IRS1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description insulin receptor substrate 1|This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] (NCBI Entrez Gene Database, 3667)
External Link http://www.ncbi.nlm.nih.gov/gene/3667
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Genes

355 interacting proteins for IRS1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APP amyloid beta (A4) precursor protein
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARF6 ADP-ribosylation factor 6
ARHGAP12 Rho GTPase activating protein 12
ARHGAP20 Rho GTPase activating protein 20
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATR ATR serine/threonine kinase
ATXN2L ataxin 2-like
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCR breakpoint cluster region
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
BUB3 BUB3 mitotic checkpoint protein
C11ORF84 chromosome 11 open reading frame 84
C1ORF116 chromosome 1 open reading frame 116
C1ORF27 chromosome 1 open reading frame 27
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD247 CD247 molecule
CD28 CD28 molecule
CD2AP CD2-associated protein
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD80 CD80 molecule
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK11A cyclin-dependent kinase 11A
CHD8 chromodomain helicase DNA binding protein 8
CHUK conserved helix-loop-helix ubiquitous kinase
CNTRL centriolin
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSK c-src tyrosine kinase
CSNK1D casein kinase 1, delta
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CSRP1 cysteine and glycine-rich protein 1
CTTN cortactin
CUL7 cullin 7
CUX1 cut-like homeobox 1
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DCAF7 DDB1 and CUL4 associated factor 7
DDR1 discoidin domain receptor tyrosine kinase 1
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DIAPH1 diaphanous-related formin 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DOCK4 dedicator of cytokinesis 4
DOCK5 dedicator of cytokinesis 5
DOCK9 dedicator of cytokinesis 9
DVL2 dishevelled segment polarity protein 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
ELMO2 engulfment and cell motility 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB2IP erbb2 interacting protein
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FBXO25 F-box protein 25
FBXW8 F-box and WD repeat domain containing 8
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FER fer (fps/fes related) tyrosine kinase
FES FES proto-oncogene, tyrosine kinase
FGD6 FYVE, RhoGEF and PH domain containing 6
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FGFR1OP2 FGFR1 oncogene partner 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FN1 fibronectin 1
FRS2 fibroblast growth factor receptor substrate 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GAREML GRB2 associated, regulator of MAPK1-like
GH1 growth hormone 1
GH2 growth hormone 2
GHR growth hormone receptor
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRAP2 GRB2-related adaptor protein 2
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRB2 growth factor receptor-bound protein 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HDAC2 histone deacetylase 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1B heat shock 70kDa protein 1B
HUNK hormonally up-regulated Neu-associated kinase
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2R insulin-like growth factor 2 receptor
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL11 interleukin 11
IL11RA interleukin 11 receptor, alpha
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL1A interleukin 1, alpha
IL2 interleukin 2
IL20RA interleukin 20 receptor, alpha
IL21 interleukin 21
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL9 interleukin 9
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSR insulin receptor
INSRR insulin receptor-related receptor
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIRREL kin of IRRE like (Drosophila)
KL klotho
KLB klotho beta
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEMD3 LEM domain containing 3
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRK2 leucine-rich repeat kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYCBP MYC binding protein
MYO18A myosin XVIIIA
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NGF nerve growth factor (beta polypeptide)
NISCH nischarin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRF1 nuclear respiratory factor 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OPA1 optic atrophy 1 (autosomal dominant)
PABPC1 poly(A) binding protein, cytoplasmic 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PHIP pleckstrin homology domain interacting protein
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP5C protein phosphatase 5, catalytic subunit
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PSPC1 paraspeckle component 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTK2 protein tyrosine kinase 2
PTK6 protein tyrosine kinase 6
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRU protein tyrosine phosphatase, receptor type, U
PXN paxillin
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RADIL Ras association and DIL domains
RBBP6 retinoblastoma binding protein 6
RHOA ras homolog family member A
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL3 ribosomal protein L3
RPL4 ribosomal protein L4
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
SACK1G scaffolding CK1 anchoring protein G
SFN stratifin
SH2B1 SH2B adaptor protein 1
SH2B2 SH2B adaptor protein 2
SH2D5 SH2 domain containing 5
SH3PXD2A SH3 and PX domains 2A
SH3PXD2B SH3 and PX domains 2B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SLA2 Src-like-adaptor 2
SLAIN2 SLAIN motif family, member 2
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNW1 SNW domain containing 1
SNX18 sorting nexin 18
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SORBS1 sorbin and SH3 domain containing 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
STAMBP STAM binding protein
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
SYNJ1 synaptojanin 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCP1 t-complex 1
TEC tec protein tyrosine kinase
TRIM24 tripartite motif containing 24
TSG101 tumor susceptibility 101
TTYH2 tweety family member 2
TUB tubby bipartite transcription factor
TXK TXK tyrosine kinase
TYK2 tyrosine kinase 2
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBC ubiquitin C
UBTF upstream binding transcription factor, RNA polymerase I
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WASL Wiskott-Aldrich syndrome-like
WDR44 WD repeat domain 44
WDR6 WD repeat domain 6
WDR77 WD repeat domain 77
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
WWP2 WW domain containing E3 ubiquitin protein ligase 2
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
YY1 YY1 transcription factor
ZFYVE9 zinc finger, FYVE domain containing 9
ZMYM2 zinc finger, MYM-type 2