IRAK4_knockout_41_GSE12124 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE12124
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Genes

600 genes differentially expressed following the IRAK4_knockout_41_GSE12124 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
SRPX2 sushi-repeat containing protein, X-linked 2 3.3093
ATOX1 antioxidant 1 copper chaperone 3.23686
NMB neuromedin B 3.16379
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 2.90938
SUB1 SUB1 homolog (S. cerevisiae) 2.89101
EMG1 EMG1 N1-specific pseudouridine methyltransferase 2.87517
LTBP2 latent transforming growth factor beta binding protein 2 2.86607
PEPD peptidase D 2.81592
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 2.80167
PRKCE protein kinase C, epsilon 2.78257
TMEM38B transmembrane protein 38B 2.74194
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.72593
TCP11L1 t-complex 11, testis-specific-like 1 2.7054
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 2.70401
CHPT1 choline phosphotransferase 1 2.70181
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 2.69855
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.66797
PFDN1 prefoldin subunit 1 2.65987
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 2.65885
EBP emopamil binding protein (sterol isomerase) 2.65446
BOLA2 bolA family member 2 2.61559
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.61558
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.60913
ERO1L ERO1-like (S. cerevisiae) 2.6053
COL6A1 collagen, type VI, alpha 1 2.58185
IRAK1 interleukin-1 receptor-associated kinase 1 2.56365
CCNI cyclin I 2.5631
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.56102
STAG1 stromal antigen 1 2.55142
MPDU1 mannose-P-dolichol utilization defect 1 2.55106
RPA2 replication protein A2, 32kDa 2.53327
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.53095
FN1 fibronectin 1 2.51077
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.50276
HEXB hexosaminidase B (beta polypeptide) 2.50237
VAMP4 vesicle-associated membrane protein 4 2.49472
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.47927
RHEB Ras homolog enriched in brain 2.47764
C6ORF48 chromosome 6 open reading frame 48 2.47749
VDAC3 voltage-dependent anion channel 3 2.4612
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 2.41896
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 2.40778
COL6A3 collagen, type VI, alpha 3 2.39638
DARS aspartyl-tRNA synthetase 2.3955
YBX1 Y box binding protein 1 2.37862
KPNB1 karyopherin (importin) beta 1 2.37618
FTL ferritin, light polypeptide 2.35561
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 2.34839
NCBP1 nuclear cap binding protein subunit 1, 80kDa 2.34514
COMMD1 copper metabolism (Murr1) domain containing 1 2.3301
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.3294
SPA17 sperm autoantigenic protein 17 2.32606
TPRKB TP53RK binding protein 2.32218
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.31766
NUBP1 nucleotide binding protein 1 2.30725
OLFML3 olfactomedin-like 3 2.29235
RPLP2 ribosomal protein, large, P2 2.29209
C1ORF123 chromosome 1 open reading frame 123 2.27324
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 2.26546
TRAPPC4 trafficking protein particle complex 4 2.25344
ECM1 extracellular matrix protein 1 2.25188
PHPT1 phosphohistidine phosphatase 1 2.24929
PGRMC1 progesterone receptor membrane component 1 2.24214
SLC35B1 solute carrier family 35, member B1 2.23745
GLO1 glyoxalase I 2.23394
COX5A cytochrome c oxidase subunit Va 2.23154
KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 2.23137
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.22967
NPC2 Niemann-Pick disease, type C2 2.22718
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 2.2258
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2.21504
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 2.21108
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 2.2108
PCBP1 poly(rC) binding protein 1 2.20395
PHTF1 putative homeodomain transcription factor 1 2.20249
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.19623
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 2.18276
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 2.17777
GPS2 G protein pathway suppressor 2 2.1692
DAD1 defender against cell death 1 2.16664
