IRF7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description interferon regulatory factor 7|IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3665)
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Genes

288 genes differentially expressed following the IRF7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LIPJ lipase, family member J 2.31248
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.31248
GJA10 gap junction protein, alpha 10, 62kDa 2.31248
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.31248
APOA2 apolipoprotein A-II 2.31248
XCL1 chemokine (C motif) ligand 1 2.31248
OLFM4 olfactomedin 4 2.31248
TUBB8 tubulin, beta 8 class VIII 2.31248
TLX2 T-cell leukemia homeobox 2 2.31248
SSTR5 somatostatin receptor 5 2.31248
UPB1 ureidopropionase, beta 2.31248
C5ORF63 chromosome 5 open reading frame 63 2.31248
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.31248
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.31248
COL4A2 collagen, type IV, alpha 2 2.31248
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.31248
FGF21 fibroblast growth factor 21 2.31248
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.31248
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.31248
IL22RA1 interleukin 22 receptor, alpha 1 2.31248
SPINK4 serine peptidase inhibitor, Kazal type 4 2.31248
ADAD2 adenosine deaminase domain containing 2 2.31248
CA6 carbonic anhydrase VI 2.31248
ARSF arylsulfatase F 2.31248
PRDM12 PR domain containing 12 2.31248
MRC1 mannose receptor, C type 1 2.31248
ETV2 ets variant 2 2.31248
RXRG retinoid X receptor, gamma 2.31248
IL23R interleukin 23 receptor 2.31248
TPRX1 tetra-peptide repeat homeobox 1 2.31248
FAM81B family with sequence similarity 81, member B 2.31248
CTAG2 cancer/testis antigen 2 2.31248
GRM4 glutamate receptor, metabotropic 4 2.31248
MPO myeloperoxidase 2.31248
KRT77 keratin 77, type II 2.31248
SP7 Sp7 transcription factor 2.31248
OTUD6A OTU deubiquitinase 6A 2.31248
TRAT1 T cell receptor associated transmembrane adaptor 1 2.31248
BAAT bile acid CoA:amino acid N-acyltransferase 2.31248
FSCN2 fascin actin-bundling protein 2, retinal 2.31248
DCP1B decapping mRNA 1B 2.31248
CRX cone-rod homeobox 2.31248
SOWAHB sosondowah ankyrin repeat domain family member B 2.31248
WNT8B wingless-type MMTV integration site family, member 8B 2.31248
FXYD3 FXYD domain containing ion transport regulator 3 2.31248
CD300LG CD300 molecule-like family member g 2.31248
C3ORF85 chromosome 3 open reading frame 85 2.31248
MEIOSIN meiosis initiator 2.31248
H2AC1 H2A clustered histone 1 2.31248
DIPK1C divergent protein kinase domain 1C 2.31248
MINAR2 membrane integral NOTCH2 associated receptor 2 2.31248
LORICRIN loricrin cornified envelope precursor protein 2.31248
DERPC DERPC proline and glycine rich nuclear protein 2.31248
CCDC9B coiled-coil domain containing 9B 2.31248
VSIR V-set immunoregulatory receptor 2.31248
GBP2 guanylate binding protein 2, interferon-inducible 2.31248
STPG3 sperm-tail PG-rich repeat containing 3 2.31248
SERTM2 serine rich and transmembrane domain containing 2 2.31248
PNMA6F PNMA family member 6F 2.31248
TBC1D3I TBC1 domain family member 3I 2.31248
EXOC1L exocyst complex component 1 like 2.31248
DPEP2NB DPEP2 neighbor 2.31248
LRRC8C-DT LRRC8C divergent transcript 2.31248
CIMAP1C ciliary microtubule associated protein 1C 2.31248
TMA7B translation machinery associated 7 homolog B 2.31248
SMIM43 small integral membrane protein 43 2.31248
SMIM35 small integral membrane protein 35 2.31248
LTB4R2 leukotriene B4 receptor 2 2.31248
CD300LF CD300 molecule-like family member f 2.31248
DNAAF1 dynein, axonemal, assembly factor 1 2.31248
RGS21 regulator of G-protein signaling 21 2.31248
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 2.31248
TFEC transcription factor EC 2.31248
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.31248
GOLGA6L4 golgin A6 family-like 4 2.31248
LOC107986837 uncharacterized LOC107986837 2.31248
CCR6 chemokine (C-C motif) receptor 6 2.31248
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.31248
PCDHB14 protocadherin beta 14 2.31248
UTS2 urotensin 2 2.31248
C7 complement component 7 2.31248
IQCF3 IQ motif containing F3 2.31248
SMPX small muscle protein, X-linked 2.31248
FCMR Fc fragment of IgM receptor 2.31248
LY6H lymphocyte antigen 6 complex, locus H 2.31248
LY6K lymphocyte antigen 6 complex, locus K 2.31248
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.31248
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.31248
NDP Norrie disease (pseudoglioma) 2.31248
ZG16B zymogen granule protein 16B 2.31248
FOXD1 forkhead box D1 2.31248
GLOD5 glyoxalase domain containing 5 2.31248
