IRF3 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description interferon regulatory factor 3|This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 3661)
External Link https://ncbi.nlm.nih.gov/gene/3661
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Genes

498 genes differentially expressed following the IRF3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 0.0182484
ASS1 argininosuccinate synthase 1 0.0148071
KRT19 keratin 19, type I 0.0136797
CXCL8 chemokine (C-X-C motif) ligand 8 0.013603
PRAME preferentially expressed antigen in melanoma 0.0133759
PEG10 paternally expressed 10 0.0121489
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0113577
DDIT3 DNA-damage-inducible transcript 3 0.0111642
LTF lactotransferrin 0.0109873
ATF3 activating transcription factor 3 0.0109161
XIC X chromosome inactivation center 0.0106446
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.0105477
HMOX1 heme oxygenase 1 0.0104447
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.0103812
ODC1 ornithine decarboxylase 1 0.00986484
CXCL13 chemokine (C-X-C motif) ligand 13 0.00971279
TAC1 tachykinin, precursor 1 0.00960081
CRIP1 cysteine-rich protein 1 (intestinal) 0.00952014
DSP desmoplakin 0.00934914
GPM6B glycoprotein M6B 0.00917077
EGR1 early growth response 1 0.00908448
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.00905064
SNAI2 snail family zinc finger 2 0.00900089
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 0.00892735
C21ORF91 chromosome 21 open reading frame 91 0.00880508
EPCAM epithelial cell adhesion molecule 0.00864562
S100A8 S100 calcium binding protein A8 0.00850609
FAM117A family with sequence similarity 117, member A 0.00834635
CCL20 chemokine (C-C motif) ligand 20 0.00818137
MARCHF6 membrane associated ring-CH-type finger 6 0.00806882
CA2 carbonic anhydrase II 0.00804988
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00803835
BTG1 B-cell translocation gene 1, anti-proliferative 0.00803232
STC2 stanniocalcin 2 0.00802887
AREG amphiregulin 0.00797729
ISG20 interferon stimulated exonuclease gene 20kDa 0.00793477
HSPA2 heat shock 70kDa protein 2 0.00790136
HILPDA hypoxia inducible lipid droplet-associated 0.00782325
MAP7 microtubule-associated protein 7 0.00781771
IER5 immediate early response 5 0.00778523
SAT1 spermidine/spermine N1-acetyltransferase 1 0.0077554
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.00774511
VEGFA vascular endothelial growth factor A 0.00773899
IPO13 importin 13 0.00771196
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.00761106
INHBA inhibin, beta A 0.00759541
RTN2 reticulon 2 0.00757244
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.00744807
CSTA cystatin A (stefin A) 0.00739999
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00735915
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.00731622
NVL nuclear VCP-like 0.00729927
AKAP9 A kinase (PRKA) anchor protein 9 0.0072317
FKBP11 FK506 binding protein 11, 19 kDa 0.00722592
GOLT1B golgi transport 1B 0.0072248
CREM cAMP responsive element modulator 0.00722133
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00721483
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 0.00719379
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00716477
FMOD fibromodulin 0.00714743
CRABP1 cellular retinoic acid binding protein 1 0.00709025
S100P S100 calcium binding protein P 0.00708612
LUM lumican 0.00707987
EGFL6 EGF-like-domain, multiple 6 0.00707246
SCGB2A1 secretoglobin, family 2A, member 1 0.00704912
CXCL5 chemokine (C-X-C motif) ligand 5 0.00703843
JMJD6 jumonji domain containing 6 0.00695723
COL11A1 collagen, type XI, alpha 1 0.00695405
OPN3 opsin 3 0.00694166
ANKRD12 ankyrin repeat domain 12 0.00693614
STK10 serine/threonine kinase 10 0.00693022
RND3 Rho family GTPase 3 0.00692408
KLHL24 kelch-like family member 24 0.00690554
KRT8 keratin 8, type II 0.0068808
CST6 cystatin E/M 0.0068743
KIN Kin17 DNA and RNA binding protein 0.00686101
CD9 CD9 molecule 0.00685743
KLF6 Kruppel-like factor 6 0.00681247
C3ORF52 chromosome 3 open reading frame 52 0.00680817
SCGB1D2 secretoglobin, family 1D, member 2 0.00678713
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00676742
MAPK1 mitogen-activated protein kinase 1 0.00675511
