IQ 1_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.229625
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.179
PSD3 pleckstrin and Sec7 domain containing 3 0.148078
EEF2 eukaryotic translation elongation factor 2 0.137308
FTH1 ferritin, heavy polypeptide 1 0.133209
MCL1 myeloid cell leukemia 1 0.121217
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.111635
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.106925
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.104847
ASPH aspartate beta-hydroxylase 0.098317
GRAMD1B GRAM domain containing 1B 0.0947482
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0826273
VIM vimentin 0.0786591
RPL7A ribosomal protein L7a 0.0776257
DOCK4 dedicator of cytokinesis 4 0.0767219
SH3KBP1 SH3-domain kinase binding protein 1 0.0734834
MAML3 mastermind-like 3 (Drosophila) 0.065791
RPL19 ribosomal protein L19 0.0626323
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.058718
PTMA prothymosin, alpha 0.0586445
RPL12 ribosomal protein L12 0.0558686
TMSB10 thymosin beta 10 0.0553783
ACTG1 actin gamma 1 0.0546548
PRKN parkin RBR E3 ubiquitin protein ligase 0.0543179
HSPA8 heat shock 70kDa protein 8 0.0541805
PDE10A phosphodiesterase 10A 0.0537583
SOX4 SRY (sex determining region Y)-box 4 0.0526939
CDH13 cadherin 13 0.0520138
RPS6 ribosomal protein S6 0.0517547
CTSL cathepsin L 0.051532
SRRM2 serine/arginine repetitive matrix 2 0.0514865
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0503504
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0483518
BASP1 brain abundant, membrane attached signal protein 1 0.0478666
RPS4X ribosomal protein S4, X-linked 0.0477748
PDLIM5 PDZ and LIM domain 5 0.0473903
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0465491
SMOC1 SPARC related modular calcium binding 1 0.0463823
NRCAM neuronal cell adhesion molecule 0.0462486
RPS8 ribosomal protein S8 0.046077
FMNL2 formin-like 2 0.0458226
LDHA lactate dehydrogenase A 0.0457412
TPM3 tropomyosin 3 0.0453798
MT2A metallothionein 2A 0.0452181
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0449738
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0447989
PKM pyruvate kinase, muscle 0.0446421
RPS3 ribosomal protein S3 0.0440628
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0439696
PCBP3 poly(rC) binding protein 3 0.0439049
RPS19 ribosomal protein S19 0.0438323
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0432871
RGS2 regulator of G-protein signaling 2 0.041995
FLNB filamin B, beta 0.041988
RPL3 ribosomal protein L3 0.0408067
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0405017
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0399267
NFE2L2 nuclear factor, erythroid 2-like 2 0.0399069
RPS17 ribosomal protein S17 0.0399
RPL4 ribosomal protein L4 0.0394771
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0393695
B2M beta-2-microglobulin 0.0393428
DUSP4 dual specificity phosphatase 4 0.0393107
TMSB4X thymosin beta 4, X-linked 0.0389477
RPH3AL rabphilin 3A-like (without C2 domains) 0.0385166
DST dystonin 0.0381661
EIF4A1 eukaryotic translation initiation factor 4A1 0.0380869
PRRC2C proline-rich coiled-coil 2C 0.0373275
CTIF CBP80/20-dependent translation initiation factor 0.0372358
SMAD2 SMAD family member 2 0.0369538
RPL26 ribosomal protein L26 0.0368897
RAB3B RAB3B, member RAS oncogene family 0.0368307
NCOR2 nuclear receptor corepressor 2 0.0368076
CXCL8 chemokine (C-X-C motif) ligand 8 0.0367464
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0366721
IGFBP3 insulin-like growth factor binding protein 3 0.0363477
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0361735
ENO1 enolase 1, (alpha) 0.0359425
KYNU kynureninase 0.0356111
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0356099
TPT1 tumor protein, translationally-controlled 1 0.0354424
HLA-A major histocompatibility complex, class I, A 0.0353448
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0349478
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0347866
RPL9 ribosomal protein L9 0.0343467
INHBA inhibin, beta A 0.0342328
RPL23 ribosomal protein L23 0.0338377
EEF1G eukaryotic translation elongation factor 1 gamma 0.0336823
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0335447
RPL31 ribosomal protein L31 0.03245
IGFBP6 insulin-like growth factor binding protein 6 0.0321051
DOCK5 dedicator of cytokinesis 5 0.0318707
FLNA filamin A, alpha 0.0317903
S100A10 S100 calcium binding protein A10 0.0316188
RPS23 ribosomal protein S23 0.0314215
RPS12 ribosomal protein S12 0.0313931
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0310934
LOC102724023 ES1 protein homolog, mitochondrial 0.0310514
DDIT4 DNA-damage-inducible transcript 4 0.030986
YBX3 Y box binding protein 3 0.0306746

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.161209
PDE4D phosphodiesterase 4D, cAMP-specific -0.083902
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0493779
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0480253
