IRF5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description interferon regulatory factor 5|This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 3663)
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Genes

342 genes differentially expressed following the IRF5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RPS11 ribosomal protein S11 2.40249
RAX retina and anterior neural fold homeobox 2.40249
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.40249
HES4 hes family bHLH transcription factor 4 2.40249
UMOD uromodulin 2.40249
NRAP nebulin-related anchoring protein 2.40249
TMEM191B transmembrane protein 191B 2.40249
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.40249
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.40249
GFAP glial fibrillary acidic protein 2.40249
RSPO1 R-spondin 1 2.40249
BTC betacellulin 2.40249
TMEM176A transmembrane protein 176A 2.40249
NKX2-4 NK2 homeobox 4 2.40249
ACTL8 actin-like 8 2.40249
IZUMO1 izumo sperm-egg fusion 1 2.40249
TAS2R3 taste receptor, type 2, member 3 2.40249
ZNF852 zinc finger protein 852 2.40249
GJA5 gap junction protein, alpha 5, 40kDa 2.40249
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.40249
COLEC10 collectin sub-family member 10 (C-type lectin) 2.40249
CD14 CD14 molecule 2.40249
PLIN1 perilipin 1 2.40249
RSPO3 R-spondin 3 2.40249
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.40249
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.40249
FABP12 fatty acid binding protein 12 2.40249
OCSTAMP osteoclast stimulatory transmembrane protein 2.40249
MEIKIN meiotic kinetochore factor 2.40249
CSTL1 cystatin-like 1 2.40249
ADAT3 adenosine deaminase, tRNA-specific 3 2.40249
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.40249
MISP mitotic spindle positioning 2.40249
PRDM13 PR domain containing 13 2.40249
JCHAIN joining chain of multimeric IgA and IgM 2.40249
HMX2 H6 family homeobox 2 2.40249
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.40249
TMEM217 transmembrane protein 217 2.40249
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.40249
NUGGC nuclear GTPase, germinal center associated 2.40249
HCRTR2 hypocretin (orexin) receptor 2 2.40249
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2.40249
TRIM74 tripartite motif containing 74 2.40249
RFPL2 ret finger protein-like 2 2.40249
OTUD6A OTU deubiquitinase 6A 2.40249
RAPSN receptor-associated protein of the synapse 2.40249
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.40249
C3ORF22 chromosome 3 open reading frame 22 2.40249
PBDC1 polysaccharide biosynthesis domain containing 1 2.40249
UROC1 urocanate hydratase 1 2.40249
OR2I1 olfactory receptor family 2 subfamily I member 1 (gene/pseudogene) 2.40249
GBP3 guanylate binding protein 3 2.40249
KY kyphoscoliosis peptidase 2.40249
YIPF7 Yip1 domain family, member 7 2.40249
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.40249
LTB4R2 leukotriene B4 receptor 2 2.40249
ALX3 ALX homeobox 3 2.40249
SPIC Spi-C transcription factor (Spi-1/PU.1 related) 2.40249
TCERG1L transcription elongation regulator 1-like 2.40249
DNAAF1 dynein, axonemal, assembly factor 1 2.40249
FRG2C FSHD region gene 2 family, member C 2.40249
H1-6 H1.6 linker histone, cluster member 2.40249
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.40249
H3Y2 H3.Y histone 2 2.40249
TBC1D3I TBC1 domain family member 3I 2.40249
CPNE8-AS1 CPNE8 antisense RNA 1 2.40249
DUSP13B dual specificity phosphatase 13B 2.40249
INSYN1 inhibitory synaptic factor 1 2.40249
H4C12 H4 clustered histone 12 2.40249
MINDY4B MINDY family member 4B 2.40249
MAJIN membrane anchored junction protein 2.40249
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.40249
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.40249
STX11 syntaxin 11 2.40249
FIMP1 fertilization-influencing membrane protein 1 2.40249
MLN motilin 2.40249
PCDHGC4 protocadherin gamma subfamily C, 4 2.40249
STARD6 StAR-related lipid transfer (START) domain containing 6 2.40249
IL1R1 interleukin 1 receptor, type I 2.40249
C9 complement component 9 2.40249
UTS2 urotensin 2 2.40249
EXOC3L1 exocyst complex component 3-like 1 2.40249
EXOC3L4 exocyst complex component 3-like 4 2.40249
RNF113B ring finger protein 113B 2.40249