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00674204
H1-2 H1.2 linker histone, cluster member 0.00673263
KRT18 keratin 18, type I 0.0067247
ITCH itchy E3 ubiquitin protein ligase 0.00672233
ACP1 acid phosphatase 1, soluble 0.00669122
COL9A3 collagen, type IX, alpha 3 0.00667817
SSX1 synovial sarcoma, X breakpoint 1 0.00667093
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.00665826
OSER1 oxidative stress responsive serine-rich 1 0.00664105
TSC22D1 TSC22 domain family, member 1 0.00658373
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.00654744
LPAR1 lysophosphatidic acid receptor 1 0.00653535
EGR3 early growth response 3 0.00652773
CCNE1 cyclin E1 0.0064942
CA12 carbonic anhydrase XII 0.00649063
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.00648992
BIRC3 baculoviral IAP repeat containing 3 0.00646946
SIX2 SIX homeobox 2 0.0064676
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.00644996
G6PD glucose-6-phosphate dehydrogenase 0.00643799
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.00643788
ZNF165 zinc finger protein 165 0.00643106
MAGEA1 melanoma antigen family A1 0.00642285
HOXC10 homeobox C10 0.00640482
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.00639632
MAGEA3 melanoma antigen family A3 0.00638632
PRPF18 pre-mRNA processing factor 18 0.00631854
BTG3 BTG family, member 3 0.00631502
IL6 interleukin 6 0.00626486
UVRAG UV radiation resistance associated 0.00626051
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.00623559
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.00622158
SERTAD2 SERTA domain containing 2 0.00621928
BAG2 BCL2-associated athanogene 2 0.0062165
MED21 mediator complex subunit 21 0.00615844
CLGN calmegin 0.0061284
IDS iduronate 2-sulfatase 0.00612359
SLC38A1 solute carrier family 38, member 1 0.0061101
SULF1 sulfatase 1 0.00610824
DUSP2 dual specificity phosphatase 2 0.00609446
NFIL3 nuclear factor, interleukin 3 regulated 0.00608882
KDM6A lysine (K)-specific demethylase 6A 0.00606637
SUGCT succinyl-CoA:glutarate-CoA transferase 0.00606003
EFHD1 EF-hand domain family, member D1 0.00604502
TANK TRAF family member-associated NFKB activator 0.00603516
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.00603227
RIT1 Ras-like without CAAX 1 0.00603029
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.0060064
CADM1 cell adhesion molecule 1 0.00598773
HIST1H2BK histone cluster 1, H2bk 0.00598094
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.00596647
TNNT1 troponin T type 1 (skeletal, slow) 0.00594039
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.00593726
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.00590769
DNALI1 dynein, axonemal, light intermediate chain 1 0.00590628
SORT1 sortilin 1 0.00588851
AKR1C2 aldo-keto reductase family 1, member C2 0.00585068
AVPI1 arginine vasopressin-induced 1 0.00583074
PREPL prolyl endopeptidase-like 0.00582809
NGDN neuroguidin, EIF4E binding protein 0.00581193
ATP5F1C ATP synthase F1 subunit gamma 0.00580883
PTBP3 polypyrimidine tract binding protein 3 0.00579047
GCH1 GTP cyclohydrolase 1 0.00577709
MOSPD1 motile sperm domain containing 1 0.00577268
YPEL5 yippee-like 5 (Drosophila) 0.00576935
SCG5 secretogranin V 0.00575228
SH3BGR SH3 domain binding glutamate-rich protein 0.00575188
CNTN1 contactin 1 0.00574801
LRRC15 leucine rich repeat containing 15 0.00574268
TFPI2 tissue factor pathway inhibitor 2 0.00574026
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.00573943
MAP1A microtubule-associated protein 1A 0.00572753
PERP PERP, TP53 apoptosis effector 0.00571954
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.00570137
VCAM1 vascular cell adhesion molecule 1 0.00569468
TKTL1 transketolase-like 1 0.00569147
UFD1 ubiquitin recognition factor in ER associated degradation 1 0.00566939
UGT8 UDP glycosyltransferase 8 0.00566697
MOB4 MOB family member 4, phocein 0.00566664
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00565167
KRT23 keratin 23, type I 0.00564209
PFN2 profilin 2 0.0056393
STK26 serine/threonine protein kinase 26 0.0056315
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00562401
DNM1L dynamin 1-like 0.00561157
EREG epiregulin 0.00559221
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.005586
