IRF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description interferon regulatory factor 1|IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3659)
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Genes

320 genes differentially expressed following the IRF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PADI4 peptidyl arginine deiminase, type IV 3.22853
CST11 cystatin 11 2.82794
BMP8A bone morphogenetic protein 8a 2.82794
SIGLEC9 sialic acid binding Ig-like lectin 9 2.82794
CEP152 centrosomal protein 152kDa 2.82794
XCL1 chemokine (C motif) ligand 1 2.82794
ALPK2 alpha-kinase 2 2.82794
SPRR1B small proline-rich protein 1B 2.82794
OTUD6A OTU deubiquitinase 6A 2.82794
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.82794
PCDH8 protocadherin 8 2.82794
PTH2 parathyroid hormone 2 2.82794
AFM afamin 2.82794
MYBPHL myosin binding protein H-like 2.82794
CEMP1 cementum protein 1 2.82794
MAP3K7CL MAP3K7 C-terminal like 2.82794
ZNF503 zinc finger protein 503 2.82794
NXPH4 neurexophilin 4 2.82794
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.82794
GLUD2 glutamate dehydrogenase 2 2.82794
RAB1B RAB1B, member RAS oncogene family 2.82794
GPR151 G protein-coupled receptor 151 2.82794
RGPD4 RANBP2-like and GRIP domain containing 4 2.82794
RGPD3 RANBP2-like and GRIP domain containing 3 2.82794
ANXA2R annexin A2 receptor 2.82794
PSD2 pleckstrin and Sec7 domain containing 2 2.82794
GHRH growth hormone releasing hormone 2.82794
APOA1 apolipoprotein A-I 2.82794
IRX1 iroquois homeobox 1 2.82794
ICAM2 intercellular adhesion molecule 2 2.82794
ZNF648 zinc finger protein 648 2.82794
GPR179 G protein-coupled receptor 179 2.82794
GPR17 G protein-coupled receptor 17 2.82794
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.82794
EVPL envoplakin 2.82794
TREML2 triggering receptor expressed on myeloid cells-like 2 2.82794
BHMT2 betaine--homocysteine S-methyltransferase 2 2.82794
TAS2R13 taste receptor, type 2, member 13 2.82794
MPL MPL proto-oncogene, thrombopoietin receptor 2.82794
PRDM13 PR domain containing 13 2.82794
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.82794
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.82794
REM2 RAS (RAD and GEM)-like GTP binding 2 2.82794
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.82794
IL37 interleukin 37 2.82794
SBK3 SH3 domain binding kinase family, member 3 2.82794
SPATA31H1 SPATA31 subfamily H member 1 2.82794
MGAT4D MGAT4 family, member D 2.82794
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.82794
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.82794
PROX2 prospero homeobox 2 2.82794
TREX2 three prime repair exonuclease 2 2.82794
SYT15 synaptotagmin XV 2.82794
SMCP sperm mitochondria-associated cysteine-rich protein 2.82794
ROPN1 rhophilin associated tail protein 1 2.82794
STARD6 StAR-related lipid transfer (START) domain containing 6 2.82794
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.82794
KY kyphoscoliosis peptidase 2.82794
H2BK1 H2B.K variant histone 1 2.82794
H3-7 H3.7 histone (putative) 2.82794
SMIM31 small integral membrane protein 31 2.82794
H3C3 H3 clustered histone 3 2.82794
SEPTIN12 septin 12 2.82794
H2AC1 H2A clustered histone 1 2.82794
DUSP29 dual specificity phosphatase 29 2.82794
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.82794
CCN5 cellular communication network factor 5 2.82794
PTH parathyroid hormone 2.82794
VCX3A variable charge, X-linked 3A 2.82794
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.82794
DMP1 dentin matrix acidic phosphoprotein 1 2.82794
GGT6 gamma-glutamyltransferase 6 2.82794
KLHL33 kelch-like family member 33 2.82794
PCDHA8 protocadherin alpha 8 2.82794
CAPN14 calpain 14 2.82794
GAGE2A G antigen 2A 2.82794
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.82794
ZNF99 zinc finger protein 99 2.82794
