IRF8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description interferon regulatory factor 8|Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3394)
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Genes

274 genes differentially expressed following the IRF8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DKK2 dickkopf WNT signaling pathway inhibitor 2 3.1051
SHCBP1L SHC SH2-domain binding protein 1-like 3.1051
XCL1 chemokine (C motif) ligand 1 3.1051
MSC musculin 3.1051
DMRTC1B DMRT-like family C1B 3.1051
SLC16A6 solute carrier family 16, member 6 3.1051
LRRC52 leucine rich repeat containing 52 3.1051
ACVR1C activin A receptor, type IC 3.1051
PDYN prodynorphin 3.1051
NXPH4 neurexophilin 4 3.1051
ALOX15 arachidonate 15-lipoxygenase 3.1051
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.1051
USP26 ubiquitin specific peptidase 26 3.1051
FAM167B family with sequence similarity 167, member B 3.1051
CARD18 caspase recruitment domain family, member 18 3.1051
FGF23 fibroblast growth factor 23 3.1051
FGF21 fibroblast growth factor 21 3.1051
LRRD1 leucine-rich repeats and death domain containing 1 3.1051
CA1 carbonic anhydrase I 3.1051
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.1051
TPSD1 tryptase delta 1 3.1051
CD226 CD226 molecule 3.1051
PSD2 pleckstrin and Sec7 domain containing 2 3.1051
TSHR thyroid stimulating hormone receptor 3.1051
METTL21C methyltransferase like 21C 3.1051
CCDC83 coiled-coil domain containing 83 3.1051
LEP leptin 3.1051
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.1051
SLC10A4 solute carrier family 10, member 4 3.1051
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.1051
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.1051
CRYGC crystallin, gamma C 3.1051
MISP mitotic spindle positioning 3.1051
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.1051
TMEM89 transmembrane protein 89 3.1051
PRSS36 protease, serine, 36 3.1051
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.1051
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.1051
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.1051
ZNF285 zinc finger protein 285 3.1051
FOLR1 folate receptor 1 (adult) 3.1051
FMO1 flavin containing monooxygenase 1 3.1051
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.1051
CLDN16 claudin 16 3.1051
CLDN18 claudin 18 3.1051
OTOF otoferlin 3.1051
BNIP5 BCL2 interacting protein 5 3.1051
CFAP97D1 CFAP97 domain containing 1 3.1051
TEX13C TEX13 family member C 3.1051
TEX13D TEX13 family member D 3.1051
H2BC8 H2B clustered histone 8 3.1051
LOC122526780 uncharacterized LOC122526780 3.1051
LINC02798 long intergenic non-protein coding RNA 2798 3.1051
SPEGNB SPEG neighbor 3.1051
EPCIP exosomal polycystin 1 interacting protein 3.1051
SPMIP10 sperm microtubule inner protein 10 3.1051
CIMIP2B ciliary microtubule inner protein 2B 3.1051
SPMAP2L sperm microtubule associated protein 2 like 3.1051
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.1051
ANO3 anoctamin 3 3.1051
ACSL5 acyl-CoA synthetase long-chain family member 5 3.1051
SIX2 SIX homeobox 2 3.1051
COL19A1 collagen, type XIX, alpha 1 3.1051
WEE2 WEE1 homolog 2 (S. pombe) 3.1051
CATSPERH catsper channel auxiliary subunit eta 3.1051
PCDHA3 protocadherin alpha 3 3.1051
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.1051
ITK IL2-inducible T-cell kinase 3.1051
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 3.1051
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.1051
NPNT nephronectin 3.1051
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.1051
MYOT myotilin 3.1051
EXOC3L1 exocyst complex component 3-like 1 3.1051
IL1R2 interleukin 1 receptor, type II 3.1051
GPR132 G protein-coupled receptor 132 3.1051
HNF1B HNF1 homeobox B 3.1051
TMEM190 transmembrane protein 190 3.1051
GOLGA6L25 golgin A6 family like 25 3.1051
IL33 interleukin 33 3.1051
GSDMA gasdermin A 3.1051
KLF4 Kruppel-like factor 4 (gut) 3.1051
TBC1D10C TBC1 domain family, member 10C 3.1051
MRAP melanocortin 2 receptor accessory protein 3.1051
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.1051
MUCL1 mucin-like 1 3.1051
MUC15 mucin 15, cell surface associated 3.1051
ALOXE3 arachidonate lipoxygenase 3 3.1051
VWA3A von Willebrand factor A domain containing 3A 3.1051
FAM163A family with sequence similarity 163, member A 3.1051
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.1051
KRTAP5-11 keratin associated protein 5-11 3.1051
