ISG15 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description ISG15 ubiquitin-like modifier|The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] (NCBI Entrez Gene Database, 9636)
External Link https://ncbi.nlm.nih.gov/gene/9636
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Genes

499 genes differentially expressed following the ISG15 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 0.0278462
NELL2 NEL-like 2 (chicken) 0.0158409
ACAT2 acetyl-CoA acetyltransferase 2 0.0153221
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0139199
SFTPA2 surfactant protein A2 0.013899
ENO2 enolase 2 (gamma, neuronal) 0.0130717
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.0121628
RAB25 RAB25, member RAS oncogene family 0.0118033
RAD23B RAD23 homolog B (S. cerevisiae) 0.0117312
PRKCB protein kinase C, beta 0.011671
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0114785
KIF20A kinesin family member 20A 0.0114269
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0113388
IL2RG interleukin 2 receptor, gamma 0.0112516
SFTPC surfactant protein C 0.0106383
CD2 CD2 molecule 0.0105374
SFTPB surfactant protein B 0.0103759
LTB lymphotoxin beta (TNF superfamily, member 3) 0.0103484
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0102814
CDCA4 cell division cycle associated 4 0.0102385
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0100484
ALCAM activated leukocyte cell adhesion molecule 0.00989111
GLOD4 glyoxalase domain containing 4 0.00986048
PRKCA protein kinase C, alpha 0.00969034
SPRED2 sprouty-related, EVH1 domain containing 2 0.00962626
SORBS2 sorbin and SH3 domain containing 2 0.00961856
CIT citron rho-interacting serine/threonine kinase 0.00960838
PCP4 Purkinje cell protein 4 0.00944117
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.00934385
BIRC5 baculoviral IAP repeat containing 5 0.00920533
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.00919761
AKAP7 A kinase (PRKA) anchor protein 7 0.00918881
CRLF1 cytokine receptor-like factor 1 0.0091528
C3ORF14 chromosome 3 open reading frame 14 0.00908199
CD3D CD3d molecule, delta (CD3-TCR complex) 0.00895733
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.00892719
COG7 component of oligomeric golgi complex 7 0.00891141
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.00879733
WIF1 WNT inhibitory factor 1 0.0087788
SV2A synaptic vesicle glycoprotein 2A 0.00875615
FASN fatty acid synthase 0.00874671
CCNA2 cyclin A2 0.00867171
CHKB choline kinase beta 0.00867169
CCNB2 cyclin B2 0.00858754
SSBP3 single stranded DNA binding protein 3 0.00857973
RAPSN receptor-associated protein of the synapse 0.00857463
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.00856493
NUSAP1 nucleolar and spindle associated protein 1 0.00851299
NCAPD3 non-SMC condensin II complex, subunit D3 0.0084181
SDC2 syndecan 2 0.00841576
PGAM1 phosphoglycerate mutase 1 (brain) 0.00841128
BCLAF1 BCL2-associated transcription factor 1 0.00835122
ENO1 enolase 1, (alpha) 0.0082887
LIG1 ligase I, DNA, ATP-dependent 0.00827919
LMNB2 lamin B2 0.0082583
LMO3 LIM domain only 3 (rhombotin-like 2) 0.00825427
CDC45 cell division cycle 45 0.00820861
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 0.0081973
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.00819508
PCGF2 polycomb group ring finger 2 0.00815129
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.00814681
KIF11 kinesin family member 11 0.00800178
AMD1 adenosylmethionine decarboxylase 1 0.00799614
BCL7B B-cell CLL/lymphoma 7B 0.00795163
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.00793978
AUTS2 autism susceptibility candidate 2 0.0078801
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.00787803
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.00787439
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.00787032
LGALS2 lectin, galactoside-binding, soluble, 2 0.00785965
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.00785674
MCOLN1 mucolipin 1 0.00783461
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.0077971
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.00779184
RANBP1 RAN binding protein 1 0.0077843