WEE2 WEE1 homolog 2 (S. pombe) 2.82794
PTGDR2 prostaglandin D2 receptor 2 2.82794
GOLGA6L4 golgin A6 family-like 4 2.82794
CNTFR ciliary neurotrophic factor receptor 2.82794
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.82794
CCR1 chemokine (C-C motif) receptor 1 2.82794
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.82794
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.82794
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.82794
RUNX3 runt-related transcription factor 3 2.82794
TLR7 toll-like receptor 7 2.82794
OVOL3 ovo-like zinc finger 3 2.82794
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.82794
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.82794
PKDREJ polycystin (PKD) family receptor for egg jelly 2.82794
NIPAL4 NIPA-like domain containing 4 2.82794
MAB21L1 mab-21-like 1 (C. elegans) 2.82794
CYS1 cystin 1 2.82794
WNT7B wingless-type MMTV integration site family, member 7B 2.82794
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.82794
C17ORF99 chromosome 17 open reading frame 99 2.82794
CHI3L2 chitinase 3-like 2 2.82794
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.82794
LCN1 lipocalin 1 2.82794
APLNR apelin receptor 2.82794
MRLN myoregulin 2.82794
CT55 cancer/testis antigen 55 2.82794
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.82794
OTC ornithine carbamoyltransferase 2.82794
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.82794
BTNL9 butyrophilin-like 9 2.82794
AQP7 aquaporin 7 2.82794
FBXO47 F-box protein 47 2.82794
EGR2 early growth response 2 2.82794
GPR142 G protein-coupled receptor 142 2.82794
ADCY4 adenylate cyclase 4 2.82794
LAMB4 laminin, beta 4 2.82794
TM4SF19 transmembrane 4 L six family member 19 2.82794
CXORF58 chromosome X open reading frame 58 2.82794
TTC24 tetratricopeptide repeat domain 24 2.82794
GOLGA8R golgin A8 family, member R 2.82794
LRRC24 leucine rich repeat containing 24 2.82794
NMBR neuromedin B receptor 2.82794
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.82794
HK3 hexokinase 3 (white cell) 2.82794
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.82794
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.82794
FGG fibrinogen gamma chain 2.82794
ITGB5 integrin, beta 5 2.82794
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.82794
TG thyroglobulin 2.82794
IP6K3 inositol hexakisphosphate kinase 3 2.82794
MYF6 myogenic factor 6 (herculin) 2.82794
GPR50 G protein-coupled receptor 50 2.82794
OSR2 odd-skipped related transciption factor 2 2.82794
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.82794
TGM6 transglutaminase 6 2.82794
AGR3 anterior gradient 3 2.82794
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.82794
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.82794
APOL1 apolipoprotein L, 1 2.82794
ANGPTL5 angiopoietin-like 5 2.82794
SHOX short stature homeobox 2.82794
WDFY4 WDFY family member 4 2.82794
POU3F3 POU class 3 homeobox 3 2.82794
PATE2 prostate and testis expressed 2 2.82794
LST1 leukocyte specific transcript 1 2.82794
MMP13 matrix metallopeptidase 13 2.82794
SLITRK6 SLIT and NTRK-like family, member 6 2.82794
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.82794
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.82794
PRSS51 protease, serine, 51 2.82794
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.82794
TOP1 topoisomerase (DNA) I 2.79762
ELF4 E74-like factor 4 (ets domain transcription factor) 2.79762
DNAAF19 dynein axonemal assembly factor 19 2.79762
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.7692
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.73258
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.64643
SFT2D1 SFT2 domain containing 1 2.63374
RNF166 ring finger protein 166 2.56977
LINC02798 long intergenic non-protein coding RNA 2798 2.56887
RBBP5 retinoblastoma binding protein 5 2.56498