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.14845
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.1283
S100A10 S100 calcium binding protein A10 2.1277
NGLY1 N-glycanase 1 2.12623
NUDC nudC nuclear distribution protein 2.12352
MTX3 metaxin 3 2.12274
ASCC1 activating signal cointegrator 1 complex subunit 1 2.11995
IPO11 importin 11 2.11736
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.10921
C12ORF57 chromosome 12 open reading frame 57 2.10639
PCNP PEST proteolytic signal containing nuclear protein 2.10609
SAR1B secretion associated, Ras related GTPase 1B 2.093
UXT ubiquitously-expressed, prefoldin-like chaperone 2.09108
EXOSC3 exosome component 3 2.08583
HOOK3 hook microtubule-tethering protein 3 2.08529
MAPK1 mitogen-activated protein kinase 1 2.0793
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 2.0705
MRPS18C mitochondrial ribosomal protein S18C 2.07047
ATG3 autophagy related 3 2.06735
RPL9 ribosomal protein L9 2.06564
CCT2 chaperonin containing TCP1, subunit 2 (beta) 2.06456
PHYH phytanoyl-CoA 2-hydroxylase 2.06248
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.05897
ILF2 interleukin enhancer binding factor 2 2.05753
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) 2.05688
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 2.05503
GATAD2A GATA zinc finger domain containing 2A 2.05354
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.05189
ERCC1 excision repair cross-complementation group 1 2.05062
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.03962
RAB28 RAB28, member RAS oncogene family 2.03371
ISOC2 isochorismatase domain containing 2 2.03351
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.03236
HINT2 histidine triad nucleotide binding protein 2 2.02783
MRPS36 mitochondrial ribosomal protein S36 2.02762
C11ORF48 2.02459
BANF1 barrier to autointegration factor 1 2.02353
ACVR1 activin A receptor, type I 2.02171
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.02067
LIX1L Lix1 homolog (chicken) like 2.01962
TTLL7 tubulin tyrosine ligase-like family member 7 2.01844
ST7 suppression of tumorigenicity 7 2.01462
HSPA8 heat shock 70kDa protein 8 2.01268
STK32B serine/threonine kinase 32B 2.00464
AGPS alkylglycerone phosphate synthase 2.00438
HOXB5 homeobox B5 1.9908
ODF2 outer dense fiber of sperm tails 2 1.99075
TMEM99 transmembrane protein 99 1.99047
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.96675
SNW1 SNW domain containing 1 1.96378
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 1.96297
CRIP1 cysteine-rich protein 1 (intestinal) 1.96261
SCPEP1 serine carboxypeptidase 1 1.95498
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 1.95304
NOLC1 nucleolar and coiled-body phosphoprotein 1 1.95255
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.95173
GNPAT glyceronephosphate O-acyltransferase 1.94893
HIGD2A HIG1 hypoxia inducible domain family, member 2A 1.94539
MED6 mediator complex subunit 6 1.94065
BOLA3 bolA family member 3 1.93863
RCC1 regulator of chromosome condensation 1 1.93682
CD109 CD109 molecule 1.93491
MRPS30 mitochondrial ribosomal protein S30 1.93442
C14ORF142 chromosome 14 open reading frame 142 1.93424
GTPBP8 GTP-binding protein 8 (putative) 1.93073
MAPK9 mitogen-activated protein kinase 9 1.92913
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 1.92399
TFAM transcription factor A, mitochondrial 1.92201
TPP1 tripeptidyl peptidase I 1.92133
CCL26 chemokine (C-C motif) ligand 26 1.92072
CD302 CD302 molecule 1.91797
HTATSF1 HIV-1 Tat specific factor 1 1.91743
LAMP1 lysosomal-associated membrane protein 1 1.91625
SLC38A6 solute carrier family 38, member 6 1.91617
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa 1.91348
ZNF511 zinc finger protein 511 1.90779
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 1.90773
CYBRD1 cytochrome b reductase 1 1.90334
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 1.89659
CNOT10 CCR4-NOT transcription complex, subunit 10 1.89539
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 1.88942
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.88604
SNRPC small nuclear ribonucleoprotein polypeptide C 1.8854
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 1.88292
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 1.87515
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 1.87515
