IRF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interferon regulatory factor 1|IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3659)
External Link http://www.ncbi.nlm.nih.gov/gene/3659
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Genes

41 interacting proteins for IRF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BIRC3 baculoviral IAP repeat containing 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CREBBP CREB binding protein
EP300 E1A binding protein p300
HCFC1 host cell factor C1
HIST1H3B histone cluster 1, H3b
HMGA1 high mobility group AT-hook 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
IRF2 interferon regulatory factor 2
IRF8 interferon regulatory factor 8
IRF9 interferon regulatory factor 9
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KEAP1 kelch-like ECH-associated protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PRDM1 PR domain containing 1, with ZNF domain
PTGES3 prostaglandin E synthase 3 (cytosolic)
QARS glutaminyl-tRNA synthetase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS27A ribosomal protein S27a
SEC63 SEC63 homolog (S. cerevisiae)
SET SET nuclear proto-oncogene
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SP2 Sp2 transcription factor
SPI1 Spi-1 proto-oncogene
STAT1 signal transducer and activator of transcription 1, 91kDa
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TERT telomerase reverse transcriptase
TRAF3 TNF receptor-associated factor 3
TRIM28 tripartite motif containing 28
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UBC ubiquitin C
ULK2 unc-51 like autophagy activating kinase 2
YBX1 Y box binding protein 1