IQ 1_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.184726
COL6A3 collagen, type VI, alpha 3 0.178634
MYH9 myosin, heavy chain 9, non-muscle 0.153669
SMAD3 SMAD family member 3 0.105257
ADM adrenomedullin 0.103692
FN1 fibronectin 1 0.103097
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.101374
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0892543
CALR calreticulin 0.0782623
CD44 CD44 molecule (Indian blood group) 0.0712129
TMSB4X thymosin beta 4, X-linked 0.0709621
SFTPA2 surfactant protein A2 0.0701046
VEGFA vascular endothelial growth factor A 0.066682
NAV2 neuron navigator 2 0.0640552
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0584196
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0553503
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0553477
TRIO trio Rho guanine nucleotide exchange factor 0.0508341
ANXA2 annexin A2 0.049375
FLNA filamin A, alpha 0.0482175
SDC4 syndecan 4 0.0470808
FLNB filamin B, beta 0.046805
TGFBI transforming growth factor, beta-induced, 68kDa 0.0457853
AHNAK AHNAK nucleoprotein 0.045629
PPARD peroxisome proliferator-activated receptor delta 0.0456146
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0455564
COL5A1 collagen, type V, alpha 1 0.0453271
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0445397
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0440748
HLA-B major histocompatibility complex, class I, B 0.0432944
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0428331
APP amyloid beta (A4) precursor protein 0.0419108
EXT1 exostosin glycosyltransferase 1 0.04191
THBS1 thrombospondin 1 0.040924
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0399755
DDIT4 DNA-damage-inducible transcript 4 0.0398928
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0393352
B2M beta-2-microglobulin 0.0392239
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0390515
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0390047
APLP2 amyloid beta (A4) precursor-like protein 2 0.0382445
HDAC9 histone deacetylase 9 0.037673
THBS2 thrombospondin 2 0.0362698
JUN jun proto-oncogene 0.0352317
PDE10A phosphodiesterase 10A 0.0342382
SPAG9 sperm associated antigen 9 0.0328182
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0328033
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0326587
USP9X ubiquitin specific peptidase 9, X-linked 0.032592
PGK1 phosphoglycerate kinase 1 0.0322815
EIF4H eukaryotic translation initiation factor 4H 0.0320395
MKI67 marker of proliferation Ki-67 0.0316982
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0316539
BASP1 brain abundant, membrane attached signal protein 1 0.0316451
BIRC3 baculoviral IAP repeat containing 3 0.0311791
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0311302
ZMIZ1 zinc finger, MIZ-type containing 1 0.0307451
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0306134
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0303869
HSPA8 heat shock 70kDa protein 8 0.030333
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0301126
RUNX1 runt-related transcription factor 1 0.0300612
WWTR1 WW domain containing transcription regulator 1 0.0297973
RPS4X ribosomal protein S4, X-linked 0.0295441
BACE2 beta-site APP-cleaving enzyme 2 0.028388
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0280835
HLA-C major histocompatibility complex, class I, C 0.0280417
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0279048
TENT5A terminal nucleotidyltransferase 5A 0.0278928
AKAP12 A kinase (PRKA) anchor protein 12 0.0277217
LOXL2 lysyl oxidase-like 2 0.026843
BHLHE40 basic helix-loop-helix family, member e40 0.0261269
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0259778
GADD45B growth arrest and DNA-damage-inducible, beta 0.0259126
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0255571
ARRDC3 arrestin domain containing 3 0.0255409
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0253221
MSN moesin 0.025202
COL4A2 collagen, type IV, alpha 2 0.0250608
ZSWIM6 zinc finger, SWIM-type containing 6 0.0247475
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0245254
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0245055
IRF1 interferon regulatory factor 1 0.024297
MCL1 myeloid cell leukemia 1 0.0239528
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.023774
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0234845
MAP1B microtubule-associated protein 1B 0.0231624
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0229413
ANO6 anoctamin 6 0.0228973
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.022882
SHB Src homology 2 domain containing adaptor protein B 0.0227341
KIAA1217 KIAA1217 0.0226892
COPA coatomer protein complex, subunit alpha 0.0224136
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0222373
EEF1G eukaryotic translation elongation factor 1 gamma 0.0219236
STC1 stanniocalcin 1 0.0217953
COL1A1 collagen, type I, alpha 1 0.0217642
