IRF4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description interferon regulatory factor 4|The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 3662)
External Link http://www.ncbi.nlm.nih.gov/gene/3662
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Genes

24 interacting proteins for IRF4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BATF basic leucine zipper transcription factor, ATF-like
BCL6 B-cell CLL/lymphoma 6
CARM1 coactivator-associated arginine methyltransferase 1
ETV7 ets variant 7
FKBP4 FK506 binding protein 4, 59kDa
HOXB13 homeobox B13
HOXC11 homeobox C11
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IRAK1 interleukin-1 receptor-associated kinase 1
MYD88 myeloid differentiation primary response 88
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
PEG10 paternally expressed 10
PRDM1 PR domain containing 1, with ZNF domain
PROX1 prospero homeobox 1
PRRC2B proline-rich coiled-coil 2B
SPI1 Spi-1 proto-oncogene
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TLK2 tousled-like kinase 2
TOP1 topoisomerase (DNA) I
TRAF2 TNF receptor-associated factor 2
UBC ubiquitin C
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
YTHDC2 YTH domain containing 2