IRAK2_knockout_76_GSE24264 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24264
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Genes

600 genes differentially expressed following the IRAK2_knockout_76_GSE24264 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
RPLP0 ribosomal protein, large, P0 5.53896
PLS3 plastin 3 3.48375
MRPS7 mitochondrial ribosomal protein S7 3.20843
FGFR1OP2 FGFR1 oncogene partner 2 3.18812
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 3.18798
C1ORF43 chromosome 1 open reading frame 43 3.11866
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.92226
MRPL50 mitochondrial ribosomal protein L50 2.89467
FUNDC2 FUN14 domain containing 2 2.86812
RER1 retention in endoplasmic reticulum sorting receptor 1 2.69817
HAUS1 HAUS augmin-like complex, subunit 1 2.62881
NUCB1 nucleobindin 1 2.61869
IRAK4 interleukin-1 receptor-associated kinase 4 2.6052
RALB v-ral simian leukemia viral oncogene homolog B 2.59985
VDAC2 voltage-dependent anion channel 2 2.58802
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 2.55972
TWISTNB TWIST neighbor 2.54649
SFRP1 secreted frizzled-related protein 1 2.54344
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.54228
TSEN54 TSEN54 tRNA splicing endonuclease subunit 2.46169
ERO1LB ERO1-like beta (S. cerevisiae) 2.41714
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.40375
SCAMP3 secretory carrier membrane protein 3 2.32954
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.32773
SSBP4 single stranded DNA binding protein 4 2.31265
CDC37L1 cell division cycle 37-like 1 2.21916
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.21434
LARS2 leucyl-tRNA synthetase 2, mitochondrial 2.19528
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.17231
FAM114A2 family with sequence similarity 114, member A2 2.15137
SLMAP sarcolemma associated protein 2.14035
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.10033
WDR83OS WD repeat domain 83 opposite strand 2.09057
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.08504
ILF2 interleukin enhancer binding factor 2 2.06789
E2F4 E2F transcription factor 4, p107/p130-binding 2.01465
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.00728
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.98527
KIAA0907 KIAA0907 1.97558
SAT1 spermidine/spermine N1-acetyltransferase 1 1.95444
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 1.92515
LUC7L3 LUC7-like 3 (S. cerevisiae) 1.92075
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.90579
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 1.90423
RAB8A RAB8A, member RAS oncogene family 1.89633
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 1.89504
WRN Werner syndrome, RecQ helicase-like 1.87672
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.85474
FAM132A family with sequence similarity 132, member A 1.85007
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 1.84735
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 1.84414
HIST1H4J histone cluster 1, H4j 1.84133
HNRNPM heterogeneous nuclear ribonucleoprotein M 1.82411
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.80436
PCBP2 poly(rC) binding protein 2 1.79988
HIST1H2BM histone cluster 1, H2bm 1.78099
MRPL20 mitochondrial ribosomal protein L20 1.77815
ELAVL1 ELAV like RNA binding protein 1 1.77734
ZNHIT3 zinc finger, HIT-type containing 3 1.76181
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 1.75985
ECE2 endothelin converting enzyme 2 1.75127
CDCA4 cell division cycle associated 4 1.73264
FAM120B family with sequence similarity 120B 1.73208
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 1.72803
TXN2 thioredoxin 2 1.72348
PSAT1 phosphoserine aminotransferase 1 1.71319
NXF1 nuclear RNA export factor 1 1.70549
DGKI diacylglycerol kinase, iota 1.69186
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 1.6745
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.6726
CCDC127 coiled-coil domain containing 127 1.66764
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1.66349
TNNC1 troponin C type 1 (slow) 1.66254
PARP3 poly (ADP-ribose) polymerase family, member 3 1.65711
GID8 GID complex subunit 8 1.65444
EIF4A2 eukaryotic translation initiation factor 4A2 1.65325
PF4 platelet factor 4 1.65186
ENO1 enolase 1, (alpha) 1.64294
SNX13 sorting nexin 13 1.64116
TTC37 tetratricopeptide repeat domain 37 1.64047