CIMIP2C ciliary microtubule inner protein 2C 2.40249
TLR2 toll-like receptor 2 2.40249
ACE2 angiotensin I converting enzyme 2 2.40249
LTK leukocyte receptor tyrosine kinase 2.40249
PROX2 prospero homeobox 2 2.40249
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.40249
TREX2 three prime repair exonuclease 2 2.40249
WNT16 wingless-type MMTV integration site family, member 16 2.40249
MYL10 myosin, light chain 10, regulatory 2.40249
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.40249
C15ORF62 chromosome 15 open reading frame 62 2.40249
LEKR1 leucine, glutamate and lysine rich 1 2.40249
PRDM7 PR domain containing 7 2.40249
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.40249
IL5 interleukin 5 2.40249
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.40249
VAX2 ventral anterior homeobox 2 2.40249
CYSLTR1 cysteinyl leukotriene receptor 1 2.40249
KLF2 Kruppel-like factor 2 2.40249
BPIFB4 BPI fold containing family B, member 4 2.40249
WFDC8 WAP four-disulfide core domain 8 2.40249
CALHM3 calcium homeostasis modulator 3 2.40249
HAVCR1 hepatitis A virus cellular receptor 1 2.40249
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.40249
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.40249
CDH19 cadherin 19, type 2 2.40249
TRIM50 tripartite motif containing 50 2.40249
CXCR5 chemokine (C-X-C motif) receptor 5 2.40249
AQP6 aquaporin 6, kidney specific 2.40249
LRRC43 leucine rich repeat containing 43 2.40249
KRTAP5-11 keratin associated protein 5-11 2.40249
APLNR apelin receptor 2.40249
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.40249
TCEA1 transcription elongation factor A (SII), 1 2.40249
NOG noggin 2.40249
OTC ornithine carbamoyltransferase 2.40249
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.40249
THTPA thiamine triphosphatase 2.40249
AQP8 aquaporin 8 2.40249
TRIM55 tripartite motif containing 55 2.40249
RANBP3L RAN binding protein 3-like 2.40249
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.40249
CHP1 calcineurin-like EF-hand protein 1 2.40249
GSC2 goosecoid homeobox 2 2.40249
IGIP IgA-inducing protein 2.40249
TSPAN16 tetraspanin 16 2.40249
FAIM2 Fas apoptotic inhibitory molecule 2 2.40249
GPR150 G protein-coupled receptor 150 2.40249
ADAM12 ADAM metallopeptidase domain 12 2.40249
CXORF58 chromosome X open reading frame 58 2.40249
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.40249
GOLGA8M golgin A8 family, member M 2.40249
CLEC1A C-type lectin domain family 1, member A 2.40249
CTSS cathepsin S 2.40249
VWA3A von Willebrand factor A domain containing 3A 2.40249
HOPX HOP homeobox 2.40249
EPGN epithelial mitogen 2.40249
KLK5 kallikrein-related peptidase 5 2.40249
SPATA9 spermatogenesis associated 9 2.40249
PRR35 proline rich 35 2.40249
MORN5 MORN repeat containing 5 2.40249
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.40249
NTN5 netrin 5 2.40249
GPR63 G protein-coupled receptor 63 2.40249
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.40249
SYS1 Sys1 golgi trafficking protein 2.40249
AMER2 APC membrane recruitment protein 2 2.40249
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.40249
ADGRF1 adhesion G protein-coupled receptor F1 2.40249
POTEA POTE ankyrin domain family, member A 2.40249
KRTAP13-4 keratin associated protein 13-4 2.40249
GLT6D1 glycosyltransferase 6 domain containing 1 2.40249
AQP1 aquaporin 1 (Colton blood group) 2.40249
DCST1 DC-STAMP domain containing 1 2.40249
SGK2 serum/glucocorticoid regulated kinase 2 2.40249
SOBP sine oculis binding protein homolog (Drosophila) 2.40249
ANGPTL7 angiopoietin-like 7 2.40249
PADI1 peptidyl arginine deiminase, type I 2.40249
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.40249
GREM1 gremlin 1, DAN family BMP antagonist 2.40249
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.40249
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.40249
EIF3A eukaryotic translation initiation factor 3, subunit A 2.40249
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.40249
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.40249
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.40249
SMYD1 SET and MYND domain containing 1 2.40249
NMUR2 neuromedin U receptor 2 2.40249
DUOXA1 dual oxidase maturation factor 1 2.40249
IL12B interleukin 12B 2.40249