SNIP1 Smad nuclear interacting protein 1 1.87499
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 1.87319
DHFRL1 dihydrofolate reductase-like 1 1.86765
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 1.86148
DPY19L4 dpy-19-like 4 (C. elegans) 1.8609
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.85849
FAM50A family with sequence similarity 50, member A 1.85846
NENF neudesin neurotrophic factor 1.8579
NUP43 nucleoporin 43kDa 1.85522
COPS7A COP9 signalosome subunit 7A 1.85294
EMP1 epithelial membrane protein 1 1.85282
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 1.84579
MSRA methionine sulfoxide reductase A 1.83785
SNRPA small nuclear ribonucleoprotein polypeptide A 1.8357
MFAP4 microfibrillar-associated protein 4 1.82864
CEP135 centrosomal protein 135kDa 1.82719
TNC tenascin C 1.82564
FBL fibrillarin 1.82185
DAP3 death associated protein 3 1.81953
NIP7 NIP7, nucleolar pre-rRNA processing protein 1.8184
RBM28 RNA binding motif protein 28 1.8146
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1.81392
MRPL22 mitochondrial ribosomal protein L22 1.8121
MAPKAP1 mitogen-activated protein kinase associated protein 1 1.80896
CCDC23 coiled-coil domain containing 23 1.80835
GTF3A general transcription factor IIIA 1.80783
PSAP prosaposin 1.80608
OSTM1 osteopetrosis associated transmembrane protein 1 1.80531
MRPL9 mitochondrial ribosomal protein L9 1.80197
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 1.79611
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 1.79339
NRM nurim (nuclear envelope membrane protein) 1.79007
TMEM126B transmembrane protein 126B 1.78933
RPA3 replication protein A3, 14kDa 1.78757
MRPL13 mitochondrial ribosomal protein L13 1.78733
MRPL30 mitochondrial ribosomal protein L30 1.78412
SSR1 signal sequence receptor, alpha 1.78319
THRAP3 thyroid hormone receptor associated protein 3 1.78278
TMED2 transmembrane emp24 domain trafficking protein 2 1.77814
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 1.7775
RAD23A RAD23 homolog A (S. cerevisiae) 1.77643
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 1.77378
ARHGAP12 Rho GTPase activating protein 12 1.7696
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 1.7646
GPNMB glycoprotein (transmembrane) nmb 1.76387
SLC35A4 solute carrier family 35, member A4 1.7571
MRPL18 mitochondrial ribosomal protein L18 1.75628
PHC1 polyhomeotic homolog 1 (Drosophila) 1.75626
BAALC brain and acute leukemia, cytoplasmic 1.75453
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 1.74936
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 1.74729
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 1.74637
WDR70 WD repeat domain 70 1.74636
NUP107 nucleoporin 107kDa 1.74533
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 1.74483
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 1.74257
ERH enhancer of rudimentary homolog (Drosophila) 1.74094
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 1.7384
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 1.73638
RANBP9 RAN binding protein 9 1.73407
ELMOD2 ELMO/CED-12 domain containing 2 1.73403
TMEM119 transmembrane protein 119 1.73397
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 1.73343
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 1.72707
ATG10 autophagy related 10 1.72674
TTC5 tetratricopeptide repeat domain 5 1.72351
MRPS31 mitochondrial ribosomal protein S31 1.72295
TBC1D22A TBC1 domain family, member 22A 1.71679
ZNF524 zinc finger protein 524 1.71467
GTPBP6 GTP binding protein 6 (putative) 1.70712
GALC galactosylceramidase 1.70681
MRPS11 mitochondrial ribosomal protein S11 1.70537
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.70153
ANAPC5 anaphase promoting complex subunit 5 1.6996
ARL2BP ADP-ribosylation factor-like 2 binding protein 1.69881
APP amyloid beta (A4) precursor protein 1.69789
MRPL51 mitochondrial ribosomal protein L51 1.69761
VDAC2 voltage-dependent anion channel 2 1.69447
FNTB farnesyltransferase, CAAX box, beta 1.69404
OTUD6B OTU domain containing 6B 1.6936
ALG8 ALG8, alpha-1,3-glucosyltransferase 1.69108
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 1.69078
PROS1 protein S (alpha) 1.68835
CCDC53 coiled-coil domain containing 53 1.68655
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.6847
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 1.68133
