IRAK4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description interleukin-1 receptor-associated kinase 4|This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 51135)
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Genes

339 genes differentially expressed following the IRAK4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LURAP1L leucine rich adaptor protein 1-like 3.12919
C1ORF226 chromosome 1 open reading frame 226 3.12919
SIRPB2 signal-regulatory protein beta 2 3.12919
GJB3 gap junction protein, beta 3, 31kDa 3.12919
GJB1 gap junction protein, beta 1, 32kDa 3.12919
MTTP microsomal triglyceride transfer protein 3.12919
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.12919
ESX1 ESX homeobox 1 3.12919
RSPO1 R-spondin 1 3.12919
NEU4 sialidase 4 3.12919
TM4SF20 transmembrane 4 L six family member 20 3.12919
HORMAD1 HORMA domain containing 1 3.12919
UCN urocortin 3.12919
ZSCAN5B zinc finger and SCAN domain containing 5B 3.12919
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.12919
HCRTR1 hypocretin (orexin) receptor 1 3.12919
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.12919
PRELP proline/arginine-rich end leucine-rich repeat protein 3.12919
NXPH4 neurexophilin 4 3.12919
WNT3A wingless-type MMTV integration site family, member 3A 3.12919
HES7 hes family bHLH transcription factor 7 3.12919
GYPE glycophorin E (MNS blood group) 3.12919
MYCT1 myc target 1 3.12919
LYNX1 Ly6/neurotoxin 1 3.12919
KRT72 keratin 72, type II 3.12919
LGALS2 lectin, galactoside-binding, soluble, 2 3.12919
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.12919
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 3.12919
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.12919
NMUR1 neuromedin U receptor 1 3.12919
HAND1 heart and neural crest derivatives expressed 1 3.12919
HES2 hes family bHLH transcription factor 2 3.12919
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 3.12919
SHE Src homology 2 domain containing E 3.12919
DLL4 delta-like 4 (Drosophila) 3.12919
TRIM77 tripartite motif containing 77 3.12919
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.12919
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.12919
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.12919
TMEM217 transmembrane protein 217 3.12919
TNS4 tensin 4 3.12919
ARRDC5 arrestin domain containing 5 3.12919
PSCA prostate stem cell antigen 3.12919
OCSTAMP osteoclast stimulatory transmembrane protein 3.12919
ERAP2 endoplasmic reticulum aminopeptidase 2 3.12919
DRC5 dynein regulatory complex subunit 5 3.12919
GPR35 G protein-coupled receptor 35 3.12919
ELOVL3 ELOVL fatty acid elongase 3 3.12919
PDF peptide deformylase (mitochondrial) 3.12919
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.12919
MAGIX MAGI family member, X-linked 3.12919
FAM228A family with sequence similarity 228, member A 3.12919
OSTN osteocrin 3.12919
NDP Norrie disease (pseudoglioma) 3.12919
RNF186 ring finger protein 186 3.12919
GBP4 guanylate binding protein 4 3.12919
PHF24 PHD finger protein 24 3.12919
LRRC8C-DT LRRC8C divergent transcript 3.12919
CFAP276 cilia and flagella associated protein 276 3.12919
H1-8 H1.8 linker histone 3.12919
TAFA3 TAFA chemokine like family member 3 3.12919
PLPP4 phospholipid phosphatase 4 3.12919
RTL9 retrotransposon Gag like 9 3.12919
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.12919
LORICRIN loricrin cornified envelope precursor protein 3.12919
H2BC1 H2B clustered histone 1 3.12919
DLK1 delta-like 1 homolog (Drosophila) 3.12919
FGFBP1 fibroblast growth factor binding protein 1 3.12919
SAA2 serum amyloid A2 3.12919
SCN10A sodium channel, voltage gated, type X alpha subunit 3.12919
C3ORF80 chromosome 3 open reading frame 80 3.12919
AXDND1 axonemal dynein light chain domain containing 1 3.12919
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 3.12919
KLHL33 kelch-like family member 33 3.12919
FPR2 formyl peptide receptor 2 3.12919
TSSK4 testis-specific serine kinase 4 3.12919
GJA3 gap junction protein, alpha 3, 46kDa 3.12919
TMPRSS11E transmembrane protease, serine 11E 3.12919
GOLGA6L4 golgin A6 family-like 4 3.12919
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.12919
PLB1 phospholipase B1 3.12919