NTSR2 neurotensin receptor 2 2.40249
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.40249
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.40249
MC5R melanocortin 5 receptor 2.40249
STMND1 stathmin domain containing 1 2.40249
OLFML2B olfactomedin-like 2B 2.40249
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.40249
TECRL trans-2,3-enoyl-CoA reductase-like 2.40249
NBPF8 neuroblastoma breakpoint family, member 8 2.40249
TCF19 transcription factor 19 2.3756
MARCHF10 membrane associated ring-CH-type finger 10 2.37449
TMEM121 transmembrane protein 121 2.34925
RCSD1 RCSD domain containing 1 2.34925
SPG11 spastic paraplegia 11 (autosomal recessive) 2.34684
STAB2 stabilin 2 2.34684
UBE2Z ubiquitin-conjugating enzyme E2Z 2.33002
DUOX1 dual oxidase 1 2.32003
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.31278
SERP1 stress-associated endoplasmic reticulum protein 1 2.30698
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.30698
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.29568
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.25283
OC90 otoconin 90 2.25058
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 2.21105
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 2.20177
GAS6 growth arrest-specific 6 2.19659
SSR1 signal sequence receptor, alpha 2.1765
GRPR gastrin-releasing peptide receptor 2.17604
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 2.17221
ATF2 activating transcription factor 2 2.16503
MAP3K7 mitogen-activated protein kinase kinase kinase 7 2.16503
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.14823
CPLX2 complexin 2 2.144
GPN1 GPN-loop GTPase 1 2.14075
DYNC2I1 dynein 2 intermediate chain 1 2.1392
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.11609
SLC30A8 solute carrier family 30 (zinc transporter), member 8 2.10648
ZMYM1 zinc finger, MYM-type 1 2.10648
LEMD1 LEM domain containing 1 2.10648
TFDP1 transcription factor Dp-1 2.10648
SAAL1 serum amyloid A-like 1 2.10465
NEXMIF neurite extension and migration factor 2.08771
FBXW11 F-box and WD repeat domain containing 11 2.08771
TBC1D25 TBC1 domain family, member 25 2.05478
SOCS5 suppressor of cytokine signaling 5 2.03295
CETN2 centrin, EF-hand protein, 2 2.01811

decreased expression

Symbol Name Standardized Value
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.40249
FREM1 FRAS1 related extracellular matrix 1 -2.40249
RASA4B RAS p21 protein activator 4B -2.40249
CDNF cerebral dopamine neurotrophic factor -2.40249
GLUD2 glutamate dehydrogenase 2 -2.40249
CD1D CD1d molecule -2.40249
CELF6 CUGBP, Elav-like family member 6 -2.40249
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.40249
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -2.40249
INHBA inhibin, beta A -2.40249
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 -2.40249
TEF thyrotrophic embryonic factor -2.40249
MEF2A myocyte enhancer factor 2A -2.40249
SHD Src homology 2 domain containing transforming protein D -2.40249
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -2.40249
RGPD8 RANBP2-like and GRIP domain containing 8 -2.40249
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.40249
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -2.40249
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.40249
HAS1 hyaluronan synthase 1 -2.40249
CA4 carbonic anhydrase IV -2.40249
NEU4 sialidase 4 -2.40249
KLHL34 kelch-like family member 34 -2.40249
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.40249
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -2.40249
SMPX small muscle protein, X-linked -2.40249
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.40249
ALX4 ALX homeobox 4 -2.40249
RAG2 recombination activating gene 2 -2.40249
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.40249
H1-5 H1.5 linker histone, cluster member -2.40249
AJM1 apical junction component 1 homolog -2.40249
PHAF1 phagosome assembly factor 1 -2.40249
ERFE erythroferrone -2.40249
DOK7 docking protein 7 -2.40249
COL13A1 collagen, type XIII, alpha 1 -2.40249
HNF1B HNF1 homeobox B -2.40249
PCDHA9 protocadherin alpha 9 -2.40249
CFAP99 cilia and flagella associated protein 99 -2.40249
LTBP3 latent transforming growth factor beta binding protein 3 -2.40249
