| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11983295 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in IRAK-1-4 Inhibitor I relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C4BPA | complement component 4 binding protein, alpha | 4.12 |
| CLK1 | CDC-like kinase 1 | 2.33 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.64 |
| CLK4 | CDC-like kinase 4 | 1.55 |
| TTN | titin | 1.13 |
| HBA1 | hemoglobin, alpha 1 | 1.07 |
| APOE | apolipoprotein E | 1.03 |
| MLH3 | mutL homolog 3 | 0.99 |
| CLK3 | CDC-like kinase 3 | 0.86 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.86 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.81 |
| CLK2 | CDC-like kinase 2 | 0.75 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 0.74 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.68 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.68 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 0.68 |
| CFAP58 | cilia and flagella associated protein 58 | 0.67 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.66 |
| SESN1 | sestrin 1 | 0.65 |
| C4ORF33 | chromosome 4 open reading frame 33 | 0.58 |
| JMJD8 | jumonji domain containing 8 | 0.56 |
| ACTR1B | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | 0.55 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.55 |
| SESN2 | sestrin 2 | 0.55 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.53 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.53 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.53 |
| ZNF623 | zinc finger protein 623 | 0.53 |
| CDC37 | cell division cycle 37 | 0.52 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.51 |
| CUL7 | cullin 7 | 0.5 |
| ULBP1 | UL16 binding protein 1 | 0.5 |
| FGA | fibrinogen alpha chain | 0.49 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.49 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 0.49 |
| PEX26 | peroxisomal biogenesis factor 26 | 0.48 |
| RNFT2 | ring finger protein, transmembrane 2 | 0.48 |
| COASY | CoA synthase | 0.47 |
| RFX7 | regulatory factor X, 7 | 0.47 |
| NSMCE4A | non-SMC element 4 homolog A (S. cerevisiae) | 0.46 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | 0.46 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.45 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.45 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.45 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.45 |
| TUSC2 | tumor suppressor candidate 2 | 0.44 |
| NAA80 | N-alpha-acetyltransferase 80, NatH catalytic subunit | 0.44 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | 0.44 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | 0.44 |
| FBXW8 | F-box and WD repeat domain containing 8 | 0.43 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.43 |
| TMC4 | transmembrane channel-like 4 | 0.43 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | 0.43 |
| SYTL1 | synaptotagmin-like 1 | 0.43 |
| RPL26 | ribosomal protein L26 | 0.43 |
| KRT8 | keratin 8, type II | 0.42 |
| SLFN5 | schlafen family member 5 | 0.41 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.41 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | 0.41 |
| KIAA0825 | KIAA0825 | 0.41 |
| ACVR2A | activin A receptor, type IIA | 0.4 |
| DALRD3 | DALR anticodon binding domain containing 3 | 0.4 |
| SLC38A7 | solute carrier family 38, member 7 | 0.4 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.4 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | 0.39 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.39 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.39 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | 0.39 |
| RPL36A | ribosomal protein L36a | 0.39 |
| DCAKD | dephospho-CoA kinase domain containing | 0.38 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.38 |
| NAPRT | nicotinate phosphoribosyltransferase | 0.38 |
| PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | 0.38 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.38 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | 0.37 |
| FIZ1 | FLT3-interacting zinc finger 1 | 0.37 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.37 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.37 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.36 |
| HIST1H1T | histone cluster 1, H1t | 0.36 |
| MST1R | macrophage stimulating 1 receptor | 0.35 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.35 |
| ASPHD2 | aspartate beta-hydroxylase domain containing 2 | 0.35 |
| CHKB | choline kinase beta | 0.35 |
| CCDC84 | coiled-coil domain containing 84 | 0.35 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.35 |
| TTC38 | tetratricopeptide repeat domain 38 | 0.34 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.34 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.34 |
| WDR90 | WD repeat domain 90 | 0.34 |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.34 |
| EWSR1 | EWS RNA-binding protein 1 | 0.34 |
| NOP10 | NOP10 ribonucleoprotein | 0.33 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | 0.33 |
| MAST1 | microtubule associated serine/threonine kinase 1 | 0.33 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.33 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.33 |