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0448307
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0447077
ELL2 elongation factor, RNA polymerase II, 2 -0.0444527
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0441153
SMYD3 SET and MYND domain containing 3 -0.0424001
COL5A2 collagen, type V, alpha 2 -0.0411128
NALF1 NALCN channel auxiliary factor 1 -0.0381849
SPAG9 sperm associated antigen 9 -0.0356542
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.02692
KIAA0825 KIAA0825 -0.0249674
BCAS3 breast carcinoma amplified sequence 3 -0.0238448
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.023326
TENT5A terminal nucleotidyltransferase 5A -0.0230537
OGA O-GlcNAcase -0.0229542
CANX calnexin -0.0224337
PBX1 pre-B-cell leukemia homeobox 1 -0.0213543
PUM2 pumilio RNA-binding family member 2 -0.0212253
GOLGA4 golgin A4 -0.0208939
KDM3A lysine (K)-specific demethylase 3A -0.0207937
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0207491
SRPK2 SRSF protein kinase 2 -0.0206539
RBM39 RNA binding motif protein 39 -0.0205926
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.020037
SOD2 superoxide dismutase 2, mitochondrial -0.0200076
NEK7 NIMA-related kinase 7 -0.0193806
PCDH15 protocadherin-related 15 -0.0193625
TRA2A transformer 2 alpha homolog (Drosophila) -0.0193252
NF1 neurofibromin 1 -0.0189808
BRWD3 bromodomain and WD repeat domain containing 3 -0.018681
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0185844
USP34 ubiquitin specific peptidase 34 -0.0184301
S100A6 S100 calcium binding protein A6 -0.0182152
IFIH1 interferon induced with helicase C domain 1 -0.017664
SBF2 SET binding factor 2 -0.0172713
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0168017
ZNF207 zinc finger protein 207 -0.0167395
VCL vinculin -0.0161291
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0159544
USP3 ubiquitin specific peptidase 3 -0.0157538
MARCHF6 membrane associated ring-CH-type finger 6 -0.0156892
RAB1A RAB1A, member RAS oncogene family -0.0156315
KMT2C lysine (K)-specific methyltransferase 2C -0.0155783
MON2 MON2 homolog (S. cerevisiae) -0.0155426
ZFAND3 zinc finger, AN1-type domain 3 -0.0154447
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.015315
EFNA5 ephrin-A5 -0.015219
PDE1A phosphodiesterase 1A, calmodulin-dependent -0.0151729
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0151068
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0150182
SEC31A SEC31 homolog A (S. cerevisiae) -0.0149347
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.014872
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0147492
JMJD1C jumonji domain containing 1C -0.0147279
MBD5 methyl-CpG binding domain protein 5 -0.0146995
KDM6A lysine (K)-specific demethylase 6A -0.0146807
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0145718
ATAD1 ATPase family, AAA domain containing 1 -0.0145258
GNS glucosamine (N-acetyl)-6-sulfatase -0.0145101
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0143799
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.014186
MAP4 microtubule-associated protein 4 -0.0141507
IARS1 isoleucyl-tRNA synthetase 1 -0.0141153
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0139701
NAMPT nicotinamide phosphoribosyltransferase -0.0138786
DGKD diacylglycerol kinase, delta 130kDa -0.013833
AFF4 AF4/FMR2 family, member 4 -0.0137839
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0136188
SENP6 SUMO1/sentrin specific peptidase 6 -0.0135989
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0134728
LATS2 large tumor suppressor kinase 2 -0.01336
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0132765
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0131672
TM9SF3 transmembrane 9 superfamily member 3 -0.013142
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0130776
WDR45B WD repeat domain 45B -0.0129456
FNDC3A fibronectin type III domain containing 3A -0.012794
AGFG1 ArfGAP with FG repeats 1 -0.0127782
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0127732
TLK1 tousled-like kinase 1 -0.0127708
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0127625
SLC16A6 solute carrier family 16, member 6 -0.0126656
HBP1 HMG-box transcription factor 1 -0.0123949
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0123889
WDR43 WD repeat domain 43 -0.0123471
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0123334
P3H2 prolyl 3-hydroxylase 2 -0.0122879
ZFC3H1 zinc finger, C3H1-type containing -0.012223
TAS2R14 taste receptor, type 2, member 14 -0.0121939
RPL34 ribosomal protein L34 -0.0121877
QPCT glutaminyl-peptide cyclotransferase -0.012179
VEZT vezatin, adherens junctions transmembrane protein -0.0121758
NCOA7 nuclear receptor coactivator 7 -0.0121469
TENM3 teneurin transmembrane protein 3 -0.0120617
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0119276
LCORL ligand dependent nuclear receptor corepressor-like -0.0118049
TCF12 transcription factor 12 -0.0117793