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 1.68124
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 1.68075
GSPT1 G1 to S phase transition 1 1.67907
KHSRP KH-type splicing regulatory protein 1.67577
ENO1 enolase 1, (alpha) 1.67326
FAP fibroblast activation protein, alpha 1.67255
ARPC5L actin related protein 2/3 complex, subunit 5-like 1.67206
NUP98 nucleoporin 98kDa 1.67195
TICAM2 toll-like receptor adaptor molecule 2 1.6681
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 1.6678
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 1.6616
RPS2 ribosomal protein S2 1.66113
DDB2 damage-specific DNA binding protein 2, 48kDa 1.66
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 1.65599
FRG1 FSHD region gene 1 1.65578
DGCR6 DiGeorge syndrome critical region gene 6 1.6556
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 1.651
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 1.64649
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 1.64588
MRPL15 mitochondrial ribosomal protein L15 1.64505
KIF5B kinesin family member 5B 1.64199
SCNM1 sodium channel modifier 1 1.64163
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 1.63976
REP15 RAB15 effector protein 1.63909
DGCR8 DGCR8 microprocessor complex subunit 1.63906
PA2G4 proliferation-associated 2G4, 38kDa 1.63594
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 1.63477
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 1.62706
DUSP12 dual specificity phosphatase 12 1.62221
RPN1 ribophorin I 1.62093
FAM96A family with sequence similarity 96, member A 1.61872
MAGEF1 melanoma antigen family F1 1.61772
SRFBP1 serum response factor binding protein 1 1.61592
MDH1 malate dehydrogenase 1, NAD (soluble) 1.61464
BPHL biphenyl hydrolase-like (serine hydrolase) 1.60963
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 1.60896
RBM25 RNA binding motif protein 25 1.60663
TXN thioredoxin 1.60628
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.60475
CKLF chemokine-like factor 1.60282
RPL26L1 ribosomal protein L26-like 1 1.59905
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.5973
BBS4 Bardet-Biedl syndrome 4 1.59416
SNRPB2 small nuclear ribonucleoprotein polypeptide B 1.59272
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 1.59111
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 1.58921
ANKRD40 ankyrin repeat domain 40 1.58865
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 1.58856

decreased expression

Symbol Name Standardized Value
LMAN2 lectin, mannose-binding 2 -4.11321
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.99507
C9ORF89 chromosome 9 open reading frame 89 -3.41982
SERINC3 serine incorporator 3 -3.37461
HEBP2 heme binding protein 2 -3.32104
KIAA2013 KIAA2013 -3.21953
SORT1 sortilin 1 -3.14775
TPM2 tropomyosin 2 (beta) -3.12583
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -3.06486
CORO1B coronin, actin binding protein, 1B -2.93988
NID2 nidogen 2 (osteonidogen) -2.92247
CHMP2A charged multivesicular body protein 2A -2.92142
CTBS chitobiase, di-N-acetyl- -2.88158
MVP major vault protein -2.80787
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.8068
SERINC2 serine incorporator 2 -2.79791
MFGE8 milk fat globule-EGF factor 8 protein -2.7834
IGFBP7 insulin-like growth factor binding protein 7 -2.75088
RNF10 ring finger protein 10 -2.73772
CYBA cytochrome b-245, alpha polypeptide -2.7313
EML2 echinoderm microtubule associated protein like 2 -2.71193
FLOT2 flotillin 2 -2.70758
RHOA ras homolog family member A -2.69305
DDAH1 dimethylarginine dimethylaminohydrolase 1 -2.66201
FBXL15 F-box and leucine-rich repeat protein 15 -2.66039
EPN1 epsin 1 -2.64917
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.63802
FBN2 fibrillin 2 -2.6283
SUSD1 sushi domain containing 1 -2.61133
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -2.54389
CNN1 calponin 1, basic, smooth muscle -2.53713
HSPB1 heat shock 27kDa protein 1 -2.52996
TRAM1 translocation associated membrane protein 1 -2.52984
CHRAC1 chromatin accessibility complex 1 -2.51477
COL4A2 collagen, type IV, alpha 2 -2.50554
SOD1 superoxide dismutase 1, soluble -2.5034
ECHDC2 enoyl CoA hydratase domain containing 2 -2.50178
CAPN1 calpain 1, (mu/I) large subunit -2.47981
ARL8B ADP-ribosylation factor-like 8B -2.46721
KIAA0556 KIAA0556 -2.4661