ALK anaplastic lymphoma receptor tyrosine kinase 2.52656
JMY junction mediating and regulatory protein, p53 cofactor 2.45791
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.45426
MIS18BP1 MIS18 binding protein 1 2.43465
CHD1L chromodomain helicase DNA binding protein 1-like 2.43371
PGPEP1 pyroglutamyl-peptidase I 2.43011
TMPRSS9 transmembrane protease, serine 9 2.419
SCG2 secretogranin II 2.41582
MRPL40 mitochondrial ribosomal protein L40 2.4132
UNC93A unc-93 homolog A (C. elegans) 2.40383
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.40383
CPXM1 carboxypeptidase X (M14 family), member 1 2.39051
GLIPR1 GLI pathogenesis-related 1 2.39051
HIP1 huntingtin interacting protein 1 2.37898
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.35446
ZBED8L ZBED8 like 2.3525
SOS2 son of sevenless homolog 2 (Drosophila) 2.32469
TLR5 toll-like receptor 5 2.32469
PANO1 proapoptotic nucleolar protein 1 2.32469
RRM2 ribonucleotide reductase M2 2.31325
NR2E3 nuclear receptor subfamily 2, group E, member 3 2.28332
TLCD3A TLC domain containing 3A 2.28029
RINT1 RAD50 interactor 1 2.26399
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.25993
MACIR macrophage immunometabolism regulator 2.24653
MCF2 MCF.2 cell line derived transforming sequence 2.24208
GOLGA6C golgin A6 family, member C 2.2376
LOC122526780 uncharacterized LOC122526780 2.2376
TMPRSS2 transmembrane protease, serine 2 2.23497
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 2.22741
IST1 increased sodium tolerance 1 homolog (yeast) 2.22396
RPL31 ribosomal protein L31 2.21978
ADAM19 ADAM metallopeptidase domain 19 2.19601
NCK1 NCK adaptor protein 1 2.16989
RUFY3 RUN and FYVE domain containing 3 2.16902
ZFP30 ZFP30 zinc finger protein 2.15967
KIF18A kinesin family member 18A 2.12694
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.1189
PLK5 polo-like kinase 5 2.11776
ARL6 ADP-ribosylation factor-like 6 2.1004
PCTP phosphatidylcholine transfer protein 2.09806
PINK1 PTEN induced putative kinase 1 2.08556
TRAPPC12 trafficking protein particle complex 12 2.08227
POU3F1 POU class 3 homeobox 1 2.07926
GEMIN8 gem (nuclear organelle) associated protein 8 2.07926
PRXL2B peroxiredoxin like 2B 2.04533
ZNFX1 zinc finger, NFX1-type containing 1 2.03714
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.03192
NOL6 nucleolar protein 6 (RNA-associated) 2.02918
IGSF9 immunoglobulin superfamily, member 9 2.02696
EVC Ellis van Creveld protein 2.02211
ANKRD61 ankyrin repeat domain 61 2.02211
ZNF16 zinc finger protein 16 2.02211

decreased expression

Symbol Name Standardized Value
FAIM Fas apoptotic inhibitory molecule -2.82794
ADRA1A adrenoceptor alpha 1A -2.82794
PCDHGA8 protocadherin gamma subfamily A, 8 -2.82794
RASAL1 RAS protein activator like 1 (GAP1 like) -2.82794
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -2.82794
CYTIP cytohesin 1 interacting protein -2.82794
MID2 midline 2 -2.82794
VMP1 vacuole membrane protein 1 -2.82794
ADRA2B adrenoceptor alpha 2B -2.82794
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -2.82794
GPRIN2 G protein regulated inducer of neurite outgrowth 2 -2.80035
HIGD1C HIG1 hypoxia inducible domain family, member 1C -2.79762
ICAM5 intercellular adhesion molecule 5, telencephalin -2.79762
CD86 CD86 molecule -2.79762
ROM1 retinal outer segment membrane protein 1 -2.79762
EPO erythropoietin -2.79762
INHBC inhibin, beta C -2.79762
GJA4 gap junction protein, alpha 4, 37kDa -2.79762
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -2.79762
SFTPB surfactant protein B -2.79762
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -2.79762
LCN12 lipocalin 12 -2.79762
CD300A CD300a molecule -2.79762
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.79762
PCDHB9 protocadherin beta 9 -2.79762
LRRD1 leucine-rich repeats and death domain containing 1 -2.79762