RBMX RNA binding motif protein, X-linked 0.00775945
LMNB1 lamin B1 0.00775314
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.00773707
CCNF cyclin F 0.00773211
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 0.00772753
TRAF4 TNF receptor-associated factor 4 0.00771456
LYZ lysozyme 0.00770831
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.0076964
EPCAM epithelial cell adhesion molecule 0.00769588
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.00767754
HOXC10 homeobox C10 0.00766713
KIF15 kinesin family member 15 0.00763145
MAOA monoamine oxidase A 0.00762905
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.00761207
CPVL carboxypeptidase, vitellogenic-like 0.00759677
CD1E CD1e molecule 0.00757898
NME4 NME/NM23 nucleoside diphosphate kinase 4 0.00757658
LBR lamin B receptor 0.00756929
RRM1 ribonucleotide reductase M1 0.00754774
PDIA3 protein disulfide isomerase family A, member 3 0.00750457
TRMT5 tRNA methyltransferase 5 0.00747655
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.00743899
AARS1 alanyl-tRNA synthetase 1 0.00742877
SREBF2 sterol regulatory element binding transcription factor 2 0.00742043
HOXC6 homeobox C6 0.00741086
UNC13B unc-13 homolog B (C. elegans) 0.00733096
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.00732362
RACGAP1 Rac GTPase activating protein 1 0.00731446
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.0072692
GRK6 G protein-coupled receptor kinase 6 0.00725676
GSTT1 glutathione S-transferase theta 1 0.00724207
INSIG1 insulin induced gene 1 0.00723518
DEK DEK proto-oncogene 0.00722468
SLC2A4RG SLC2A4 regulator 0.00721722
CENPF centromere protein F, 350/400kDa 0.00720056
ELOVL6 ELOVL fatty acid elongase 6 0.00719718
ACACA acetyl-CoA carboxylase alpha 0.00719695
KIAA0226L KIAA0226-like 0.00719122
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.00716376
BPIFA1 BPI fold containing family A, member 1 0.00714052
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.00714012
MOXD1 monooxygenase, DBH-like 1 0.00713336
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.00712587
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.00711998
VWA1 von Willebrand factor A domain containing 1 0.00710593
IRX5 iroquois homeobox 5 0.00710174
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00710135
TTLL1 tubulin tyrosine ligase-like family member 1 0.00708336
FLRT3 fibronectin leucine rich transmembrane protein 3 0.00708331
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00704949
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.00703955
SELL selectin L 0.00703952
RERE arginine-glutamic acid dipeptide (RE) repeats 0.00702854
CD1B CD1b molecule 0.0070105
ALDOC aldolase C, fructose-bisphosphate 0.00701001
NTS neurotensin 0.00700895
DHCR7 7-dehydrocholesterol reductase 0.00700367
LPXN leupaxin 0.00699547
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.00698045
THYN1 thymocyte nuclear protein 1 0.00697842
CBX5 chromobox homolog 5 0.00697255
EPN2 epsin 2 0.00697088
OSBPL8 oxysterol binding protein-like 8 0.00695117
SALL2 spalt-like transcription factor 2 0.00694707
SVIL supervillin 0.00693993
CD1A CD1a molecule 0.00693381
ZDHHC4 zinc finger, DHHC-type containing 4 0.00693201
DCK deoxycytidine kinase 0.00689021
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.00688381
NPM3 nucleophosmin/nucleoplasmin 3 0.00687564
NREP neuronal regeneration related protein 0.0068726
NQO1 NAD(P)H dehydrogenase, quinone 1 0.00687162
OCRL oculocerebrorenal syndrome of Lowe 0.00686598
NOTCH3 notch 3 0.00684922
TLK1 tousled-like kinase 1 0.00684849
BARD1 BRCA1 associated RING domain 1 0.00684743
LRRN3 leucine rich repeat neuronal 3 0.00684367
CABIN1 calcineurin binding protein 1 0.00683993
THAP12 THAP domain containing 12 0.00682717
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.00681856
SEPTIN9 septin 9 0.00681651
TRAPPC3 trafficking protein particle complex 3 0.00680875
ACP6 acid phosphatase 6, lysophosphatidic 0.00679515
WNT5B wingless-type MMTV integration site family, member 5B 0.00678975
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.00678808
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.00678065