PSG4 pregnancy specific beta-1-glycoprotein 4 -2.4358
ADAM10 ADAM metallopeptidase domain 10 -2.43333
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.42853
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.40514
SH3PXD2A SH3 and PX domains 2A -2.40422
ZNHIT1 zinc finger, HIT-type containing 1 -2.40147
RPS27L ribosomal protein S27-like -2.40107
PERP PERP, TP53 apoptosis effector -2.39047
NPDC1 neural proliferation, differentiation and control, 1 -2.387
APEH acylaminoacyl-peptide hydrolase -2.37455
DMPK dystrophia myotonica-protein kinase -2.36509
ZDHHC3 zinc finger, DHHC-type containing 3 -2.35883
MALL mal, T-cell differentiation protein-like -2.35027
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) -2.34792
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.3274
RFXANK regulatory factor X-associated ankyrin-containing protein -2.32429
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.32091
PFDN5 prefoldin subunit 5 -2.30427
SLC38A1 solute carrier family 38, member 1 -2.29341
NADSYN1 NAD synthetase 1 -2.29182
CTXN1 cortexin 1 -2.28106
F10 coagulation factor X -2.27733
HES6 hes family bHLH transcription factor 6 -2.27352
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.26612
PARVA parvin, alpha -2.25789
CA12 carbonic anhydrase XII -2.23963
CRYAB crystallin, alpha B -2.23759
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 -2.22042
RAB11A RAB11A, member RAS oncogene family -2.21298
FNDC4 fibronectin type III domain containing 4 -2.20979
RBPMS RNA binding protein with multiple splicing -2.20625
MSH3 mutS homolog 3 -2.20285
LITAF lipopolysaccharide-induced TNF factor -2.18567
RAB5B RAB5B, member RAS oncogene family -2.18448
IGFBP6 insulin-like growth factor binding protein 6 -2.17932
CAB39 calcium binding protein 39 -2.17558
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.17443
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.17106
PHACTR2 phosphatase and actin regulator 2 -2.16293
MAPK3 mitogen-activated protein kinase 3 -2.15909
THY1 Thy-1 cell surface antigen -2.1585
YPEL5 yippee-like 5 (Drosophila) -2.14859
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.14061
PRAF2 PRA1 domain family, member 2 -2.13464
CSNK1D casein kinase 1, delta -2.12926
CHMP2B charged multivesicular body protein 2B -2.12739
ZNF226 zinc finger protein 226 -2.12565
DCTN6 dynactin 6 -2.11602
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.1069
WDR41 WD repeat domain 41 -2.10668
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -2.10072
DDR1 discoidin domain receptor tyrosine kinase 1 -2.09502
AGA aspartylglucosaminidase -2.09409
RHPN2 rhophilin, Rho GTPase binding protein 2 -2.08834
REEP2 receptor accessory protein 2 -2.08697
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.08649
TM2D1 TM2 domain containing 1 -2.08401
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -2.07763
EXOC2 exocyst complex component 2 -2.07755
SDF2 stromal cell-derived factor 2 -2.07537
LOC389033 placenta-specific 9 pseudogene -2.073
C1ORF53 chromosome 1 open reading frame 53 -2.07291
LMAN2L lectin, mannose-binding 2-like -2.07055
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.06897
LRRC8D leucine rich repeat containing 8 family, member D -2.068
SFRP1 secreted frizzled-related protein 1 -2.06562
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.05795
LAMA4 laminin, alpha 4 -2.05623
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.05331
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.04766
PON2 paraoxonase 2 -2.04295
TST thiosulfate sulfurtransferase (rhodanese) -2.03989
FADS3 fatty acid desaturase 3 -2.03823
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -2.03792
NDFIP2 Nedd4 family interacting protein 2 -2.02887
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 -2.01881
LY96 lymphocyte antigen 96 -2.017
SURF1 surfeit 1 -2.0121
H2AFJ H2A histone family, member J -2.00988
C1QTNF5 C1q and tumor necrosis factor related protein 5 -2.00558
MFSD3 major facilitator superfamily domain containing 3 -2.00415
MAP3K11 mitogen-activated protein kinase kinase kinase 11 -2.00306
BCAP31 B-cell receptor-associated protein 31 -2.00146
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 -1.99933
TCEAL4 transcription elongation factor A (SII)-like 4 -1.98261
NLGN1 neuroligin 1 -1.9819
RGL2 ral guanine nucleotide dissociation stimulator-like 2 -1.97137