ZNF213 zinc finger protein 213 1.63898
MON1B MON1 secretory trafficking family member B 1.63337
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 1.59605
CD1D CD1d molecule 1.58259
MFSD1 major facilitator superfamily domain containing 1 1.58155
MSL1 male-specific lethal 1 homolog (Drosophila) 1.57693
ANXA4 annexin A4 1.55597
BMX BMX non-receptor tyrosine kinase 1.53751
PEBP1 phosphatidylethanolamine binding protein 1 1.51462
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.4961
ZNF442 zinc finger protein 442 1.49371
CAPRIN1 cell cycle associated protein 1 1.48593
TBC1D23 TBC1 domain family, member 23 1.48494
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 1.46394
WBP2 WW domain binding protein 2 1.46257
SSR4 signal sequence receptor, delta 1.44822
PKM pyruvate kinase, muscle 1.4311
DNM1L dynamin 1-like 1.42681
CLK4 CDC-like kinase 4 1.42586
IPO5 importin 5 1.41966
NCLN nicalin 1.41529
AXL AXL receptor tyrosine kinase 1.40462
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.40365
BCLAF1 BCL2-associated transcription factor 1 1.39964
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 1.39507
MAPK1 mitogen-activated protein kinase 1 1.38823
FAM107B family with sequence similarity 107, member B 1.38269
IQGAP1 IQ motif containing GTPase activating protein 1 1.38145
RPS13 ribosomal protein S13 1.37852
NIFK nucleolar protein interacting with the FHA domain of MKI67 1.36437
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 1.36165
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 1.36041
FAM162A family with sequence similarity 162, member A 1.35126
EXOC2 exocyst complex component 2 1.34841
RPS14 ribosomal protein S14 1.34688
METAP2 methionyl aminopeptidase 2 1.34325
RBM8A RNA binding motif protein 8A 1.34253
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.34203
CDC16 cell division cycle 16 1.33848
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 1.33765
ASTE1 asteroid homolog 1 (Drosophila) 1.32228
PFN1 profilin 1 1.31966
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 1.30786
GBAS glioblastoma amplified sequence 1.30546
GRAMD1B GRAM domain containing 1B 1.29832
MAP2K4 mitogen-activated protein kinase kinase 4 1.29653
LPGAT1 lysophosphatidylglycerol acyltransferase 1 1.29511
ARRDC2 arrestin domain containing 2 1.29254
RPL19 ribosomal protein L19 1.2876
UBC ubiquitin C 1.28573
NUBP1 nucleotide binding protein 1 1.28484
ISCU iron-sulfur cluster assembly enzyme 1.28302
RPL13A ribosomal protein L13a 1.28097
PTGER3 prostaglandin E receptor 3 (subtype EP3) 1.26922
ASPA aspartoacylase 1.26744
PHKG2 phosphorylase kinase, gamma 2 (testis) 1.26645
PHF6 PHD finger protein 6 1.26497
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 1.26085
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 1.23567
MED23 mediator complex subunit 23 1.22526
SERBP1 SERPINE1 mRNA binding protein 1 1.22419
POPDC2 popeye domain containing 2 1.22379
CRYZL1 crystallin, zeta (quinone reductase)-like 1 1.2195
SLC39A6 solute carrier family 39 (zinc transporter), member 6 1.2192
TMEM63A transmembrane protein 63A 1.21704
SLC10A3 solute carrier family 10, member 3 1.2163
SRRD SRR1 domain containing 1.2138
SSBP1 single-stranded DNA binding protein 1, mitochondrial 1.21273
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 1.21039
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 1.21007
MYDGF myeloid-derived growth factor 1.2069
SLC22A24 solute carrier family 22, member 24 1.20437
USP39 ubiquitin specific peptidase 39 1.20206
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.20138
BNIPL BCL2/adenovirus E1B 19kD interacting protein like 1.20015
MTMR9 myotubularin related protein 9 1.19498
COPS7A COP9 signalosome subunit 7A 1.19482
RAI14 retinoic acid induced 14 1.19115
COMMD9 COMM domain containing 9 1.1904
GABPA GA binding protein transcription factor, alpha subunit 60kDa 1.18697
ZRANB1 zinc finger, RAN-binding domain containing 1 1.17807
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 1.17262
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 1.17187
CPTP ceramide-1-phosphate transfer protein 1.1688
CD109 CD109 molecule 1.16599
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 1.16568
ZNF451 zinc finger protein 451 1.16518
KIAA0101 KIAA0101 1.1594
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 1.15675