MYO1B myosin IB 0.00558109
STX4 syntaxin 4 0.00557911
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00557723
ALAS2 5'-aminolevulinate synthase 2 0.00557343
GLRX glutaredoxin (thioltransferase) 0.00554945
ZFP36 ZFP36 ring finger protein 0.00554714
PDCD10 programmed cell death 10 0.00553476
OLFML2A olfactomedin-like 2A 0.00552975
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.005527
AKR1C3 aldo-keto reductase family 1, member C3 0.00552634
FOSL2 FOS-like antigen 2 0.00547678
TBCC tubulin folding cofactor C 0.00547315
G0S2 G0/G1 switch 2 0.00546922
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 0.00546428
MMP1 matrix metallopeptidase 1 0.00544248
FRS2 fibroblast growth factor receptor substrate 2 0.0054407
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.0054313
OGA O-GlcNAcase 0.00541901
MBL2 mannose-binding lectin (protein C) 2, soluble 0.00540664
TDP2 tyrosyl-DNA phosphodiesterase 2 0.00539981
CD8A CD8a molecule 0.00539928
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00539732
SMYD3 SET and MYND domain containing 3 0.0053932
NELFE negative elongation factor complex member E 0.00539256
NCAM1 neural cell adhesion molecule 1 0.00538827
GBAP1 glucosidase, beta, acid pseudogene 1 0.0053863
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00538161
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.00537162
GTF2B general transcription factor IIB 0.00537131
RORA RAR-related orphan receptor A 0.00534756
GHITM growth hormone inducible transmembrane protein 0.00534171
ITM2C integral membrane protein 2C 0.00533884
SLC38A2 solute carrier family 38, member 2 0.00533201
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00530872
MAGED2 melanoma antigen family D2 0.00529978
FOXD1 forkhead box D1 0.00529517
PEX13 peroxisomal biogenesis factor 13 0.005295
LGALS8 lectin, galactoside-binding, soluble, 8 0.00529393
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 0.00527734
PELO pelota homolog (Drosophila) 0.00527318
INSL3 insulin-like 3 (Leydig cell) 0.00526648
TSLIG2 tRNA splicing ligase complex subunit 2 0.00525464
COX17 COX17 cytochrome c oxidase copper chaperone 0.00525447
MARS1 methionyl-tRNA synthetase 1 0.00525212
MTX2 metaxin 2 0.00525003
DSTN destrin (actin depolymerizing factor) 0.00524043
AFF4 AF4/FMR2 family, member 4 0.00523401
PLIN2 perilipin 2 0.00523258
SGCE sarcoglycan, epsilon 0.00522664
CLDND1 claudin domain containing 1 0.00522414
TFRC transferrin receptor 0.00521744
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.00519684
IDI1 isopentenyl-diphosphate delta isomerase 1 0.00518823
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.00517176
KLF4 Kruppel-like factor 4 (gut) 0.00516864
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.00516224
MRPL35 mitochondrial ribosomal protein L35 0.00516021
RAB9A RAB9A, member RAS oncogene family 0.00515728
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.00513866
DSG2 desmoglein 2 0.00512738
WDR26 WD repeat domain 26 0.00512726
TMEM50B transmembrane protein 50B 0.00512576
BCL2A1 BCL2-related protein A1 0.00511607
TMEM185B transmembrane protein 185B 0.00510989
USP15 ubiquitin specific peptidase 15 0.00509996
HIRA histone cell cycle regulator 0.00509359
COMMD3 COMM domain containing 3 0.00508304
AGR2 anterior gradient 2 0.00507849
MCL1 myeloid cell leukemia 1 0.0050767
CCDC88A coiled-coil domain containing 88A 0.00506824
CCNG2 cyclin G2 0.00505605
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.00505605
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00504687
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.00504443
EVI2A ecotropic viral integration site 2A 0.00502108
VLDLR very low density lipoprotein receptor 0.00501534
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 0.00501092
CA8 carbonic anhydrase VIII 0.00500475
CSRP2 cysteine and glycine-rich protein 2 0.00500416
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.00500289

decreased expression

Symbol Name Standardized Value
C7 complement component 7 -0.0151889
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0132628
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.0117307
PXDN peroxidasin -0.0116072
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0114708
KDM5D lysine (K)-specific demethylase 5D -0.0113929