RANBP3L RAN binding protein 3-like 2.31248
C22ORF42 chromosome 22 open reading frame 42 2.31248
ISL1 ISL LIM homeobox 1 2.31248
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.31248
EGR2 early growth response 2 2.31248
C20ORF144 chromosome 20 open reading frame 144 2.31248
ZNF843 zinc finger protein 843 2.31248
TBX1 T-box 1 2.31248
PRR35 proline rich 35 2.31248
MAB21L3 mab-21-like 3 (C. elegans) 2.31248
IL36R interleukin 36 receptor 2.31248
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.31248
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.31248
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.31248
SPINK9 serine peptidase inhibitor, Kazal type 9 2.31248
BHMT betaine--homocysteine S-methyltransferase 2.31248
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 2.31248
SPATA3 spermatogenesis associated 3 2.31248
CDH10 cadherin 10, type 2 (T2-cadherin) 2.31248
PAGE4 P antigen family, member 4 (prostate associated) 2.31248
TPPP3 tubulin polymerization-promoting protein family member 3 2.31248
INSM1 insulinoma-associated 1 2.31248
MEPE matrix extracellular phosphoglycoprotein 2.31248
PCNT pericentrin 2.31248
FKBP1C FK506 binding protein 1C 2.31248
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.31248
SYT5 synaptotagmin V 2.31248
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.31248
GOLGA8K golgin A8 family, member K 2.31248
GOLGA8R golgin A8 family, member R 2.31248
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.31248
OTP orthopedia homeobox 2.31248
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.31248
CTSW cathepsin W 2.31248
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.31248
CD28 CD28 molecule 2.31248
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.31248
CLEC1A C-type lectin domain family 1, member A 2.31248
LEUTX leucine twenty homeobox 2.31248
ZNF383 zinc finger protein 383 2.31248
FAIM2 Fas apoptotic inhibitory molecule 2 2.31248
PLA2G2C phospholipase A2, group IIC 2.31248
MZB1 marginal zone B and B1 cell-specific protein 2.31248
CTAGE4 CTAGE family, member 4 2.31248
PITX3 paired-like homeodomain 3 2.31248
GABPB2 GA binding protein transcription factor, beta subunit 2 2.31248
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.31248
LIMS3 LIM and senescent cell antigen-like domains 3 2.31248
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 2.31248
KIF4B kinesin family member 4B 2.31248
ELANE elastase, neutrophil expressed 2.31248
KRT15 keratin 15, type I 2.31248
CPO carboxypeptidase O 2.31248
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.31248
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.31248
CD80 CD80 molecule 2.31248
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.31248
MMP19 matrix metallopeptidase 19 2.31248
TNS2 tensin 2 2.31248
TAS2R46 taste receptor, type 2, member 46 2.31248
TEX35 testis expressed 35 2.31248
TMPRSS13 transmembrane protease, serine 13 2.31248
FOXP3 forkhead box P3 2.31248
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.31248
PHOSPHO1 phosphatase, orphan 1 2.31248
HCRT hypocretin (orexin) neuropeptide precursor 2.31248
HBE1 hemoglobin, epsilon 1 2.31248
CRYBB2 crystallin, beta B2 2.31248
RETNLB resistin like beta 2.31248
ANKRD30BL ankyrin repeat domain 30B-like 2.31248
MR1 major histocompatibility complex, class I-related 2.31248
CSTA cystatin A (stefin A) 2.31248
FATE1 fetal and adult testis expressed 1 2.31248
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.31248
ZNF132 zinc finger protein 132 2.31248
APOD apolipoprotein D 2.31248
CERKL ceramide kinase-like 2.31248
SCAF11 SR-related CTD-associated factor 11 2.27479
TSPAN14 tetraspanin 14 2.27479
FZD9 frizzled class receptor 9 2.27479
XKRX XK, Kell blood group complex subunit-related, X-linked 2.27479
XK X-linked Kx blood group 2.27479
TMEM117 transmembrane protein 117 2.25265
BMERB1 bMERB domain containing 1 2.24788
AMER3 APC membrane recruitment protein 3 2.2478
RNF213 ring finger protein 213 2.22772
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 2.22772
RTN1 reticulon 1 2.22079
ZER1 zyg-11 related, cell cycle regulator 2.20089
PWWP3A PWWP domain containing 3A, DNA repair factor 2.20029
SFT2D1 SFT2 domain containing 1 2.15722
CES2 carboxylesterase 2 2.15605
SYMPK symplekin 2.14626
NCLN nicalin 2.14626
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 2.13868
PTGFRN prostaglandin F2 receptor inhibitor 2.13321
ZBTB32 zinc finger and BTB domain containing 32 2.12933
COMMD10 COMM domain containing 10 2.09336
KSR2 kinase suppressor of ras 2 2.07456
POMZP3 POM121 and ZP3 fusion 2.06068
GEMIN7 gem (nuclear organelle) associated protein 7 2.05504
REEP2 receptor accessory protein 2 2.02627