ARL14EP ADP-ribosylation factor-like 14 effector protein 1.15511
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 1.15308
IARS isoleucyl-tRNA synthetase 1.15267
RPL5 ribosomal protein L5 1.15018
CLTB clathrin, light chain B 1.14371
SPOP speckle-type POZ protein 1.14312
RPIA ribose 5-phosphate isomerase A 1.14147
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.13685
ACLY ATP citrate lyase 1.13629
TBC1D10C TBC1 domain family, member 10C 1.13086
U2SURP U2 snRNP-associated SURP domain containing 1.13007
BZW1 basic leucine zipper and W2 domains 1 1.12707
IFRD2 interferon-related developmental regulator 2 1.12273
TARDBP TAR DNA binding protein 1.11922
LYPLAL1 lysophospholipase-like 1 1.11668
VAMP4 vesicle-associated membrane protein 4 1.11131
MYH9 myosin, heavy chain 9, non-muscle 1.10803
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 1.10251
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.10098
AHCYL2 adenosylhomocysteinase-like 2 1.09997
CCT8 chaperonin containing TCP1, subunit 8 (theta) 1.09948
KCTD6 potassium channel tetramerization domain containing 6 1.0933
PSEN1 presenilin 1 1.0918
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) 1.09113
EIF5A eukaryotic translation initiation factor 5A 1.08838
TSC2 tuberous sclerosis 2 1.08321
FBL fibrillarin 1.08225
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 1.0812
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.07837
ZNF665 zinc finger protein 665 1.07568
PDIA4 protein disulfide isomerase family A, member 4 1.0686
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.06613
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.06219
RARS arginyl-tRNA synthetase 1.06196
GOLT1B golgi transport 1B 1.06195
PHB2 prohibitin 2 1.06069
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 1.05874
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.05258
FGF22 fibroblast growth factor 22 1.05229
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 1.052
ITGB7 integrin, beta 7 1.0507
TFRC transferrin receptor 1.04974
HIST4H4 histone cluster 4, H4 1.04809
BBS7 Bardet-Biedl syndrome 7 1.04355
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M 1.04029
RUVBL2 RuvB-like AAA ATPase 2 1.03726
ANXA5 annexin A5 1.0207
OPN3 opsin 3 1.02028
SRM spermidine synthase 1.01924
PRKCSH protein kinase C substrate 80K-H 1.01826
CDV3 CDV3 homolog (mouse) 1.01808
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 1.01801
SRPR signal recognition particle receptor (docking protein) 1.01716
SRSF6 serine/arginine-rich splicing factor 6 1.0103
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 1.00819
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 1.00483
PDGFA platelet-derived growth factor alpha polypeptide 1.00109
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.999169
FKBP11 FK506 binding protein 11, 19 kDa 0.999166
FKBP8 FK506 binding protein 8, 38kDa 0.995447
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.994543
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.993922
PARVG parvin, gamma 0.987477
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.981639
PEF1 penta-EF-hand domain containing 1 0.980349
SORT1 sortilin 1 0.977633
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 0.972411
HSPA4 heat shock 70kDa protein 4 0.970725
RPS12 ribosomal protein S12 0.969413
STRA13 stimulated by retinoic acid 13 0.966284
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.965731
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.95989
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.959492
PRTN3 proteinase 3 0.956379
C1QA complement component 1, q subcomponent, A chain 0.955337
C20ORF24 chromosome 20 open reading frame 24 0.954799
AIF1 allograft inflammatory factor 1 0.953535
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 0.95016
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 0.950022
EIF3L eukaryotic translation initiation factor 3, subunit L 0.948903
GPNMB glycoprotein (transmembrane) nmb 0.948553
FARSB phenylalanyl-tRNA synthetase, beta subunit 0.945784
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.942166
EFCAB14 EF-hand calcium binding domain 14 0.939745
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.936036
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.93406
TRDMT1 tRNA aspartic acid methyltransferase 1 0.9264
