IRAK4 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description interleukin-1 receptor-associated kinase 4|This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 51135)
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100 substrates of the kinase IRAK4 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
UBE2O ubiquitin-conjugating enzyme E2O
ARHGAP32 Rho GTPase activating protein 32
SQSTM1 sequestosome 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
NCF4 neutrophil cytosolic factor 4, 40kDa
TOR4A torsin family 4, member A
VTN vitronectin
NDRG2 NDRG family member 2
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
SRSF1 serine/arginine-rich splicing factor 1
ARMC1 armadillo repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
ORAI1 ORAI calcium release-activated calcium modulator 1
LARP1 La ribonucleoprotein domain family, member 1
TACC1 transforming, acidic coiled-coil containing protein 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRA2B transformer 2 beta homolog (Drosophila)
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
IRS1 insulin receptor substrate 1
PPP1R8 protein phosphatase 1, regulatory subunit 8
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
VRK1 vaccinia related kinase 1
LBR lamin B receptor
SRSF3 serine/arginine-rich splicing factor 3
SRSF2 serine/arginine-rich splicing factor 2
FRMD4B FERM domain containing 4B
SELL selectin L
PELI1 pellino E3 ubiquitin protein ligase 1
WDR62 WD repeat domain 62
RPS7 ribosomal protein S7
SF3B1 splicing factor 3b, subunit 1, 155kDa
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
STK39 serine threonine kinase 39
BNC1 basonuclin 1
NADK NAD kinase
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
NCAPD3 non-SMC condensin II complex, subunit D3
ARHGAP19 Rho GTPase activating protein 19
AKAP5 A kinase (PRKA) anchor protein 5
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
PTGDR2 prostaglandin D2 receptor 2
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
PA2G4 proliferation-associated 2G4, 38kDa
TACSTD2 tumor-associated calcium signal transducer 2
GPATCH8 G patch domain containing 8
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
MRVI1 murine retrovirus integration site 1 homolog
MDC1 mediator of DNA-damage checkpoint 1
KDM1A lysine (K)-specific demethylase 1A
DRD2 dopamine receptor D2
CKAP2 cytoskeleton associated protein 2
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
PRM2 protamine 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
DAPK3 death-associated protein kinase 3
GPR15 G protein-coupled receptor 15
RGS18 regulator of G-protein signaling 18
NOP2 NOP2 nucleolar protein
SRRM1 serine/arginine repetitive matrix 1
PHF2 PHD finger protein 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
CHERP calcium homeostasis endoplasmic reticulum protein
FHOD1 formin homology 2 domain containing 1
SYT6 synaptotagmin VI
RSRC1 arginine/serine-rich coiled-coil 1
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CYTH2 cytohesin 2
SRSF10 serine/arginine-rich splicing factor 10
RAN RAN, member RAS oncogene family
CDCA2 cell division cycle associated 2
ZCCHC17 zinc finger, CCHC domain containing 17
DSP desmoplakin
SRRM2 serine/arginine repetitive matrix 2
SCAF11 SR-related CTD-associated factor 11
CASR calcium-sensing receptor
BRAF B-Raf proto-oncogene, serine/threonine kinase
KCNK12 potassium channel, two pore domain subfamily K, member 12
SETD1A SET domain containing 1A
FXYD1 FXYD domain containing ion transport regulator 1
TWIST1 twist family bHLH transcription factor 1
OSBPL10 oxysterol binding protein-like 10
TP53 tumor protein p53
MYL9 myosin, light chain 9, regulatory
CHD1 chromodomain helicase DNA binding protein 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
CDC25A cell division cycle 25A
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
LMNA lamin A/C
H2AFX H2A histone family, member X
MEPCE methylphosphate capping enzyme
CLK2 CDC-like kinase 2
IFI16 interferon, gamma-inducible protein 16
SF1 splicing factor 1
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
DLG1 discs, large homolog 1 (Drosophila)
DGAT1 diacylglycerol O-acyltransferase 1
IL2RA interleukin 2 receptor, alpha