BARX2 BARX homeobox 2 3.12919
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.12919
CCDC121 coiled-coil domain containing 121 3.12919
RASAL3 RAS protein activator like 3 3.12919
C6ORF118 chromosome 6 open reading frame 118 3.12919
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.12919
PRRT4 proline-rich transmembrane protein 4 3.12919
ZIC4 Zic family member 4 3.12919
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.12919
SAMD5 sterile alpha motif domain containing 5 3.12919
INSM1 insulinoma-associated 1 3.12919
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.12919
OR4D1 olfactory receptor, family 4, subfamily D, member 1 3.12919
OTC ornithine carbamoyltransferase 3.12919
TNR tenascin R 3.12919
GP2 glycoprotein 2 (zymogen granule membrane) 3.12919
DNAH10 dynein, axonemal, heavy chain 10 3.12919
SLC38A8 solute carrier family 38, member 8 3.12919
KCNK2 potassium channel, two pore domain subfamily K, member 2 3.12919
CCDC154 coiled-coil domain containing 154 3.12919
EBF3 early B-cell factor 3 3.12919
EBF2 early B-cell factor 2 3.12919
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.12919
DES desmin 3.12919
CIDEA cell death-inducing DFFA-like effector a 3.12919
NYX nyctalopin 3.12919
WFDC9 WAP four-disulfide core domain 9 3.12919
C11ORF16 chromosome 11 open reading frame 16 3.12919
SPEF1 sperm flagellar 1 3.12919
MAOB monoamine oxidase B 3.12919
KIAA1210 KIAA1210 3.12919
COL6A5 collagen, type VI, alpha 5 3.12919
LY96 lymphocyte antigen 96 3.12919
VWA3A von Willebrand factor A domain containing 3A 3.12919
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.12919
MCCD1 mitochondrial coiled-coil domain 1 3.12919
C2CD4B C2 calcium-dependent domain containing 4B 3.12919
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.12919
FIBIN fin bud initiation factor homolog (zebrafish) 3.12919
BASP1 brain abundant, membrane attached signal protein 1 3.12919
SIGLEC15 sialic acid binding Ig-like lectin 15 3.12919
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.12919
RANBP3L RAN binding protein 3-like 3.12919
CRHBP corticotropin releasing hormone binding protein 3.12919
PRSS54 protease, serine, 54 3.12919
HPGDS hematopoietic prostaglandin D synthase 3.12919
LRRC38 leucine rich repeat containing 38 3.12919
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.12919
TTC24 tetratricopeptide repeat domain 24 3.12919
PHACTR3 phosphatase and actin regulator 3 3.12919
TEX38 testis expressed 38 3.12919
ZNF831 zinc finger protein 831 3.12919
GREM1 gremlin 1, DAN family BMP antagonist 3.12919
LRRC26 leucine rich repeat containing 26 3.12919
MEIOB meiosis specific with OB domains 3.12919
FOXG1 forkhead box G1 3.12919
GOLGA8M golgin A8 family, member M 3.12919
ASCL3 achaete-scute family bHLH transcription factor 3 3.12919
IRX4 iroquois homeobox 4 3.12919
WFDC13 WAP four-disulfide core domain 13 3.12919
C17ORF100 chromosome 17 open reading frame 100 3.12919
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.12919
AMER3 APC membrane recruitment protein 3 3.12919
ALOX15B arachidonate 15-lipoxygenase, type B 3.12919
KLHDC1 kelch domain containing 1 3.12919
C5AR2 complement component 5a receptor 2 3.12919
BTBD18 BTB (POZ) domain containing 18 3.12919
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.12919
OSR1 odd-skipped related transciption factor 1 3.12919
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.12919
LRRC24 leucine rich repeat containing 24 3.12919
FGF16 fibroblast growth factor 16 3.12919
PXT1 peroxisomal, testis specific 1 3.12919
NLRP14 NLR family, pyrin domain containing 14 3.12919
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.12919
FGF7 fibroblast growth factor 7 3.12919
STOML2 stomatin (EPB72)-like 2 3.05959
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.04689
PITRM1 pitrilysin metallopeptidase 1 2.90341
KRT7 keratin 7, type II 2.90011
CMSS1 cms1 ribosomal small subunit homolog (yeast) 2.85955
MLX MLX, MAX dimerization protein 2.75944
NEK6 NIMA-related kinase 6 2.7101
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.66337
COL6A3 collagen, type VI, alpha 3 2.61973
NCBP1 nuclear cap binding protein subunit 1, 80kDa 2.60725
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.55209