CETN2 centrin, EF-hand protein, 2 0.00673431
GDI2 GDP dissociation inhibitor 2 0.00672949
MMP12 matrix metallopeptidase 12 0.00672789
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.00672443
FGFR3 fibroblast growth factor receptor 3 0.00671609
RNASE6 ribonuclease, RNase A family, k6 0.00669489
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.00668894
CEP55 centrosomal protein 55kDa 0.00668224
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.00667968
CD200 CD200 molecule 0.00666577
BSPRY B-box and SPRY domain containing 0.00666533
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.006656
CPB1 carboxypeptidase B1 (tissue) 0.00665265
HAUS4 HAUS augmin-like complex, subunit 4 0.00661778
TSPYL5 TSPY-like 5 0.00661726
TNC tenascin C 0.00660232
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.00659413
OIP5 Opa interacting protein 5 0.0065799
PIMREG PICALM interacting mitotic regulator 0.00656407
GSTA4 glutathione S-transferase alpha 4 0.00655972
WWOX WW domain containing oxidoreductase 0.00655958
CUL4B cullin 4B 0.00655221
IQCE IQ motif containing E 0.00654886
ADK adenosine kinase 0.00654485
SIRT3 sirtuin 3 0.00654401
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.00653443
NDRG3 NDRG family member 3 0.0065283
SCAMP1 secretory carrier membrane protein 1 0.00651604
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.00651233
UNC119B unc-119 homolog B (C. elegans) 0.00650389
KIFC1 kinesin family member C1 0.00650364
HMGB2 high mobility group box 2 0.00649375
SHTN1 shootin 1 0.00649121
CCNB1 cyclin B1 0.00647997
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.00647871
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.00647322
ADRA2A adrenoceptor alpha 2A 0.00647165
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 0.00647005
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.00645589
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.00642686
ZNF266 zinc finger protein 266 0.00642107
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.00641469
SPC25 SPC25, NDC80 kinetochore complex component 0.00640707
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.00639142
GPR183 G protein-coupled receptor 183 0.006363
H2AX H2A.X variant histone 0.00635945
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.00635203
FOXM1 forkhead box M1 0.00635076
CD1C CD1c molecule 0.00634642
DHFR dihydrofolate reductase 0.00634436
MAPK1 mitogen-activated protein kinase 1 0.00633839
CA9 carbonic anhydrase IX 0.00633671
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00633366
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.00633181
DCXR dicarbonyl/L-xylulose reductase 0.00633139
FCMR Fc fragment of IgM receptor 0.00632052
ESRP2 epithelial splicing regulatory protein 2 0.00631675
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.00631268
FKBP10 FK506 binding protein 10, 65 kDa 0.00629867
TMC5 transmembrane channel-like 5 0.00629801
PRUNE1 prune exopolyphosphatase 1 0.00628784
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.00627758
FANCL Fanconi anemia, complementation group L 0.00627377
KIF1B kinesin family member 1B 0.00626536
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.00624203
CEMIP cell migration inducing protein, hyaluronan binding 0.00623745
GRAMD4 GRAM domain containing 4 0.00622588
PFKL phosphofructokinase, liver 0.00622366
LTA4H leukotriene A4 hydrolase 0.0062084
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.00620631
DHCR24 24-dehydrocholesterol reductase 0.00619685
NIPSNAP2 nipsnap homolog 2 0.00619399
CDK1 cyclin-dependent kinase 1 0.00618734
CBR3 carbonyl reductase 3 0.00618397
CAND1 cullin-associated and neddylation-dissociated 1 0.00618341
PRUNE2 prune homolog 2 (Drosophila) 0.0061773
FLOT2 flotillin 2 0.00617015
TYRO3 TYRO3 protein tyrosine kinase 0.00616657
CNPY3 canopy FGF signaling regulator 3 0.00615904
SEC23A Sec23 homolog A (S. cerevisiae) 0.00614422
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.00614251
PKP4 plakophilin 4 0.00613454
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.00613395
HMGN2 high mobility group nucleosomal binding domain 2 0.00612952