GJD3 gap junction protein, delta 3, 31.9kDa -2.79762
DENND6B DENN/MADD domain containing 6B -2.79762
EPPIN epididymal peptidase inhibitor -2.79762
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -2.79762
OIT3 oncoprotein induced transcript 3 -2.79762
ETV7 ets variant 7 -2.79762
CDC20B cell division cycle 20B -2.79762
PRTN3 proteinase 3 -2.79762
SPATA22 spermatogenesis associated 22 -2.79762
CDK20 cyclin-dependent kinase 20 -2.79762
LY6G6D lymphocyte antigen 6 complex, locus G6D -2.79762
CCDC170 coiled-coil domain containing 170 -2.79762
HPX hemopexin -2.79762
OAZ3 ornithine decarboxylase antizyme 3 -2.79762
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.79762
BTNL8 butyrophilin-like 8 -2.79762
ANKRD55 ankyrin repeat domain 55 -2.79762
PRR4 proline rich 4 (lacrimal) -2.79762
CCDC121 coiled-coil domain containing 121 -2.79762
SPDL1 spindle apparatus coiled-coil protein 1 -2.74244
HTRA3 HtrA serine peptidase 3 -2.67665
PCDHGB7 protocadherin gamma subfamily B, 7 -2.67665
BCAS3 breast carcinoma amplified sequence 3 -2.67114
FCHO2 FCH domain only 2 -2.64714
ZNF549 zinc finger protein 549 -2.6384
PKD1L3 polycystic kidney disease 1-like 3 -2.63767
ANKRD49 ankyrin repeat domain 49 -2.59027
PNMA8C PNMA family member 8C -2.57554
DPYSL5 dihydropyrimidinase-like 5 -2.56635
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.55099
WDTC1 WD and tetratricopeptide repeats 1 -2.54201
TTLL5 tubulin tyrosine ligase-like family member 5 -2.53712
LEFTY2 left-right determination factor 2 -2.51308
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.49308
PP2D1 protein phosphatase 2C-like domain containing 1 -2.49308
PZP pregnancy-zone protein -2.47884
NBEA neurobeachin -2.46476
NPAS2 neuronal PAS domain protein 2 -2.4395
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -2.42478
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.40772
NT5C2 5'-nucleotidase, cytosolic II -2.39046
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -2.36003
FANK1 fibronectin type III and ankyrin repeat domains 1 -2.32477
CDK18 cyclin-dependent kinase 18 -2.32469
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.26392
OBSL1 obscurin-like 1 -2.26238
OSBP2 oxysterol binding protein 2 -2.26238
JPT1 Jupiter microtubule associated homolog 1 -2.25375
RAB17 RAB17, member RAS oncogene family -2.25064
IL6ST-DT IL6ST divergent transcript -2.24821
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.24821
WDR77 WD repeat domain 77 -2.24143
GRTP1 growth hormone regulated TBC protein 1 -2.22741
NMB neuromedin B -2.20227
SLC61A1 solute carrier family 61 member 1 -2.19601
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.19601
CELF5 CUGBP, Elav-like family member 5 -2.17341
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -2.17329
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.1663
RAB42 RAB42, member RAS oncogene family -2.15848
FOSL2 FOS-like antigen 2 -2.15058
TMCO6 transmembrane and coiled-coil domains 6 -2.12892
DEPDC1B DEP domain containing 1B -2.12823
FBXL22 F-box and leucine-rich repeat protein 22 -2.09109
FOXM1 forkhead box M1 -2.07926
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -2.07926
PLK3 polo-like kinase 3 -2.07926
PHC1 polyhomeotic homolog 1 (Drosophila) -2.07926
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.07683
HDAC4 histone deacetylase 4 -2.07544
IER5 immediate early response 5 -2.04934
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -2.03973
ZC3H7B zinc finger CCCH-type containing 7B -2.03973
MAK16 MAK16 homolog (S. cerevisiae) -2.03342
ASB7 ankyrin repeat and SOCS box containing 7 -2.02697
PLEKHA7 pleckstrin homology domain containing, family A member 7 -2.02697
RBBP6 retinoblastoma binding protein 6 -2.02697
CFAP251 cilia and flagella associated protein 251 -2.02696
STXBP4 syntaxin binding protein 4 -2.01033
WDR13 WD repeat domain 13 -2.00259