CD81 CD81 molecule -1.96361
GLB1 galactosidase, beta 1 -1.96155
PNPLA2 patatin-like phospholipase domain containing 2 -1.9556
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -1.95552
MANSC1 MANSC domain containing 1 -1.95059
TGM2 transglutaminase 2 -1.93405
ELL2 elongation factor, RNA polymerase II, 2 -1.9303
MAN1B1 mannosidase, alpha, class 1B, member 1 -1.92989
PISD phosphatidylserine decarboxylase -1.92843
NR1H2 nuclear receptor subfamily 1, group H, member 2 -1.92635
NSFL1C NSFL1 (p97) cofactor (p47) -1.9192
ADHFE1 alcohol dehydrogenase, iron containing, 1 -1.91007
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -1.90934
NCOA4 nuclear receptor coactivator 4 -1.90645
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -1.90019
MYL9 myosin, light chain 9, regulatory -1.89553
CYB5R1 cytochrome b5 reductase 1 -1.89345
REEP5 receptor accessory protein 5 -1.89268
EML3 echinoderm microtubule associated protein like 3 -1.89149
IGBP1 immunoglobulin (CD79A) binding protein 1 -1.88921
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -1.8874
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -1.88538
C14ORF2 chromosome 14 open reading frame 2 -1.87473
TMED9 transmembrane emp24 protein transport domain containing 9 -1.85637
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -1.85598
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -1.85531
ALCAM activated leukocyte cell adhesion molecule -1.84821
ZNF12 zinc finger protein 12 -1.84623
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -1.84181
ADD1 adducin 1 (alpha) -1.84147
TMCO3 transmembrane and coiled-coil domains 3 -1.8411
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -1.83701
SELM selenoprotein M -1.83373
KCNK1 potassium channel, two pore domain subfamily K, member 1 -1.83261
MAN2B2 mannosidase, alpha, class 2B, member 2 -1.83259
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -1.8322
NCKAP1 NCK-associated protein 1 -1.82165
FAM89A family with sequence similarity 89, member A -1.81885
AVEN apoptosis, caspase activation inhibitor -1.81633
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -1.81522
PPAPDC2 phosphatidic acid phosphatase type 2 domain containing 2 -1.81405
MEIS1 Meis homeobox 1 -1.80546
TIPRL TOR signaling pathway regulator -1.80541
IGFBP4 insulin-like growth factor binding protein 4 -1.80101
DNM1L dynamin 1-like -1.79891
TRAPPC1 trafficking protein particle complex 1 -1.79849
RHOC ras homolog family member C -1.79725
VPS33B vacuolar protein sorting 33 homolog B (yeast) -1.79656
GSTO2 glutathione S-transferase omega 2 -1.79564
ATPIF1 ATPase inhibitory factor 1 -1.79537
MRPL49 mitochondrial ribosomal protein L49 -1.79415
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -1.79297
LIMS2 LIM and senescent cell antigen-like domains 2 -1.79173
TSC2 tuberous sclerosis 2 -1.79061
TSPAN9 tetraspanin 9 -1.78988
SAP18 Sin3A-associated protein, 18kDa -1.78777
TNS3 tensin 3 -1.78663
KTN1 kinectin 1 (kinesin receptor) -1.78656
RPUSD1 RNA pseudouridylate synthase domain containing 1 -1.78543
RNF123 ring finger protein 123 -1.78383
FLNC filamin C, gamma -1.77945
TAGLN transgelin -1.77202
DEXI Dexi homolog (mouse) -1.76483
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -1.76384
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -1.76365
BGLAP bone gamma-carboxyglutamate (gla) protein -1.76342
LGTN ligatin -1.76129
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -1.75691
LRP10 low density lipoprotein receptor-related protein 10 -1.75587
PPOX protoporphyrinogen oxidase -1.75516
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -1.752
IRAK4 interleukin-1 receptor-associated kinase 4 -1.7511
NCSTN nicastrin -1.74861
TRHDE thyrotropin-releasing hormone degrading enzyme -1.74554
KCTD17 potassium channel tetramerization domain containing 17 -1.7451
QARS glutaminyl-tRNA synthetase -1.73924
CCDC6 coiled-coil domain containing 6 -1.73779
PEBP1 phosphatidylethanolamine binding protein 1 -1.73664
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -1.73542
NRBP2 nuclear receptor binding protein 2 -1.73203
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -1.72891
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -1.72552
TPD52L2 tumor protein D52-like 2 -1.72308
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -1.72307