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.54987
TMEM50A transmembrane protein 50A 2.54088
GLDN gliomedin 2.46485
NOL4L nucleolar protein 4-like 2.46432
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.44017
MED12 mediator complex subunit 12 2.32254
CELF2 CUGBP, Elav-like family member 2 2.31115
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 2.29818
UCK2 uridine-cytidine kinase 2 2.29818
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.29818
MAGEB17 melanoma antigen family B17 2.29818
HLA-DOA major histocompatibility complex, class II, DO alpha 2.29818
CRIP2 cysteine-rich protein 2 2.29818
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.29629
BTG3 BTG family, member 3 2.29273
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 2.2895
MADD MAP-kinase activating death domain 2.26117
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 2.24815
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 2.23543
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.21823
POU5F2 POU domain class 5, transcription factor 2 2.21133
C19ORF84 chromosome 19 open reading frame 84 2.21133
MPL MPL proto-oncogene, thrombopoietin receptor 2.21133
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.21133
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.21133
TEDC1 tubulin epsilon and delta complex 1 2.21133
SUMO4 small ubiquitin-like modifier 4 2.21133
CLEC19A C-type lectin domain family 19, member A 2.21133
ZGLP1 zinc finger, GATA-like protein 1 2.21133
SLA2 Src-like-adaptor 2 2.21133
SETD4 SET domain containing 4 2.21084
UBXN2B UBX domain protein 2B 2.17233
RRAGC Ras-related GTP binding C 2.17233
RBM26 RNA binding motif protein 26 2.10694
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 2.0761
MLH1 mutL homolog 1 2.04637
SAMD1 sterile alpha motif domain containing 1 2.04637
SLBP stem-loop binding protein 2.04274
ZSCAN30 zinc finger and SCAN domain containing 30 2.03468
ZNF263 zinc finger protein 263 2.0316
ADSS2 adenylosuccinate synthase 2 2.01672
FBXO42 F-box protein 42 2.00447
TMEM63C transmembrane protein 63C 2.00447
ZPR1 ZPR1 zinc finger 2.00155

decreased expression

Symbol Name Standardized Value
SLC67A1 solute carrier family 67 member 1 -3.12919
ZNF486 zinc finger protein 486 -3.12919
BOLA2B bolA family member 2B -3.12919
YBX1 Y box binding protein 1 -3.12919
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 -3.12919
MARCHF5 membrane associated ring-CH-type finger 5 -3.12919
STARD6 StAR-related lipid transfer (START) domain containing 6 -3.04689
CBY3 chibby homolog 3 (Drosophila) -3.04689
ANO3 anoctamin 3 -3.04689
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -3.04689
PRDM12 PR domain containing 12 -3.04689
KIF1C-AS1 KIF1C antisense RNA 1 -3.04689
PLK5 polo-like kinase 5 -3.04689
ADRA1A adrenoceptor alpha 1A -3.04689
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -3.04689
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.04689
FBLN7 fibulin 7 -3.04689
SCNN1G sodium channel, non voltage gated 1 gamma subunit -3.04689
SMTNL1 smoothelin-like 1 -3.04689
ACTL8 actin-like 8 -3.04689
CES3 carboxylesterase 3 -3.04689
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -3.04689
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -3.04689
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -3.04689
MBLAC1 metallo-beta-lactamase domain containing 1 -3.04689
H3C13 H3 clustered histone 13 -3.04689
CEP295NL CEP295 N-terminal like -3.04689
FZD1 frizzled class receptor 1 -3.04689
SEMG1 semenogelin I -3.04689
LIF leukemia inhibitory factor -3.04689
COL17A1 collagen, type XVII, alpha 1 -3.04689
DENND2D DENN/MADD domain containing 2D -3.04689
PSD pleckstrin and Sec7 domain containing -3.04689
KLK7 kallikrein-related peptidase 7 -3.04689
BAIAP3 BAI1-associated protein 3 -3.04689
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -3.04689
IFI35 interferon-induced protein 35 -3.04689
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -3.04117
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.93793
RBAK RB-associated KRAB zinc finger -2.91391
NPC2 Niemann-Pick disease, type C2 -2.8793
FIGNL1 fidgetin-like 1 -2.82269
MGST1 microsomal glutathione S-transferase 1 -2.81019