RETREG1 reticulophagy regulator 1 0.00612576
NPAT nuclear protein, ataxia-telangiectasia locus 0.00612547
CES1 carboxylesterase 1 0.00611826
ATXN10 ataxin 10 0.0061057
CXCR4 chemokine (C-X-C motif) receptor 4 0.00610546

decreased expression

Symbol Name Standardized Value
FABP4 fatty acid binding protein 4, adipocyte -0.025254
IFI27 interferon, alpha-inducible protein 27 -0.0231385
HSPA1A heat shock 70kDa protein 1A -0.0199095
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.0177806
ADIRF adipogenesis regulatory factor -0.0172214
IFI6 interferon, alpha-inducible protein 6 -0.0170351
CLU clusterin -0.0166431
CX3CR1 chemokine (C-X3-C motif) receptor 1 -0.0150238
PDGFD platelet derived growth factor D -0.0148067
LRRC17 leucine rich repeat containing 17 -0.0147629
C3 complement component 3 -0.0147483
KRT23 keratin 23, type I -0.0144397
ASS1 argininosuccinate synthase 1 -0.0141074
CA2 carbonic anhydrase II -0.0141007
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -0.0140428
ISG15 ISG15 ubiquitin-like modifier -0.0139265
IFI44L interferon-induced protein 44-like -0.0138462
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0138193
HIST1H2BD histone cluster 1, H2bd -0.0136999
SCGB2A1 secretoglobin, family 2A, member 1 -0.0136804
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.0136141
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0136099
MFAP5 microfibrillar associated protein 5 -0.0136076
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) -0.0133967
HMOX1 heme oxygenase 1 -0.0132943
SLPI secretory leukocyte peptidase inhibitor -0.0132731
RTN2 reticulon 2 -0.0131589
HIST1H2AC histone cluster 1, H2ac -0.0130839
WDR7 WD repeat domain 7 -0.0130485
PDGFRL platelet-derived growth factor receptor-like -0.0128723
LMO2 LIM domain only 2 (rhombotin-like 1) -0.0127242
MT1X metallothionein 1X -0.0124888
MMP1 matrix metallopeptidase 1 -0.0124886
TRIM22 tripartite motif containing 22 -0.0123084
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.0122694
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0122305
ASPN asporin -0.0121827
DCN decorin -0.0121635
FTH1 ferritin, heavy polypeptide 1 -0.0121128
ACKR3 atypical chemokine receptor 3 -0.0120363
SNAI2 snail family zinc finger 2 -0.012022
PLAAT3 phospholipase A and acyltransferase 3 -0.0120015
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0119991
TNS3 tensin 3 -0.0119981
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.0119965
TNNT1 troponin T type 1 (skeletal, slow) -0.011986
SPINK1 serine peptidase inhibitor, Kazal type 1 -0.0119832
MT1E metallothionein 1E -0.0119378
AMIGO2 adhesion molecule with Ig-like domain 2 -0.0119232
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0119231
RND3 Rho family GTPase 3 -0.0118894
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0118318
KLF5 Kruppel-like factor 5 (intestinal) -0.0117786
NNMT nicotinamide N-methyltransferase -0.0117703
MIR22HG MIR22 host gene -0.0116794
CXCL14 chemokine (C-X-C motif) ligand 14 -0.0116332
AREG amphiregulin -0.0115956
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0115197
CD163 CD163 molecule -0.0115044
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0114928
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0114046
H1-2 H1.2 linker histone, cluster member -0.0113856
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0113811
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.011299
CXCL10 chemokine (C-X-C motif) ligand 10 -0.0112911
L1CAM L1 cell adhesion molecule -0.0112615
KRT14 keratin 14, type I -0.0112287
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.0111542
MAGEA3 melanoma antigen family A3 -0.0111415
HSPB8 heat shock 22kDa protein 8 -0.0111317
SGK1 serum/glucocorticoid regulated kinase 1 -0.0110779
SFRP1 secreted frizzled-related protein 1 -0.0110582
RGS5 regulator of G-protein signaling 5 -0.010982
AQP1 aquaporin 1 (Colton blood group) -0.0109489
MVP major vault protein -0.0109223
LXN latexin -0.0108773
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.010779
EGR1 early growth response 1 -0.0107696
NRCAM neuronal cell adhesion molecule -0.0107243
CD93 CD93 molecule -0.0106905