CD93 CD93 molecule -0.0113417
CRYBG1 crystallin beta-gamma domain containing 1 -0.0112464
CFI complement factor I -0.0111156
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.0110974
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.0105804
IFRD2 interferon-related developmental regulator 2 -0.0104377
DPYD dihydropyrimidine dehydrogenase -0.0104031
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00996115
C1QB complement component 1, q subcomponent, B chain -0.00989135
IFITM2 interferon induced transmembrane protein 2 -0.00977005
FBP1 fructose-1,6-bisphosphatase 1 -0.00966967
WFS1 Wolfram syndrome 1 (wolframin) -0.00957402
ZMYM2 zinc finger, MYM-type 2 -0.0093683
DPYSL3 dihydropyrimidinase-like 3 -0.00936514
DCXR dicarbonyl/L-xylulose reductase -0.00935378
CXCL14 chemokine (C-X-C motif) ligand 14 -0.00932142
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.00927667
IFITM1 interferon induced transmembrane protein 1 -0.00917236
VWF von Willebrand factor -0.00905292
NFIB nuclear factor I/B -0.0090131
ZBTB20 zinc finger and BTB domain containing 20 -0.00883152
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -0.00865969
F2R coagulation factor II (thrombin) receptor -0.00860231
PRKCA protein kinase C, alpha -0.008535
IFITM3 interferon induced transmembrane protein 3 -0.00844288
BST2 bone marrow stromal cell antigen 2 -0.00842513
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00840833
KIF20A kinesin family member 20A -0.00836448
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) -0.00835104
MGP matrix Gla protein -0.00829773
WWTR1 WW domain containing transcription regulator 1 -0.00822154
RGS5 regulator of G-protein signaling 5 -0.00815796
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.00809098
ABHD2 abhydrolase domain containing 2 -0.00809082
KANK1 KN motif and ankyrin repeat domains 1 -0.00797783
ZMIZ1 zinc finger, MIZ-type containing 1 -0.00791796
DEFB1 defensin, beta 1 -0.0079141
EPAS1 endothelial PAS domain protein 1 -0.00787763
SYBU syntabulin (syntaxin-interacting) -0.00787714
TMEM100 transmembrane protein 100 -0.00781573
PALMD palmdelphin -0.00776815
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -0.00774204
FILIP1L filamin A interacting protein 1-like -0.00772367
MYH10 myosin, heavy chain 10, non-muscle -0.00771353
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.007665
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.00766331
CD163 CD163 molecule -0.00758464
IFI16 interferon, gamma-inducible protein 16 -0.00751305
TRIM22 tripartite motif containing 22 -0.00746841
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.00744663
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.00744385
CCP110 centriolar coiled coil protein 110kDa -0.00744364
ZNF185 zinc finger protein 185 (LIM domain) -0.00742979
ALCAM activated leukocyte cell adhesion molecule -0.00739956
PNMA2 paraneoplastic Ma antigen 2 -0.00737377
KANK2 KN motif and ankyrin repeat domains 2 -0.00734966
SHCBP1 SHC SH2-domain binding protein 1 -0.00733554
PTPRE protein tyrosine phosphatase, receptor type, E -0.00728037
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.00727266
PDZD8 PDZ domain containing 8 -0.00724337
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00723474
TACC1 transforming, acidic coiled-coil containing protein 1 -0.00723148
LMO3 LIM domain only 3 (rhombotin-like 2) -0.00722428
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -0.00719875
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.00718022
MSLN mesothelin -0.00717321
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -0.00717183
LAMA4 laminin, alpha 4 -0.00717129
C1QA complement component 1, q subcomponent, A chain -0.00716146
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -0.00715521
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.00713639
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -0.00713234
C1R complement component 1, r subcomponent -0.00710942
ASF1B anti-silencing function 1B histone chaperone -0.00710391
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.00709241
AK4 adenylate kinase 4 -0.00706528
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00703836
OSBPL3 oxysterol binding protein-like 3 -0.00702924