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.40249
CRLF2 cytokine receptor-like factor 2 -2.40249
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -2.40249
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -2.40249
SASH1 SAM and SH3 domain containing 1 -2.40249
PP2D1 protein phosphatase 2C-like domain containing 1 -2.40249
RSKR ribosomal protein S6 kinase related -2.40249
SPX spexin hormone -2.40249
FGF18 fibroblast growth factor 18 -2.40249
RAD21L1 RAD21-like 1 (S. pombe) -2.40249
BAIAP3 BAI1-associated protein 3 -2.40249
ALAS2 5'-aminolevulinate synthase 2 -2.40249
HDLBP high density lipoprotein binding protein -2.40249
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.40249
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.40249
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -2.40249
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -2.40249
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -2.40249
NLRC3 NLR family, CARD domain containing 3 -2.40249
LCN2 lipocalin 2 -2.40249
WNT2 wingless-type MMTV integration site family member 2 -2.40249
KLK14 kallikrein-related peptidase 14 -2.40249
PCDH12 protocadherin 12 -2.40249
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.40249
PCDHGA8 protocadherin gamma subfamily A, 8 -2.40249
PCDHGA4 protocadherin gamma subfamily A, 4 -2.40249
TBXA2R thromboxane A2 receptor -2.40249
FAM209A family with sequence similarity 209, member A -2.40249
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -2.40249
PPL periplakin -2.40249
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -2.40249
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.40249
VWC2L von Willebrand factor C domain containing protein 2-like -2.40249
SLC45A1 solute carrier family 45, member 1 -2.40249
RHOV ras homolog family member V -2.40249
NLRP2 NLR family, pyrin domain containing 2 -2.40249
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 -2.40249
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -2.40249
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.39296
VENTX VENT homeobox -2.39296
DKC1 dyskeratosis congenita 1, dyskerin -2.38876
TMEM178A transmembrane protein 178A -2.38266
UNC45A unc-45 homolog A (C. elegans) -2.37449
CREBZF CREB/ATF bZIP transcription factor -2.35189
HPS4 Hermansky-Pudlak syndrome 4 -2.34934
SDE2 SDE2 telomere maintenance homolog (S. pombe) -2.3438
EHBP1L1 EH domain binding protein 1-like 1 -2.33781
THOC6 THO complex 6 -2.30265
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13 -2.29535
PILRA paired immunoglobin-like type 2 receptor alpha -2.28853
HMGN4 high mobility group nucleosomal binding domain 4 -2.28433
HLA-DMA major histocompatibility complex, class II, DM alpha -2.24596
MCL1 myeloid cell leukemia 1 -2.24327
ZNF526 zinc finger protein 526 -2.23071
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.18054
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.17662
TSC22D1 TSC22 domain family, member 1 -2.17662
DPYSL4 dihydropyrimidinase-like 4 -2.11848
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -2.11848
TEX22 testis expressed 22 -2.10931
FHIP2A FHF complex subunit HOOK interacting protein 2A -2.10822
ELK1 ELK1, member of ETS oncogene family -2.10648
ZAN zonadhesin (gene/pseudogene) -2.08771
CD37 CD37 molecule -2.08771
MTRF1L mitochondrial translational release factor 1-like -2.08771
GP6 glycoprotein VI (platelet) -2.08771
METTL4 methyltransferase like 4 -2.08771
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -2.08107
OXLD1 oxidoreductase-like domain containing 1 -2.08107
ZC3H18 zinc finger CCCH-type containing 18 -2.07597
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.07597
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit -2.05099
NPIPB2 nuclear pore complex interacting protein family member B2 -2.04659
TMT1B thiol methyltransferase 1B -2.03764
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 -2.03764
FLT4 fms-related tyrosine kinase 4 -2.03764
ANKRD40 ankyrin repeat domain 40 -2.02662
TMEM167A transmembrane protein 167A -2.00913
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) -2.00873
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -2.00873
NPAT nuclear protein, ataxia-telangiectasia locus -2.00873
RTN3 reticulon 3 -2.00854