| TLE2 | transducin-like enhancer of split 2 | 0.33 |
| ECI1 | enoyl-CoA delta isomerase 1 | 0.33 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PAH | phenylalanine hydroxylase | -1.33 |
| TATDN2 | TatD DNase domain containing 2 | -0.71 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.67 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.67 |
| TLE5 | TLE family member 5, transcriptional modulator | -0.66 |
| PLPP3 | phospholipid phosphatase 3 | -0.62 |
| WDR25 | WD repeat domain 25 | -0.61 |
| MSMO1 | methylsterol monooxygenase 1 | -0.61 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.6 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.58 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.57 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | -0.57 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -0.56 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.55 |
| REEP3 | receptor accessory protein 3 | -0.54 |
| TMEM200A | transmembrane protein 200A | -0.54 |
| CEP55 | centrosomal protein 55kDa | -0.52 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | -0.52 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.52 |
| ANTXR2 | anthrax toxin receptor 2 | -0.49 |
| NOVA2 | neuro-oncological ventral antigen 2 | -0.49 |
| EXPH5 | exophilin 5 | -0.48 |
| NES | nestin | -0.48 |
| KIAA1107 | KIAA1107 | -0.48 |
| SQLE | squalene epoxidase | -0.47 |
| CHST7 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 | -0.47 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.47 |
| F10 | coagulation factor X | -0.47 |
| RAB40C | RAB40C, member RAS oncogene family | -0.47 |
| BBS2 | Bardet-Biedl syndrome 2 | -0.47 |
| PLAUR | plasminogen activator, urokinase receptor | -0.46 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.46 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.46 |
| LOXL2 | lysyl oxidase-like 2 | -0.46 |
| MYT1 | myelin transcription factor 1 | -0.46 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.46 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.46 |
| IFI35 | interferon-induced protein 35 | -0.46 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.46 |
| TSPAN5 | tetraspanin 5 | -0.46 |
| FAR2 | fatty acyl CoA reductase 2 | -0.46 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.46 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.45 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.45 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.45 |
| RNF17 | ring finger protein 17 | -0.45 |
| SLC35A5 | solute carrier family 35, member A5 | -0.45 |
| KLK6 | kallikrein-related peptidase 6 | -0.45 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.45 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.44 |
| PWWP3B | PWWP domain containing 3B | -0.44 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.44 |
| FGFR1OP | FGFR1 oncogene partner | -0.43 |
| ITGA1 | integrin, alpha 1 | -0.43 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.42 |
| MLPH | melanophilin | -0.42 |
| PHF1 | PHD finger protein 1 | -0.42 |
| ENO1 | enolase 1, (alpha) | -0.41 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.41 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.41 |
| CMC4 | C-x(9)-C motif containing 4 | -0.4 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.4 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | -0.4 |
| PER2 | period circadian clock 2 | -0.4 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.4 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.4 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.39 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.39 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | -0.39 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.39 |
| SMAD3 | SMAD family member 3 | -0.39 |
| ATG4A | autophagy related 4A, cysteine peptidase | -0.39 |
| SURF2 | surfeit 2 | -0.39 |
| GJB3 | gap junction protein, beta 3, 31kDa | -0.39 |
| KIF20B | kinesin family member 20B | -0.38 |
| TPM2 | tropomyosin 2 (beta) | -0.38 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.38 |
| PLK1 | polo-like kinase 1 | -0.38 |
| STMN3 | stathmin-like 3 | -0.38 |
| PTK6 | protein tyrosine kinase 6 | -0.38 |
| SPIN4 | spindlin family, member 4 | -0.38 |
| DNMBP | dynamin binding protein | -0.38 |
| HAS3 | hyaluronan synthase 3 | -0.38 |
| MEX3A | mex-3 RNA binding family member A | -0.38 |
| SORT1 | sortilin 1 | -0.38 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.38 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.38 |
| PLEC | plectin | -0.37 |
| LDLR | low density lipoprotein receptor | -0.37 |
| BAIAP2 | BAI1-associated protein 2 | -0.37 |
| STK17B | serine/threonine kinase 17b | -0.37 |
| MSRA | methionine sulfoxide reductase A | -0.37 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | -0.37 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.37 |
| ADIPOR1 | adiponectin receptor 1 | -0.37 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.36 |
| RCAN1 | regulator of calcineurin 1 | -0.36 |
| MPDZ | multiple PDZ domain protein | -0.36 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.36 |
