IRS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description insulin receptor substrate 1|This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] (NCBI Entrez Gene Database, 3667)
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Genes

279 genes differentially expressed following the IRS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PSD2 pleckstrin and Sec7 domain containing 2 2.3351
PADI2 peptidyl arginine deiminase, type II 2.3351
SLC38A8 solute carrier family 38, member 8 2.3351
ZNF575 zinc finger protein 575 2.3351
SCNN1A sodium channel, non voltage gated 1 alpha subunit 2.3351
IRF9 interferon regulatory factor 9 2.3351
UPP2 uridine phosphorylase 2 2.3351
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.3351
MCHR1 melanin-concentrating hormone receptor 1 2.3351
SLC35D3 solute carrier family 35, member D3 2.3351
DNAAF8 dynein axonemal assembly factor 8 2.3351
ADAT3 adenosine deaminase, tRNA-specific 3 2.3351
LTF lactotransferrin 2.3351
SOX21 SRY (sex determining region Y)-box 21 2.3351
PARN poly(A)-specific ribonuclease 2.3351
GPR146 G protein-coupled receptor 146 2.3351
TBC1D3L TBC1 domain family, member 3L 2.3351
ARSI arylsulfatase family, member I 2.3351
NKX3-1 NK3 homeobox 1 2.3351
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.3351
FAM187B family with sequence similarity 187, member B 2.32762
CFAP74 cilia and flagella associated protein 74 2.32762
ZACN zinc activated ligand-gated ion channel 2.32762
NKAPL NFKB activating protein-like 2.32762
GJA3 gap junction protein, alpha 3, 46kDa 2.32762
SIX2 SIX homeobox 2 2.32762
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.32762
FABP9 fatty acid binding protein 9, testis 2.32762
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.32762
CA7 carbonic anhydrase VII 2.32762
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.32762
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.32762
FGD2 FYVE, RhoGEF and PH domain containing 2 2.32762
SKOR2 SKI family transcriptional corepressor 2 2.32762
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.32762
GDNF glial cell derived neurotrophic factor 2.32762
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.32762
MYOM2 myomesin 2 2.32762
SLC23A3 solute carrier family 23, member 3 2.32762
TCAF2 TRPM8 channel-associated factor 2 2.32762
BSX brain-specific homeobox 2.32762
USP54 ubiquitin specific peptidase 54 2.32762
TNS4 tensin 4 2.32762
ARHGAP30 Rho GTPase activating protein 30 2.32762
PAX5 paired box 5 2.32762
WNT3A wingless-type MMTV integration site family, member 3A 2.32762
FAM180B family with sequence similarity 180, member B 2.32762
SERP1 stress-associated endoplasmic reticulum protein 1 2.32762
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.32762
KNG1 kininogen 1 2.32762
OR51G2 olfactory receptor, family 51, subfamily G, member 2 2.32762
GNLY granulysin 2.32762
AKR1C2 aldo-keto reductase family 1, member C2 2.32762
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.32762
FAM229A family with sequence similarity 229, member A 2.32762
IL15RA interleukin 15 receptor, alpha 2.32762
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.32762
CES4A carboxylesterase 4A 2.32762
RAG1 recombination activating gene 1 2.32762
CAPN3 calpain 3, (p94) 2.32762
RIPK4 receptor-interacting serine-threonine kinase 4 2.32762
PNLIPRP1 pancreatic lipase-related protein 1 2.32762
MOSPD2 motile sperm domain containing 2 2.32762
C9ORF40 chromosome 9 open reading frame 40 2.32762
CD48 CD48 molecule 2.32762
LEAP2 liver expressed antimicrobial peptide 2 2.32762
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.32762
STING1 stimulator of interferon response cGAMP interactor 1 2.32762
GMCL2 germ cell-less 2, spermatogenesis associated 2.32762
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.32762
SAXO5 stabilizer of axonemal microtubules 5 2.32762
CIMAP1A ciliary microtubule associated protein 1A 2.32762
EXOC1L exocyst complex component 1 like 2.32762
REELD1 reeler domain containing 1 2.32762
CATSPERZ catsper channel auxiliary subunit zeta 2.32762
CFAP100 cilia and flagella associated protein 100 2.32762
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.32762
MYOCOS myocilin opposite strand 2.32762
NBPF14 neuroblastoma breakpoint family, member 14 2.32762
SAG S-antigen; retina and pineal gland (arrestin) 2.32762
PRR18 proline rich 18 2.32762
RUNX2 runt-related transcription factor 2 2.32762
MYH15 myosin, heavy chain 15 2.32762
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.32762
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.32762
CHRD chordin 2.32762