C1QB complement component 1, q subcomponent, B chain 0.925622
CCDC47 coiled-coil domain containing 47 0.924504
JOSD2 Josephin domain containing 2 0.922349
ERI3 ERI1 exoribonuclease family member 3 0.92081
KLC1 kinesin light chain 1 0.920111
C1QBP complement component 1, q subcomponent binding protein 0.918973
HOXD1 homeobox D1 0.916113
EIF4A1 eukaryotic translation initiation factor 4A1 0.915111
SRRT serrate, RNA effector molecule 0.914002
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.913557
CASKIN2 CASK interacting protein 2 0.913249
AMIGO3 adhesion molecule with Ig-like domain 3 0.909668
HN1L hematological and neurological expressed 1-like 0.908058
PANX1 pannexin 1 0.906345
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.905894
CREM cAMP responsive element modulator 0.903989
PDIA3 protein disulfide isomerase family A, member 3 0.902213
ADGRL1 adhesion G protein-coupled receptor L1 0.897823
MTMR2 myotubularin related protein 2 0.897802
QTRT1 queuine tRNA-ribosyltransferase 1 0.897622
SBF1 SET binding factor 1 0.895734
MSN moesin 0.891672
ERCC8 excision repair cross-complementation group 8 0.885747
ESYT2 extended synaptotagmin-like protein 2 0.885428
MRPL1 mitochondrial ribosomal protein L1 0.885061
KDM5D lysine (K)-specific demethylase 5D 0.884958
ATF4 activating transcription factor 4 0.884103
PACRGL PARK2 co-regulated-like 0.881167
KIF1A kinesin family member 1A 0.880746
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 0.88022
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.879935
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.872867
STRAP serine/threonine kinase receptor associated protein 0.87212
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.870731
TESK1 testis-specific kinase 1 0.870706
PCSK7 proprotein convertase subtilisin/kexin type 7 0.87
DCAF10 DDB1 and CUL4 associated factor 10 0.86982
CASC3 cancer susceptibility candidate 3 0.866537
USP22 ubiquitin specific peptidase 22 0.866069
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 0.865518
MMP8 matrix metallopeptidase 8 0.863887
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.863835
ARGLU1 arginine and glutamate rich 1 0.862955
ZNF410 zinc finger protein 410 0.860756

decreased expression

Symbol Name Standardized Value
GSTM3 glutathione S-transferase mu 3 (brain) -3.73095
MRPL55 mitochondrial ribosomal protein L55 -3.42249
CCR10 chemokine (C-C motif) receptor 10 -3.32954
REXO2 RNA exonuclease 2 -3.29815
SMIM7 small integral membrane protein 7 -3.10234
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -3.06386
OVCA2 ovarian tumor suppressor candidate 2 -2.93961
SENP1 SUMO1/sentrin specific peptidase 1 -2.93389
TMX3 thioredoxin-related transmembrane protein 3 -2.90117
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -2.80785
DYNLT3 dynein, light chain, Tctex-type 3 -2.79217
PITPNB phosphatidylinositol transfer protein, beta -2.77422
THAP4 THAP domain containing 4 -2.71587
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.68408
EDIL3 EGF-like repeats and discoidin I-like domains 3 -2.67135
GOLPH3L golgi phosphoprotein 3-like -2.64471
PICALM phosphatidylinositol binding clathrin assembly protein -2.39841
KRT16 keratin 16, type I -2.37035
ARSB arylsulfatase B -2.35152
TMEM135 transmembrane protein 135 -2.31897
DLAT dihydrolipoamide S-acetyltransferase -2.30783
FBXO6 F-box protein 6 -2.25188
INSL6 insulin-like 6 -2.22183
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -2.20883
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.20672
ITFG2 integrin alpha FG-GAP repeat containing 2 -2.17515
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.17202
TSTA3 tissue specific transplantation antigen P35B -2.14109
QPCT glutaminyl-peptide cyclotransferase -2.14003
SELO selenoprotein O -2.13649
STARD4 StAR-related lipid transfer (START) domain containing 4 -2.10074
C3ORF14 chromosome 3 open reading frame 14 -2.08066
ST7L suppression of tumorigenicity 7 like -2.07289
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.06354
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.05938
SMAD4 SMAD family member 4 -2.01672
COL4A5 collagen, type IV, alpha 5 -2.00502
RPS15A ribosomal protein S15a -1.99791
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) -1.97211
MRPL48 mitochondrial ribosomal protein L48 -1.97091
B9D2 B9 protein domain 2 -1.97086