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -1.7223
LASP1 LIM and SH3 protein 1 -1.71799
KCNK6 potassium channel, two pore domain subfamily K, member 6 -1.71309
TMEM9B TMEM9 domain family, member B -1.71287
CUTA cutA divalent cation tolerance homolog (E. coli) -1.70858
PLD2 phospholipase D2 -1.7071
SNX1 sorting nexin 1 -1.70456
FOXC1 forkhead box C1 -1.70447
IL13RA1 interleukin 13 receptor, alpha 1 -1.70425
TSPYL5 TSPY-like 5 -1.70145
CBX6 chromobox homolog 6 -1.69781
PEX16 peroxisomal biogenesis factor 16 -1.6914
DDT D-dopachrome tautomerase -1.69129
KIAA0196 KIAA0196 -1.68635
ABHD8 abhydrolase domain containing 8 -1.68222
FKRP fukutin related protein -1.68132
TEAD3 TEA domain family member 3 -1.68077
PGK1 phosphoglycerate kinase 1 -1.6789
LTA4H leukotriene A4 hydrolase -1.67783
CTSW cathepsin W -1.67391
IPO8 importin 8 -1.67294
PDIA6 protein disulfide isomerase family A, member 6 -1.66727
PDCD6 programmed cell death 6 -1.66181
PLXNB1 plexin B1 -1.6617
CD46 CD46 molecule, complement regulatory protein -1.65648
CDC37 cell division cycle 37 -1.65614
GULP1 GULP, engulfment adaptor PTB domain containing 1 -1.65599
MAPK13 mitogen-activated protein kinase 13 -1.65556
RPL17 ribosomal protein L17 -1.65203
SIL1 SIL1 nucleotide exchange factor -1.64881
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -1.64825
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -1.64542
DHRS1 dehydrogenase/reductase (SDR family) member 1 -1.64085
CLN5 ceroid-lipofuscinosis, neuronal 5 -1.63971
RRAS related RAS viral (r-ras) oncogene homolog -1.63955
SH3BGRL SH3 domain binding glutamate-rich protein like -1.63572
MKRN1 makorin ring finger protein 1 -1.63327
FKBP8 FK506 binding protein 8, 38kDa -1.63297
GABARAPL1 GABA(A) receptor-associated protein like 1 -1.63224
PPP1R12C protein phosphatase 1, regulatory subunit 12C -1.6297
CYB5R3 cytochrome b5 reductase 3 -1.62933
CAPNS1 calpain, small subunit 1 -1.62752
OAF OAF homolog (Drosophila) -1.62639
NUDT22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 -1.62526
PLXNA3 plexin A3 -1.6223
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -1.62005
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -1.61513
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -1.61486
TSEN34 TSEN34 tRNA splicing endonuclease subunit -1.61343
TGOLN2 trans-golgi network protein 2 -1.61288
RPS29 ribosomal protein S29 -1.61224
WDR13 WD repeat domain 13 -1.60616
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.60402
UBE2F ubiquitin-conjugating enzyme E2F (putative) -1.6039
TSPYL1 TSPY-like 1 -1.59843
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -1.59759
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -1.59406
PPAPDC1B phosphatidic acid phosphatase type 2 domain containing 1B -1.59357
XPR1 xenotropic and polytropic retrovirus receptor 1 -1.59335
FSTL1 follistatin-like 1 -1.59078
CD320 CD320 molecule -1.58739
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -1.58458
PEX19 peroxisomal biogenesis factor 19 -1.58409
CSK c-src tyrosine kinase -1.58297
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -1.58078
REXO2 RNA exonuclease 2 -1.58018
MTCH1 mitochondrial carrier 1 -1.57896
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 -1.57849
HIBADH 3-hydroxyisobutyrate dehydrogenase -1.57798
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -1.57279
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) -1.57226
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -1.57111
MSRB3 methionine sulfoxide reductase B3 -1.5659
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -1.56568
ATXN10 ataxin 10 -1.56457
RAB11FIP3 RAB11 family interacting protein 3 (class II) -1.5644
RABAC1 Rab acceptor 1 (prenylated) -1.56245
TSPAN14 tetraspanin 14 -1.56094
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) -1.56002
ITM2B integral membrane protein 2B -1.55309
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -1.55084
B3GAT3 beta-1,3-glucuronyltransferase 3 -1.54936
IK IK cytokine, down-regulator of HLA II -1.54804
COMMD7 COMM domain containing 7 -1.54738
C1ORF54 chromosome 1 open reading frame 54 -1.54437
MRPL52 mitochondrial ribosomal protein L52 -1.5435
LRRK1 leucine-rich repeat kinase 1 -1.54204
RPL13 ribosomal protein L13 -1.5416
SLC44A2 solute carrier family 44 (choline transporter), member 2 -1.54022