MARCKS myristoylated alanine-rich protein kinase C substrate 2.01757
CENPX centromere protein X 2.00144

decreased expression

Symbol Name Standardized Value
DGKI diacylglycerol kinase, iota -2.31248
PDZD7 PDZ domain containing 7 -2.31248
ECEL1 endothelin converting enzyme-like 1 -2.31248
CARD10 caspase recruitment domain family, member 10 -2.31248
G0S2 G0/G1 switch 2 -2.31248
ZSCAN2 zinc finger and SCAN domain containing 2 -2.31248
APP amyloid beta (A4) precursor protein -2.31248
PANX2 pannexin 2 -2.31248
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 -2.31248
EXOSC9 exosome component 9 -2.31248
TSHR thyroid stimulating hormone receptor -2.31248
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.31248
KRTAP13-4 keratin associated protein 13-4 -2.31248
CMTR1 cap methyltransferase 1 -2.31248
POLK polymerase (DNA directed) kappa -2.31248
TMEM81 transmembrane protein 81 -2.31248
PGM2 phosphoglucomutase 2 -2.31248
ANKRD7 ankyrin repeat domain 7 -2.31248
PLA2G15 phospholipase A2, group XV -2.31248
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -2.31248
CGNL1 cingulin-like 1 -2.31248
TMEM69 transmembrane protein 69 -2.31248
FKBP11 FK506 binding protein 11, 19 kDa -2.31248
MUCL3 mucin like 3 -2.31248
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.31248
COL6A1 collagen, type VI, alpha 1 -2.31248
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.31248
ZNF221 zinc finger protein 221 -2.31248
TTC17 tetratricopeptide repeat domain 17 -2.31248
UBE2J2 ubiquitin-conjugating enzyme E2, J2 -2.31248
GNL1 guanine nucleotide binding protein-like 1 -2.31248
XG Xg blood group -2.31248
ZDHHC9 zinc finger, DHHC-type containing 9 -2.30034
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.29414
CHD8 chromodomain helicase DNA binding protein 8 -2.29197
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.27479
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.27479
SCN10A sodium channel, voltage gated, type X alpha subunit -2.27479
NOTCH2NLB notch 2 N-terminal like B -2.27479
C7ORF57 chromosome 7 open reading frame 57 -2.27479
FBLN7 fibulin 7 -2.27479
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.27479
SMIM38 small integral membrane protein 38 -2.27479
C11ORF86 chromosome 11 open reading frame 86 -2.27479
KLHL35 kelch-like family member 35 -2.27479
XKR3 XK, Kell blood group complex subunit-related family, member 3 -2.27479
REP15 RAB15 effector protein -2.27479
PLAAT4 phospholipase A and acyltransferase 4 -2.27479
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.27479
S100A14 S100 calcium binding protein A14 -2.27479
HSPB9 heat shock protein, alpha-crystallin-related, B9 -2.27479
COL17A1 collagen, type XVII, alpha 1 -2.27479
SAMD7 sterile alpha motif domain containing 7 -2.27479
TDRD10 tudor domain containing 10 -2.27479
TMEM31 transmembrane protein 31 -2.27479
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.27479
TCAP titin-cap -2.27479
SF1 splicing factor 1 -2.27479
KLF1 Kruppel-like factor 1 (erythroid) -2.27479
VPREB3 pre-B lymphocyte 3 -2.27479
ADGRA2 adhesion G protein-coupled receptor A2 -2.27479
FMN1 formin 1 -2.25324
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.23911
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide -2.22772
TTYH2 tweety family member 2 -2.22643
HMGN1 high mobility group nucleosome binding domain 1 -2.19437
CCK cholecystokinin -2.15722
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.15722
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.15722
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.15722
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -2.15605
DDHD1 DDHD domain containing 1 -2.15605
GAS2L3 growth arrest-specific 2 like 3 -2.14626
IP6K2 inositol hexakisphosphate kinase 2 -2.14626
SGK3 serum/glucocorticoid regulated kinase family, member 3 -2.14626
ZNF675 zinc finger protein 675 -2.13868
BBS12 Bardet-Biedl syndrome 12 -2.10039
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -2.095
ARF5 ADP-ribosylation factor 5 -2.09125
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.07072
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -2.06068
PKLR pyruvate kinase, liver and RBC -2.06068
TLR3 toll-like receptor 3 -2.06068
SPON1 spondin 1, extracellular matrix protein -2.06063
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.06063
REPS1 RALBP1 associated Eps domain containing 1 -2.04797
FASTK Fas-activated serine/threonine kinase -2.04682
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.02627
TYW2 tRNA wybutosine-synthesizing protein 2 -2.02483
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.01645
CDC42SE1 CDC42 small effector 1 -2.015
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.00773