BCAP31 B-cell receptor-associated protein 31 -1.95762
ADAT2 adenosine deaminase, tRNA-specific 2 -1.94951
C3ORF38 chromosome 3 open reading frame 38 -1.91225
NMT1 N-myristoyltransferase 1 -1.89501
EAF2 ELL associated factor 2 -1.88066
KDM1A lysine (K)-specific demethylase 1A -1.86719
PRRC2B proline-rich coiled-coil 2B -1.86275
NDE1 nudE neurodevelopment protein 1 -1.82207
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -1.80197
LZTS2 leucine zipper, putative tumor suppressor 2 -1.79849
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -1.79037
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -1.78818
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -1.77761
NFU1 NFU1 iron-sulfur cluster scaffold -1.73884
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 -1.72628
SPAG7 sperm associated antigen 7 -1.71599
TUBD1 tubulin, delta 1 -1.71084
FGF21 fibroblast growth factor 21 -1.70642
HN1 hematological and neurological expressed 1 -1.69638
CHD8 chromodomain helicase DNA binding protein 8 -1.69614
C1GALT1C1 C1GALT1-specific chaperone 1 -1.69444
CUEDC2 CUE domain containing 2 -1.69289
SNX7 sorting nexin 7 -1.68848
ETFB electron-transfer-flavoprotein, beta polypeptide -1.68438
MCFD2 multiple coagulation factor deficiency 2 -1.67817
MRPL27 mitochondrial ribosomal protein L27 -1.6776
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -1.66681
STAU2 staufen double-stranded RNA binding protein 2 -1.66067
TMEM9B TMEM9 domain family, member B -1.63768
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -1.63431
MYLK3 myosin light chain kinase 3 -1.6255
KLHL26 kelch-like family member 26 -1.62037
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -1.61078
SKP1 S-phase kinase-associated protein 1 -1.58857
ZNF91 zinc finger protein 91 -1.57895
CHMP1B charged multivesicular body protein 1B -1.57489
STK25 serine/threonine kinase 25 -1.57261
CADPS Ca++-dependent secretion activator -1.5696
DCAF11 DDB1 and CUL4 associated factor 11 -1.56193
TMBIM6 transmembrane BAX inhibitor motif containing 6 -1.56118
CARKD carbohydrate kinase domain containing -1.56085
PANK4 pantothenate kinase 4 -1.55683
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -1.54813
MRPL9 mitochondrial ribosomal protein L9 -1.54797
CHRAC1 chromatin accessibility complex 1 -1.54356
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -1.54085
PRDX2 peroxiredoxin 2 -1.53713
TMEM167B transmembrane protein 167B -1.53643
A4GNT alpha-1,4-N-acetylglucosaminyltransferase -1.53408
BEX1 brain expressed, X-linked 1 -1.53305
PON3 paraoxonase 3 -1.52709
ABHD2 abhydrolase domain containing 2 -1.51766
EXO5 exonuclease 5 -1.51713
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -1.51155
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -1.50957
TWSG1 twisted gastrulation BMP signaling modulator 1 -1.5056
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -1.50518
RIT1 Ras-like without CAAX 1 -1.50403
CCDC124 coiled-coil domain containing 124 -1.48749
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) -1.48727
DARS aspartyl-tRNA synthetase -1.48652
MAGED2 melanoma antigen family D2 -1.48413
C14ORF119 chromosome 14 open reading frame 119 -1.48038
EXD2 exonuclease 3'-5' domain containing 2 -1.4784
VAMP8 vesicle-associated membrane protein 8 -1.46002
KPTN kaptin (actin binding protein) -1.45981
GFER growth factor, augmenter of liver regeneration -1.45973
NPY neuropeptide Y -1.4495
TRAPPC13 trafficking protein particle complex 13 -1.44643
TTC1 tetratricopeptide repeat domain 1 -1.44614
MRPL47 mitochondrial ribosomal protein L47 -1.43544
GIF gastric intrinsic factor (vitamin B synthesis) -1.42251
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -1.42187
FBXO33 F-box protein 33 -1.41457
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -1.41363
DPP7 dipeptidyl-peptidase 7 -1.41121
NSDHL NAD(P) dependent steroid dehydrogenase-like -1.41083
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -1.41032
WDR61 WD repeat domain 61 -1.40895
TBC1D19 TBC1 domain family, member 19 -1.40764
LRRC49 leucine rich repeat containing 49 -1.40505
SLFN13 schlafen family member 13 -1.40312
RPS20 ribosomal protein S20 -1.40179
ARTN artemin -1.39433
TBRG1 transforming growth factor beta regulator 1 -1.39254
LXN latexin -1.38221
MTX1 metaxin 1 -1.38028
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -1.37845
PLK1 polo-like kinase 1 -1.37439