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.00699833
C4BPA complement component 4 binding protein, alpha -0.00697384
NME4 NME/NM23 nucleoside diphosphate kinase 4 -0.00690497
ACVR1B activin A receptor, type IB -0.00683985
MACF1 microtubule-actin crosslinking factor 1 -0.00681732
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -0.00679466
WDFY3 WD repeat and FYVE domain containing 3 -0.00678912
RGL1 ral guanine nucleotide dissociation stimulator-like 1 -0.00678721
GSTT1 glutathione S-transferase theta 1 -0.00677428
NID1 nidogen 1 -0.00676543
DRAM1 DNA-damage regulated autophagy modulator 1 -0.0066764
PLSCR4 phospholipid scramblase 4 -0.00667476
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.00663717
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -0.00662189
CRISP3 cysteine-rich secretory protein 3 -0.00661557
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0066147
MGLL monoglyceride lipase -0.00661183
SFRP1 secreted frizzled-related protein 1 -0.00660277
FGFR3 fibroblast growth factor receptor 3 -0.00659195
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -0.00656058
MDFIC MyoD family inhibitor domain containing -0.00654376
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.00654317
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -0.00651801
ANOS1 anosmin 1 -0.00647729
PLPBP pyridoxal phosphate binding protein -0.00645982
GBP1 guanylate binding protein 1, interferon-inducible -0.0064574
TNC tenascin C -0.00645728
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -0.00644502
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.00643588
CADPS2 Ca++-dependent secretion activator 2 -0.00643126
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.00642194
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.00642039
KIF14 kinesin family member 14 -0.0064193
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.00640809
KCTD12 potassium channel tetramerization domain containing 12 -0.00637532
HELLS helicase, lymphoid-specific -0.00636625
HEATR1 HEAT repeat containing 1 -0.00635461
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -0.00635006
HOPX HOP homeobox -0.00633605
SHMT1 serine hydroxymethyltransferase 1 (soluble) -0.00633551
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.00630461
ZCCHC24 zinc finger, CCHC domain containing 24 -0.00629184
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.00628366
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.00625975
PBX1 pre-B-cell leukemia homeobox 1 -0.00625398
IFI44L interferon-induced protein 44-like -0.0062353
ETV5 ets variant 5 -0.00623482
LYZ lysozyme -0.00623348
SPAG16 sperm associated antigen 16 -0.00620797
MANSC1 MANSC domain containing 1 -0.00620394
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -0.00620089
ZBTB16 zinc finger and BTB domain containing 16 -0.00619824
PXMP2 peroxisomal membrane protein 2, 22kDa -0.00619337
ACTB actin, beta -0.00617999
DMD dystrophin -0.00616727
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 -0.00613058
ZNF512B zinc finger protein 512B -0.00613031
DAPK1 death-associated protein kinase 1 -0.00612685
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -0.00611898
APOL2 apolipoprotein L, 2 -0.00610391
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.00608907
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00607
ARHGAP6 Rho GTPase activating protein 6 -0.00606703
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.00605818
FSTL1 follistatin-like 1 -0.0060541
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.00604952
OLFM4 olfactomedin 4 -0.00604923
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.00604329
MARCKSL1 MARCKS-like 1 -0.00601381
PLK1 polo-like kinase 1 -0.00596821
CHSY1 chondroitin sulfate synthase 1 -0.00595135
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -0.00594135
PDZK1IP1 PDZK1 interacting protein 1 -0.00593368
FZD6 frizzled class receptor 6 -0.00592747
SRM spermidine synthase -0.00592127
ATP9A ATPase, class II, type 9A -0.00591778
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.00589527
TESC tescalcin -0.00589123
C6 complement component 6 -0.00588651
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -0.00587375
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.00584093
