IRAK4 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description interleukin-1 receptor-associated kinase 4|This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 51135)
External Link http://www.ncbi.nlm.nih.gov/gene/51135
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Genes

4 substrates of the kinase IRAK4 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
NCF1 neutrophil cytosolic factor 1
PELI1 pellino E3 ubiquitin protein ligase 1