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0215111
TPM3 tropomyosin 3 0.0214558
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0213768

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.143198
FTL ferritin, light polypeptide -0.0801592
SOD2 superoxide dismutase 2, mitochondrial -0.0558578
HMGA2 high mobility group AT-hook 2 -0.0453786
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0449655
FTH1 ferritin, heavy polypeptide 1 -0.043337
RPS6 ribosomal protein S6 -0.042956
CTSD cathepsin D -0.0419145
RPLP2 ribosomal protein, large, P2 -0.0367168
HMGA1 high mobility group AT-hook 1 -0.0360792
RPS12 ribosomal protein S12 -0.0358117
PLIN2 perilipin 2 -0.0352591
ZBTB20 zinc finger and BTB domain containing 20 -0.0347007
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0340703
RPS13 ribosomal protein S13 -0.0335189
IFITM3 interferon induced transmembrane protein 3 -0.0323421
RAI14 retinoic acid induced 14 -0.0322079
DIAPH2 diaphanous-related formin 2 -0.0317301
IER3 immediate early response 3 -0.0316684
IL6 interleukin 6 -0.0313868
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0312779
RPS23 ribosomal protein S23 -0.0296188
RPLP1 ribosomal protein, large, P1 -0.0287102
ZMYND8 zinc finger, MYND-type containing 8 -0.0275849
RPL11 ribosomal protein L11 -0.0270593
TMSB10 thymosin beta 10 -0.0263125
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0250408
RPL37A ribosomal protein L37a -0.0249593
TAPBP TAP binding protein (tapasin) -0.0246018
IFI6 interferon, alpha-inducible protein 6 -0.0241197
MAML2 mastermind-like 2 (Drosophila) -0.0240697
ZNF292 zinc finger protein 292 -0.0238828
EGFR epidermal growth factor receptor -0.0235682
MMP12 matrix metallopeptidase 12 -0.0232862
RPS25 ribosomal protein S25 -0.0222448
BTG1 B-cell translocation gene 1, anti-proliferative -0.0218141
RPL35A ribosomal protein L35a -0.0214625
RPL31 ribosomal protein L31 -0.0211192
S100A9 S100 calcium binding protein A9 -0.0199938
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.019885
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0198273
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0193568
RPL10A ribosomal protein L10a -0.0193509
SLC35F3 solute carrier family 35, member F3 -0.019338
RPS14 ribosomal protein S14 -0.0192719
ISG15 ISG15 ubiquitin-like modifier -0.0192453
FBXO32 F-box protein 32 -0.0190777
PDE4D phosphodiesterase 4D, cAMP-specific -0.0190757
SRSF3 serine/arginine-rich splicing factor 3 -0.0190091
RPL32 ribosomal protein L32 -0.0184549
FLOT1 flotillin 1 -0.0182941
SDCBP syndecan binding protein (syntenin) -0.0177998
RPS27 ribosomal protein S27 -0.0175629
RPL27A ribosomal protein L27a -0.0174863
RPL9 ribosomal protein L9 -0.0173427
HILPDA hypoxia inducible lipid droplet-associated -0.0172804
RPL28 ribosomal protein L28 -0.0171823
SOX5 SRY (sex determining region Y)-box 5 -0.0171602
PFN1 profilin 1 -0.0166861
RPLP0 ribosomal protein, large, P0 -0.0166533
CNTN6 contactin 6 -0.0166371
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0162824
RPL21 ribosomal protein L21 -0.0159683
C6ORF62 chromosome 6 open reading frame 62 -0.0158626
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0158436
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0158215
PKM pyruvate kinase, muscle -0.0157557
PRR16 proline rich 16 -0.0156291
ENO1 enolase 1, (alpha) -0.0154596
RPL39 ribosomal protein L39 -0.0153948
DENND5B DENN/MADD domain containing 5B -0.0152939
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0152005
RPS10 ribosomal protein S10 -0.0147443
PDIA3 protein disulfide isomerase family A, member 3 -0.0145487
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0145415
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0144145
SRSF11 serine/arginine-rich splicing factor 11 -0.0141731
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0141441
RPS27A ribosomal protein S27a -0.0140912
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0139561
RPL36A ribosomal protein L36a -0.0139047
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0138348
RPS29 ribosomal protein S29 -0.0138295
UBE2B ubiquitin-conjugating enzyme E2B -0.0138086
S100A6 S100 calcium binding protein A6 -0.0137717
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0137674
RPS3 ribosomal protein S3 -0.0137138
TPM1 tropomyosin 1 (alpha) -0.0135134
PNISR PNN-interacting serine/arginine-rich protein -0.0134794
CD164 CD164 molecule, sialomucin -0.0133245
RPL26 ribosomal protein L26 -0.013304
CYB5R3 cytochrome b5 reductase 3 -0.0132401
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0132328
FRMPD4 FERM and PDZ domain containing 4 -0.0131852
GDF15 growth differentiation factor 15 -0.0130986
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0130858
SBF2 SET binding factor 2 -0.013037
DST dystonin -0.0128076
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0127514
ADAM12 ADAM metallopeptidase domain 12 -0.0127473