IFI44 interferon-induced protein 44 -0.00582741
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.00582545
LIG1 ligase I, DNA, ATP-dependent -0.00582266
CDCA4 cell division cycle associated 4 -0.00579402
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.00578118
PTK2 protein tyrosine kinase 2 -0.00578097
RPIA ribose 5-phosphate isomerase A -0.00577796
COL5A2 collagen, type V, alpha 2 -0.00577364
MUC4 mucin 4, cell surface associated -0.00575581
IGF1 insulin-like growth factor 1 (somatomedin C) -0.00574682
MTMR11 myotubularin related protein 11 -0.00574211
BGN biglycan -0.00572398
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.00572182
TBC1D4 TBC1 domain family, member 4 -0.00569355
IGFBP5 insulin-like growth factor binding protein 5 -0.00569107
MT1H metallothionein 1H -0.00567383
SORBS3 sorbin and SH3 domain containing 3 -0.0056738
CHPT1 choline phosphotransferase 1 -0.00566402
C2CD5 C2 calcium-dependent domain containing 5 -0.00566129
CBR3 carbonyl reductase 3 -0.00564241
TRIM14 tripartite motif containing 14 -0.00564056
SUB1 SUB1 homolog (S. cerevisiae) -0.00563164
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.00562613
ICAM2 intercellular adhesion molecule 2 -0.0056194
AOX1 aldehyde oxidase 1 -0.00561861
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.00561855
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.00561355
SRPX sushi-repeat containing protein, X-linked -0.00559935
APOL1 apolipoprotein L, 1 -0.00559459
PTCH1 patched 1 -0.00558917
ZC3H13 zinc finger CCCH-type containing 13 -0.00557009
PURA purine-rich element binding protein A -0.0055625
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.00554892
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -0.00554648
HLA-B major histocompatibility complex, class I, B -0.00554214
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -0.00553796
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 -0.0055352
RAB22A RAB22A, member RAS oncogene family -0.0055333
NNMT nicotinamide N-methyltransferase -0.00553125
NPY neuropeptide Y -0.00553069
LMO2 LIM domain only 2 (rhombotin-like 1) -0.00552062
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -0.00551893
LAT2 linker for activation of T cells family, member 2 -0.00551596
ZNF106 zinc finger protein 106 -0.00549594
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.00547513
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -0.00547015
FKTN fukutin -0.0054662
PCTP phosphatidylcholine transfer protein -0.00546318
SNX1 sorting nexin 1 -0.00544901
ICMT isoprenylcysteine carboxyl methyltransferase -0.00544533
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -0.00543583
HNMT histamine N-methyltransferase -0.00542176
LY96 lymphocyte antigen 96 -0.00540633
AQP1 aquaporin 1 (Colton blood group) -0.0054001
ISOC1 isochorismatase domain containing 1 -0.00539802
NAV2 neuron navigator 2 -0.00539306
SPARCL1 SPARC-like 1 (hevin) -0.0053661
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.00535878
LGALS13 lectin, galactoside-binding, soluble, 13 -0.00535595
NCOA2 nuclear receptor coactivator 2 -0.0053514
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -0.00535003
EI24 etoposide induced 2.4 -0.00533145
CP ceruloplasmin (ferroxidase) -0.00532743
ISG15 ISG15 ubiquitin-like modifier -0.00530965
ANXA10 annexin A10 -0.00530524
PLTP phospholipid transfer protein -0.00529874
CFH complement factor H -0.00527877
NCAPG2 non-SMC condensin II complex, subunit G2 -0.00526788
OXCT1 3-oxoacid CoA transferase 1 -0.00526681
RAB21 RAB21, member RAS oncogene family -0.00525742
CTSH cathepsin H -0.00524017
TMEM63A transmembrane protein 63A -0.00523652
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -0.00523131
CCR1 chemokine (C-C motif) receptor 1 -0.00522604
PITPNA phosphatidylinositol transfer protein, alpha -0.0052183
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.00521625
SORBS1 sorbin and SH3 domain containing 1 -0.00520852
TMCC1 transmembrane and coiled-coil domain family 1 -0.00520753
LMNB2 lamin B2 -0.00520242
PER3 period circadian clock 3 -0.00520201
CELF2 CUGBP, Elav-like family member 2 -0.00519569
DCHS1 dachsous cadherin-related 1 -0.0051951
SEC63 SEC63 homolog (S. cerevisiae) -0.0051933
DUOX2 dual oxidase 2 -0.00518744