IQ 1_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description IQ 1 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the IQ 1_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.188272
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0900847
EEF2 eukaryotic translation elongation factor 2 0.0863707
SMAD3 SMAD family member 3 0.084295
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0598313
HLA-B major histocompatibility complex, class I, B 0.0514225
IGFBP3 insulin-like growth factor binding protein 3 0.0507188
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0495927
GOLGB1 golgin B1 0.0489225
SRRM2 serine/arginine repetitive matrix 2 0.0480143
RNF213 ring finger protein 213 0.0480025
B2M beta-2-microglobulin 0.0470522
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0457288
SQSTM1 sequestosome 1 0.0439817
MBNL2 muscleblind-like splicing regulator 2 0.0435146
FLNA filamin A, alpha 0.0427047
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0426418
HLA-C major histocompatibility complex, class I, C 0.0424186
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0411276
EXT1 exostosin glycosyltransferase 1 0.0402006
OASL 2'-5'-oligoadenylate synthetase-like 0.0390379
YBX3 Y box binding protein 3 0.0383662
RPL12 ribosomal protein L12 0.0380603
SFTPA2 surfactant protein A2 0.0377259
HSPA8 heat shock 70kDa protein 8 0.0375364
NCEH1 neutral cholesterol ester hydrolase 1 0.035936
GPX4 glutathione peroxidase 4 0.0350456
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0350146
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0342058
ACTG1 actin gamma 1 0.0339746
RPL19 ribosomal protein L19 0.0335123
FNDC3A fibronectin type III domain containing 3A 0.0335011
LOC102724023 ES1 protein homolog, mitochondrial 0.0333855
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0325412
CALR calreticulin 0.0324665
MYH9 myosin, heavy chain 9, non-muscle 0.0324537
RPS17 ribosomal protein S17 0.032207
SIK3 SIK family kinase 3 0.0321002
CSRNP1 cysteine-serine-rich nuclear protein 1 0.0318305
NUMA1 nuclear mitotic apparatus protein 1 0.0318058
KIF5B kinesin family member 5B 0.0311189
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0305279
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0294512
CHD3 chromodomain helicase DNA binding protein 3 0.02934
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0288028
ADM adrenomedullin 0.0286626
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0284222
TMED9 transmembrane emp24 protein transport domain containing 9 0.0283297
CCL5 chemokine (C-C motif) ligand 5 0.0280746
PDE10A phosphodiesterase 10A 0.0280641
SHB Src homology 2 domain containing adaptor protein B 0.0278962
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 0.0275746
PRRC2C proline-rich coiled-coil 2C 0.0273082
BRD2 bromodomain containing 2 0.0272778
NSD1 nuclear receptor binding SET domain protein 1 0.0270745
TSPYL2 TSPY-like 2 0.0267889
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0257015
AEBP2 AE binding protein 2 0.0256083
PDZD8 PDZ domain containing 8 0.0254961
CTNND1 catenin (cadherin-associated protein), delta 1 0.0253747
SATB2 SATB homeobox 2 0.0252836
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0251776
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0251703
RPL7A ribosomal protein L7a 0.0249254
TTC28 tetratricopeptide repeat domain 28 0.0248499
ZC3H13 zinc finger CCCH-type containing 13 0.0247524
EP300 E1A binding protein p300 0.0246416
ATP10D ATPase, class V, type 10D 0.0245946
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0244416
BRD8 bromodomain containing 8 0.0241897
TUT7 terminal uridylyl transferase 7 0.0241184
FUS FUS RNA binding protein 0.0240823
MGA MGA, MAX dimerization protein 0.0240337
AHNAK2 AHNAK nucleoprotein 2 0.023984
GIGYF2 GRB10 interacting GYF protein 2 0.0238187
CHD4 chromodomain helicase DNA binding protein 4 0.0237735
NFE2L2 nuclear factor, erythroid 2-like 2 0.0237233
SEPTIN9 septin 9 0.0236138
YJEFN3 YjeF N-terminal domain containing 3 0.023331
APOLD1 apolipoprotein L domain containing 1 0.0232519
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0232464
SVIL supervillin 0.0231076
DDIT4 DNA-damage-inducible transcript 4 0.0229625
BRD4 bromodomain containing 4 0.0226064
IFITM3 interferon induced transmembrane protein 3 0.022596
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0225904
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0224461
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0222774
AREG amphiregulin 0.0220882
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0220132
MCFD2 multiple coagulation factor deficiency 2 0.0218413
RPS3 ribosomal protein S3 0.0215966
C1D C1D nuclear receptor corepressor 0.021556
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0214792
TPR translocated promoter region, nuclear basket protein 0.0213597
NAV2 neuron navigator 2 0.021269
ADIPOR1 adiponectin receptor 1 0.0211932
QKI QKI, KH domain containing, RNA binding 0.0211542
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0211513
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0210612