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.32762
CLDN5 claudin 5 2.32762
TUBA3D tubulin, alpha 3d 2.32762
CCDC121 coiled-coil domain containing 121 2.32762
S100B S100 calcium binding protein B 2.32762
LRRC3C leucine rich repeat containing 3C 2.32762
RDH8 retinol dehydrogenase 8 (all-trans) 2.32762
MIOX myo-inositol oxygenase 2.32762
DOK7 docking protein 7 2.32762
ZNF705D zinc finger protein 705D 2.32762
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.32762
HNF1A HNF1 homeobox A 2.32762
PMP22 peripheral myelin protein 22 2.32762
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.32762
FMR1NB fragile X mental retardation 1 neighbor 2.32762
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.32762
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.32762
RGS11 regulator of G-protein signaling 11 2.32762
CDC20B cell division cycle 20B 2.32762
CTAGE15 CTAGE family, member 15 2.32762
MAMDC4 MAM domain containing 4 2.32762
BTNL9 butyrophilin-like 9 2.32762
KRT222 keratin 222, type II 2.32762
ANKRD61 ankyrin repeat domain 61 2.32762
RNFT1 ring finger protein, transmembrane 1 2.32762
FAM163A family with sequence similarity 163, member A 2.32762
ZNF703 zinc finger protein 703 2.32762
KRTAP5-11 keratin associated protein 5-11 2.32762
SLFN12L schlafen family member 12-like 2.32762
ZMYND15 zinc finger, MYND-type containing 15 2.32762
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.32762
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.32762
PMP2 peripheral myelin protein 2 2.32762
ALAS2 5'-aminolevulinate synthase 2 2.32762
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.32762
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.32762
ZNF132 zinc finger protein 132 2.32762
JSRP1 junctional sarcoplasmic reticulum protein 1 2.32762
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.32762
PTDSS1 phosphatidylserine synthase 1 2.32762
ILDR2 immunoglobulin-like domain containing receptor 2 2.32762
CTXN2 cortexin 2 2.32762
DMRT1 doublesex and mab-3 related transcription factor 1 2.32762
CSDC2 cold shock domain containing C2, RNA binding 2.32762
IGIP IgA-inducing protein 2.32762
CLUL1 clusterin-like 1 (retinal) 2.32762
IL27 interleukin 27 2.32762
LMX1B LIM homeobox transcription factor 1, beta 2.32762
ZCCHC18 zinc finger, CCHC domain containing 18 2.32762
DHH desert hedgehog 2.32762
CALHM3 calcium homeostasis modulator 3 2.32762
CPA2 carboxypeptidase A2 (pancreatic) 2.32762
CLEC4D C-type lectin domain family 4, member D 2.32762
PSKH2 protein serine kinase H2 2.32762
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.32762
FAM209A family with sequence similarity 209, member A 2.32762
CAGE1 cancer antigen 1 2.32762
BAHCC1 BAH domain and coiled-coil containing 1 2.32762
SHISA8 shisa family member 8 2.32762
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.32762
SHE Src homology 2 domain containing E 2.32762
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.32762
TLN1 talin 1 2.32762
GRM2 glutamate receptor, metabotropic 2 2.32762
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.32762
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.32762
ASCL2 achaete-scute family bHLH transcription factor 2 2.32762
MROH2A maestro heat-like repeat family member 2A 2.32762
LPA lipoprotein, Lp(a) 2.32762
EPHB3 EPH receptor B3 2.32762
NWD2 NACHT and WD repeat domain containing 2 2.32762
STEAP4 STEAP family member 4 2.32762
GPR101 G protein-coupled receptor 101 2.32762
TAS2R13 taste receptor, type 2, member 13 2.32762
CAPS calcyphosine 2.32762
ASGR2 asialoglycoprotein receptor 2 2.32762
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.32762
PODNL1 podocan-like 1 2.32762
PRDM8 PR domain containing 8 2.32762
PRDM1 PR domain containing 1, with ZNF domain 2.32762
MMP13 matrix metallopeptidase 13 2.32762
SHBG sex hormone-binding globulin 2.32762
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.32762
SLC7A4 solute carrier family 7, member 4 2.32762
AMER3 APC membrane recruitment protein 3 2.32762
ZNF534 zinc finger protein 534 2.32762
LPAR5 lysophosphatidic acid receptor 5 2.32762
TBC1D28 TBC1 domain family, member 28 2.32762
GLT6D1 glycosyltransferase 6 domain containing 1 2.32762
TSKS testis-specific serine kinase substrate 2.32762
IFNK interferon, kappa 2.32762
SDSL serine dehydratase-like 2.32762
TGM2 transglutaminase 2 2.32762
LAMP5 lysosomal-associated membrane protein family, member 5 2.32762
NTSR1 neurotensin receptor 1 (high affinity) 2.31239
SPOCD1 SPOC domain containing 1 2.31239
PTPRM protein tyrosine phosphatase, receptor type, M 2.31239
