IQ 1_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

89 genes differentially expressed following the IQ 1_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.202995
NDRG1 N-myc downstream regulated 1 0.202916
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.200445
MYO1E myosin IE 0.195047
DSCAM Down syndrome cell adhesion molecule 0.172897
PTMA prothymosin, alpha 0.158166
EEF2 eukaryotic translation elongation factor 2 0.151974
PTK2 protein tyrosine kinase 2 0.134807
LDHA lactate dehydrogenase A 0.125369
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117828
PSD3 pleckstrin and Sec7 domain containing 3 0.107674
ANXA2 annexin A2 0.105461
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0982849
MYOF myoferlin 0.095472
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0925022
MCL1 myeloid cell leukemia 1 0.0922584
LMO7 LIM domain 7 0.0867069
DOCK5 dedicator of cytokinesis 5 0.0866489
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0715737
SQSTM1 sequestosome 1 0.0641463
ANKRD11 ankyrin repeat domain 11 0.0590059
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0561681
RAP1B RAP1B, member of RAS oncogene family 0.0498467
FTH1 ferritin, heavy polypeptide 1 0.0493815
SLTM SAFB-like, transcription modulator 0.0436301
ASPH aspartate beta-hydroxylase 0.0373339
CDH13 cadherin 13 0.0166802
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0156764
TTC3 tetratricopeptide repeat domain 3 0.0141812
RAB1A RAB1A, member RAS oncogene family 0.0140505
MAP7 microtubule-associated protein 7 0.0116588
GOLGB1 golgin B1 0.0109805
TRIO trio Rho guanine nucleotide exchange factor 0.00956229
PDE4D phosphodiesterase 4D, cAMP-specific 0.00626922
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00536128
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00490345
RORA RAR-related orphan receptor A 0.00234416
ABLIM1 actin binding LIM protein 1 0.00103616
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 5.60036E-4

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.190838
VIM vimentin -0.173588
OGA O-GlcNAcase -0.161603
ELL2 elongation factor, RNA polymerase II, 2 -0.126306
DST dystonin -0.109405
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.103139
CANX calnexin -0.090331
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0892337
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0872981
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0860151
RPL35A ribosomal protein L35a -0.0826543
MT2A metallothionein 2A -0.0799007
THSD4 thrombospondin, type I, domain containing 4 -0.0790516
WSB1 WD repeat and SOCS box containing 1 -0.0741907
EIF1 eukaryotic translation initiation factor 1 -0.0738481
EFNA5 ephrin-A5 -0.0736496
EXT1 exostosin glycosyltransferase 1 -0.0701021
MBNL1 muscleblind-like splicing regulator 1 -0.0698652
IGFBP3 insulin-like growth factor binding protein 3 -0.0695268
COL6A3 collagen, type VI, alpha 3 -0.0681012
FN1 fibronectin 1 -0.0661093
SAMD4A sterile alpha motif domain containing 4A -0.0644317
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0635294
NAMPT nicotinamide phosphoribosyltransferase -0.0617003
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0615184
CD44 CD44 molecule (Indian blood group) -0.0612297
TMSB4X thymosin beta 4, X-linked -0.0606538
INHBA inhibin, beta A -0.0586748
FTL ferritin, light polypeptide -0.0568084
RTN4 reticulon 4 -0.0496991
LMNA lamin A/C -0.0457823
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0457363
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0435781
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0416462
RPL12 ribosomal protein L12 -0.0396951
B2M beta-2-microglobulin -0.0394493
RPLP0 ribosomal protein, large, P0 -0.0358838
MAML3 mastermind-like 3 (Drosophila) -0.0346973
PKM pyruvate kinase, muscle -0.0341155
EGFR epidermal growth factor receptor -0.0294215
SMYD3 SET and MYND domain containing 3 -0.0288076
HMGA2 high mobility group AT-hook 2 -0.0214659
TPT1 tumor protein, translationally-controlled 1 -0.0185429
AKAP12 A kinase (PRKA) anchor protein 12 -0.0180461
FNDC3B fibronectin type III domain containing 3B -0.0131624
RPS17 ribosomal protein S17 -0.0127682
NALF1 NALCN channel auxiliary factor 1 -0.00904611
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00822264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00548876
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0015085