circadian clock 1 | 0.0218802 |
| MCL1 | myeloid cell leukemia 1 | 0.0218409 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0217249 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0215929 |
| RASAL2 | RAS protein activator like 2 | 0.0215589 |
| CLTC | clathrin, heavy chain (Hc) | 0.0212668 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0210178 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0209423 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0209333 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0208697 |
| WDR43 | WD repeat domain 43 | 0.0208467 |
| CBX3 | chromobox homolog 3 | 0.0207986 |
| RPS8 | ribosomal protein S8 | 0.0207874 |
| UBC | ubiquitin C | 0.0207178 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0205629 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0205566 |
| RUNX1 | runt-related transcription factor 1 | 0.0205155 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.149931 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0749025 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0657183 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0647837 |
| RAD51B | RAD51 paralog B | -0.0620386 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0618075 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0578585 |
| PDE10A | phosphodiesterase 10A | -0.0566093 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0555282 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0541724 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.050816 |
| HMGA2 | high mobility group AT-hook 2 | -0.0494436 |
| OSMR | oncostatin M receptor | -0.0491645 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0489804 |
| ATXN1 | ataxin 1 | -0.0487527 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.047056 |
| EXOC4 | exocyst complex component 4 | -0.0447633 |
| RYR3 | ryanodine receptor 3 | -0.0436046 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0432076 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0403543 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0396359 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0383146 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0375622 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0364482 |
| NF1 | neurofibromin 1 | -0.0359857 |
| EGFR | epidermal growth factor receptor | -0.0354517 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0346924 |
| USP34 | ubiquitin specific peptidase 34 | -0.0346196 |
| DENND5B | DENN/MADD domain containing 5B | -0.0339425 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0333788 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0324416 |
| CUX1 | cut-like homeobox 1 | -0.0321297 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0315315 |
| EHBP1 | EH domain binding protein 1 | -0.0312407 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0311226 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0298003 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0295938 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0287292 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0281357 |
| RSF1 | remodeling and spacing factor 1 | -0.0278532 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0277161 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0272247 |
| ETV6 | ets variant 6 | -0.026919 |
| RNF213 | ring finger protein 213 | -0.0265343 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0263029 |
| PRELID2 | PRELI domain containing 2 | -0.026042 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0259593 |
| ATG7 | autophagy related 7 | -0.0258015 |
| WWOX | WW domain containing oxidoreductase | -0.0252236 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0249489 |
| FMN1 | formin 1 | -0.0246373 |
| PHF21A | PHD finger protein 21A | -0.0245353 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0236616 |
| FMNL2 | formin-like 2 | -0.0236159 |
| CCDC91 | coiled-coil domain containing 91 | -0.0236015 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0231003 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0229389 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0228868 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0228192 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0226122 |
| ENOSF1 | enolase superfamily member 1 | -0.0223373 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0220473 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0216094 |
| AEBP2 | AE binding protein 2 | -0.0215337 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0213566 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0212427 |
| PHF20 | PHD finger protein 20 | -0.0206378 |
| HDAC8 | histone deacetylase 8 | -0.0202177 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0200409 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0199856 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.019719 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0196241 |
| HLA-B | major histocompatibility complex, class I, B | -0.0195918 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0193276 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0191576 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0190015 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0187234 |
| CD2AP | CD2-associated protein | -0.0185533 |
| BNC2 | basonuclin 2 | -0.0184778 |
| CANX | calnexin | -0.0184617 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0183024 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0178194 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0177974 |
| SMYD3 | SET and MYND domain containing 3 | -0.0177706 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0174369 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0174367 |
| SUMF1 | sulfatase modifying factor 1 | -0.0174247 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0173564 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0173505 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0173423 |
| NBEAL1 | neurobeachin-like 1 | -0.0172691 |
| RPL31 | ribosomal protein L31 | -0.0170847 |
| KLHL5 | kelch-like family member 5 | -0.0167738 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0166716 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0165149 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0165136 |
| RPL37 | ribosomal protein L37 | -0.0162946 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.016205 |
| PRKCE | protein kinase C, epsilon | -0.0159986 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0159542 |