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.0105784
FN1 fibronectin 1 -0.0104653
MYBPC1 myosin binding protein C, slow type -0.0104612
GJA1 gap junction protein, alpha 1, 43kDa -0.0104558
PSCA prostate stem cell antigen -0.0104504
CFD complement factor D (adipsin) -0.0104497
SGCE sarcoglycan, epsilon -0.010351
RHOBTB3 Rho-related BTB domain containing 3 -0.0102845
CST1 cystatin SN -0.0102792
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0102476
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0101752
LUM lumican -0.0101613
NUAK1 NUAK family, SNF1-like kinase, 1 -0.0101106
GPX1 glutathione peroxidase 1 -0.0100878
FHL2 four and a half LIM domains 2 -0.0100439
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00996371
BTG2 BTG family, member 2 -0.00994624
FNDC3B fibronectin type III domain containing 3B -0.0098531
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00976447
KLHL41 kelch-like family member 41 -0.00966655
C1S complement component 1, s subcomponent -0.00965902
TAGLN transgelin -0.00965597
S100A8 S100 calcium binding protein A8 -0.00964725
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -0.00955644
PLK2 polo-like kinase 2 -0.00954137
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.00953186
SLC38A1 solute carrier family 38, member 1 -0.00951543
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -0.00950297
KRT17 keratin 17, type I -0.00949483
STC2 stanniocalcin 2 -0.00947742
PLAU plasminogen activator, urokinase -0.00946551
PRSS23 protease, serine, 23 -0.00946312
CFB complement factor B -0.00946185
LIMS1 LIM and senescent cell antigen-like domains 1 -0.00943817
PARP12 poly (ADP-ribose) polymerase family, member 12 -0.00938062
TAC1 tachykinin, precursor 1 -0.00936804
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.00936669
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.00933021
MECOM MDS1 and EVI1 complex locus -0.00927157
GREM1 gremlin 1, DAN family BMP antagonist -0.00926933
CRYAB crystallin, alpha B -0.00926509
MXRA5 matrix-remodelling associated 5 -0.00925487
HIST1H2BK histone cluster 1, H2bk -0.00921308
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -0.00919606
MT1G metallothionein 1G -0.00919001
COL3A1 collagen, type III, alpha 1 -0.00915418
TM4SF1 transmembrane 4 L six family member 1 -0.00911333
RFTN1 raftlin, lipid raft linker 1 -0.00911319
SPARCL1 SPARC-like 1 (hevin) -0.00908976
HSPB1 heat shock 27kDa protein 1 -0.00908202
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -0.00907741
ZNF91 zinc finger protein 91 -0.00906056
VSIG4 V-set and immunoglobulin domain containing 4 -0.00905412
TMEM176B transmembrane protein 176B -0.00903889
MOSPD1 motile sperm domain containing 1 -0.00901364
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -0.00899291
FKBP11 FK506 binding protein 11, 19 kDa -0.00897956
MITF microphthalmia-associated transcription factor -0.00897299
DUSP7 dual specificity phosphatase 7 -0.00897029
MT1H metallothionein 1H -0.00896419
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -0.0089457
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.00892048
RAB9A RAB9A, member RAS oncogene family -0.00891774
ZCCHC2 zinc finger, CCHC domain containing 2 -0.00890417
MAP3K7CL MAP3K7 C-terminal like -0.00888936
EGR3 early growth response 3 -0.00887033
TNNC1 troponin C type 1 (slow) -0.00883389
F13A1 coagulation factor XIII, A1 polypeptide -0.00880961
STOM stomatin -0.00880489
THBS2 thrombospondin 2 -0.00879087
E2F2 E2F transcription factor 2 -0.00878201
C8ORF4 chromosome 8 open reading frame 4 -0.00877246
CCL8 chemokine (C-C motif) ligand 8 -0.008757
EHD3 EH-domain containing 3 -0.00875064
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.00871474
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.00870391
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.00870134
LEPROT leptin receptor overlapping transcript -0.00868331
COL5A2 collagen, type V, alpha 2 -0.00867497
CD36 CD36 molecule (thrombospondin receptor) -0.0086693
ADIPOQ adiponectin, C1Q and collagen domain containing -0.00863312
CFH complement factor H -0.00862421
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) -0.00861646