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.114709
VIM vimentin -0.0999661
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0829795
BIRC6 baculoviral IAP repeat containing 6 -0.0822561
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0801677
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0788702
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0743379
RAI14 retinoic acid induced 14 -0.0716392
HMGA2 high mobility group AT-hook 2 -0.0681817
TM4SF1 transmembrane 4 L six family member 1 -0.0633303
CANX calnexin -0.0631188
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0623049
ZNF292 zinc finger protein 292 -0.0586526
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0551188
NDRG1 N-myc downstream regulated 1 -0.0547657
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0513673
PRKCA protein kinase C, alpha -0.0510829
ZBTB20 zinc finger and BTB domain containing 20 -0.0510828
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0502254
IL1RAP interleukin 1 receptor accessory protein -0.0498786
ATXN1 ataxin 1 -0.0493241
ATM ATM serine/threonine kinase -0.0478517
GPC6 glypican 6 -0.0459831
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0452798
HILPDA hypoxia inducible lipid droplet-associated -0.0438851
MEF2A myocyte enhancer factor 2A -0.0434541
ZMYND8 zinc finger, MYND-type containing 8 -0.0425003
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0417637
ZBTB35 zinc finger and BTB domain containing 35 -0.040839
PTK2 protein tyrosine kinase 2 -0.0404946
NF1 neurofibromin 1 -0.0402141
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0400673
ELL2 elongation factor, RNA polymerase II, 2 -0.039967
DNER delta/notch-like EGF repeat containing -0.0385451
SEPTIN7 septin 7 -0.038434
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0379333
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0378583
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0375076
SRPK2 SRSF protein kinase 2 -0.037333
TMSB10 thymosin beta 10 -0.0370921
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0367317
CD44 CD44 molecule (Indian blood group) -0.0362698
ASPH aspartate beta-hydroxylase -0.0362633
MAP1B microtubule-associated protein 1B -0.0359653
TMEM123 transmembrane protein 123 -0.0352891
PHF20 PHD finger protein 20 -0.0351532
OSMR oncostatin M receptor -0.0349637
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0349307
THSD4 thrombospondin, type I, domain containing 4 -0.0346891
PCNX4 pecanex 4 -0.034377
WAC WW domain containing adaptor with coiled-coil -0.0340749
CLIP1 CAP-GLY domain containing linker protein 1 -0.0337462
PYGL phosphorylase, glycogen, liver -0.0334016
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0331041
RTN4 reticulon 4 -0.033084
PNISR PNN-interacting serine/arginine-rich protein -0.0328961
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0327121
TPD52 tumor protein D52 -0.0325256
FMN1 formin 1 -0.0317814
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0317722
PICALM phosphatidylinositol binding clathrin assembly protein -0.0316993
ZFAND3 zinc finger, AN1-type domain 3 -0.0311149
GOLGA4 golgin A4 -0.0310507
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0309722
DENND4A DENN/MADD domain containing 4A -0.0308646
RAB1A RAB1A, member RAS oncogene family -0.0308638
FBXO11 F-box protein 11 -0.0308002
TUT4 terminal uridylyl transferase 4 -0.0304524
CALU calumenin -0.0298934
MT2A metallothionein 2A -0.0297879
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0297575
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0295754
COG6 component of oligomeric golgi complex 6 -0.0295677
LCORL ligand dependent nuclear receptor corepressor-like -0.0291518
HDAC9 histone deacetylase 9 -0.0290468
ACER3 alkaline ceramidase 3 -0.0286117
KPNB1 karyopherin (importin) beta 1 -0.0284371
RPL27A ribosomal protein L27a -0.0284361
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0284147
PBX3 pre-B-cell leukemia homeobox 3 -0.0281752
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0281668
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0280746
NKTR natural killer cell triggering receptor -0.0279273
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0277627
MYO10 myosin X -0.0276646
ATP13A3 ATPase type 13A3 -0.0274979
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.027488
MARCHF6 membrane associated ring-CH-type finger 6 -0.0274578
BZW1 basic leucine zipper and W2 domains 1 -0.027413
S100A9 S100 calcium binding protein A9 -0.0273132
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0272011
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0270932
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.027002
RPL34 ribosomal protein L34 -0.0269949
DTNA dystrobrevin, alpha -0.0268938
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0267591
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0266015
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.026335
DERA deoxyribose-phosphate aldolase (putative) -0.0261003
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0259121