IRAK4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interleukin-1 receptor-associated kinase 4|This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 51135)
External Link http://www.ncbi.nlm.nih.gov/gene/51135
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Genes

59 interacting proteins for IRAK4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARNT aryl hydrocarbon receptor nuclear translocator
BTK Bruton agammaglobulinemia tyrosine kinase
CCDC47 coiled-coil domain containing 47
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHUK conserved helix-loop-helix ubiquitous kinase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
HIST1H1A histone cluster 1, H1a
HIST1H1B histone cluster 1, H1b
HIST1H1C histone cluster 1, H1c
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H1T histone cluster 1, H1t
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1R1 interleukin 1 receptor, type I
IL1RL1 interleukin 1 receptor-like 1
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRF7 interferon regulatory factor 7
JAK1 Janus kinase 1
LTN1 listerin E3 ubiquitin protein ligase 1
LY96 lymphocyte antigen 96
MBP myelin basic protein
MYD88 myeloid differentiation primary response 88
NCF1 neutrophil cytosolic factor 1
NF1 neurofibromin 1
NRF1 nuclear respiratory factor 1
PDS5A PDS5 cohesin associated factor A
PELI1 pellino E3 ubiquitin protein ligase 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PELI3 pellino E3 ubiquitin protein ligase family member 3
RPTOR regulatory associated protein of MTOR, complex 1
SAMHD1 SAM domain and HD domain 1
SASH1 SAM and SH3 domain containing 1
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBPL1 TBP-like 1
TICAM2 toll-like receptor adaptor molecule 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TOLLIP toll interacting protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2