EGFL6 EGF-like-domain, multiple 6 -0.00860499
SRPX sushi-repeat containing protein, X-linked -0.0085388
IRF7 interferon regulatory factor 7 -0.00852606
CD14 CD14 molecule -0.0085036
FSTL1 follistatin-like 1 -0.00848561
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.00847589
S100A9 S100 calcium binding protein A9 -0.00846477
CLIC5 chloride intracellular channel 5 -0.00844816
S100A2 S100 calcium binding protein A2 -0.00844595
COL15A1 collagen, type XV, alpha 1 -0.00844026
CPM carboxypeptidase M -0.00843899
INHBB inhibin, beta B -0.00842372
MET MET proto-oncogene, receptor tyrosine kinase -0.00840965
MYOT myotilin -0.00840419
CAV1 caveolin 1, caveolae protein, 22kDa -0.00838638
FMO1 flavin containing monooxygenase 1 -0.00838623
INHBE inhibin, beta E -0.008386
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.00837561
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.00837211
HSPA2 heat shock 70kDa protein 2 -0.00836208
RRAD Ras-related associated with diabetes -0.00834491
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.00833559
CCL2 chemokine (C-C motif) ligand 2 -0.00832022
CYB5R1 cytochrome b5 reductase 1 -0.00827793
RGS13 regulator of G-protein signaling 13 -0.0082753
SOD2 superoxide dismutase 2, mitochondrial -0.00826427
ZFHX4 zinc finger homeobox 4 -0.00825037
PALMD palmdelphin -0.00824905
OLFML2A olfactomedin-like 2A -0.00824378
RGS16 regulator of G-protein signaling 16 -0.00823267
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.00822633
MT1HL1 metallothionein 1H-like 1 -0.00822568
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.00822184
PROCR protein C receptor, endothelial -0.00815236
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.00814108
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00812513
IL6 interleukin 6 -0.00809119
CCNG2 cyclin G2 -0.00807284
SFRP4 secreted frizzled-related protein 4 -0.00806851
MTUS1 microtubule associated tumor suppressor 1 -0.00805396
IFITM1 interferon induced transmembrane protein 1 -0.00804832
MYOZ2 myozenin 2 -0.00804696
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.00802525
SLC31A2 solute carrier family 31 (copper transporter), member 2 -0.00801636
DUSP6 dual specificity phosphatase 6 -0.00798828
CTSL cathepsin L -0.00798087
MB myoglobin -0.00797762
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -0.00796782
MYL2 myosin, light chain 2, regulatory, cardiac, slow -0.0079558
FABP5 fatty acid binding protein 5 (psoriasis-associated) -0.00793944
ELOB elongin B -0.00789437
IL18 interleukin 18 -0.00788467
ASPA aspartoacylase -0.00788287
TPBG trophoblast glycoprotein -0.00786961
MYOF myoferlin -0.0078673
CP ceruloplasmin (ferroxidase) -0.00786516
MXI1 MAX interactor 1, dimerization protein -0.00785763
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0078173
RET ret proto-oncogene -0.00780972
CXCL5 chemokine (C-X-C motif) ligand 5 -0.00778913
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -0.00777811
FOXO1 forkhead box O1 -0.00776856
GAS1 growth arrest-specific 1 -0.00775697
IER5 immediate early response 5 -0.00774893
SPP1 secreted phosphoprotein 1 -0.00774518
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00774125
PPL periplakin -0.00773845
ZBED2 zinc finger, BED-type containing 2 -0.00769957
CRCT1 cysteine-rich C-terminal 1 -0.00769558
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -0.00767114
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.00765847
LOXL2 lysyl oxidase-like 2 -0.00764669
PITX3 paired-like homeodomain 3 -0.00763308
PPIF peptidylprolyl isomerase F -0.00763155
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00762438
IL1RN interleukin 1 receptor antagonist -0.00761299
IL32 interleukin 32 -0.00759904
MX1 MX dynamin-like GTPase 1 -0.00757461
HBP1 HMG-box transcription factor 1 -0.00756758
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.00756283
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.00755472
SLN sarcolipin -0.00752931
PLTP phospholipid transfer protein -0.00752606
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.00752192
RBM34 RNA binding motif protein 34 -0.00751408
LGI1 leucine-rich, glioma inactivated 1 -0.00751215