TSPYL1 TSPY-like 1 -1.36855
LPPR2 lipid phosphate phosphatase-related protein type 2 -1.36212
SHCBP1 SHC SH2-domain binding protein 1 -1.35573
ECD ecdysoneless homolog (Drosophila) -1.34821
RNF113A ring finger protein 113A -1.34299
RTFDC1 replication termination factor 2 domain containing 1 -1.34238
CBX1 chromobox homolog 1 -1.33992
HCST hematopoietic cell signal transducer -1.32813
SREBF1 sterol regulatory element binding transcription factor 1 -1.32002
FBXO42 F-box protein 42 -1.31913
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -1.31475
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit -1.30441
NOXO1 NADPH oxidase organizer 1 -1.29891
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -1.29817
ARHGAP4 Rho GTPase activating protein 4 -1.29319
MRPS30 mitochondrial ribosomal protein S30 -1.2793
CCNK cyclin K -1.2781
MON2 MON2 homolog (S. cerevisiae) -1.27179
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -1.26261
TBCA tubulin folding cofactor A -1.25945
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -1.2503
ATP2A3 ATPase, Ca++ transporting, ubiquitous -1.24859
XDH xanthine dehydrogenase -1.24471
MRPS18A mitochondrial ribosomal protein S18A -1.24193
GPR108 G protein-coupled receptor 108 -1.24
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 -1.23803
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) -1.23179
RTN4 reticulon 4 -1.23091
PDHB pyruvate dehydrogenase (lipoamide) beta -1.22926
ANXA2 annexin A2 -1.22871
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -1.21806
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -1.21139
TSPAN31 tetraspanin 31 -1.20979
RILPL1 Rab interacting lysosomal protein-like 1 -1.2054
B2M beta-2-microglobulin -1.19688
AP2M1 adaptor-related protein complex 2, mu 1 subunit -1.19641
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -1.19164
C18ORF21 chromosome 18 open reading frame 21 -1.18975
ANAPC2 anaphase promoting complex subunit 2 -1.1888
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -1.18695
LEFTY2 left-right determination factor 2 -1.18601
DCTN6 dynactin 6 -1.18577
LONP2 lon peptidase 2, peroxisomal -1.18385
COX18 COX18 cytochrome c oxidase assembly factor -1.17855
MRPL11 mitochondrial ribosomal protein L11 -1.17568
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -1.16869
PHTF1 putative homeodomain transcription factor 1 -1.16831
CPB2 carboxypeptidase B2 (plasma) -1.16315
OLFML3 olfactomedin-like 3 -1.15838
YIPF3 Yip1 domain family, member 3 -1.15626
XPA xeroderma pigmentosum, complementation group A -1.15543
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -1.15312
CDK11A cyclin-dependent kinase 11A -1.15188
ALDOC aldolase C, fructose-bisphosphate -1.1516
TXNL4A thioredoxin-like 4A -1.14834
NUBP2 nucleotide binding protein 2 -1.14741
LPL lipoprotein lipase -1.14637
INO80C INO80 complex subunit C -1.14522
FAM63A family with sequence similarity 63, member A -1.13927
DPEP2 dipeptidase 2 -1.13607
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -1.13604
EMC2 ER membrane protein complex subunit 2 -1.13569
CHURC1 churchill domain containing 1 -1.13492
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -1.1314
TMOD3 tropomodulin 3 (ubiquitous) -1.13103
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -1.12823
PDCD2L programmed cell death 2-like -1.12445
LYZ lysozyme -1.12214
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -1.11778
TGM4 transglutaminase 4 -1.11532
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -1.114
RCE1 Ras converting CAAX endopeptidase 1 -1.11106
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -1.10851
MGST1 microsomal glutathione S-transferase 1 -1.1085
SUGP2 SURP and G patch domain containing 2 -1.10371
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -1.10223
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -1.10088
LRP4 low density lipoprotein receptor-related protein 4 -1.09906
CD63 CD63 molecule -1.09802
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) -1.09524
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -1.09511
ACAD10 acyl-CoA dehydrogenase family, member 10 -1.09046
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -1.08999
LPCAT3 lysophosphatidylcholine acyltransferase 3 -1.08248
WDR83 WD repeat domain 83 -1.08225
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -1.08214