FAM131A family with sequence similarity 131, member A 2.30421
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.26874
ANAPC7 anaphase promoting complex subunit 7 2.25881
PTX3 pentraxin 3, long 2.24992
LDAH lipid droplet associated hydrolase 2.24812
MSRB3 methionine sulfoxide reductase B3 2.24079
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.23422
SEM1 SEM1 26S proteasome subunit 2.23416
PDE11A phosphodiesterase 11A 2.22145
DPEP3 dipeptidase 3 2.22145
MAGEL2 melanoma antigen family L2 2.22145
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 2.21777
MSN moesin 2.17314
ARL6 ADP-ribosylation factor-like 6 2.14268
CPE carboxypeptidase E 2.13409
KIAA2013 KIAA2013 2.12303
RPS27L ribosomal protein S27-like 2.07859
CLDN10 claudin 10 2.05936
L1TD1 LINE-1 type transposase domain containing 1 2.05936
SLC66A3 solute carrier family 66 member 3 2.04009
TMEM141 transmembrane protein 141 2.02039
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.02039
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.01013

decreased expression

Symbol Name Standardized Value
VIPR2 vasoactive intestinal peptide receptor 2 -2.3351
DSEL dermatan sulfate epimerase-like -2.3351
TBKBP1 TBK1 binding protein 1 -2.3351
IRS1 insulin receptor substrate 1 -2.3351
STK32A serine/threonine kinase 32A -2.3351
ZNF470 zinc finger protein 470 -2.32762
LRRN2 leucine rich repeat neuronal 2 -2.32762
LIMCH1 LIM and calponin homology domains 1 -2.32762
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.32762
ADGRL4 adhesion G protein-coupled receptor L4 -2.32762
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.32762
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.32762
ZNF157 zinc finger protein 157 -2.32762
DMRTA1 DMRT-like family A1 -2.32762
PPIF peptidylprolyl isomerase F -2.32762
DSCAM Down syndrome cell adhesion molecule -2.32762
BCL3 B-cell CLL/lymphoma 3 -2.32762
EMC6 ER membrane protein complex subunit 6 -2.32762
C21ORF91 chromosome 21 open reading frame 91 -2.32762
FAT2 FAT atypical cadherin 2 -2.32762
CPTP ceramide-1-phosphate transfer protein -2.32762
ATP2A3 ATPase, Ca++ transporting, ubiquitous -2.32762
CASR calcium-sensing receptor -2.32762
FEZF1 FEZ family zinc finger 1 -2.32762
ZNF304 zinc finger protein 304 -2.3261
RNF2 ring finger protein 2 -2.31239
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -2.30289
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.30289
RAD50 RAD50 homolog (S. cerevisiae) -2.29862
FBRSL1 fibrosin-like 1 -2.25526
IQCN IQ motif containing N -2.24812
MPP1 membrane protein, palmitoylated 1, 55kDa -2.24812
PKP1 plakophilin 1 -2.24812
SAMD14 sterile alpha motif domain containing 14 -2.24812
LINC02798 long intergenic non-protein coding RNA 2798 -2.24812
AZIN2 antizyme inhibitor 2 -2.24812
GHRHR growth hormone releasing hormone receptor -2.24812
CFAP99 cilia and flagella associated protein 99 -2.24812
EHD2 EH-domain containing 2 -2.24812
SOX7 SRY (sex determining region Y)-box 7 -2.24812
FCRL5 Fc receptor-like 5 -2.24812
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.24812
LRRC19 leucine rich repeat containing 19 -2.24812
INPP1 inositol polyphosphate-1-phosphatase -2.24812
CUX2 cut-like homeobox 2 -2.24812
DIABLO diablo, IAP-binding mitochondrial protein -2.24812
VMAC vimentin-type intermediate filament associated coiled-coil protein -2.24812
POTEI POTE ankyrin domain family, member I -2.24812
LGALS14 lectin, galactoside-binding, soluble, 14 -2.24812
DAPL1 death associated protein-like 1 -2.24812
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.24812
MLIP muscular LMNA-interacting protein -2.24812
COL27A1 collagen, type XXVII, alpha 1 -2.21927
BCR breakpoint cluster region -2.21777
CD320 CD320 molecule -2.20917
MYO5C myosin VC -2.20917
FEM1A fem-1 homolog a (C. elegans) -2.20917
COL6A6 collagen, type VI, alpha 6 -2.14641
PAQR8 progestin and adipoQ receptor family member VIII -2.09324
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.08911
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 -2.06894
COL13A1 collagen, type XIII, alpha 1 -2.06364
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -2.05368
WDR91 WD repeat domain 91 -2.04533
NBPF15 neuroblastoma breakpoint family, member 15 -2.04533
RPGRIP1L RPGRIP1-like -2.04009
PCYOX1 prenylcysteine oxidase 1 -2.03874
STK11IP serine/threonine kinase 11 interacting protein -2.03739
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.03739
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.03739
ALPK3 alpha-kinase 3 -2.02565
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.02039
PPME1 protein phosphatase methylesterase 1 -2.01441