APLNR apelin receptor 3.1051
IGFBP7 insulin-like growth factor binding protein 7 3.1051
OTC ornithine carbamoyltransferase 3.1051
ZDHHC11B zinc finger, DHHC-type containing 11B 3.1051
HHLA2 HERV-H LTR-associating 2 3.1051
DPRX divergent-paired related homeobox 3.1051
CTAGE9 CTAGE family, member 9 3.1051
C8ORF89 chromosome 8 open reading frame 89 3.1051
KLK12 kallikrein-related peptidase 12 3.1051
HLA-G major histocompatibility complex, class I, G 3.1051
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.1051
ADCY4 adenylate cyclase 4 3.1051
CPN2 carboxypeptidase N, polypeptide 2 3.1051
ETV3L ets variant 3-like 3.1051
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.1051
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.1051
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.1051
RBBP8NL RBBP8 N-terminal like 3.1051
MOBP myelin-associated oligodendrocyte basic protein 3.1051
FBXO43 F-box protein 43 3.1051
CFAP47 cilia and flagella associated protein 47 3.1051
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.1051
CRHBP corticotropin releasing hormone binding protein 3.1051
SDS serine dehydratase 3.1051
INSM1 insulinoma-associated 1 3.1051
HAND2 heart and neural crest derivatives expressed 2 3.1051
LYPD5 LY6/PLAUR domain containing 5 3.1051
MAGEA2B melanoma antigen family A2B 3.1051
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.1051
PRRX1 paired related homeobox 1 3.1051
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.1051
LST1 leukocyte specific transcript 1 3.1051
EPN3 epsin 3 3.1051
LRRC74B leucine rich repeat containing 74B 3.1051
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.1051
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.1051
LRRC38 leucine rich repeat containing 38 3.1051
TMEM45B transmembrane protein 45B 3.1051
ITPKA inositol-trisphosphate 3-kinase A 3.1051
POTEJ POTE ankyrin domain family, member J 3.1051
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.1051
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.1051
OR11G2 olfactory receptor, family 11, subfamily G, member 2 3.1051
PAQR6 progestin and adipoQ receptor family member VI 3.1051
ALAS2 5'-aminolevulinate synthase 2 3.1051
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.1051
TMEM215 transmembrane protein 215 3.1051
CIDEA cell death-inducing DFFA-like effector a 3.1051
MST1 macrophage stimulating 1 3.1051
ACKR2 atypical chemokine receptor 2 3.1051
TMEM86A transmembrane protein 86A 3.1051
ADIRF adipogenesis regulatory factor 3.1051
SP100 SP100 nuclear antigen 3.1051
CHAD chondroadherin 3.1051
AMER2 APC membrane recruitment protein 2 3.1051
SPEF2 sperm flagellar 2 2.73932
NOL12 nucleolar protein 12 2.71005
NOP14 NOP14 nucleolar protein 2.63871
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.61346
FADS2 fatty acid desaturase 2 2.584
SP140 SP140 nuclear body protein 2.55059
LINS1 lines homolog 1 2.47993
LEMD2 LEM domain containing 2 2.47236
GREP1 glycine rich extracellular protein 1 2.43498
ERBB4 erb-b2 receptor tyrosine kinase 4 2.41868
MYADML2 myeloid-associated differentiation marker-like 2 2.36124
GMFG glia maturation factor, gamma 2.36124
INMT indolethylamine N-methyltransferase 2.31877
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.31877
RTN4IP1 reticulon 4 interacting protein 1 2.31107
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.29982
ENDOV endonuclease V 2.28093
CFL2 cofilin 2 (muscle) 2.18455
CMC4 C-x(9)-C motif containing 4 2.14824
EEIG2 EEIG family member 2 2.14524
OVCH1 ovochymase 1 2.14504
OSBPL7 oxysterol binding protein-like 7 2.14504
GLIS3 GLIS family zinc finger 3 2.1352
WDR4 WD repeat domain 4 2.13272
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2.11917
NT5M 5',3'-nucleotidase, mitochondrial 2.10215
TTC38 tetratricopeptide repeat domain 38 2.07847
MYO1C myosin IC 2.07754
SF3B1 splicing factor 3b, subunit 1, 155kDa 2.05682
IDNK idnK, gluconokinase homolog (E. coli) 2.05682
GPM6B glycoprotein M6B 2.05673
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.03035
MID1IP1 MID1 interacting protein 1 2.01967
STK39 serine threonine kinase 39 2.01066

decreased expression

Symbol Name Standardized Value
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.1051
DERL1 derlin 1 -3.1051
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -3.1051
GRM2 glutamate receptor, metabotropic 2 -3.1051
DCST1 DC-STAMP domain containing 1 -3.1051