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.78
ZNF707 zinc finger protein 707 -2.74743
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.71469
LRRC45 leucine rich repeat containing 45 -2.69713
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.66408
CSNK1G3 casein kinase 1, gamma 3 -2.65364
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -2.61161
STMN3 stathmin-like 3 -2.61033
IRAK4 interleukin-1 receptor-associated kinase 4 -2.56963
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -2.54219
MRPL34 mitochondrial ribosomal protein L34 -2.54173
STX4 syntaxin 4 -2.54011
ANXA5 annexin A5 -2.54011
CAV3 caveolin 3 -2.54009
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -2.54009
MUC12 mucin 12, cell surface associated -2.49912
SPDYE2 speedy/RINGO cell cycle regulator family member E2 -2.49912
ADAP2 ArfGAP with dual PH domains 2 -2.46078
EFNB1 ephrin-B1 -2.46078
CRACDL CRACD like -2.41929
PCGF1 polycomb group ring finger 1 -2.41929
POU2F3 POU class 2 homeobox 3 -2.41929
IL7 interleukin 7 -2.41561
CHML choroideremia-like (Rab escort protein 2) -2.38364
PLPPR3 phospholipid phosphatase related 3 -2.37673
SMOC2 SPARC related modular calcium binding 2 -2.37043
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -2.36911
SYT7 synaptotagmin VII -2.36713
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -2.36057
C6ORF89 chromosome 6 open reading frame 89 -2.34791
LRRC8A leucine rich repeat containing 8 family, member A -2.3431
ARL3 ADP-ribosylation factor-like 3 -2.32871
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.32488
RPL35A ribosomal protein L35a -2.32254
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -2.31665
USP9X ubiquitin specific peptidase 9, X-linked -2.29369
USP15 ubiquitin specific peptidase 15 -2.28761
RPS3A ribosomal protein S3A -2.28761
STAP2 signal transducing adaptor family member 2 -2.28761
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa -2.2849
BGLAP bone gamma-carboxyglutamate (gla) protein -2.28291
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.25671
INHBA inhibin, beta A -2.2499
ZNF581 zinc finger protein 581 -2.24662
PON3 paraoxonase 3 -2.24416
EFNA1 ephrin-A1 -2.24416
VSTM4 V-set and transmembrane domain containing 4 -2.23754
CASR calcium-sensing receptor -2.21499
C22ORF23 chromosome 22 open reading frame 23 -2.21499
NHLH2 nescient helix loop helix 2 -2.21499
SYNPO2L synaptopodin 2-like -2.21499
ADM5 adrenomedullin 5 (putative) -2.21499
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.21133
TMTC3 transmembrane and tetratricopeptide repeat containing 3 -2.21133
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -2.21133
PRC1 protein regulator of cytokinesis 1 -2.19798
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.19723
SORCS2 sortilin-related VPS10 domain containing receptor 2 -2.19103
BOD1 biorientation of chromosomes in cell division 1 -2.19098
TMEM39A transmembrane protein 39A -2.171
AARS1 alanyl-tRNA synthetase 1 -2.17032
MTCH2 mitochondrial carrier 2 -2.16354
PRIMPOL primase and polymerase (DNA-directed) -2.12219
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -2.12219
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.12219
LENG1 leukocyte receptor cluster (LRC) member 1 -2.11393
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.11069
PLEKHO2 pleckstrin homology domain containing, family O member 2 -2.10742
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.1037
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.08137
LRP10 low density lipoprotein receptor-related protein 10 -2.08137
WASHC3 WASH complex subunit 3 -2.0761
CFAP95 cilia and flagella associated protein 95 -2.0761
CNPY3 canopy FGF signaling regulator 3 -2.07152
BVES blood vessel epicardial substance -2.04905
ARK2C arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C -2.04905
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.04905
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -2.04274
CCDC60 coiled-coil domain containing 60 -2.0413
SAAL1 serum amyloid A-like 1 -2.03011
YAE1 YAE1 maturation factor of ABCE1 -2.01362
ATAD1 ATPase family, AAA domain containing 1 -2.01362
C19ORF53 chromosome 19 open reading frame 53 -2.01042
MAP6D1 MAP6 domain containing 1 -2.01042