PPIF peptidylprolyl isomerase F -1.07875
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) -1.07686
COPS8 COP9 signalosome subunit 8 -1.07505
SNX6 sorting nexin 6 -1.07444
TMEM5 transmembrane protein 5 -1.07407
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -1.07099
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -1.06979
PCDHGB7 protocadherin gamma subfamily B, 7 -1.06131
EXT2 exostosin glycosyltransferase 2 -1.05757
MRPL54 mitochondrial ribosomal protein L54 -1.05558
ASUN asunder spermatogenesis regulator -1.05223
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -1.05186
LMAN1 lectin, mannose-binding, 1 -1.05171
IFT43 intraflagellar transport 43 -1.05058
DEGS1 delta(4)-desaturase, sphingolipid 1 -1.05021
SRSF3 serine/arginine-rich splicing factor 3 -1.04817
LYPLA1 lysophospholipase I -1.04488
TMEM106B transmembrane protein 106B -1.04268
FNTA farnesyltransferase, CAAX box, alpha -1.04248
OCRL oculocerebrorenal syndrome of Lowe -1.04178
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -1.04129
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta -1.04098
GKAP1 G kinase anchoring protein 1 -1.04011
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -1.03936
CST3 cystatin C -1.03831
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -1.03687
SUGP1 SURP and G patch domain containing 1 -1.03475
TERF2IP telomeric repeat binding factor 2, interacting protein -1.0345
PRNP prion protein -1.03327
SCD stearoyl-CoA desaturase (delta-9-desaturase) -1.03074
SCARB2 scavenger receptor class B, member 2 -1.02951
NXT2 nuclear transport factor 2-like export factor 2 -1.02733
ZFP64 ZFP64 zinc finger protein -1.02701
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -1.0263
GAS8 growth arrest-specific 8 -1.02397
TDRD7 tudor domain containing 7 -1.02225
MIPEP mitochondrial intermediate peptidase -1.02049
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) -1.01647
SHARPIN SHANK-associated RH domain interactor -1.01635
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -1.01316
GSTK1 glutathione S-transferase kappa 1 -1.01312
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -1.01299
CCDC53 coiled-coil domain containing 53 -1.00969
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -1.0082
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -1.00812
PGPEP1 pyroglutamyl-peptidase I -1.00697
EMC4 ER membrane protein complex subunit 4 -1.00554
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -1.00458
DIABLO diablo, IAP-binding mitochondrial protein -1.00215
PARL presenilin associated, rhomboid-like -0.998008
CCNDBP1 cyclin D-type binding-protein 1 -0.996968
ZDHHC4 zinc finger, DHHC-type containing 4 -0.994663
DIAPH3 diaphanous-related formin 3 -0.991101
LRRC28 leucine rich repeat containing 28 -0.989314
PPP4C protein phosphatase 4, catalytic subunit -0.989096
RPL9 ribosomal protein L9 -0.985602
GLT8D1 glycosyltransferase 8 domain containing 1 -0.983756
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.980106
HEMK1 HemK methyltransferase family member 1 -0.979929
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.97796
C17ORF59 chromosome 17 open reading frame 59 -0.975608
IFT172 intraflagellar transport 172 -0.974826
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -0.974133
HIST1H2BK histone cluster 1, H2bk -0.973159
TPMT thiopurine S-methyltransferase -0.972523
BAD BCL2-associated agonist of cell death -0.967916
TRAPPC8 trafficking protein particle complex 8 -0.967755
LAMP2 lysosomal-associated membrane protein 2 -0.967225
MED9 mediator complex subunit 9 -0.966221
GPN1 GPN-loop GTPase 1 -0.958859
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -0.957768
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -0.957125
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -0.956952
FER fer (fps/fes related) tyrosine kinase -0.956671
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.955776
PLXNA2 plexin A2 -0.955387
JAZF1 JAZF zinc finger 1 -0.955201
MBNL1 muscleblind-like splicing regulator 1 -0.952946
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -0.952634
NELFE negative elongation factor complex member E -0.950525
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 -0.948017
AKAP10 A kinase (PRKA) anchor protein 10 -0.947248
FLT3 fms-related tyrosine kinase 3 -0.945888
FOLR1 folate receptor 1 (adult) -0.93803