ADGRG1 adhesion G protein-coupled receptor G1 -3.1051
ACAN aggrecan -3.1051
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -3.1051
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -3.1051
BARX1 BARX homeobox 1 -3.1051
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -3.1051
NPIPA5 nuclear pore complex interacting protein family, member A5 -3.1051
FOXJ1 forkhead box J1 -3.1051
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -3.1051
NIPSNAP3B nipsnap homolog 3B (C. elegans) -3.1051
AKAP5 A kinase (PRKA) anchor protein 5 -3.1051
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -3.1051
FNDC7 fibronectin type III domain containing 7 -3.1051
TLE6 transducin-like enhancer of split 6 -3.1051
SHISA7 shisa family member 7 -3.1051
KCNIP2 Kv channel interacting protein 2 -3.1051
YY2 YY2 transcription factor -3.1051
RBM46 RNA binding motif protein 46 -3.1051
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -3.1051
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -3.1051
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -3.1051
H4C14 H4 clustered histone 14 -3.1051
MROH9 maestro heat-like repeat family member 9 -3.1051
DENND1C DENN/MADD domain containing 1C -3.1051
LRRC19 leucine rich repeat containing 19 -3.1051
H4C11 H4 clustered histone 11 -3.1051
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -3.1051
ZNF835 zinc finger protein 835 -3.1051
CCDC194 coiled-coil domain containing 194 -3.1051
FAM50A family with sequence similarity 50, member A -3.1051
ABHD15 abhydrolase domain containing 15 -3.1051
CNOT10 CCR4-NOT transcription complex, subunit 10 -3.1051
NGFR nerve growth factor receptor -3.1051
ELN elastin -3.1051
MINDY1 MINDY lysine 48 deubiquitinase 1 -3.1051
MARCHF8 membrane associated ring-CH-type finger 8 -2.99921
CERCAM cerebral endothelial cell adhesion molecule -2.99921
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 -2.81055
LARP4B La ribonucleoprotein domain family, member 4B -2.67405
PNMA8A PNMA family member 8A -2.65784
RTP1 receptor (chemosensory) transporter protein 1 -2.62942
DENND3 DENN/MADD domain containing 3 -2.59875
LMO2 LIM domain only 2 (rhombotin-like 1) -2.56132
C2CD4C C2 calcium-dependent domain containing 4C -2.56132
METTL8 methyltransferase like 8 -2.54319
PCDHB16 protocadherin beta 16 -2.47236
CEP85 centrosomal protein 85kDa -2.47236
TMED2 transmembrane emp24 domain trafficking protein 2 -2.47236
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.47236
FNDC5 fibronectin type III domain containing 5 -2.47236
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -2.46366
LIPA lipase A, lysosomal acid, cholesterol esterase -2.43498
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.36076
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.36076
GET1 guided entry of tail-anchored proteins factor 1 -2.36076
MFSD1 major facilitator superfamily domain containing 1 -2.33502
MYO5C myosin VC -2.31729
LSM11 LSM11, U7 small nuclear RNA associated -2.30955
TMEM200B transmembrane protein 200B -2.30955
METTL4 methyltransferase like 4 -2.30955
B3GLCT beta 3-glucosyltransferase -2.29464
TMEM154 transmembrane protein 154 -2.29353
ACBD4 acyl-CoA binding domain containing 4 -2.28477
NOMO1 NODAL modulator 1 -2.28041
S1PR1 sphingosine-1-phosphate receptor 1 -2.25096
TMEM33 transmembrane protein 33 -2.25096
SPMIP4 sperm microtubule inner protein 4 -2.25096
ATG7 autophagy related 7 -2.16634
STOX2 storkhead box 2 -2.156
MIB1 mindbomb E3 ubiquitin protein ligase 1 -2.1555
CCDC142 coiled-coil domain containing 142 -2.14853
KIAA1549L KIAA1549-like -2.14853
PDLIM5 PDZ and LIM domain 5 -2.14611
FAM161A family with sequence similarity 161, member A -2.14539
VWA1 von Willebrand factor A domain containing 1 -2.11062
SH2D3C SH2 domain containing 3C -2.09309
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.0923
CCDC124 coiled-coil domain containing 124 -2.08857
HEXIM2 hexamethylene bis-acetamide inducible 2 -2.07773
MFAP1 microfibrillar-associated protein 1 -2.07773
SFMBT1 Scm-like with four mbt domains 1 -2.06985
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 -2.0696
FAM3C family with sequence similarity 3, member C -2.06193
PCED1A PC-esterase domain containing 1A -2.05682
MRPL30 mitochondrial ribosomal protein L30 -2.05682
RAB37 RAB37, member RAS oncogene family -2.01962
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 -2.01913
ELOVL2 ELOVL fatty acid elongase 2 -2.00307