IRF3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interferon regulatory factor 3|This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 3661)
External Link http://www.ncbi.nlm.nih.gov/gene/3661
Similar Terms
Downloads & Tools

Genes

147 interacting proteins for IRF3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
AGO2 argonaute RISC catalytic component 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ATG9A autophagy related 9A
AZI2 5-azacytidine induced 2
BAX BCL2-associated X protein
C14ORF166 chromosome 14 open reading frame 166
CALCOCO2 calcium binding and coiled-coil domain 2
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD14 CD14 molecule
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CEP55 centrosomal protein 55kDa
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CREBBP CREB binding protein
CUL1 cullin 1
CXCL10 chemokine (C-X-C motif) ligand 10
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEAF1 DEAF1 transcription factor
DTX4 deltex 4, E3 ubiquitin ligase
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A1P5 eukaryotic translation elongation factor 1 alpha 1 pseudogene 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EP300 E1A binding protein p300
EWSR1 EWS RNA-binding protein 1
FMR1 fragile X mental retardation 1
FOXO1 forkhead box O1
FUS FUS RNA binding protein
FXR2 fragile X mental retardation, autosomal homolog 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GOLGA2 golgin A2
GRIP1 glutamate receptor interacting protein 1
GSS glutathione synthetase
HDAC3 histone deacetylase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFI16 interferon, gamma-inducible protein 16
IFIH1 interferon induced with helicase C domain 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KCTD9 potassium channel tetramerization domain containing 9
KHSRP KH-type splicing regulatory protein
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LY96 lymphocyte antigen 96
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAVS mitochondrial antiviral signaling protein
MAX MYC associated factor X
MIB1 mindbomb E3 ubiquitin protein ligase 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPS27 mitochondrial ribosomal protein S27
MTPAP mitochondrial poly(A) polymerase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NLRP4 NLR family, pyrin domain containing 4
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRF1 nuclear respiratory factor 1
NUP62 nucleoporin 62kDa
ONECUT1 one cut homeobox 1
OPTN optineurin
PEX19 peroxisomal biogenesis factor 19
PFKP phosphofructokinase, platelet
PIAS4 protein inhibitor of activated STAT, 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRDX1 peroxiredoxin 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RB1 retinoblastoma 1
RBBP5 retinoblastoma binding protein 5
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF135 ring finger protein 135
RUVBL1 RuvB-like AAA ATPase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOCS1 suppressor of cytokine signaling 1
SUMO2 small ubiquitin-like modifier 2
SYT1 synaptotagmin I
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TCP1 t-complex 1
TFG TRK-fused gene
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMEM109 transmembrane protein 109
TMEM173 transmembrane protein 173
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TRIM25 tripartite motif containing 25
TSGA10 testis specific, 10
TSSC1 tumor suppressing subtransferable candidate 1
TUBA1A tubulin, alpha 1a
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
TXLNA taxilin alpha
UBC ubiquitin C
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WRNIP1 Werner helicase interacting protein 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO5 exportin 5
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBP1 Z-DNA binding protein 1